7YND
| Cryo-EM structure of Cas7-11-crRNA-Csx29 ternary complex | Descriptor: | CHAT domain-containing protein, CRISPR-associated RAMP family protein, crRNA (38-MER) | Authors: | Huo, Y, Dong, Q, Zhao, H, Jiang, T. | Deposit date: | 2022-07-30 | Release date: | 2023-02-01 | Last modified: | 2023-03-15 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | Cryo-EM structure and protease activity of the type III-E CRISPR-Cas effector. Nat Microbiol, 8, 2023
|
|
7DSM
| |
4W5X
| |
7DSO
| |
6DQ5
| |
7DSR
| |
6DUZ
| Structure of the periplasmic domains of PrgH and PrgK from the assembled Salmonella type III secretion injectisome needle complex | Descriptor: | Lipoprotein PrgK, Protein PrgH | Authors: | Hu, J, Worrall, L.J, Vuckovic, M, Atkinson, C.E, Strynadka, N.C.J. | Deposit date: | 2018-06-22 | Release date: | 2018-10-03 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin. Nat Commun, 9, 2018
|
|
6DQE
| |
6DX2
| Crystal structure of the viral OTU domain protease from Dera Ghazi Khan virus | Descriptor: | RNA-dependent RNA polymerase | Authors: | Beldon, B.S, Dzimianski, J.V, Daczkowski, C.M, Goodwin, O.Y, Pegan, S.D. | Deposit date: | 2018-06-28 | Release date: | 2018-12-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.614 Å) | Cite: | Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity. PLoS Pathog., 15, 2019
|
|
7Z6U
| Pim1 in complex with (E)-4-((6-amino-2-oxoindolin-3-ylidene)methyl)benzoic acid and Pimtide | Descriptor: | 4-[(~{E})-(6-azanyl-2-oxidanylidene-1~{H}-indol-3-ylidene)methyl]benzoic acid, GLYCEROL, Isoform 1 of Serine/threonine-protein kinase pim-1, ... | Authors: | Hochban, P.M.M, Heine, A, Diederich, W.E. | Deposit date: | 2022-03-14 | Release date: | 2023-02-01 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Pose, duplicate, then elaborate: Steps towards increased affinity for inhibitors targeting the specificity surface of the Pim-1 kinase. Eur.J.Med.Chem., 245, 2023
|
|
6DXV
| Citrobacter freundii tyrosine phenol-lyase F448A mutant | Descriptor: | POTASSIUM ION, Tyrosine phenol-lyase | Authors: | Phillips, R.S. | Deposit date: | 2018-07-01 | Release date: | 2018-10-10 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structures of Wild-Type and F448A Mutant Citrobacter freundii Tyrosine Phenol-Lyase Complexed with a Substrate and Inhibitors: Implications for the Reaction Mechanism. Biochemistry, 57, 2018
|
|
4W7Z
| Tetrameric BAP29 vDED without disulfide bonds | Descriptor: | ACETATE ION, B-cell receptor-associated protein 29, SULFATE ION | Authors: | Quistgaard, E.M. | Deposit date: | 2014-08-22 | Release date: | 2014-10-29 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A disulfide polymerized protein crystal. Chem.Commun.(Camb.), 50, 2014
|
|
7DSP
| |
7Z9G
| E.coli gyrase holocomplex with 217 bp DNA and Albi-2 | Descriptor: | 4-[[3-(2-azanylethoxy)-2-oxidanyl-4-[[5-[[(2~{S})-2-[[4-[(6-oxidanylnaphthalen-2-yl)carbonylamino]phenyl]carbonylamino]-3-(1~{H}-1,2,3-triazol-4-yl)propanoyl]amino]pyridin-2-yl]carbonylamino]phenyl]carbonylamino]-3-methoxy-2-oxidanyl-benzoic acid, DNA (5'-D(*AP*AP*TP*CP*AP*CP*CP*CP*GP*CP*AP*CP*AP*GP*AP*TP*TP*T)-3'), DNA (5'-D(*GP*AP*TP*TP*TP*TP*AP*TP*GP*CP*CP*TP*GP*AP*TP*TP*CP*T)-3'), ... | Authors: | Ghilarov, D, Heddle, J.G.H. | Deposit date: | 2022-03-21 | Release date: | 2023-02-15 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Molecular mechanism of topoisomerase poisoning by the peptide antibiotic albicidin. Nat Catal, 6, 2023
|
|
7Z9M
| E.coli gyrase holocomplex with 217 bp DNA and Albi-1 (site AA) | Descriptor: | 4-[[4-[[5-[[(2S)-2-[[5-[(4-cyanophenyl)carbonylamino]pyridin-2-yl]carbonylamino]-3-(1H-1,2,3-triazol-4-yl)propanoyl]amino]pyridin-2-yl]carbonylamino]-2-oxidanyl-3-propan-2-yloxy-phenyl]carbonylamino]benzoic acid, DNA (5'-D(*AP*AP*TP*CP*AP*CP*CP*CP*GP*CP*AP*CP*AP*GP*AP*TP*TP*T)-3'), DNA (5'-D(*GP*AP*TP*TP*TP*TP*AP*TP*GP*CP*CP*TP*GP*AP*TP*TP*CP*T)-3'), ... | Authors: | Ghilarov, D, Heddle, J.G.H. | Deposit date: | 2022-03-21 | Release date: | 2023-02-15 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Molecular mechanism of topoisomerase poisoning by the peptide antibiotic albicidin. Nat Catal, 6, 2023
|
|
6DV0
| HIV-1 wild type protease with GRL-02815A, a thiochroman heterocycle with (S)-Boc-amine functionality as the P2 ligand | Descriptor: | CHLORIDE ION, GLYCEROL, Protease, ... | Authors: | Wang, Y.-F, Agniswamy, J, Weber, I.T. | Deposit date: | 2018-06-22 | Release date: | 2018-10-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands. Eur J Med Chem, 160, 2018
|
|
4W8G
| |
6DVW
| Cryo-EM structure of mouse TRPV3 | Descriptor: | Transient receptor potential cation channel subfamily V member 3 | Authors: | Singh, A.K, McGoldrick, L.L, Sobolevsky, A.I. | Deposit date: | 2018-06-25 | Release date: | 2018-09-05 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structure and gating mechanism of the transient receptor potential channel TRPV3. Nat. Struct. Mol. Biol., 25, 2018
|
|
6DTZ
| Crystal structure of eukaryotic DNA primase large subunit iron-sulfur cluster domain, Y397F mutant | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, DNA primase large subunit, ... | Authors: | Salay, L.E, Chazin, W.J. | Deposit date: | 2018-06-18 | Release date: | 2018-12-12 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.36 Å) | Cite: | Yeast require redox switching in DNA primase. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
7YOJ
| Structure of CasPi with guide RNA and target DNA | Descriptor: | CasPi, DNA (30-MER), DNA (5'-D(P*CP*GP*GP*GP*AP*TP*GP*CP*CP*CP*AP*G)-3'), ... | Authors: | Li, C.P, Wang, J, Liu, J.J. | Deposit date: | 2022-08-01 | Release date: | 2023-02-15 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | The compact Cas pi (Cas12l) 'bracelet' provides a unique structural platform for DNA manipulation. Cell Res., 33, 2023
|
|
4WBO
| |
4W9X
| Crystal Structure of BMP-2-inducible kinase in complex with baricitinib | Descriptor: | 1,2-ETHANEDIOL, BMP-2-inducible protein kinase, Baricitinib | Authors: | Sorrell, F.J, Elkins, J.M, Krojer, T, Williams, E, Savitsky, P, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2014-08-28 | Release date: | 2014-09-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Family-wide Structural Analysis of Human Numb-Associated Protein Kinases. Structure, 24, 2016
|
|
4WAA
| Crystal structure of Nix LIR-fused human LC3B_2-119 | Descriptor: | Microtubule-associated proteins 1A/1B light chain 3B | Authors: | Suzuki, H, Ravichandran, A.C, Dobson, R.C.J, Novak, I, Wakatsuki, S. | Deposit date: | 2014-08-29 | Release date: | 2015-09-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins. Sci Rep, 7, 2017
|
|
7Z9C
| E.coli gyrase holocomplex with 217 bp DNA and albicidin | Descriptor: | DNA (5'-D(*AP*AP*TP*CP*AP*CP*CP*CP*GP*CP*AP*CP*AP*GP*AP*TP*TP*T)-3'), DNA (5'-D(*GP*AP*TP*TP*TP*TP*AP*TP*GP*CP*CP*TP*GP*AP*TP*TP*CP*T)-3'), DNA (5'-D(P*AP*AP*AP*TP*CP*TP*GP*TP*GP*CP*GP*GP*GP*T)-3'), ... | Authors: | Ghilarov, D, Heddle, J.G.H, Suessmuth, R. | Deposit date: | 2022-03-21 | Release date: | 2023-02-15 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Molecular mechanism of topoisomerase poisoning by the peptide antibiotic albicidin. Nat Catal, 6, 2023
|
|
6DX5
| Crystal structure of the viral OTU domain protease from Farallon virus | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, RNA-dependent RNA polymerase | Authors: | Beldon, B.S, Dzimianski, J.V, Daczkowski, C.M, Goodwin, O.Y, Pegan, S.D. | Deposit date: | 2018-06-28 | Release date: | 2018-12-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.224 Å) | Cite: | Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity. PLoS Pathog., 15, 2019
|
|