PDB: 142 resultsInfo pagesStatus searchChemie searchBIRD

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1OQA	Solution structure of the BRCT-c domain from human BRCA1 Descriptor: Breast cancer type 1 susceptibility protein Authors: Gaiser, O.J, Ball, L.J, Schmieder, P, Leitner, D, Strauss, H, Wahl, M, Kuhne, R, Oschkinat, H, Heinemann, U. Deposit date: 2003-03-07 Release date: 2004-06-15 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Solution structure, backbone dynamics, and association behavior of the C-terminal BRCT domain from the breast cancer-associated protein BRCA1. Biochemistry, 43, 2004
6RML	Crystal structure of TOPBP1 BRCT0,1,2 in complex with a 53BP1 phosphopeptide Descriptor: 53BP1, DNA topoisomerase 2-binding protein 1 Authors: Day, M, Oliver, A.W, Pearl, L.H. Deposit date: 2019-05-07 Release date: 2019-06-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.81 Å) Cite: Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint. Elife, 8, 2019
6M14	Crystal Structure of the BARD1 BRCT Mutant Descriptor: BRCA1-associated RING domain protein 1, SULFATE ION Authors: Chen, T, Huang, W.T. Deposit date: 2020-02-24 Release date: 2021-02-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.88001835 Å) Cite: BARD1 is an ATPase activating protein for OLA1. Biochim Biophys Acta Gen Subj, 1866, 2022
3L46	Crystal structure of the second BRCT domain of epithelial cell transforming 2 (ECT2) Descriptor: Protein ECT2, UNKNOWN ATOM OR ION Authors: Nedyalkova, L, Tempel, W, Tong, Y, Crombet, L, Wang, H, Guan, X, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) Deposit date: 2009-12-18 Release date: 2010-01-12 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.482 Å) Cite: Crystal structure of the second BRCT domain of epithelial cell transforming 2 (ECT2) to be published
6RMM	Crystal structure of TOPBP1 BRCT4,5 in complex with a 53BP1 phosphopeptide Descriptor: 53BP1, DNA topoisomerase 2-binding protein 1 Authors: Day, M, Oliver, A.W, Pearl, L.H. Deposit date: 2019-05-07 Release date: 2019-06-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.53 Å) Cite: Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint. Elife, 8, 2019
1N5O	Structural consequences of a cancer-causing BRCA1-BRCT missense mutation Descriptor: Breast cancer type 1 susceptibility protein, COBALT (II) ION, SULFATE ION Authors: Williams, R.S, Glover, J.N.M. Deposit date: 2002-11-06 Release date: 2002-12-25 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural consequences of a cancer-causing BRCA1-BRCT missense mutation J.Biol.Chem., 278, 2003
4Y18	Structure of BRCA1 BRCT domains in complex with Abraxas double phosphorylated peptide Descriptor: BRCA1-A complex subunit Abraxas, Breast cancer type 1 susceptibility protein Authors: Wu, Q, Blundell, T.L. Deposit date: 2015-02-06 Release date: 2016-01-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites. Mol.Cell, 61, 2016
4U4A	Complex Structure of BRCA1 BRCT with singly phospho Abraxas Descriptor: BRCA1-A complex subunit Abraxas, Breast cancer type 1 susceptibility protein Authors: Badgujar, D, Hosur, M.V, Varma, A.K. Deposit date: 2014-07-23 Release date: 2015-08-26 Method: X-RAY DIFFRACTION (3.51 Å) Cite: Complex Structure of BRCA1 BRCT with singly phospho Abraxas To Be Published
4OFB	Crystal structure of human BRCA1 BRCT in complex with nonphosphopeptide inhibitor Descriptor: Breast cancer type 1 susceptibility protein, nonphosphopeptide inhibitor Authors: Sun, L, Edwards, R.A, Glover, J.N.M. Deposit date: 2014-01-14 Release date: 2015-04-15 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (3.05 Å) Cite: Peptide Library Approach to Uncover Phosphomimetic Inhibitors of the BRCA1 C-Terminal Domain. Acs Chem.Biol., 10, 2015
3OLC	Crystal structure of the N-terminal region of TopBP1 Descriptor: DNA topoisomerase 2-binding protein 1 Authors: Huo, Y.G, Bai, L, Xu, M, Jiang, T. Deposit date: 2010-08-25 Release date: 2011-03-30 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of the N-terminal region of human Topoisomerase II beta binding protein 1 Biochem.Biophys.Res.Commun., 401, 2010
4Y2G	Structure of BRCA1 BRCT domains in complex with Abraxas single phosphorylated peptide Descriptor: BRCA1-A complex subunit Abraxas, Breast cancer type 1 susceptibility protein Authors: Wu, Q, Blundell, T.L. Deposit date: 2015-02-09 Release date: 2016-01-27 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites. Mol.Cell, 61, 2016
7P0L	Crystal structure of S.pombe Mdb1 BRCT domains in complex with a H2A phosphopeptide Descriptor: DNA damage response protein Mdb1, Histone H2A-beta Authors: Day, M, Oliver, A.W, Pearl, L.H. Deposit date: 2021-06-29 Release date: 2021-12-01 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1. DNA Repair (Amst), 108, 2021
7P0J	Crystal structure of S.pombe Mdb1 BRCT domains Descriptor: CITRIC ACID, DNA damage response protein Mdb1, MAGNESIUM ION, ... Authors: Day, M, Oliver, A.W, Pearl, L.H. Deposit date: 2021-06-29 Release date: 2022-07-13 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1. DNA Repair (Amst), 108, 2021
1CDZ	BRCT DOMAIN FROM DNA-REPAIR PROTEIN XRCC1 Descriptor: PROTEIN (DNA-REPAIR PROTEIN XRCC1) Authors: Zhang, X, Morera, S, Bates, P, Whitehead, P, Coffer, A, Hainbucher, K, Nash, R, Sternberg, M, Lindahl, T, Freemont, P. Deposit date: 1999-03-04 Release date: 2000-02-28 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structure of an XRCC1 BRCT domain: a new protein-protein interaction module. EMBO J., 17, 1998
3COJ	Crystal Structure of the BRCT Domains of Human BRCA1 in Complex with a Phosphorylated Peptide from Human Acetyl-CoA Carboxylase 1 Descriptor: Acetyl-CoA carboxylase 1, Breast cancer type 1 susceptibility protein Authors: Shen, Y, Tong, L. Deposit date: 2008-03-28 Release date: 2008-05-27 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3.21 Å) Cite: Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1 Biochemistry, 47, 2008
2VXC	Structure of the Crb2-BRCT2 domain complex with phosphopeptide. Descriptor: DNA REPAIR PROTEIN RHP9, H2A1 PEPTIDE, PRASEODYMIUM ION Authors: Kilkenny, M.L, Roe, S.M, Pearl, L.H. Deposit date: 2008-07-03 Release date: 2008-08-12 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structural and Functional Analysis of the Crb2-Brct2 Domain Reveals Distinct Roles in Checkpoint Signaling and DNA Damage Repair. Genes Dev., 22, 2008
4JLU	Crystal structure of BRCA1 BRCT with doubly phosphorylated Abraxas Descriptor: BRCA1-A complex subunit Abraxas, Breast cancer type 1 susceptibility protein Authors: Badgujar, D, Varma, A.K. Deposit date: 2013-03-13 Release date: 2014-09-10 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Crystal structure of BRCA1 BRCT with doubly phosphorylated Abraxas To be Published
6WH2	Structure of the C-terminal BRCT domain of human XRCC1 Descriptor: X-ray repair cross complementing protein 1 variant Authors: Pourfarjam, Y, Ellenberger, T, Tainer, J.A, Tomkinson, A.E, Kim, I.K. Deposit date: 2020-04-07 Release date: 2020-12-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.414 Å) Cite: An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase III alpha within a flexible DNA repair complex. Nucleic Acids Res., 49, 2021
3UEN	Crystal structure of TopBP1 BRCT4/5 domains Descriptor: DNA topoisomerase 2-binding protein 1, GLYCEROL, THIOCYANATE ION Authors: Leung, C.C, Glover, J.N.M. Deposit date: 2011-10-31 Release date: 2013-07-03 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural insights into recognition of MDC1 by TopBP1 in DNA replication checkpoint control. Structure, 21, 2013
3UEO	Crystal structure of TopBP1 BRCT4/5 domains in complex with a phospho-peptide Descriptor: DNA topoisomerase 2-binding protein 1, phospho-peptide Authors: Leung, C.C, Glover, J.N.M. Deposit date: 2011-10-31 Release date: 2013-07-03 Last modified: 2014-03-26 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural insights into recognition of MDC1 by TopBP1 in DNA replication checkpoint control. Structure, 21, 2013
3FA2	Crystal Structure of the BRCA1 Associated Ring Domain (BARD1) Tandem BRCT Domains Descriptor: BRCA1-associated RING domain protein 1, GLYCEROL, PHOSPHATE ION Authors: Fox III, D, Le Trong, I, Stenkamp, R.E, Klevit, R.E. Deposit date: 2008-11-14 Release date: 2008-12-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal Structure of the BRCA1 Associated Ring Domain (BARD1) Tandem BRCT Domains TO BE PUBLISHED
7CMZ	Crystal Structure of BRCT7/8 in Complex with the APS Motif of PHF8 Descriptor: DNA topoisomerase 2-binding protein 1, Histone lysine demethylase PHF8, POTASSIUM ION, ... Authors: Che, S.Y, Ma, S, Cao, C, Yao, Z, Shi, L, Yang, N. Deposit date: 2020-07-29 Release date: 2021-03-17 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.695 Å) Cite: PHF8-promoted TOPBP1 demethylation drives ATR activation and preserves genome stability. Sci Adv, 7, 2021
4IGK	Structure of human BRCA1 BRCT in complex with ATRIP peptide Descriptor: ATRIP peptide, Breast cancer type 1 susceptibility protein, GLYCEROL Authors: Liu, X, Ladias, J.A.A. Deposit date: 2012-12-17 Release date: 2013-10-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural Basis for the BRCA1 BRCT Interaction with the Proteins ATRIP and BAAT1. Biochemistry, 52, 2013
2VXB	Structure of the Crb2-BRCT2 domain Descriptor: DNA REPAIR PROTEIN RHP9, PRASEODYMIUM ION Authors: Kilkenny, M.L, Roe, S.M, Pearl, L.H. Deposit date: 2008-07-03 Release date: 2008-08-12 Last modified: 2019-05-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and Functional Analysis of the Crb2-Brct2 Domain Reveals Distinct Roles in Checkpoint Signaling and DNA Damage Repair. Genes Dev., 22, 2008
4IFI	Structure of human BRCA1 BRCT in complex with BAAT peptide Descriptor: ACETATE ION, BAAT peptide, Breast cancer type 1 susceptibility protein Authors: Liu, X, Ladias, J.A.A. Deposit date: 2012-12-14 Release date: 2013-10-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural Basis for the BRCA1 BRCT Interaction with the Proteins ATRIP and BAAT1. Biochemistry, 52, 2013

 

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