8XOG
 
 | Cryo-EM structure of apo-GPR30-Gq complex structure | Descriptor: | G-protein coupled estrogen receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Liu, H, Xu, P, Xu, H.E. | Deposit date: | 2024-01-01 | Release date: | 2024-04-10 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural and functional evidence that GPR30 is not a direct estrogen receptor. Cell Res., 34, 2024
|
|
8XZG
 
 | Cryo-EM structure of the [Pyr1]-apelin-13-bound human APLNR-Gi complex | Descriptor: | Apelin receptor, Apelin-13, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Wang, W, Ji, S, Zhang, Y. | Deposit date: | 2024-01-21 | Release date: | 2024-03-27 | Last modified: | 2025-07-16 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure-based design of non-hypertrophic apelin receptor modulator. Cell, 187, 2024
|
|
8XOF
 
 | Cryo-EM structure of Lys05 bound GPR30-Gq complex structure | Descriptor: | G protein subunit q, G-protein coupled estrogen receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Liu, H, Xu, P, Xu, H.E. | Deposit date: | 2024-01-01 | Release date: | 2024-04-10 | Last modified: | 2025-06-18 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural and functional evidence that GPR30 is not a direct estrogen receptor. Cell Res., 34, 2024
|
|
8XZF
 
 | Cryo-EM structure of the WN561-bound human APLNR-Gi complex | Descriptor: | Apelin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Wang, W, Ji, S, Zhang, Y. | Deposit date: | 2024-01-21 | Release date: | 2024-03-20 | Last modified: | 2024-11-13 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure-based design of non-hypertrophic apelin receptor modulator. Cell, 187, 2024
|
|
8XZJ
 
 | Cryo-EM structure of the WN353-bound human APLNR-Gi complex | Descriptor: | Apelin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Wang, W, Ji, S, Zhang, Y. | Deposit date: | 2024-01-21 | Release date: | 2024-03-20 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure-based design of non-hypertrophic apelin receptor modulator. Cell, 187, 2024
|
|
8ZPL
 
 | Cryo-EM strucutre of CXCR4 complexed with antagonist HF51116 | Descriptor: | (2S)-N-[[4-[[3-(cyclohexylamino)propylamino]methyl]phenyl]methyl]-5-(diaminomethylideneamino)-2-(pyridin-2-ylmethylamino)pentanamide, CHOLESTEROL, Nb6 nanobody, ... | Authors: | Jiao, H.Z, Hu, H.L. | Deposit date: | 2024-05-30 | Release date: | 2025-02-26 | Last modified: | 2025-07-16 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Structural mechanisms underlying the modulation of CXCR4 by diverse small-molecule antagonists. Proc.Natl.Acad.Sci.USA, 122, 2025
|
|
8ZR5
 
 | Cryo-EM Structure of GPR119-Gs-Firuglipel complex | Descriptor: | 4-[5-[(1~{R})-1-(4-cyclopropylcarbonylphenoxy)propyl]-1,2,4-oxadiazol-3-yl]-2-fluoranyl-~{N}-[(2~{R})-1-oxidanylpropan-2-yl]benzamide, Glucose-dependent insulinotropic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Wong, T.S, Zeng, Z.C, Xiong, T.T, Gan, S.Y, Qiu, C, Du, Y. | Deposit date: | 2024-06-04 | Release date: | 2024-06-19 | Last modified: | 2024-11-13 | Method: | ELECTRON MICROSCOPY (3.31 Å) | Cite: | Cryo-EM structure of GPR119-Gs complex To Be Published
|
|
8ZJE
 
 | Cryo-EM structure of kisspeptin receptor bound to TAK-448 | Descriptor: | ACE-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Shen, S, Liu, H, Xu, H.E. | Deposit date: | 2024-05-14 | Release date: | 2024-07-03 | Last modified: | 2025-01-15 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Structural basis for hormone recognition and distinctive Gq protein coupling by the kisspeptin receptor. Cell Rep, 43, 2024
|
|
8ZRK
 
 | Cryo-EM structure of GPR119-Gs Complex with small molecule agonist GSK-1292263 | Descriptor: | GSK-1292263, Glucose-dependent insulinotropic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Wong, T.S, Xiong, T.T, Zeng, Z.C, Gan, S.Y, Qiu, C, Du, Y. | Deposit date: | 2024-06-04 | Release date: | 2024-06-19 | Last modified: | 2025-07-16 | Method: | ELECTRON MICROSCOPY (2.82 Å) | Cite: | Cryo-EM structure of GPR119-Gs complex To be published
|
|
9AS0
 
 | Global reconstruction of 5-HT2AR bound to 2-bromo-LSD in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM) | Descriptor: | 2-bromo-N,N-diethyl-6-methyl-9,10-didehydroergoline-8beta-carboxamide, 5-hydroxytryptamine receptor 2A, G subunit q (Gi2-mini-Gq chimeric), ... | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | Deposit date: | 2024-02-24 | Release date: | 2025-04-02 | Last modified: | 2025-05-28 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | The structural diversity of psychedelic drug actions revealed. Nat Commun, 16, 2025
|
|
9AS2
 
 | Global reconstruction of 5-HT2AR bound to DMT in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM) | Descriptor: | 2-(1H-indol-3-yl)-N,N-dimethylethan-1-amine, 5-hydroxytryptamine receptor 2A, G subunit q (Gi2-mini-Gq chimeric), ... | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | Deposit date: | 2024-02-24 | Release date: | 2025-04-02 | Last modified: | 2025-05-14 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | The structural diversity of psychedelic drug actions revealed. Nat Commun, 16, 2025
|
|
9AS6
 
 | Global reconstruction of 5-HT2AR bound to mescaline in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM) | Descriptor: | 2-(3,4,5-trimethoxyphenyl)ethan-1-amine, 5-hydroxytryptamine receptor 2A, G subunit q (Gi2-mini-Gq chimeric), ... | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | Deposit date: | 2024-02-24 | Release date: | 2025-04-02 | Last modified: | 2025-05-28 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | The structural diversity of psychedelic drug actions revealed. Nat Commun, 16, 2025
|
|
9ASA
 
 | Global reconstruction of 5-HT2AR bound to RS130-180 in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM) | Descriptor: | 2,5-dimethoxy-N,N-dimethyl-4-{2-[({2-[(prop-2-yn-1-yl)oxy]phenyl}methyl)amino]ethyl}aniline, 5-hydroxytryptamine receptor 2A, G subunit q (Gi2-mini-Gq chimeric), ... | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | Deposit date: | 2024-02-24 | Release date: | 2025-04-02 | Last modified: | 2025-05-21 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | The structural diversity of psychedelic drug actions revealed. Nat Commun, 16, 2025
|
|
8ZYU
 
 | Cryo-EM structure of neurotensin receptor 1 in complex with beta-arrestin1 and SBI-553 (complex 1) | Descriptor: | 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-arrestin-1, Fab30 heavy chain, ... | Authors: | Sun, D, Li, X, Yuan, Q, Yin, W, Xu, H.E, Tian, C. | Deposit date: | 2024-06-18 | Release date: | 2025-04-16 | Method: | ELECTRON MICROSCOPY (2.65 Å) | Cite: | Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator. Cell Res., 35, 2025
|
|
9AS4
 
 | Global reconstruction of 5-HT2AR bound to LSD in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM) | Descriptor: | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 2A, G subunit q (Gi2-mini-Gq chimeric), ... | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | Deposit date: | 2024-02-24 | Release date: | 2025-04-02 | Last modified: | 2025-06-04 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | The structural diversity of psychedelic drug actions revealed. Nat Commun, 16, 2025
|
|
9ARY
 
 | Global reconstruction 5-HT2AR bound to 5-HT in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM) | Descriptor: | 5-hydroxytryptamine receptor 2A, G subunit q (Gi2-mini-Gq chimeric), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | Deposit date: | 2024-02-24 | Release date: | 2025-04-02 | Last modified: | 2025-05-28 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | The structural diversity of psychedelic drug actions revealed. Nat Commun, 16, 2025
|
|
9AS8
 
 | Global reconstruction of 5-HT2AR bound to psilocin in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM) | Descriptor: | 3-[2-(dimethylamino)ethyl]-1~{H}-indol-4-ol, 5-hydroxytryptamine receptor 2A, G subunit q (Gi2-mini-Gq chimeric), ... | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | Deposit date: | 2024-02-24 | Release date: | 2025-04-02 | Last modified: | 2025-05-21 | Method: | ELECTRON MICROSCOPY (2.54 Å) | Cite: | The structural diversity of psychedelic drug actions revealed. Nat Commun, 16, 2025
|
|
8ZYT
 
 | Cryo-EM structure of neurotensin receptor 1 in complex with beta-arrestin1 and SBI-553 (complex 3) | Descriptor: | 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-arrestin-1, Fab30 heavy chain, ... | Authors: | Sun, D, Li, X, Yuan, Q, Yin, W, Xu, H.E, Tian, C. | Deposit date: | 2024-06-18 | Release date: | 2025-04-09 | Last modified: | 2025-05-28 | Method: | ELECTRON MICROSCOPY (2.65 Å) | Cite: | Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator. Cell Res., 35, 2025
|
|
8ZCF
 
 | Cryo-EM structure of GPR4 complexed with Gs in pH7.5 | Descriptor: | G-protein coupled receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Yue, X.L, Wu, L.J, Hua, T, Liu, Z.J. | Deposit date: | 2024-04-29 | Release date: | 2025-04-23 | Last modified: | 2025-06-25 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of stepwise proton sensing-mediated GPCR activation. Cell Res., 35, 2025
|
|
8ZYY
 
 | Cryo-EM structure of neurotensin receptor 1 in complex with beta-arrestin1 and SBI-553 (complex 2) | Descriptor: | 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-arrestin-1, Fab30 heavy chain, ... | Authors: | Sun, D, Li, X, Yuan, Q, Yin, W, Xu, H.E, Tian, C. | Deposit date: | 2024-06-18 | Release date: | 2025-04-09 | Last modified: | 2025-07-16 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator. Cell Res., 35, 2025
|
|
8ZBI
 
 | Cryo-EM structure of Somatostatin receptor 3 (SSTR3) with Gi1 complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Yun, J.H. | Deposit date: | 2024-04-26 | Release date: | 2025-04-30 | Method: | ELECTRON MICROSCOPY (2.79 Å) | Cite: | The structures of SSTR3 and SSTR5 provide insights into the specificity among somatostatin receptors To Be Published
|
|
8ZCE
 
 | Cryo-EM structure of GPR4 complexed with Gs in pH6.0 | Descriptor: | G-protein coupled receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Yue, X.L, Wu, L.J, Hua, T, Liu, Z.J. | Deposit date: | 2024-04-29 | Release date: | 2025-04-23 | Last modified: | 2025-06-18 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of stepwise proton sensing-mediated GPCR activation. Cell Res., 35, 2025
|
|
8ZBJ
 
 | Cryo-EM structure of Somatostatin receptor 5 (SSTR5) with Gi1 complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Kim, Y, Yun, J.H. | Deposit date: | 2024-04-26 | Release date: | 2025-04-30 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | The structure of SSTR3 and SSTR5 provide insights into the specificity among somatostatin receptos. To Be Published
|
|