7CIJ
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![BU of 7cij by Molmil](/molmil-images/mine/7cij) | Crystal structure of L-methionine decarboxylase from Streptomyces sp.590 in complexed with 3-methlythiopropylamine (external aldimine form). | Descriptor: | L-methionine decarboxylase, [6-methyl-4-[(E)-3-methylsulfanylpropyliminomethyl]-5-oxidanyl-pyridin-3-yl]methyl dihydrogen phosphate | Authors: | Okawa, A, Shiba, T, Hayashi, M, Onoue, Y, Murota, M, Sato, D, Inagaki, J, Tamura, T, Harada, S, Inagaki, K. | Deposit date: | 2020-07-07 | Release date: | 2021-01-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Structural basis for substrate specificity of l-methionine decarboxylase. Protein Sci., 30, 2021
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7CL4
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![BU of 7cl4 by Molmil](/molmil-images/mine/7cl4) | The crystal structure of KanJ in complex with N-oxalylglycine | Descriptor: | Kanamycin B dioxygenase, N-OXALYLGLYCINE, NICKEL (II) ION | Authors: | Kitayama, Y, Miyanaga, A, Kudo, F, Eguchi, T. | Deposit date: | 2020-07-20 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Stepwise Post-glycosylation Modification of Sugar Moieties in Kanamycin Biosynthesis. Chembiochem, 22, 2021
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7C6B
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![BU of 7c6b by Molmil](/molmil-images/mine/7c6b) | Crystal structure of Ago2 MID domain in complex with 6-(3-(2-carboxyethyl)phenyl)purine riboside monophosphate | Descriptor: | 3-[3-[9-[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]purin-6-yl]phenyl]propanoic acid, PHOSPHATE ION, Protein argonaute-2 | Authors: | Suzuki, M, Takahashi, Y, Saito, J, Miyagi, H, Shinohara, F. | Deposit date: | 2020-05-21 | Release date: | 2020-11-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | siRNA potency enhancement via chemical modifications of nucleotide bases at the 5'-end of the siRNA guide strand. Rna, 27, 2021
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7C7L
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![BU of 7c7l by Molmil](/molmil-images/mine/7c7l) | Cryo-EM structure of the Cas12f1-sgRNA-target DNA complex | Descriptor: | CRISPR-associated protein Cas14a.1, DNA (40-mer), ZINC ION, ... | Authors: | Takeda, N.S, Nakagawa, R, Okazaki, S, Hirano, H, Kobayashi, K, Kusakizako, T, Nishizawa, T, Yamashita, K, Nishimasu, H, Nureki, O. | Deposit date: | 2020-05-26 | Release date: | 2020-12-23 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of the miniature type V-F CRISPR-Cas effector enzyme. Mol.Cell, 81, 2021
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7CIB
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![BU of 7cib by Molmil](/molmil-images/mine/7cib) | Crystal structure of P.aeruginosa LpxC in complex with inhibitor | Descriptor: | 2-oxidanyl-4-phenyl-benzoic acid, DIMETHYL SULFOXIDE, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ... | Authors: | Baker, L.M, Mima, M, Surgenor, A, Robertson, A. | Deposit date: | 2020-07-07 | Release date: | 2020-12-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity. J.Med.Chem., 63, 2020
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7CIF
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![BU of 7cif by Molmil](/molmil-images/mine/7cif) | Crystal structure of L-methionine decarboxylase from Streptomyces sp.590 (internal aldimine form). | Descriptor: | L-methionine decarboxylase | Authors: | Okawa, A, Shiba, T, Hayashi, M, Onoue, Y, Murota, M, Sato, D, Inagaki, J, Tamura, T, Harada, S, Inagaki, K. | Deposit date: | 2020-07-07 | Release date: | 2021-01-27 | Last modified: | 2021-03-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for substrate specificity of l-methionine decarboxylase. Protein Sci., 30, 2021
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7C8B
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![BU of 7c8b by Molmil](/molmil-images/mine/7c8b) | Crystal structure of the SARS-CoV-2 main protease in complex with Z-VAD(OMe)-FMK | Descriptor: | 3C-like proteinase, CHLORIDE ION, Z-VAD(OMe)-FMK | Authors: | Zeng, R, Qiao, J.X, Wang, Y.F, Li, Y.S, Yao, R, Yang, S.Y, Lei, J. | Deposit date: | 2020-05-29 | Release date: | 2020-09-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the SARS-CoV-2 main protease in complex with Z-VAD(OMe)-FMK To Be Published
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7CBH
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![BU of 7cbh by Molmil](/molmil-images/mine/7cbh) | Crystal structure of threonyl-tRNA synthetase (ThrRS) from Salmonella enterica in complex with an inhibitor | Descriptor: | Threonine--tRNA ligase, ZINC ION, [(E)-4-(7-bromanyl-6-chloranyl-4-oxidanylidene-quinazolin-3-yl)but-2-enyl] (2S,3R)-2-azanyl-3-oxidanyl-butanoate | Authors: | Guo, J, Chen, B, Zhou, H. | Deposit date: | 2020-06-12 | Release date: | 2020-10-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure-guided optimization and mechanistic study of a class of quinazolinone-threonine hybrids as antibacterial ThrRS inhibitors. Eur.J.Med.Chem., 207, 2020
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7CC7
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![BU of 7cc7 by Molmil](/molmil-images/mine/7cc7) | |
7C61
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![BU of 7c61 by Molmil](/molmil-images/mine/7c61) | Crystal structure of 5-HT1B-BRIL and SRP2070_Fab complex | Descriptor: | 5-hydroxytryptamine receptor 1B,Soluble cytochrome b562,5-hydroxytryptamine receptor 1B, Ergotamine, IGG HEAVY CHAIN, ... | Authors: | Suzuki, M, Miyagi, H, Asada, H, Yasunaga, M, Suno, C, Takahashi, Y, Saito, J, Iwata, S. | Deposit date: | 2020-05-21 | Release date: | 2020-07-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The discovery of a new antibody for BRIL-fused GPCR structure determination. Sci Rep, 10, 2020
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7CNT
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![BU of 7cnt by Molmil](/molmil-images/mine/7cnt) | Structure of 2,5-dihydroxypridine Dioxygenase from Pseudomonas putida KT2440 in complex with product N-formylmaleamic acid formed via in crystallo reaction with 2,5-dihydroxypridine | Descriptor: | 2,5-dihydroxypyridine 5,6-dioxygenase, FE (II) ION | Authors: | Liu, G.Q, Tang, H.Z. | Deposit date: | 2020-08-03 | Release date: | 2020-12-16 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | 2,5-dihydroxypridine Dioxygenase in complex with 2,5-dihydroxypridine and product N-formylmaleamic acid Nat Commun, 2020
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7CL6
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![BU of 7cl6 by Molmil](/molmil-images/mine/7cl6) | The crystal structure of KanJ in complex with neamine and N-oxalylglycine | Descriptor: | (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside, Kanamycin B dioxygenase, N-OXALYLGLYCINE, ... | Authors: | Kitayama, Y, Miyanaga, A, Kudo, F, Eguchi, T. | Deposit date: | 2020-07-20 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Stepwise Post-glycosylation Modification of Sugar Moieties in Kanamycin Biosynthesis. Chembiochem, 22, 2021
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7CQE
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![BU of 7cqe by Molmil](/molmil-images/mine/7cqe) | |
7CBS
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![BU of 7cbs by Molmil](/molmil-images/mine/7cbs) | Crystal structure of SpaB basal pilin from Lactobacillus rhamnosus GG | Descriptor: | CHLORIDE ION, LPXTG cell wall anchor domain-containing protein, MAGNESIUM ION | Authors: | Megta, A.K, Pratap, S, Kant, A, Krishnan, V. | Deposit date: | 2020-06-13 | Release date: | 2020-12-30 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Crystal structure of the atypically adhesive SpaB basal pilus subunit: Mechanistic insights about its incorporation in lactobacillar SpaCBA pili. Curr Res Struct Biol, 2, 2020
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7CUP
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![BU of 7cup by Molmil](/molmil-images/mine/7cup) | Structure of 2,5-dihydroxypridine Dioxygenase from Pseudomonas putida KT2440 | Descriptor: | 2,5-dihydroxypyridine 5,6-dioxygenase, FE (III) ION | Authors: | Liu, G.Q, Tang, H.Z. | Deposit date: | 2020-08-23 | Release date: | 2020-12-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | 2,5-dihydroxypridine Dioxygenase in complex with 2,5-dihydroxypridine and product N-formylmaleamic acid Nat Commun, 2020
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7C4A
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![BU of 7c4a by Molmil](/molmil-images/mine/7c4a) | nicA2 with cofactor FAD | Descriptor: | Amine oxidase, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Xu, P, Zang, K. | Deposit date: | 2020-05-15 | Release date: | 2020-06-03 | Last modified: | 2020-12-16 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Molecular Deceleration Regulates Toxicant Release to Prevent Cell Damage in Pseudomonas putida S16 (DSM 28022). Mbio, 11, 2020
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7CGV
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![BU of 7cgv by Molmil](/molmil-images/mine/7cgv) | Full consensus L-threonine 3-dehydrogenase, FcTDH-IIYM (NAD+ bound form) | Descriptor: | Artificial L-threonine 3-dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Motoyama, T, Hiramatsu, N, Asano, Y, Nakano, S, Ito, S. | Deposit date: | 2020-07-02 | Release date: | 2020-10-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Protein Sequence Selection Method That Enables Full Consensus Design of Artificial l-Threonine 3-Dehydrogenases with Unique Enzymatic Properties. Biochemistry, 59, 2020
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7CL2
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![BU of 7cl2 by Molmil](/molmil-images/mine/7cl2) | The crystal structure of KanJ | Descriptor: | GLYCEROL, Kanamycin B dioxygenase, NICKEL (II) ION, ... | Authors: | Kitayama, Y, Miyanaga, A, Kudo, F, Eguchi, T. | Deposit date: | 2020-07-20 | Release date: | 2021-01-13 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Stepwise Post-glycosylation Modification of Sugar Moieties in Kanamycin Biosynthesis. Chembiochem, 22, 2021
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7CIE
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![BU of 7cie by Molmil](/molmil-images/mine/7cie) | Crystal structure of P.aeruginosa LpxC in complex with inhibitor | Descriptor: | (2R)-2-azanyl-3-oxidanyl-N-[3-(trifluoromethyloxy)phenyl]propanamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION | Authors: | Baker, L.M, Mima, M, Surgenor, A, Robertson, A. | Deposit date: | 2020-07-07 | Release date: | 2020-12-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity. J.Med.Chem., 63, 2020
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7CL3
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![BU of 7cl3 by Molmil](/molmil-images/mine/7cl3) | The crystal structure of KanJ in complex with kanamycin B | Descriptor: | (1R,2S,3S,4R,6S)-4,6-DIAMINO-3-[(3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYCYCLOHEXYL 2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSIDE, Kanamycin B dioxygenase, NICKEL (II) ION, ... | Authors: | Kitayama, Y, Miyanaga, A, Kudo, F, Eguchi, T. | Deposit date: | 2020-07-20 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Stepwise Post-glycosylation Modification of Sugar Moieties in Kanamycin Biosynthesis. Chembiochem, 22, 2021
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2YJW
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![BU of 2yjw by Molmil](/molmil-images/mine/2yjw) | Tricyclic series of Hsp90 inhibitors | Descriptor: | 4-(5-METHYL-4-PHENYLISOXAZOL-3-YL)BENZENE-1,3-DIOL, HEAT SHOCK PROTEIN HSP 90-ALPHA | Authors: | Dupuy, A, Vallee, F. | Deposit date: | 2011-05-24 | Release date: | 2011-10-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone. J.Med.Chem., 54, 2011
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7CTO
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![BU of 7cto by Molmil](/molmil-images/mine/7cto) | Staphylococcus aureus MsrB | Descriptor: | Peptide methionine sulfoxide reductase MsrB | Authors: | Kim, H.J. | Deposit date: | 2020-08-19 | Release date: | 2020-10-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.47 Å) | Cite: | Implication of Staphylococcus aureus MsrB dimerization upon oxidation. Biochem.Biophys.Res.Commun., 533, 2020
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7CUC
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![BU of 7cuc by Molmil](/molmil-images/mine/7cuc) | |
7CW5
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![BU of 7cw5 by Molmil](/molmil-images/mine/7cw5) | Acetyl-CoA acetyltransferase from Bacillus cereus ATCC 14579 | Descriptor: | Acetyl-CoA acetyltransferase, COENZYME A | Authors: | Hong, J, Kim, K.J. | Deposit date: | 2020-08-27 | Release date: | 2020-10-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of an acetyl-CoA acetyltransferase from PHB producing bacterium Bacillus cereus ATCC 14579. Biochem.Biophys.Res.Commun., 533, 2020
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7CVX
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![BU of 7cvx by Molmil](/molmil-images/mine/7cvx) | |