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PDB: 67 件
1MH1
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SMALL G-PROTEIN
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, RAC1
著者Hirshberg, M, Stockley, R.W, Dodson, G, Webb, M.R.
登録日1997-01-21
公開日1998-01-21
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue.
Nat.Struct.Biol., 4, 1997
6X1G
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BU of 6x1g by Molmil
Crystal structure of a GEF domain from the Orientia tsutsugamushi protein OtDUB in complex with Rac1
分子名称: MAGNESIUM ION, Ras-related C3 botulinum toxin substrate 1, ULP_PROTEASE domain-containing protein
著者Lim, C.S, Xiong, Y.
登録日2020-05-18
公開日2020-11-25
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structure of a guanine nucleotide exchange factor encoded by the scrub typhus pathogen Orientia tsutsugamushi .
Proc.Natl.Acad.Sci.USA, 117, 2020
2WKQ
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Structure of a photoactivatable Rac1 containing the Lov2 C450A Mutant
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, FLAVIN MONONUCLEOTIDE, ...
著者Wu, Y.I, Frey, D, Lungu, O.I, Jaehrig, A, Schlichting, I, Kuhlman, B, Hahn, K.M.
登録日2009-06-16
公開日2009-08-18
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献A Genetically Encoded Photoactivatable Rac Controls the Motility of Living Cells.
Nature, 461, 2009
5O33
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BU of 5o33 by Molmil
A structure of the GEF Kalirin DH1 domain in complex with the small GTPase Rac1
分子名称: 1,2-ETHANEDIOL, GUANOSINE-5'-DIPHOSPHATE, Kalirin, ...
著者Gray, J, Krojer, T, Talon, R, Fairhead, M, Bountra, C, Arrowsmith, C.H, Edwards, A, Brennan, P, von Delft, F.
登録日2017-05-23
公開日2017-05-31
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献A structure of the GEF Kalirin DH1 domain in complex with the small GTPase Rac1
To Be Published
8I5V
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BU of 8i5v by Molmil
DOCK10 mutant L1903Y complexed with Rac1
分子名称: Dedicator of cytokinesis protein 10, Ras-related C3 botulinum toxin substrate 1, SULFATE ION
著者Kukimoto-Niino, M, Mishima-Tsumagari, C, Ihara, K, Fukui, Y, Yokoyama, S, Shirouzu, M.
登録日2023-01-26
公開日2023-03-15
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.726 Å)
主引用文献Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor.
Biochem.Biophys.Res.Commun., 653, 2023
1RYH
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Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ras-related C3 botulinum toxin substrate 1 isoform Rac1b
著者Ahmadian, M.R, Fiegen, D.
登録日2003-12-22
公開日2004-01-27
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase
J.Biol.Chem., 279, 2004
1RYF
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Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ras-related C3 botulinum toxin substrate 1 isoform Rac1b
著者Ahmadian, M.R, Fiegen, D.
登録日2003-12-22
公開日2004-01-27
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase
J.Biol.Chem., 279, 2004
2VRW
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BU of 2vrw by Molmil
Critical structural role for the PH and C1 domains of the Vav1 exchange factor
分子名称: PROTO-ONCOGENE VAV, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1, ZINC ION
著者Rapley, J, Tybulewicz, V, Rittinger, K.
登録日2008-04-16
公開日2008-06-17
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crucial Structural Role for the Ph and C1 Domains of the Vav1 Exchange Factor.
Embo Rep., 9, 2008
2P2L
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Rac1-GDP-Zinc Complex
分子名称: GUANOSINE-5'-DIPHOSPHATE, Ras-related C3 botulinum toxin substrate 1, ZINC ION
著者Prehna, G, Stebbins, C.E.
登録日2007-03-07
公開日2007-05-01
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A Rac1-GDP trimer complex binds zinc with tetrahedral and octahedral coordination, displacing magnesium.
Acta Crystallogr.,Sect.D, 63, 2007
2WKP
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Structure of a photoactivatable Rac1 containing Lov2 Wildtype
分子名称: CALCIUM ION, FLAVIN MONONUCLEOTIDE, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Wu, Y.I, Frey, D, Lungu, O.I, Jaehrig, A, Schlichting, I, Kuhlman, B, Hahn, K.M.
登録日2009-06-16
公開日2009-08-18
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A Genetically Encoded Photoactivatable Rac Controls the Motility of Living Cells.
Nature, 461, 2009
5QQJ
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PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-009-587-558
分子名称: 1,2-ETHANEDIOL, Kalirin, N-{1-[(imidazo[1,2-a]pyridin-2-yl)methyl]-1H-pyrazol-4-yl}-N'-(5-methyl-1,2-oxazol-3-yl)urea, ...
著者Gray, J.L, Krojer, T, Talon, R, Douangamath, A, Jimenez Antunez, C, Bountra, C, Arrowsmith, C.H, Edwards, A, Brennan, P.E, von Delft, F.
登録日2019-05-03
公開日2019-12-18
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献PanDDA analysis group deposition
To Be Published
5QQD
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PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with Z56880342
分子名称: 1,2-ETHANEDIOL, Kalirin, N-ethyl-N'-(5-methyl-1,2-oxazol-3-yl)urea, ...
著者Gray, J.L, Krojer, T, Talon, R, Douangamath, A, Jimenez Antunez, C, Bountra, C, Arrowsmith, C.H, Edwards, A, Brennan, P.E, von Delft, F.
登録日2019-05-03
公開日2019-12-18
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献PanDDA analysis group deposition
To Be Published
5QQE
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PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-009-531-494
分子名称: 1,2-ETHANEDIOL, Kalirin, N-(5-methyl-1,2-oxazol-3-yl)-N'-[(3S)-4,4,4-trifluoro-3-hydroxy-3-(5-methylfuran-2-yl)butyl]urea, ...
著者Gray, J.L, Krojer, T, Talon, R, Douangamath, A, Jimenez Antunez, C, Bountra, C, Arrowsmith, C.H, Edwards, A, Brennan, P.E, von Delft, F.
登録日2019-05-03
公開日2019-12-18
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献PanDDA analysis group deposition
To Be Published
4YON
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BU of 4yon by Molmil
P-Rex1:Rac1 complex
分子名称: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1
著者Lucato, C.M, Whisstock, J.C, Ellisdon, A.M.
登録日2015-03-11
公開日2015-07-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.
J.Biol.Chem., 290, 2015
2NZ8
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BU of 2nz8 by Molmil
N-terminal DHPH cassette of Trio in complex with nucleotide-free Rac1
分子名称: ras-related C3 botulinum toxin substrate 1 isoform Rac1, triple functional domain protein
著者Chhatriwala, M.K, Betts, L, Worthylake, D.K, Sondek, J.
登録日2006-11-22
公開日2007-04-10
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation
J.Mol.Biol., 368, 2007
5QU9
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BU of 5qu9 by Molmil
PanDDA analysis group deposition of ground-state model of Kalirin/Rac1 screened against a customized urea fragment library by X-ray Crystallography at the XChem facility of Diamond Light Source beamline I04-1
分子名称: 1,2-ETHANEDIOL, Kalirin, Ras-related C3 botulinum toxin substrate 1
著者Gray, J.L, Krojer, T, Talon, R, Douangamath, A, Jimenez Antunez, C, Bountra, C, Arrowsmith, C.H, Edwards, A, Brennan, P.E, von Delft, F.
登録日2019-12-13
公開日2020-01-29
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献PanDDA analysis group deposition of ground-state model
To Be Published
4GZL
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BU of 4gzl by Molmil
Crystal structure of RAC1 Q61L mutant
分子名称: ISOPROPYL ALCOHOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Ha, B.H, Boggon, T.J.
登録日2012-09-06
公開日2012-12-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献RAC1P29S is a spontaneously activating cancer-associated GTPase.
Proc.Natl.Acad.Sci.USA, 110, 2013
1HE1
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BU of 1he1 by Molmil
Crystal structure of the complex between the GAP domain of the Pseudomonas aeruginosa ExoS toxin and human Rac
分子名称: ALUMINUM FLUORIDE, EXOENZYME S, GUANOSINE-5'-DIPHOSPHATE, ...
著者Wurtele, M, Wolf, E, Pederson, K.J, Buchwald, G, Ahmadian, M.R, Barbieri, J.T, Wittinghofer, A.
登録日2000-11-18
公開日2001-01-02
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献How the Pseudomonas Aeruginosa Exos Toxin Downregulates Rac
Nat.Struct.Biol., 8, 2001
5QQM
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BU of 5qqm by Molmil
PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-009-565-325
分子名称: 1,2-ETHANEDIOL, Kalirin, N-(1-benzyl-1H-pyrazol-4-yl)-N'-(5-methyl-1,2-oxazol-3-yl)urea, ...
著者Gray, J.L, Krojer, T, Talon, R, Douangamath, A, Jimenez Antunez, C, Bountra, C, Arrowsmith, C.H, Edwards, A, Brennan, P.E, von Delft, F.
登録日2019-05-03
公開日2019-12-18
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献PanDDA analysis group deposition
To Be Published
5QQI
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BU of 5qqi by Molmil
PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-009-178-994
分子名称: 1,2-ETHANEDIOL, Kalirin, N-[3-(methoxymethyl)phenyl]-N'-(5-methyl-1,2-oxazol-3-yl)urea, ...
著者Gray, J.L, Krojer, T, Talon, R, Douangamath, A, Jimenez Antunez, C, Bountra, C, Arrowsmith, C.H, Edwards, A, Brennan, P.E, von Delft, F.
登録日2019-05-03
公開日2019-12-18
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献PanDDA analysis group deposition
To Be Published
5QQH
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BU of 5qqh by Molmil
PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-020-096-465
分子名称: 1,2-ETHANEDIOL, Kalirin, N-methyl-5-({[(5-methyl-1,2-oxazol-3-yl)carbamoyl]amino}methyl)thiophene-2-sulfonamide, ...
著者Gray, J.L, Krojer, T, Talon, R, Douangamath, A, Jimenez Antunez, C, Bountra, C, Arrowsmith, C.H, Edwards, A, Brennan, P.E, von Delft, F.
登録日2019-05-03
公開日2019-12-18
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献PanDDA analysis group deposition
To Be Published
3SBD
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BU of 3sbd by Molmil
Crystal structure of RAC1 P29S mutant
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related C3 botulinum toxin substrate 1
著者Ha, B.H, Boggon, T.J.
登録日2011-06-03
公開日2012-07-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Nat.Genet., 44, 2012
2WKR
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BU of 2wkr by Molmil
Structure of a photoactivatable Rac1 containing the Lov2 C450M Mutant
分子名称: CHLORIDE ION, FLAVIN MONONUCLEOTIDE, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Wu, Y.I, Frey, D, Lungu, O.I, Jaehrig, A, Schlichting, I, Kuhlman, B, Hahn, K.M.
登録日2009-06-16
公開日2009-08-18
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献A Genetically Encoded Photoactivatable Rac Controls the Motility of Living Cells.
Nature, 461, 2009
2FJU
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Activated Rac1 bound to its effector phospholipase C beta 2
分子名称: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, CALCIUM ION, ...
著者Jezyk, M.R, Snyder, J.T, Harden, T.K, Sondek, J.
登録日2006-01-03
公開日2006-11-21
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of Rac1 bound to its effector phospholipase C-beta2.
Nat.Struct.Mol.Biol., 13, 2006
5QQG
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PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-009-541-216
分子名称: 1,2-ETHANEDIOL, Kalirin, N-(5-methyl-1,2-oxazol-3-yl)-N'-[3-(4-phenylpiperazin-1-yl)propyl]urea, ...
著者Gray, J.L, Krojer, T, Talon, R, Douangamath, A, Jimenez Antunez, C, Bountra, C, Arrowsmith, C.H, Edwards, A, Brennan, P.E, von Delft, F.
登録日2019-05-03
公開日2019-12-18
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献PanDDA analysis group deposition
To Be Published

 

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