PDB: 343 resultsInfo pagesStatus searchChemie searchBIRD

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1CA0	BOVINE CHYMOTRYPSIN COMPLEXED TO APPI Descriptor: BOVINE CHYMOTRYPSIN, PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR Authors: Scheidig, A.J, Kossiakoff, A.A. Deposit date: 1997-01-23 Release date: 1997-07-23 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities. Protein Sci., 6, 1997
1CBW	BOVINE CHYMOTRYPSIN COMPLEXED TO BPTI Descriptor: BOVINE CHYMOTRYPSIN, BPTI, SULFATE ION Authors: Hynes, T.R, Scheidig, A.J, Kossiakoff, A.A. Deposit date: 1996-12-22 Release date: 1997-07-23 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities. Protein Sci., 6, 1997
3GCT	STRUCTURE OF GAMMA-*CHYMOTRYPSIN IN THE RANGE $P*H 2.0 TO $P*H 10.5 SUGGESTS THAT GAMMA-CHYMOTRYPSIN IS A COVALENT ACYL-ENZYME ADDUCT AT LOW $P*H Descriptor: GAMMA-CHYMOTRYPSIN A, SULFATE ION, UNK PRO GLY ALA TYR PEPTIDE Authors: Dixon, M.M, Matthews, B.W. Deposit date: 1990-09-04 Release date: 1991-10-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structure of gamma-chymotrypsin in the range pH 2.0 to pH 10.5 suggests that gamma-chymotrypsin is a covalent acyl-enzyme adduct at low pH. Int.J.Biol.Macromol., 13, 1991
3GCH	CHEMISTRY OF CAGED ENZYMES. BINDING OF PHOTOREVERSIBLE CINNAMATES TO CHYMOTRYPSIN Descriptor: GAMMA-CHYMOTRYPSIN, TRANS-O-HYDROXY-ALPHA-METHYL CINNAMATE Authors: Stoddard, B.L, Ringe, D, Petsko, G.A. Deposit date: 1989-09-25 Release date: 1990-10-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure and activity of two photoreversible cinnamates bound to chymotrypsin. Biochemistry, 29, 1990
3HZQ	Structure of a tetrameric MscL in an expanded intermediate state Descriptor: Large-conductance mechanosensitive channel Authors: Liu, Z.F, Gandhi, C.S, Rees, D.C. Deposit date: 2009-06-24 Release date: 2009-08-25 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3.82 Å) Cite: Structure of a tetrameric MscL in an expanded intermediate state. Nature, 461, 2009
3IGL	Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 1) Descriptor: 1,2-ETHANEDIOL, Cellular tumor antigen p53, DNA (5'-D(*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*G)-3'), ... Authors: Kitayner, M, Suad, O, Rozenberg, H, Shakked, Z. Deposit date: 2009-07-28 Release date: 2010-03-31 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs Nat.Struct.Mol.Biol., 17, 2010
3T62	Crystal structure of recombinant Kunitz Type serine protease Inhibitor-1 from the Caribbean Sea anemone Stichodactyla helianthus in complex with bovine chymotrypsin Descriptor: Chymotrypsinogen A, Kunitz-type proteinase inhibitor SHPI-1, SULFATE ION Authors: Garcia-Fernandez, R, Dominguez, R, Oberthuer, D, Pons, T, Gonzalez-Gonzalez, Y, Chavez, M.A, Betzel, C, Redecke, L. Deposit date: 2011-07-28 Release date: 2012-08-01 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural insights into chymotrypsin inhibition by the Kunitz-type inhibitor-1 from the marine invertebrate Stichodactyla helianthus To be Published
5CHA	THE REFINEMENT AND THE STRUCTURE OF THE DIMER OF ALPHA-*CHYMOTRYPSIN AT 1.67-*ANGSTROMS RESOLUTION Descriptor: ALPHA-CHYMOTRYPSIN A Authors: Blevins, R.A, Tulinsky, A. Deposit date: 1985-01-22 Release date: 1985-04-01 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.67 Å) Cite: The refinement and the structure of the dimer of alpha-chymotrypsin at 1.67-A resolution. J.Biol.Chem., 260, 1985
6CHA	STRUCTURE OF A TETRAHEDRAL TRANSITION STATE COMPLEX OF ALPHA-*CHYMOTRYPSIN AT 1.8-*ANGSTROMS RESOLUTION Descriptor: ALPHA-CHYMOTRYPSIN A, PHENYLETHANE BORONIC ACID Authors: Tulinsky, A, Blevins, R.A. Deposit date: 1987-02-06 Release date: 1987-04-16 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure of a tetrahedral transition state complex of alpha-chymotrypsin dimer at 1.8-A resolution. J.Biol.Chem., 262, 1987
3Q06	An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity Descriptor: Cellular tumor antigen p53, DNA (26-MER), ZINC ION Authors: Petty, T.J, Halazonetis, T.D. Deposit date: 2010-12-15 Release date: 2011-05-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.2 Å) Cite: An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. Embo J., 30, 2011
5ECG	Crystal structure of the BRCT domains of 53BP1 in complex with p53 and H2AX-pSer139 (gammaH2AX) Descriptor: Cellular tumor antigen p53, SEP-GLN-GLU-TYR, Tumor suppressor p53-binding protein 1, ... Authors: Day, M, Oliver, A.W, Pearl, L.H. Deposit date: 2015-10-20 Release date: 2015-12-16 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3 Å) Cite: ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with gamma H2AX. Cell Rep, 13, 2015
7DVD	The crystal structure of p53 DNA binding domain and PUMA complex Descriptor: Bcl-2-binding component 3, isoforms 1/2, Cellular tumor antigen p53, ... Authors: Han, C.W, Lee, H.N, Jeong, M.S, Jang, S.B. Deposit date: 2021-01-13 Release date: 2021-08-04 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.59 Å) Cite: Structural basis of the p53 DNA binding domain and PUMA complex. Biochem.Biophys.Res.Commun., 548, 2021
6RZ3	Crystal structure of a complex between the DNA-binding domain of p53 and the carboxyl-terminal conserved region of iASPP Descriptor: Cellular tumor antigen p53, RelA-associated inhibitor, ZINC ION Authors: Chen, S, Ren, J, Jones, E.Y, Lu, X. Deposit date: 2019-06-12 Release date: 2019-10-30 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (4.23 Å) Cite: iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition. Proc.Natl.Acad.Sci.USA, 116, 2019
6DI8	Crystal structure of bovine alpha-chymotrypsin in space group P65 Descriptor: Chymotrypsin A chain A, Chymotrypsin A chain B, Chymotrypsin A chain C, ... Authors: Marshall, A.C, Keiller, B.G, Bruning, J.B. Deposit date: 2018-05-23 Release date: 2019-01-23 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.859 Å) Cite: Crystal Structure of Bovine Alpha-Chymotrypsin in Space Group P65 Crystals, 8, 2018
3VGC	GAMMA-CHYMOTRYPSIN L-NAPHTHYL-1-ACETAMIDO BORONIC ACID ACID INHIBITOR COMPLEX Descriptor: GAMMA CHYMOTRYPSIN, L-1-NAPHTHYL-2-ACETAMIDO-ETHANE BORONIC ACID, SULFATE ION Authors: Stoll, V.S, Eger, B.T, Hynes, R.C, Martichonok, V, Jones, J.B, Pai, E.F. Deposit date: 1997-05-01 Release date: 1997-11-12 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Differences in binding modes of enantiomers of 1-acetamido boronic acid based protease inhibitors: crystal structures of gamma-chymotrypsin and subtilisin Carlsberg complexes. Biochemistry, 37, 1998
7EAX	Crystal complex of p53-V272M and antimony ion Descriptor: ANTIMONY (III) ION, Cellular tumor antigen p53, ZINC ION Authors: Lu, M, Tang, Y. Deposit date: 2021-03-08 Release date: 2022-02-16 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Repurposing antiparasitic antimonials to noncovalently rescue temperature-sensitive p53 mutations. Cell Rep, 39, 2022
3Q05	An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity Descriptor: Cellular tumor antigen p53, DNA (26-MER), ZINC ION Authors: Petty, T.J, Halazonetis, T.D. Deposit date: 2010-12-15 Release date: 2011-05-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. Embo J., 30, 2011
5BUA	Lysine 120-acetylated P53 DNA binding domain in a complex with DNA. Descriptor: Cellular tumor antigen p53, DNA (5'-D(P*GP*GP*AP*CP*AP*TP*GP*TP*CP*C)-3'), ZINC ION Authors: Arbely, E, Vainer, R. Deposit date: 2015-06-03 Release date: 2016-07-06 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.812 Å) Cite: Structural Basis for p53 Lys120-Acetylation-Dependent DNA-Binding Mode. J.Mol.Biol., 428, 2016
3TS8	Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element Descriptor: CDKN1A(p21) anti-sense strand, CDKN1A(p21) sense strand, Cellular tumor antigen p53, ... Authors: Halazonetis, T.D, Emamzadah, S. Deposit date: 2011-09-12 Release date: 2011-11-23 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal Structure of a Multidomain Human p53 Tetramer Bound to the Natural CDKN1A (p21) p53-Response Element. Mol Cancer Res, 9, 2011
6FF9	Mutant R280K of human P53 Descriptor: Cellular tumor antigen p53, ZINC ION Authors: Trovao, F.G, Gomes, A.S, Pinheiro, B, Carvalho, A.L, Romao, M.J. Deposit date: 2018-01-04 Release date: 2018-04-25 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2 Å) Cite: The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding. Int J Mol Sci, 19, 2018
7EDS	Human p53 core domain with germline hot spot mutation M133T in complex with the natural PIG3 p53-response element and Arsenic Descriptor: ARSENIC, Cellular tumor antigen p53, PIG3 anti-sense strand, ... Authors: Xing, Y.F, Lu, M. Deposit date: 2021-03-17 Release date: 2022-06-22 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Arsenic-bound p53 Hotspot mutant M133T in complex with the natural PIG3 p53-response element To Be Published
7EEU	Human p53 core domain with hot spot mutation R282W in complex with the natural CDKN1A(p21) p53-response element and Arsenic Descriptor: ARSENIC, CDKN1A(p21) anti-sense strand, CDKN1A(p21) sense strand, ... Authors: Xing, Y.F, Lu, M. Deposit date: 2021-03-19 Release date: 2022-06-22 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Human p53 core domain with hot spot mutation R282W in complex with the natural CDKN1A(p21) p53-response element and Arsenic To Be Published
6FJ5	New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-AGG-HG) Descriptor: 1,2-ETHANEDIOL, Cellular tumor antigen p53, DNA, ... Authors: Golovenko, D, Rozenberg, H, Shakked, Z. Deposit date: 2018-01-20 Release date: 2018-06-27 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.051 Å) Cite: New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins. Structure, 26, 2018
6SL6	p53 charged core Descriptor: Cellular tumor antigen p53, GLYCEROL, ZINC ION Authors: Gallardo, R, Langenberg, T, Schymkowitz, J, Rousseau, F, Ulens, C. Deposit date: 2019-08-18 Release date: 2020-03-11 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Thermodynamic and Evolutionary Coupling between the Native and Amyloid State of Globular Proteins. Cell Rep, 31, 2020
3Q01	An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity Descriptor: Cellular tumor antigen p53, ZINC ION Authors: Petty, T.J, Halazonetis, T.D. Deposit date: 2010-12-15 Release date: 2011-05-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. Embo J., 30, 2011

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