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3U57	Structures of Alkaloid Biosynthetic Glucosidases Decode Substrate Specificity Descriptor: (2beta,7beta,16S,17R,19E,21beta)-21-(beta-D-glucopyranosyloxy)-2,7-dihydro-7,17-cyclosarpagan-17-yl acetate, CHLORIDE ION, Raucaffricine-O-beta-D-glucosidase Authors: Xia, L, Ruppert, M, Wang, M, Panjikar, S, Lin, H, Rajendran, C, Barleben, L, Stoeckigt, J. Deposit date: 2011-10-11 Release date: 2011-11-30 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.43 Å) Cite: Structures of alkaloid biosynthetic glucosidases decode substrate specificity. Acs Chem.Biol., 7, 2012
3U5Y	Structures of Alkaloid Biosynthetic Glucosidases Decode Substrate Specificity Descriptor: CHLORIDE ION, Raucaffricine-O-beta-D-glucosidase, Secologanin Authors: Xia, L, Ruppert, M, Wang, M, Panjikar, S, Lin, H, Rajendran, C, Barleben, L, Stoeckigt, J. Deposit date: 2011-10-11 Release date: 2011-11-30 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structures of alkaloid biosynthetic glucosidases decode substrate specificity. Acs Chem.Biol., 7, 2012
1H41	Pseudomonas cellulosa E292A alpha-D-glucuronidase mutant complexed with aldotriuronic acid Descriptor: 1,2-ETHANEDIOL, 4-O-methyl-alpha-D-glucopyranuronic acid, ALPHA-GLUCURONIDASE, ... Authors: Nurizzo, D, Nagy, T, Gilbert, H.J, Davies, G.J. Deposit date: 2002-09-25 Release date: 2003-05-01 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: The Alpha-Glucuronidase,Glca67A,of Cellvibrio Japonicus Utilizes the Carboxylate and Methyl Groups of Aldobiouronic Acid as Important Substrate Recognition Determinants J.Biol.Chem., 278, 2003
6UKD	Co-complex of S. pyogenes 10782 streptopain bound with a nitrile-based specific covalent inhibitor Descriptor: NITRATE ION, Streptopain, benzyl [(2S)-1-(3-nitrophenyl)-3-oxobutan-2-yl]carbamate Authors: Wolan, D.W, Woehl, J.L, Kitamura, S. Deposit date: 2019-10-04 Release date: 2020-09-09 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.589 Å) Cite: An Irreversible Inhibitor to Probe the Role ofStreptococcus pyogenesCysteine Protease SpeB in Evasion of Host Complement Defenses. Acs Chem.Biol., 15, 2020
6UQD	Co-complex of S. pyogenes 10782 streptopain bound with a SuFEx-based optimized small molecule inhibitor Descriptor: Streptopain, benzyl [(1S)-2-(3-{[(4-carbamoylpiperidin-1-yl)(fluoro)oxo-lambda~6~-sulfanylidene]amino}phenyl)-1-cyanoethyl]carbamate Authors: Wolan, D.W, Woehl, J.L, Kitamura, S. Deposit date: 2019-10-18 Release date: 2020-08-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry. J.Am.Chem.Soc., 142, 2020
1HWG	1:2 COMPLEX OF HUMAN GROWTH HORMONE WITH ITS SOLUBLE BINDING PROTEIN Descriptor: GROWTH HORMONE, GROWTH HORMONE BINDING PROTEIN Authors: Sundstrom, S.M, Lundqvist, T. Deposit date: 1996-11-13 Release date: 1997-11-19 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution. J.Biol.Chem., 271, 1996
1HWH	1:1 COMPLEX OF HUMAN GROWTH HORMONE MUTANT G120R WITH ITS SOLUBLE BINDING PROTEIN Descriptor: GROWTH HORMONE, GROWTH HORMONE BINDING PROTEIN Authors: Sundstrom, S.M, Lundqvist, T. Deposit date: 1996-11-13 Release date: 1997-11-19 Last modified: 2021-11-03 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution. J.Biol.Chem., 271, 1996
1V8Z	X-ray crystal structure of the Tryptophan Synthase b2 Subunit from Hyperthermophile, Pyrococcus furiosus Descriptor: PYRIDOXAL-5'-PHOSPHATE, SODIUM ION, Tryptophan synthase beta chain 1 Authors: Hioki, Y, Ogasahara, K, Lee, S.J, Ma, J, Ishida, M, Yamagata, Y, Matsuura, Y, Ota, M, Kuramitsu, S, Yutani, K, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2004-01-15 Release date: 2005-02-22 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.21 Å) Cite: The crystal structure of the tryptophan synthase beta subunit from the hyperthermophile Pyrococcus furiosus. Investigation of stabilization factors Eur.J.Biochem., 271, 2004
1GNE	THE THREE-DIMENSIONAL STRUCTURE OF GLUTATHIONE S-TRANSFERASE OF SCHISTOSOMA JAPONICUM FUSED WITH A CONSERVED NEUTRALIZING EPITOPE ON GP41 OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 Descriptor: GLUTATHIONE, GLUTATHIONE S-TRANSFERASE Authors: Lim, K, Ho, J.X, Keeling, K, Gilliland, G.L, Ji, X, Ruker, F, Carter, D.C. Deposit date: 1994-06-16 Release date: 1994-11-30 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Three-dimensional structure of Schistosoma japonicum glutathione S-transferase fused with a six-amino acid conserved neutralizing epitope of gp41 from HIV. Protein Sci., 3, 1994
1IIL	CRYSTAL STRUCTURE OF PRO253ARG APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2 Descriptor: FIBROBLAST GROWTH FACTOR RECEPTOR 2, HEPARIN-BINDING GROWTH FACTOR 2 Authors: Ibrahimi, O.A, Eliseenkova, A.V, Plotnikov, A.N, Ornitz, D.M, Mohammadi, M. Deposit date: 2001-04-23 Release date: 2001-05-09 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome. Proc.Natl.Acad.Sci.USA, 98, 2001
3U5U	Structures of Alkaloid Biosynthetic Glucosidases Decode Substrate Specificity Descriptor: CHLORIDE ION, Raucaffricine-O-beta-D-glucosidase Authors: Xia, L, Ruppert, M, Wang, M, Panjikar, S, Lin, H, Rajendran, C, Barleben, L, Stoeckigt, J. Deposit date: 2011-10-11 Release date: 2011-11-30 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structures of alkaloid biosynthetic glucosidases decode substrate specificity. Acs Chem.Biol., 7, 2012
1G6V	Complex of the camelid heavy-chain antibody fragment CAB-CA05 with bovine carbonic anhydrase Descriptor: ANTIBODY HEAVY CHAIN, CARBONIC ANHYDRASE, ZINC ION Authors: Desmyter, A, Decanniere, K, Muyldermans, S, Wyns, L. Deposit date: 2000-11-08 Release date: 2000-11-22 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Antigen specificity and high affinity binding provided by one single loop of a camel single-domain antibody. J.Biol.Chem., 276, 2001
1IMI	SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1 Descriptor: PROTEIN (ALPHA-CONOTOXIN IMI) Authors: Maslennikov, I.V, Shenkarev, Z.O, Zhmak, M.N, Tsetlin, V.I, Ivanov, V.T, Arseniev, A.S. Deposit date: 1998-11-27 Release date: 1999-04-23 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: NMR spatial structure of alpha-conotoxin ImI reveals a common scaffold in snail and snake toxins recognizing neuronal nicotinic acetylcholine receptors. FEBS Lett., 444, 1999
8GCH	GAMMA-CHYMOTRYPSIN IS A COMPLEX OF ALPHA-CHYMOTRYPSIN WITH ITS OWN AUTOLYSIS PRODUCTS Descriptor: GAMMA-CHYMOTRYPSIN A, GLY ALA TRP PEPTIDE, SULFATE ION Authors: Harel, M, Sussman, J.L, Silman, I. Deposit date: 1991-03-27 Release date: 1992-04-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Gamma-chymotrypsin is a complex of alpha-chymotrypsin with its own autolysis products. Biochemistry, 30, 1991
3H4G	Structure of aldehyde reductase holoenzyme in complex with potent aldose reductase inhibitor Fidarestat: Implications for inhibitor binding and selectivity Descriptor: (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, Alcohol dehydrogenase [NADP+], NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Carbone, V, El-Kabbani, O. Deposit date: 2009-04-20 Release date: 2009-05-05 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity J.Med.Chem., 48, 2005
1VZX	Roles of active site tryptophans in substrate binding and catalysis by ALPHA-1,3 GALACTOSYLTRANSFERASE Descriptor: GLYCEROL, MANGANESE (II) ION, N-ACETYLLACTOSAMINIDE ALPHA-1,3-GALACTOSYLTRANSFERASE, ... Authors: Zhang, Y, Deshpande, A, Xie, Z, Natesh, R, Acharya, K.R, Brew, K. Deposit date: 2004-05-28 Release date: 2004-07-08 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Roles of active site tryptophans in substrate binding and catalysis by alpha-1,3 galactosyltransferase. Glycobiology, 14, 2004
2DZV	Structure of mutant tryptophan synthase alpha-subunit (D146A) from a hyperthermophile, Pyrococcus furiosus Descriptor: Tryptophan synthase alpha chain Authors: Ogasahara, K, Yamagata, Y, Yutani, K, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2006-09-30 Release date: 2007-08-28 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structures of mutant tryptophan synthase alpha-subunits from a hyperthermophile, Pyrococcus furiosus To be Published
2DZP	Structure of mutant tryptophan synthase alpha-subunit (D17N) from a hyperthermophile, Pyrococcus furiosus Descriptor: Tryptophan synthase alpha chain Authors: Ogasahara, K, Yamagata, Y, Yutani, K, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2006-09-30 Release date: 2007-08-28 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structures of mutant tryptophan synthase alpha-subunits from a hyperthermophile, Pyrococcus furiosus To be Published
2DZX	Structure of mutant tryptophan synthase alpha-subunit (E131-132A) from a hyperthermophile, Pyrococcus furiosus Descriptor: Tryptophan synthase alpha chain Authors: Ogasahara, K, Yamagata, Y, Yutani, K, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2006-09-30 Release date: 2007-08-28 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structures of mutant tryptophan synthase alpha-subunits from a hyperthermophile, Pyrococcus furiosus To be Published
1YHR	T-To-T(High) quaternary transitions in human hemoglobin: HbA OXY (10.0MM IHP, 20% PEG) (10 test sets) Descriptor: Hemoglobin alpha chain, Hemoglobin beta chain, OXYGEN MOLECULE, ... Authors: Kavanaugh, J.S, Rogers, P.H, Arnone, A. Deposit date: 2005-01-10 Release date: 2005-01-18 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions. Biochemistry, 44, 2005
1YIE	T-to-thigh quaternary transitions in human hemoglobin: betaW37A oxy (2.2MM IHP, 13% PEG) (1 test set) Descriptor: Hemoglobin alpha chain, Hemoglobin beta chain, OXYGEN MOLECULE, ... Authors: Kavanaugh, J.S, Rogers, P.H, Arnone, A. Deposit date: 2005-01-11 Release date: 2005-01-18 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions. Biochemistry, 44, 2005
1Y2Z	T-To-T(High) quaternary transitions in human hemoglobin: betaV34G deoxy low-salt (1 test set) Descriptor: Hemoglobin alpha chain, Hemoglobin beta chain, PROTOPORPHYRIN IX CONTAINING FE Authors: Kavanaugh, J.S, Rogers, P.H, Arnone, A. Deposit date: 2004-11-23 Release date: 2004-12-07 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions. Biochemistry, 44, 2005
1Y0D	T-to-THigh Quaternary Transitions in Human Hemoglobin: desArg141alpha deoxy low-salt Descriptor: Hemoglobin alpha chain, Hemoglobin beta chain, PROTOPORPHYRIN IX CONTAINING FE Authors: Kavanaugh, J.S, Rogers, P.H, Arnone, A. Deposit date: 2004-11-15 Release date: 2004-11-30 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions. Biochemistry, 44, 2005
1Y5J	T-To-T(High) quaternary transitions in human hemoglobin: betaH97A deoxy low-salt (1 test set) Descriptor: Hemoglobin alpha chain, Hemoglobin beta chain, PROTOPORPHYRIN IX CONTAINING FE Authors: Kavanaugh, J.S, Rogers, P.H, Arnone, A. Deposit date: 2004-12-02 Release date: 2004-12-14 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions. Biochemistry, 44, 2005
1YG5	T-To-T(High) quaternary transitions in human hemoglobin: betaW37H OXY (2MM IHP, 20% PEG) (10 test sets) Descriptor: Hemoglobin alpha chain, Hemoglobin beta chain, OXYGEN MOLECULE, ... Authors: Kavanaugh, J.S, Rogers, P.H, Arnone, A. Deposit date: 2005-01-04 Release date: 2005-01-11 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions. Biochemistry, 44, 2005

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