7D2A
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![BU of 7d2a by Molmil](/molmil-images/mine/7d2a) | CBM32 of AlyQ in complex with 4,5-unsaturated mannuronic acid | Descriptor: | 4-deoxy-alpha-L-erythro-hex-4-enopyranuronic acid-(1-4)-alpha-L-gulopyranuronic acid, AlyQ, CALCIUM ION, ... | Authors: | Teh, A.H, Sim, P.F. | Deposit date: | 2020-09-16 | Release date: | 2020-12-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Structural basis for binding uronic acids by family 32 carbohydrate-binding modules. Biochem.Biophys.Res.Commun., 533, 2020
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4ZJJ
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3F34
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![BU of 3f34 by Molmil](/molmil-images/mine/3f34) | Apoferritin: complex with 2,6-diethylphenol | Descriptor: | 2,6-diethylphenol, ACETATE ION, CADMIUM ION, ... | Authors: | Vedula, L.S, Economou, N.J, Rossi, M.J, Eckenhoff, R.G, Loll, P.J. | Deposit date: | 2008-10-30 | Release date: | 2009-07-14 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | A unitary anesthetic binding site at high resolution. J.Biol.Chem., 284, 2009
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2Q8D
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![BU of 2q8d by Molmil](/molmil-images/mine/2q8d) | Crystal structure of JMJ2D2A in ternary complex with histone H3-K36me2 and succinate | Descriptor: | HISTONE 3 peptide, JmjC domain-containing histone demethylation protein 3A, NICKEL (II) ION, ... | Authors: | Couture, J.-F, Collazo, E, Ortiz-Tello, P, Brunzelle, J.S, Trievel, R.C. | Deposit date: | 2007-06-10 | Release date: | 2007-07-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase. Nat.Struct.Mol.Biol., 14, 2007
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2Q9I
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3PJ0
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5XDM
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3NEW
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![BU of 3new by Molmil](/molmil-images/mine/3new) | p38-alpha complexed with Compound 10 | Descriptor: | 4-(trifluoromethyl)-3-[3-(trifluoromethyl)phenyl]-1,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one, Mitogen-activated protein kinase 14 | Authors: | Goedken, E.R, Comess, K.M, Sun, C, Argiriadi, M, Jia, Y, Quinn, C.M, Banach, D.L, Marcotte, D, Borhani, D. | Deposit date: | 2010-06-09 | Release date: | 2010-12-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases. Acs Chem.Biol., 6, 2011
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3NFK
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![BU of 3nfk by Molmil](/molmil-images/mine/3nfk) | Crystal structure of the PTPN4 PDZ domain complexed with the C-terminus of a rabies virus G protein | Descriptor: | GLYCEROL, Glycoprotein G, Tyrosine-protein phosphatase non-receptor type 4 | Authors: | Babault, N, Cordier, F, Lafage, M, Cockburn, J, Haouz, A, Rey, F.A, Delepierre, M, Buc, H, Lafon, M, Wolff, N. | Deposit date: | 2010-06-10 | Release date: | 2011-08-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | Peptides Targeting the PDZ Domain of PTPN4 Are Efficient Inducers of Glioblastoma Cell Death. Structure, 19, 2011
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5HZB
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![BU of 5hzb by Molmil](/molmil-images/mine/5hzb) | Crystal structure of GII.10 P domain in complex with 2-fucosyllactose (2'FL) | Descriptor: | 1,2-ETHANEDIOL, Capsid protein, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Hansman, G.S, Koromyslova, A.D, Singh, B.K.S. | Deposit date: | 2016-02-02 | Release date: | 2016-03-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.553 Å) | Cite: | Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides. J.Virol., 90, 2016
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3NFL
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![BU of 3nfl by Molmil](/molmil-images/mine/3nfl) | Crystal structure of the PTPN4 PDZ domain complexed with the C-terminus of the GluN2A NMDA receptor subunit | Descriptor: | Glutamate [NMDA] receptor subunit epsilon-1, Tyrosine-protein phosphatase non-receptor type 4 | Authors: | Babault, N, Cordier, F, Lafage, M, Cockburn, J, Haouz, A, Rey, F.A, Delepierre, M, Buc, H, Lafon, M, Wolff, N. | Deposit date: | 2010-06-10 | Release date: | 2011-08-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Peptides Targeting the PDZ Domain of PTPN4 Are Efficient Inducers of Glioblastoma Cell Death. Structure, 19, 2011
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3NJD
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3GPE
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![BU of 3gpe by Molmil](/molmil-images/mine/3gpe) | Crystal Structure Analysis of PKC (alpha)-C2 domain complexed with Ca2+ and PtdIns(4,5)P2 | Descriptor: | CALCIUM ION, PHOSPHATE ION, Protein kinase C alpha type, ... | Authors: | Ferrer-Orta, C, Querol-Audi, J, Fita, I, Verdaguer, N. | Deposit date: | 2009-03-23 | Release date: | 2009-05-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and mechanistic insights into the association of PKCalpha-C2 domain to PtdIns(4,5)P2. Proc.Natl.Acad.Sci.USA, 106, 2009
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3H2G
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2OJM
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5HEZ
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![BU of 5hez by Molmil](/molmil-images/mine/5hez) | JAK2 kinase (JH1 domain) mutant P1057A in complex with TG101209 | Descriptor: | CHLORIDE ION, N-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide, Tyrosine-protein kinase JAK2, ... | Authors: | Ultsch, M, Eigenbrot, C. | Deposit date: | 2016-01-06 | Release date: | 2016-11-09 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity. Sci Transl Med, 8, 2016
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2NTF
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3H81
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3H0L
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![BU of 3h0l by Molmil](/molmil-images/mine/3h0l) | Structure of trna-dependent amidotransferase gatcab from aquifex aeolicus | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ASPARAGINE, Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, ... | Authors: | Wu, J, Bu, W, Sheppard, K, Kitabatake, M, Soll, D, Smith, J.L. | Deposit date: | 2009-04-09 | Release date: | 2009-07-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Insights into tRNA-Dependent Amidotransferase Evolution and Catalysis from the Structure of the Aquifex aeolicus Enzyme J.Mol.Biol., 391, 2009
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3GL6
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3NAQ
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![BU of 3naq by Molmil](/molmil-images/mine/3naq) | Apo-form of NAD-dependent formate dehydrogenase from higher-plant Arabidopsis thaliana | Descriptor: | Formate dehydrogenase, SULFATE ION | Authors: | Shabalin, I.G, Polyakov, K.M, Serov, A.E, Skirgello, O.E, Sadykhov, E.G, Dorovatovskiy, P.V, Tishkov, V.I, Popov, V.O. | Deposit date: | 2010-06-02 | Release date: | 2010-07-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structures of the apo and holo forms of NAD-dependent formate dehydrogenase from the higher-plant Arabidopsis Thaliana to be published
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2O05
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![BU of 2o05 by Molmil](/molmil-images/mine/2o05) | Human spermidine synthase | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, Spermidine synthase | Authors: | Min, J, Wu, H, Zeng, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2006-11-27 | Release date: | 2006-12-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and mechanism of spermidine synthases. Biochemistry, 46, 2007
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3Q1E
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![BU of 3q1e by Molmil](/molmil-images/mine/3q1e) | Crystal structure of Y116T/I16A double mutant of 5-hydroxyisourate hydrolase in complex with T4 | Descriptor: | 3,5,3',5'-TETRAIODO-L-THYRONINE, 5-hydroxyisourate hydrolase | Authors: | Cendron, L, Ramazzina, I, Percudani, R, Zanotti, G, Berni, R. | Deposit date: | 2010-12-17 | Release date: | 2011-05-04 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Probing the evolution of hydroxyisourate hydrolase into transthyretin through active-site redesign. J.Mol.Biol., 409, 2011
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3Q2G
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![BU of 3q2g by Molmil](/molmil-images/mine/3q2g) | Adamts1 in complex with a novel N-hydroxyformamide inhibitors | Descriptor: | A disintegrin and metalloproteinase with thrombospondin motifs 1, CADMIUM ION, MAGNESIUM ION, ... | Authors: | Gerhardt, S, Hargreaves, D. | Deposit date: | 2010-12-20 | Release date: | 2011-03-30 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis Bioorg.Med.Chem.Lett., 21, 2011
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6A2L
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![BU of 6a2l by Molmil](/molmil-images/mine/6a2l) | Crystal structure of quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum DHFR-TS complexed with BT1, NADPH, and dUMP | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-(3-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-6-ethylpyrimidine-2,4-diamine, Bifunctional dihydrofolate reductase-thymidylate synthase, ... | Authors: | Chitnumsub, P, Jaruwat, A, Tarnchampoo, B, Yuthavong, Y. | Deposit date: | 2018-06-12 | Release date: | 2019-04-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance. ACS Med Chem Lett, 9, 2018
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