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8XOG
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BU of 8xog by Molmil
Cryo-EM structure of apo-GPR30-Gq complex structure
Descriptor: G-protein coupled estrogen receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Liu, H, Xu, P, Xu, H.E.
Deposit date:2024-01-01
Release date:2024-04-10
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural and functional evidence that GPR30 is not a direct estrogen receptor.
Cell Res., 34, 2024
8XZG
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BU of 8xzg by Molmil
Cryo-EM structure of the [Pyr1]-apelin-13-bound human APLNR-Gi complex
Descriptor: Apelin receptor, Apelin-13, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Wang, W, Ji, S, Zhang, Y.
Deposit date:2024-01-21
Release date:2024-03-27
Last modified:2025-07-16
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure-based design of non-hypertrophic apelin receptor modulator.
Cell, 187, 2024
8XOF
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BU of 8xof by Molmil
Cryo-EM structure of Lys05 bound GPR30-Gq complex structure
Descriptor: G protein subunit q, G-protein coupled estrogen receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Liu, H, Xu, P, Xu, H.E.
Deposit date:2024-01-01
Release date:2024-04-10
Last modified:2025-06-18
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural and functional evidence that GPR30 is not a direct estrogen receptor.
Cell Res., 34, 2024
8XZF
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BU of 8xzf by Molmil
Cryo-EM structure of the WN561-bound human APLNR-Gi complex
Descriptor: Apelin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Wang, W, Ji, S, Zhang, Y.
Deposit date:2024-01-21
Release date:2024-03-20
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure-based design of non-hypertrophic apelin receptor modulator.
Cell, 187, 2024
8XZJ
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BU of 8xzj by Molmil
Cryo-EM structure of the WN353-bound human APLNR-Gi complex
Descriptor: Apelin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Wang, W, Ji, S, Zhang, Y.
Deposit date:2024-01-21
Release date:2024-03-20
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure-based design of non-hypertrophic apelin receptor modulator.
Cell, 187, 2024
8ZPL
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BU of 8zpl by Molmil
Cryo-EM strucutre of CXCR4 complexed with antagonist HF51116
Descriptor: (2S)-N-[[4-[[3-(cyclohexylamino)propylamino]methyl]phenyl]methyl]-5-(diaminomethylideneamino)-2-(pyridin-2-ylmethylamino)pentanamide, CHOLESTEROL, Nb6 nanobody, ...
Authors:Jiao, H.Z, Hu, H.L.
Deposit date:2024-05-30
Release date:2025-02-26
Last modified:2025-07-16
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Structural mechanisms underlying the modulation of CXCR4 by diverse small-molecule antagonists.
Proc.Natl.Acad.Sci.USA, 122, 2025
8ZR5
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BU of 8zr5 by Molmil
Cryo-EM Structure of GPR119-Gs-Firuglipel complex
Descriptor: 4-[5-[(1~{R})-1-(4-cyclopropylcarbonylphenoxy)propyl]-1,2,4-oxadiazol-3-yl]-2-fluoranyl-~{N}-[(2~{R})-1-oxidanylpropan-2-yl]benzamide, Glucose-dependent insulinotropic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Wong, T.S, Zeng, Z.C, Xiong, T.T, Gan, S.Y, Qiu, C, Du, Y.
Deposit date:2024-06-04
Release date:2024-06-19
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:Cryo-EM structure of GPR119-Gs complex
To Be Published
8ZJE
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BU of 8zje by Molmil
Cryo-EM structure of kisspeptin receptor bound to TAK-448
Descriptor: ACE-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Shen, S, Liu, H, Xu, H.E.
Deposit date:2024-05-14
Release date:2024-07-03
Last modified:2025-01-15
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Structural basis for hormone recognition and distinctive Gq protein coupling by the kisspeptin receptor.
Cell Rep, 43, 2024
8ZRK
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BU of 8zrk by Molmil
Cryo-EM structure of GPR119-Gs Complex with small molecule agonist GSK-1292263
Descriptor: GSK-1292263, Glucose-dependent insulinotropic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Wong, T.S, Xiong, T.T, Zeng, Z.C, Gan, S.Y, Qiu, C, Du, Y.
Deposit date:2024-06-04
Release date:2024-06-19
Last modified:2025-07-16
Method:ELECTRON MICROSCOPY (2.82 Å)
Cite:Cryo-EM structure of GPR119-Gs complex
To be published
9AS0
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BU of 9as0 by Molmil
Global reconstruction of 5-HT2AR bound to 2-bromo-LSD in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM)
Descriptor: 2-bromo-N,N-diethyl-6-methyl-9,10-didehydroergoline-8beta-carboxamide, 5-hydroxytryptamine receptor 2A, G subunit q (Gi2-mini-Gq chimeric), ...
Authors:Gumpper, R.H, Fay, J.F, Roth, B.L.
Deposit date:2024-02-24
Release date:2025-04-02
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:The structural diversity of psychedelic drug actions revealed.
Nat Commun, 16, 2025
9AS2
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BU of 9as2 by Molmil
Global reconstruction of 5-HT2AR bound to DMT in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM)
Descriptor: 2-(1H-indol-3-yl)-N,N-dimethylethan-1-amine, 5-hydroxytryptamine receptor 2A, G subunit q (Gi2-mini-Gq chimeric), ...
Authors:Gumpper, R.H, Fay, J.F, Roth, B.L.
Deposit date:2024-02-24
Release date:2025-04-02
Last modified:2025-05-14
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:The structural diversity of psychedelic drug actions revealed.
Nat Commun, 16, 2025
9AS6
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BU of 9as6 by Molmil
Global reconstruction of 5-HT2AR bound to mescaline in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM)
Descriptor: 2-(3,4,5-trimethoxyphenyl)ethan-1-amine, 5-hydroxytryptamine receptor 2A, G subunit q (Gi2-mini-Gq chimeric), ...
Authors:Gumpper, R.H, Fay, J.F, Roth, B.L.
Deposit date:2024-02-24
Release date:2025-04-02
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:The structural diversity of psychedelic drug actions revealed.
Nat Commun, 16, 2025
9ASA
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BU of 9asa by Molmil
Global reconstruction of 5-HT2AR bound to RS130-180 in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM)
Descriptor: 2,5-dimethoxy-N,N-dimethyl-4-{2-[({2-[(prop-2-yn-1-yl)oxy]phenyl}methyl)amino]ethyl}aniline, 5-hydroxytryptamine receptor 2A, G subunit q (Gi2-mini-Gq chimeric), ...
Authors:Gumpper, R.H, Fay, J.F, Roth, B.L.
Deposit date:2024-02-24
Release date:2025-04-02
Last modified:2025-05-21
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:The structural diversity of psychedelic drug actions revealed.
Nat Commun, 16, 2025
8ZYU
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BU of 8zyu by Molmil
Cryo-EM structure of neurotensin receptor 1 in complex with beta-arrestin1 and SBI-553 (complex 1)
Descriptor: 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-arrestin-1, Fab30 heavy chain, ...
Authors:Sun, D, Li, X, Yuan, Q, Yin, W, Xu, H.E, Tian, C.
Deposit date:2024-06-18
Release date:2025-04-16
Method:ELECTRON MICROSCOPY (2.65 Å)
Cite:Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator.
Cell Res., 35, 2025
9AS4
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BU of 9as4 by Molmil
Global reconstruction of 5-HT2AR bound to LSD in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM)
Descriptor: (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 2A, G subunit q (Gi2-mini-Gq chimeric), ...
Authors:Gumpper, R.H, Fay, J.F, Roth, B.L.
Deposit date:2024-02-24
Release date:2025-04-02
Last modified:2025-06-04
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:The structural diversity of psychedelic drug actions revealed.
Nat Commun, 16, 2025
9ARY
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BU of 9ary by Molmil
Global reconstruction 5-HT2AR bound to 5-HT in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM)
Descriptor: 5-hydroxytryptamine receptor 2A, G subunit q (Gi2-mini-Gq chimeric), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Gumpper, R.H, Fay, J.F, Roth, B.L.
Deposit date:2024-02-24
Release date:2025-04-02
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:The structural diversity of psychedelic drug actions revealed.
Nat Commun, 16, 2025
9AS8
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BU of 9as8 by Molmil
Global reconstruction of 5-HT2AR bound to psilocin in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM)
Descriptor: 3-[2-(dimethylamino)ethyl]-1~{H}-indol-4-ol, 5-hydroxytryptamine receptor 2A, G subunit q (Gi2-mini-Gq chimeric), ...
Authors:Gumpper, R.H, Fay, J.F, Roth, B.L.
Deposit date:2024-02-24
Release date:2025-04-02
Last modified:2025-05-21
Method:ELECTRON MICROSCOPY (2.54 Å)
Cite:The structural diversity of psychedelic drug actions revealed.
Nat Commun, 16, 2025
8ZYT
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BU of 8zyt by Molmil
Cryo-EM structure of neurotensin receptor 1 in complex with beta-arrestin1 and SBI-553 (complex 3)
Descriptor: 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-arrestin-1, Fab30 heavy chain, ...
Authors:Sun, D, Li, X, Yuan, Q, Yin, W, Xu, H.E, Tian, C.
Deposit date:2024-06-18
Release date:2025-04-09
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (2.65 Å)
Cite:Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator.
Cell Res., 35, 2025
8ZCF
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BU of 8zcf by Molmil
Cryo-EM structure of GPR4 complexed with Gs in pH7.5
Descriptor: G-protein coupled receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Yue, X.L, Wu, L.J, Hua, T, Liu, Z.J.
Deposit date:2024-04-29
Release date:2025-04-23
Last modified:2025-06-25
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of stepwise proton sensing-mediated GPCR activation.
Cell Res., 35, 2025
8ZYY
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BU of 8zyy by Molmil
Cryo-EM structure of neurotensin receptor 1 in complex with beta-arrestin1 and SBI-553 (complex 2)
Descriptor: 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-arrestin-1, Fab30 heavy chain, ...
Authors:Sun, D, Li, X, Yuan, Q, Yin, W, Xu, H.E, Tian, C.
Deposit date:2024-06-18
Release date:2025-04-09
Last modified:2025-07-16
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator.
Cell Res., 35, 2025
8ZBI
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BU of 8zbi by Molmil
Cryo-EM structure of Somatostatin receptor 3 (SSTR3) with Gi1 complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Yun, J.H.
Deposit date:2024-04-26
Release date:2025-04-30
Method:ELECTRON MICROSCOPY (2.79 Å)
Cite:The structures of SSTR3 and SSTR5 provide insights into the specificity among somatostatin receptors
To Be Published
8ZCE
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BU of 8zce by Molmil
Cryo-EM structure of GPR4 complexed with Gs in pH6.0
Descriptor: G-protein coupled receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Yue, X.L, Wu, L.J, Hua, T, Liu, Z.J.
Deposit date:2024-04-29
Release date:2025-04-23
Last modified:2025-06-18
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of stepwise proton sensing-mediated GPCR activation.
Cell Res., 35, 2025
8ZBJ
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BU of 8zbj by Molmil
Cryo-EM structure of Somatostatin receptor 5 (SSTR5) with Gi1 complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Kim, Y, Yun, J.H.
Deposit date:2024-04-26
Release date:2025-04-30
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:The structure of SSTR3 and SSTR5 provide insights into the specificity among somatostatin receptos.
To Be Published

238895

PDB entries from 2025-07-16

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