8REB
 
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8REA
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7KIM
 | | Mycobacterium tuberculosis WT RNAP transcription closed promoter complex with WhiB7 transcription factor | | Descriptor: | DNA (45-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Lilic, M, Darst, S.A, Campbell, E.A. | | Deposit date: | 2020-10-23 | | Release date: | 2021-04-21 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.38 Å) | | Cite: | Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7.
Mol.Cell, 81, 2021
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6ALF
 | | CryoEM structure of crosslinked E.coli RNA polymerase elongation complex | | Descriptor: | DNA (29-MER), DNA (5'-D(*GP*GP*GP*CP*TP*AP*AP*TP*GP*AP*CP*GP*GP*CP*GP*AP*AP*TP*AP*CP*CP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Kang, J.Y, Darst, S.A. | | Deposit date: | 2017-08-07 | | Release date: | 2017-08-16 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structural basis of transcription arrest by coliphage HK022 Nun in anEscherichia coliRNA polymerase elongation complex.
Elife, 6, 2017
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6ALH
 | | CryoEM structure of E.coli RNA polymerase elongation complex | | Descriptor: | DNA (29-MER), DNA (5'-D(*GP*GP*GP*CP*TP*AP*AP*TP*GP*AP*CP*GP*GP*CP*GP*AP*AP*TP*AP*CP*CP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Kang, J.Y, Darst, S.A. | | Deposit date: | 2017-08-07 | | Release date: | 2017-08-16 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structural basis of transcription arrest by coliphage HK022 Nun in anEscherichia coliRNA polymerase elongation complex.
Elife, 6, 2017
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7AST
 | | Apo Human RNA Polymerase III | | Descriptor: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | | Authors: | Ramsay, E.P, Abascal-Palacios, G, Daiss, J.L, King, H, Gouge, J, Pilsl, M, Beuron, F, Morris, E, Gunkel, P, Engel, C, Vannini, A. | | Deposit date: | 2020-10-28 | | Release date: | 2020-12-23 | | Last modified: | 2020-12-30 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structure of human RNA polymerase III.
Nat Commun, 11, 2020
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8UIS
 | | Structure of transcription complex Pol II-DSIF-NELF-TFIIS | | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... | | Authors: | Su, B.G, Vos, S.M. | | Deposit date: | 2023-10-10 | | Release date: | 2024-03-20 | | Last modified: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing.
Mol.Cell, 84, 2024
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6CUU
 | | Thermus thermophiles RNA polymerase in complex with promoter DNA and antibiotic Kanglemycin A | | Descriptor: | DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*CP*TP*CP*TP*GP*AP*TP*GP*CP*A)-3'), DNA (5'-D(P*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Molodtsov, V, Murakami, K.S. | | Deposit date: | 2018-03-26 | | Release date: | 2018-07-25 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.994 Å) | | Cite: | Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis.
Mol. Cell, 72, 2018
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5OQJ
 | | STRUCTURE OF YEAST TRANSCRIPTION PRE-INITIATION COMPLEX WITH TFIIH | | Descriptor: | DNA repair helicase RAD25, DNA repair helicase RAD3, DNA-directed RNA polymerase II subunit RPB1, ... | | Authors: | Schilbach, S, Hantsche, M, Tegunov, D, Dienemann, C, Wigge, C, Henning, U, Cramer, P. | | Deposit date: | 2017-08-11 | | Release date: | 2018-04-25 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Structures of transcription pre-initiation complex with TFIIH and Mediator.
Nature, 551, 2017
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7KIN
 | | Mycobacterium tuberculosis WT RNAP transcription open promoter complex with WhiB7 promoter | | Descriptor: | DNA (49-MER), DNA (54-MER), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Lilic, M, Darst, S.A, Campbell, E.A. | | Deposit date: | 2020-10-23 | | Release date: | 2021-04-21 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.74 Å) | | Cite: | Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7.
Mol.Cell, 81, 2021
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5OQM
 | | STRUCTURE OF YEAST TRANSCRIPTION PRE-INITIATION COMPLEX WITH TFIIH AND CORE MEDIATOR | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | | Authors: | Schilbach, S, Hantsche, M, Tegunov, D, Dienemann, C, Wigge, C, Urlaub, H, Cramer, P. | | Deposit date: | 2017-08-13 | | Release date: | 2018-05-09 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (5.8 Å) | | Cite: | Structures of transcription pre-initiation complex with TFIIH and Mediator.
Nature, 551, 2017
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8H02
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6C05
 | | Mycobacterium tuberculosis RNAP Holo/RbpA in relaxed state | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J, Lilic, M. | | Deposit date: | 2017-12-27 | | Release date: | 2018-03-28 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (5.15 Å) | | Cite: | Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
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6ZFB
 | | Structure of the B. subtilis RNA POLYMERASE in complex with HelD (dimer) | | Descriptor: | DNA helicase, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Pei, H.-P, Hilal, T, Huang, Y.-H, Said, N, Loll, B, Wahl, M.C. | | Deposit date: | 2020-06-17 | | Release date: | 2020-10-14 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | The delta subunit and NTPase HelD institute a two-pronged mechanism for RNA polymerase recycling.
Nat Commun, 11, 2020
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8U3B
 | | Cryo-EM structure of E. coli NarL-transcription activation complex at 3.2A | | Descriptor: | DNA (69-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Liu, B, Kompaniiets, D, Wang, D. | | Deposit date: | 2023-09-07 | | Release date: | 2024-01-17 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Structural basis for transcription activation by the nitrate-responsive regulator NarL.
Nucleic Acids Res., 52, 2024
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7X76
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7X74
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7X75
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7VPZ
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6TYE
 | | Crystal structure of MTB sigma L transcription initiation complex with 5 nt long RNA primer | | Descriptor: | DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*AP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(P*GP*TP*GP*TP*CP*AP*GP*TP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Molodtsov, V, Ebright, R.H. | | Deposit date: | 2019-08-08 | | Release date: | 2020-03-11 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.79 Å) | | Cite: | RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc.Natl.Acad.Sci.USA, 117, 2020
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7AOF
 | | Atomic structure of the poxvirus transcription late pre-initiation complex | | Descriptor: | DNA-directed RNA polymerase, DNA-directed RNA polymerase 147 kDa polypeptide, DNA-directed RNA polymerase 18 kDa subunit, ... | | Authors: | Grimm, C, Bartuli, J, Fischer, U. | | Deposit date: | 2020-10-14 | | Release date: | 2021-10-06 | | Last modified: | 2021-10-20 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | Structural basis of the complete poxvirus transcription initiation process.
Nat.Struct.Mol.Biol., 28, 2021
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7AP8
 | | Atomic structure of the poxvirus initially transcribing complex in conformation 2 | | Descriptor: | DNA-directed RNA polymerase, DNA-directed RNA polymerase 147 kDa polypeptide, DNA-directed RNA polymerase 18 kDa subunit, ... | | Authors: | Grimm, C, Bartuli, J, Fischer, U. | | Deposit date: | 2020-10-16 | | Release date: | 2021-10-06 | | Last modified: | 2021-10-20 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | Structural basis of the complete poxvirus transcription initiation process.
Nat.Struct.Mol.Biol., 28, 2021
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7AOZ
 | | Atomic structure of the poxvirus transcription initiation complex in conformation 1 | | Descriptor: | DNA-directed RNA polymerase, DNA-directed RNA polymerase 147 kDa polypeptide, DNA-directed RNA polymerase 18 kDa subunit, ... | | Authors: | Grimm, C, Bartuli, J, Fischer, U. | | Deposit date: | 2020-10-15 | | Release date: | 2021-10-06 | | Last modified: | 2021-10-20 | | Method: | ELECTRON MICROSCOPY (2.85 Å) | | Cite: | Structural basis of the complete poxvirus transcription initiation process.
Nat.Struct.Mol.Biol., 28, 2021
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7AOH
 | | Atomic structure of the poxvirus late initially transcribing complex | | Descriptor: | DNA-directed RNA polymerase, DNA-directed RNA polymerase 147 kDa polypeptide, DNA-directed RNA polymerase 18 kDa subunit, ... | | Authors: | Grimm, C, Bartuli, J, Fischer, U. | | Deposit date: | 2020-10-14 | | Release date: | 2021-10-06 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural basis of the complete poxvirus transcription initiation process.
Nat.Struct.Mol.Biol., 28, 2021
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7AP9
 | | Atomic structure of the poxvirus initially transcribing complex in conformation 3 | | Descriptor: | DNA-directed RNA polymerase, DNA-directed RNA polymerase 147 kDa polypeptide, DNA-directed RNA polymerase 18 kDa subunit, ... | | Authors: | Grimm, C, Bartuli, J, Fischer, U. | | Deposit date: | 2020-10-16 | | Release date: | 2021-10-06 | | Last modified: | 2021-10-20 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Structural basis of the complete poxvirus transcription initiation process.
Nat.Struct.Mol.Biol., 28, 2021
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