2ECP
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![BU of 2ecp by Molmil](/molmil-images/mine/2ecp) | THE CRYSTAL STRUCTURE OF THE E. COLI MALTODEXTRIN PHOSPHORYLASE COMPLEX | Descriptor: | 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, GLYCEROL, MALTODEXTRIN PHOSPHORYLASE, ... | Authors: | O'Reilly, M, Watson, K.A, Johnson, L.N. | Deposit date: | 1998-10-27 | Release date: | 1999-06-15 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | The crystal structure of the Escherichia coli maltodextrin phosphorylase-acarbose complex. Biochemistry, 38, 1999
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3B8A
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![BU of 3b8a by Molmil](/molmil-images/mine/3b8a) | Crystal structure of yeast hexokinase PI in complex with glucose | Descriptor: | Hexokinase-1, SULFATE ION, beta-D-glucopyranose | Authors: | Kuser, P, Cupri, F, Bleicher, L, Polikarpov, I. | Deposit date: | 2007-10-31 | Release date: | 2008-02-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Crystal structure of yeast hexokinase PI in complex with glucose: A classical "induced fit" example revised. Proteins, 72, 2008
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6HRM
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![BU of 6hrm by Molmil](/molmil-images/mine/6hrm) | E. coli 70S d2d8 stapled ribosome | Descriptor: | 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ... | Authors: | Schmied, W.H, Tnimov, Z, Uttamapinant, C, Rae, C.D, Fried, S.D, Chin, J.W. | Deposit date: | 2018-09-27 | Release date: | 2018-12-19 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Controlling orthogonal ribosome subunit interactions enables evolution of new function. Nature, 564, 2018
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8GYM
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![BU of 8gym by Molmil](/molmil-images/mine/8gym) | Cryo-EM structure of Tetrahymena thermophila respiratory mega-complex MC IV2+(I+III2+II)2 | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | Authors: | Wu, M.C, Hu, Y.Q, Han, F.Z, Zhou, L. | Deposit date: | 2022-09-23 | Release date: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Structures of Tetrahymena thermophila respiratory megacomplexes on the tubular mitochondrial cristae. Nat Commun, 14, 2023
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6GSJ
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![BU of 6gsj by Molmil](/molmil-images/mine/6gsj) | Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAThr in the A-site | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Rozov, A, Yusupov, M, Yusupova, G. | Deposit date: | 2018-06-14 | Release date: | 2018-07-04 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.96 Å) | Cite: | Tautomeric G•U pairs within the molecular ribosomal grip and fidelity of decoding in bacteria. Nucleic Acids Res., 46, 2018
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5J91
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![BU of 5j91 by Molmil](/molmil-images/mine/5j91) | Structure of the Wild-type 70S E coli ribosome bound to Tigecycline | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1,4-DIAMINOBUTANE, ... | Authors: | Cocozaki, A, Ferguson, A. | Deposit date: | 2016-04-08 | Release date: | 2016-07-06 | Last modified: | 2016-08-03 | Method: | X-RAY DIFFRACTION (2.96 Å) | Cite: | Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors. Proc.Natl.Acad.Sci.USA, 113, 2016
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7MSC
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![BU of 7msc by Molmil](/molmil-images/mine/7msc) | Mtb 70SIC in complex with MtbEttA at Pre_R0 state | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Cui, Z, Zhang, J. | Deposit date: | 2021-05-11 | Release date: | 2022-02-02 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis. Nat Commun, 13, 2022
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8RXX
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![BU of 8rxx by Molmil](/molmil-images/mine/8rxx) | |
5MDV
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![BU of 5mdv by Molmil](/molmil-images/mine/5mdv) | Structure of ArfA and RF2 bound to the 70S ribosome (accommodated state) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | James, N.R, Brown, A, Gordiyenko, Y, Ramakrishnan, V. | Deposit date: | 2016-11-13 | Release date: | 2016-12-14 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Translational termination without a stop codon. Science, 354, 2016
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1Q82
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![BU of 1q82 by Molmil](/molmil-images/mine/1q82) | Crystal Structure of CC-Puromycin bound to the A-site of the 50S ribosomal subunit | Descriptor: | 23S ribosomal rna, 50S ribosomal protein L13P, 50S ribosomal protein L14P, ... | Authors: | Hansen, J.L, Schmeing, T.M, Moore, P.B, Steitz, T.A. | Deposit date: | 2003-08-20 | Release date: | 2003-10-07 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Structural Insights Into Peptide Bond Formation Proc.Natl.Acad.Sci.USA, 99, 2002
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8DNX
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![BU of 8dnx by Molmil](/molmil-images/mine/8dnx) | Cryo-EM structure of the human Sec61 complex inhibited by cotransin | Descriptor: | Cotransin analogue peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... | Authors: | Park, E, Itskanov, S. | Deposit date: | 2022-07-12 | Release date: | 2023-05-24 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
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6T9E
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![BU of 6t9e by Molmil](/molmil-images/mine/6t9e) | Crystal structure of a bispecific DutaFab in complex with human PDGF | Descriptor: | DutaFab mat VH chain, DutaFab mat VL chain, Platelet-derived growth factor subunit B | Authors: | Kimbung, R, Logan, D.T, Beckmann, R, Jensen, K, Speck, J, Fenn, S, Kettenberger, H. | Deposit date: | 2019-10-28 | Release date: | 2020-12-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.989 Å) | Cite: | DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously. Nat Commun, 12, 2021
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7AQC
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![BU of 7aqc by Molmil](/molmil-images/mine/7aqc) | Structure of the bacterial RQC complex (Decoding State) | Descriptor: | 23S ribosomal RNA, 50S ribosomal protein L11, 50S ribosomal protein L13, ... | Authors: | Filbeck, S, Pfeffer, S. | Deposit date: | 2020-10-21 | Release date: | 2020-11-25 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.99 Å) | Cite: | Mimicry of Canonical Translation Elongation Underlies Alanine Tail Synthesis in RQC. Mol.Cell, 81, 2021
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4V88
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![BU of 4v88 by Molmil](/molmil-images/mine/4v88) | The structure of the eukaryotic ribosome at 3.0 A resolution. | Descriptor: | 18S RIBOSOMAL RNA, 18S rRNA, 25S rRNA, ... | Authors: | Ben-Shem, A, Garreau de Loubresse, N, Melnikov, S, Jenner, L, Yusupova, G, Yusupov, M. | Deposit date: | 2011-10-11 | Release date: | 2014-07-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The structure of the eukaryotic ribosome at 3.0 angstrom resolution. Science, 334, 2011
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7PKT
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![BU of 7pkt by Molmil](/molmil-images/mine/7pkt) | Large subunit of the Chlamydomonas reinhardtii mitoribosome | Descriptor: | 50S ribosomal protein L20, 50S ribosomal protein L9, chloroplastic, ... | Authors: | Waltz, F, Soufari, H, Hashem, Y. | Deposit date: | 2021-08-26 | Release date: | 2022-06-15 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | How to build a ribosome from RNA fragments in Chlamydomonas mitochondria. Nat Commun, 12, 2021
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7BUU
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![BU of 7buu by Molmil](/molmil-images/mine/7buu) | Eucommia ulmoides TPT3, crystal form 1 | Descriptor: | FPS3 | Authors: | Kajiura, H, Yoshizawa, T, Tokumoto, Y, Suzuki, N, Takeno, S, Takeno, K.J, Yamashita, T, Tanaka, S, Kaneko, Y, Fujiyama, K, Matsumura, H, Nakazawa, Y. | Deposit date: | 2020-04-08 | Release date: | 2021-02-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure-function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis. Commun Biol, 4, 2021
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4V67
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![BU of 4v67 by Molmil](/molmil-images/mine/4v67) | Crystal structure of a translation termination complex formed with release factor RF2. | Descriptor: | 16S RRNA, 23S RRNA, 30S ribosomal protein S10, ... | Authors: | Korostelev, A, Asahara, H, Lancaster, L, Laurberg, M, Hirschi, A, Noller, H.F. | Deposit date: | 2008-10-27 | Release date: | 2014-07-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of a translation termination complex formed with release factor RF2. Proc.Natl.Acad.Sci.USA, 105, 2008
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8CD1
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![BU of 8cd1 by Molmil](/molmil-images/mine/8cd1) | 70S-PHIKZ014 | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Gerovac, M, Vogel, J. | Deposit date: | 2023-01-29 | Release date: | 2024-01-24 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Phage proteins target and co-opt host ribosomes immediately upon infection. Nat Microbiol, 9, 2024
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8C3A
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![BU of 8c3a by Molmil](/molmil-images/mine/8c3a) | Crystal structure of ailanthone bound to the Candida albicans 80S ribosome | Descriptor: | 18S, 25S, 3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-glucopyranose, ... | Authors: | Kolosova, O, Zgadzay, Y, Yusupov, M. | Deposit date: | 2022-12-23 | Release date: | 2024-01-10 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | New crystal system to promote screening for new eukaryotic inhibitors To Be Published
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1N8R
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![BU of 1n8r by Molmil](/molmil-images/mine/1n8r) | Structure of large ribosomal subunit in complex with virginiamycin M | Descriptor: | 23S ribosomal RNA, 50S ribosomal protein L10e, 50S ribosomal protein L13P, ... | Authors: | Hansen, J.L, Moore, P.B, Steitz, T.A. | Deposit date: | 2002-11-21 | Release date: | 2003-07-22 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures of Five Antibiotics Bound at the Peptidyl Transferase Center of
the Large Ribosomal Subunit J.Mol.Biol., 330, 2003
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3CCR
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![BU of 3ccr by Molmil](/molmil-images/mine/3ccr) | |
6WDE
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![BU of 6wde by Molmil](/molmil-images/mine/6wde) | Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure V-B) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Loveland, A.B, Demo, G, Korostelev, A.A. | Deposit date: | 2020-03-31 | Release date: | 2020-07-01 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading. Nature, 584, 2020
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6Y2L
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![BU of 6y2l by Molmil](/molmil-images/mine/6y2l) | Structure of human ribosome in POST state | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | Authors: | Bhaskar, V, Schenk, A.D, Cavadini, S, von Loeffelholz, O, Natchiar, S.K, Klaholz, B.P, Chao, J.A. | Deposit date: | 2020-02-16 | Release date: | 2020-04-15 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Dynamics of uS19 C-Terminal Tail during the Translation Elongation Cycle in Human Ribosomes. Cell Rep, 31, 2020
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1AHP
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![BU of 1ahp by Molmil](/molmil-images/mine/1ahp) | OLIGOSACCHARIDE SUBSTRATE BINDING IN ESCHERICHIA COLI MALTODEXTRIN PHSPHORYLASE | Descriptor: | E.COLI MALTODEXTRIN PHOSPHORYLASE, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | O'Reilly, M, Watson, K.A, Schinzel, R, Palm, D, Johnson, L.N. | Deposit date: | 1997-04-10 | Release date: | 1997-10-15 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Oligosaccharide substrate binding in Escherichia coli maltodextrin phosphorylase. Nat.Struct.Biol., 4, 1997
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7Q4K
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![BU of 7q4k by Molmil](/molmil-images/mine/7q4k) | Erythromycin-stalled Escherichia coli 70S ribosome with streptococcal MsrDL nascent chain | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Fostier, C.R, Ousalem, F, Soufari, H, Leroy, E.C, Ngo, S, Innis, A, Hashem, Y, Boel, G. | Deposit date: | 2021-10-31 | Release date: | 2022-11-16 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Regulation of the macrolide resistance ABC-F translation factor MsrD. Nat Commun, 14, 2023
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