6F59
 
 | | Crystal structure of human Brachyury (T) G177D variant in complex with DNA | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Brachyury protein, DNA (26-MER), ... | | 著者 | Newman, J.A, Gavard, A.E, Krojer, T, Shrestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | | 登録日 | 2017-12-01 | | 公開日 | 2017-12-13 | | 最終更新日 | 2025-02-26 | | 実験手法 | X-RAY DIFFRACTION (2.151 Å) | | 主引用文献 | Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy.
Nat Commun, 16, 2025
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8A10
 | | Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-020-049-143 | | 分子名称: | 5-[[(3S)-1-(2-chlorophenyl)-2-oxidanylidene-pyrrolidin-3-yl]amino]-2-methyl-benzamide, T-box transcription factor T | | 著者 | Newman, J.A, Gavard, A, Aitkenhead, H, Imprachim, N, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Bountra, C, Gileadi, O. | | 登録日 | 2022-05-30 | | 公開日 | 2022-07-13 | | 最終更新日 | 2025-02-26 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy.
Nat Commun, 16, 2025
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6F58
 | | Crystal structure of human Brachyury (T) in complex with DNA | | 分子名称: | Brachyury protein, DNA (5'-D(*AP*AP*TP*TP*TP*CP*AP*CP*AP*CP*CP*TP*AP*GP*GP*TP*GP*TP*GP*AP*AP*AP*TP*T)-3'), SODIUM ION | | 著者 | Newman, J.A, Gavard, A.E, Krojer, T, Shrestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | | 登録日 | 2017-12-01 | | 公開日 | 2017-12-13 | | 最終更新日 | 2025-02-26 | | 実験手法 | X-RAY DIFFRACTION (2.253 Å) | | 主引用文献 | Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy.
Nat Commun, 16, 2025
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8CDN
 | | Crystal structure of human Brachyury in complex with a single T box binding element DNA | | 分子名称: | DNA (5'-D(*AP*GP*GP*CP*TP*CP*AP*CP*AP*CP*CP*T)-3'), DNA (5'-D(*AP*GP*GP*TP*GP*TP*GP*AP*GP*CP*CP*T)-3'), T-box transcription factor T | | 著者 | Newman, J.A, Gavard, A.E, von Delft, F, Gileadi, O, Bountra, C. | | 登録日 | 2023-01-31 | | 公開日 | 2023-03-22 | | 最終更新日 | 2025-02-26 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy.
Nat Commun, 16, 2025
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7ZL2
 | | Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-039-246-810 | | 分子名称: | (3S)-1-(3-aminocarbonylphenyl)carbonyl-2,3-dihydroindole-3-carboxylic acid, T-box transcription factor T | | 著者 | Newman, J.A, Gavard, A, Aitkenhead, H, Imprachim, N, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Bountra, C, Gileadi, O. | | 登録日 | 2022-04-13 | | 公開日 | 2022-06-22 | | 最終更新日 | 2025-02-26 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy.
Nat Commun, 16, 2025
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7ZK2
 | | Crystal Structure of human Brachyury G177D variant in complex with CSC027898502 | | 分子名称: | N-[4-(2-morpholin-4-yl-1,3-thiazol-4-yl)phenyl]ethanamide, PHOSPHATE ION, T-box transcription factor T | | 著者 | Newman, J.A, Gavard, A, Aitkenhead, H, Imprachim, N, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Bountra, C, Gileadi, O. | | 登録日 | 2022-04-12 | | 公開日 | 2022-06-22 | | 最終更新日 | 2025-02-26 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy.
Nat Commun, 16, 2025
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7ZKF
 | | Crystal Structure of human Brachyury G177D variant in complex with CF-5-86 | | 分子名称: | N-(4-((2-fluorophenyl)(hydroxy)methyl)phenyl)acetamide, PHOSPHATE ION, T-box transcription factor T | | 著者 | Newman, J.A, Gavard, A, Aitkenhead, H, Imprachim, N, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Bountra, C, Gileadi, O. | | 登録日 | 2022-04-12 | | 公開日 | 2022-06-22 | | 最終更新日 | 2025-02-26 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy.
Nat Commun, 16, 2025
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8A7N
 | | Crystal Structure of human Brachyury G177D variant in complex with (S)-N-(3-aminopropyl)-3-((1-(2-fluorophenyl)-2-oxopyrrolidin-3-yl)amino)-N-methylbenzamide (CF-2-125) | | 分子名称: | N-(3-azanylpropyl)-3-[[(3S)-1-(2-fluorophenyl)-2-oxidanylidene-pyrrolidin-3-yl]amino]-N-methyl-benzamide, PHOSPHATE ION, T-box transcription factor T | | 著者 | Newman, J.A, Gavard, A, Aitkenhead, H, Imprachim, N, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Bountra, C, Gileadi, O. | | 登録日 | 2022-06-21 | | 公開日 | 2022-10-05 | | 最終更新日 | 2025-02-26 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy.
Nat Commun, 16, 2025
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