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7WTC	Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the ground state Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, Pyruvate carboxylase, ... Authors: Chai, P, Lan, P, Wu, J, Lei, M. Deposit date: 2022-02-04 Release date: 2022-11-09 Last modified: 2022-11-16 Method: ELECTRON MICROSCOPY (4 Å) Cite: Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA. Mol.Cell, 82, 2022
3GLK	The biotin carboxylase (BC) domain of human Acetyl-CoA Carboxylase 2 (ACC2) Descriptor: Acetyl-CoA carboxylase 2 Authors: Price, A, Kulathila, R. Deposit date: 2009-03-12 Release date: 2009-03-24 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase. Bioorg.Med.Chem.Lett., 19, 2009
3HBL	Crystal Structure of S. aureus Pyruvate Carboxylase T908A Mutant Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... Authors: Tong, L, Yu, L.P.C. Deposit date: 2009-05-04 Release date: 2009-06-30 Last modified: 2021-10-13 Method: X-RAY DIFFRACTION (2.71 Å) Cite: A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A. Structure, 17, 2009
3HB9	Crystal Structure of S. aureus Pyruvate Carboxylase A610T Mutant Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... Authors: Tong, L, Yu, L.P.C. Deposit date: 2009-05-04 Release date: 2009-06-30 Last modified: 2021-10-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A. Structure, 17, 2009
3JZF	Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazoles series Descriptor: 2-[(2-chlorobenzyl)amino]-1-(cyclohexylmethyl)-1H-benzimidazole-5-carboxamide, Biotin carboxylase, CARBONATE ION Authors: Orth, P. Deposit date: 2009-09-23 Release date: 2009-11-03 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.13 Å) Cite: Discovery and optimization of antibacterial AccC inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
3HO8	Crystal Structure of S. aureus Pyruvate Carboxylase in complex with Coenzyme A Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, MANGANESE (II) ION, ... Authors: Tong, L, Yu, L.P.C. Deposit date: 2009-06-01 Release date: 2009-06-30 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A. Structure, 17, 2009
3JZI	Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series Descriptor: 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide, Biotin carboxylase Authors: Cheng, C, Shipps, G.W, Yang, Z, Sun, B, Kawahata, N, Soucy, K, Soriano, A, Orth, P, Xiao, L, Mann, P, Black, T. Deposit date: 2009-09-23 Release date: 2009-11-03 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Discovery and optimization of antibacterial AccC inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
3JRW	Phosphorylated BC domain of ACC2 Descriptor: Acetyl-CoA carboxylase 2 Authors: Cho, Y.S, Lee, J.I, Shin, D, Kim, H.T, Lee, T.G, Heo, Y.S. Deposit date: 2009-09-09 Release date: 2010-01-12 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK Biochem.Biophys.Res.Commun., 391, 2010
3JRX	Crystal structure of the BC domain of ACC2 in complex with soraphen A Descriptor: Acetyl-CoA carboxylase 2, SORAPHEN A Authors: Cho, Y.S, Lee, J.I, Shin, D, Kim, H.T, Lee, T.G, Heo, Y.S. Deposit date: 2009-09-09 Release date: 2010-01-12 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK. Biochem.Biophys.Res.Commun., 391, 2010
8HZ4	The tetrameric structure of biotin carboxylase from Chloroflexus aurantiacus in complex with bicarbonate Descriptor: Biotin carboxylase Authors: Shen, J, Wu, W, Xu, X. Deposit date: 2023-01-08 Release date: 2024-01-10 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (3.2 Å) Cite: The tetrameric structure of biotin carboxylase from Chloroflexus aurantiacus in complex with bicarbonate To be published
8HZ5	The homodimer of a biotin carboxylase isoform from chloroflexus aurantiacus Descriptor: Biotin carboxylase Authors: Shen, J, Wu, W, Xu, X. Deposit date: 2023-01-08 Release date: 2024-01-10 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (3 Å) Cite: The homodimer of a biotin carboxylase isoform from chloroflexus aurantiacus To be published
8J7O	Human pyruvate carboxylase in BCCP-CTS state without BC Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Pyruvate carboxylase, mitochondrial Authors: Liu, D.S, Su, J.Y. Deposit date: 2023-04-27 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (3.83 Å) Cite: Human pyruvate carboxylase To Be Published
8J4Z	Human 3-methylcrotonyl-CoA carboxylase in BCCP-CTS state with substrate Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, ... Authors: Liu, D.S, Su, J.Y. Deposit date: 2023-04-21 Release date: 2024-04-24 Method: ELECTRON MICROSCOPY (2.73 Å) Cite: Human 3-methylcrotonyl-CoA carboxylase in BCCP-CTS state with substrate To Be Published
8J7D	Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, ... Authors: Liu, D.S, Su, J.Y. Deposit date: 2023-04-27 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state To Be Published
8J99	Human 3-methylcrotonyl-CoA carboxylase in BCS-mcoa state Descriptor: Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, Methylcrotonoyl-CoA carboxylase subunit alpha, ... Authors: Liu, D.S, Su, J.Y. Deposit date: 2023-05-02 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (2.87 Å) Cite: Human 3-methylcrotonyl-CoA carboxylase in BCS-mcoa state To Be Published
8J78	Human 3-methylcrotonyl-CoA carboxylase in BCCP-H2 state Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, ... Authors: Liu, D.S, Su, J.Y. Deposit date: 2023-04-27 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (3.88 Å) Cite: Human 3-methylcrotonyl-CoA carboxylase in BCCP-H2 state To Be Published
8JAW	Human MCC in MCCD state Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, ... Authors: Liu, D.S, Su, J.Y, Tian, X.Y. Deposit date: 2023-05-07 Release date: 2024-05-15 Method: ELECTRON MICROSCOPY (2.51 Å) Cite: Human MCC in BCCP-CTS state To Be Published
8JAK	Human MCC in MCCU state Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, ... Authors: Liu, D.S, Su, J.Y, Tian, X.Y. Deposit date: 2023-05-06 Release date: 2024-05-15 Method: ELECTRON MICROSCOPY (2.52 Å) Cite: Human MCC in BCCP-BCS state To Be Published
8PN7	Engineered glycolyl-CoA carboxylase (G20R variant) with bound CoA Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, Propionyl-CoA carboxylase alpha subunit, ... Authors: Zarzycki, J, Marchal, D.G, Schulz, L, Prinz, S, Erb, T.J. Deposit date: 2023-06-30 Release date: 2023-11-29 Last modified: 2023-12-27 Method: ELECTRON MICROSCOPY (2.03 Å) Cite: Machine Learning-Supported Enzyme Engineering toward Improved CO 2 -Fixation of Glycolyl-CoA Carboxylase. Acs Synth Biol, 12, 2023
8PN8	Engineered glycolyl-CoA carboxylase (L100N variant) with bound CoA Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, Propionyl-CoA carboxylase alpha subunit, ... Authors: Zarzycki, J, Marchal, D.G, Schulz, L, Prinz, S, Erb, T.J. Deposit date: 2023-06-30 Release date: 2023-11-29 Last modified: 2023-12-27 Method: ELECTRON MICROSCOPY (2.31 Å) Cite: Machine Learning-Supported Enzyme Engineering toward Improved CO 2 -Fixation of Glycolyl-CoA Carboxylase. Acs Synth Biol, 12, 2023
2V59	CRYSTAL STRUCTURE OF BIOTIN CARBOXYLASE FROM E.COLI IN COMPLEX WITH POTENT INHIBITOR 2 Descriptor: 6-(2,6-DIMETHOXYPHENYL)PYRIDO[2,3-D]PYRIMIDINE-2,7-DIAMINE, BIOTIN CARBOXYLASE Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-10-02 Release date: 2009-01-13 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: A Class of Selective Antibacterials Derived from a Protein Kinase Inhibitor Pharmacophore. Proc.Natl.Acad.Sci.USA, 106, 2009
2VQD	Crystal Structure of Biotin Carboxylase from Pseudomonas aeruginosa complexed with AMPCP Descriptor: BIOTIN CARBOXYLASE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... Authors: Mochalkin, I. Deposit date: 2008-03-13 Release date: 2008-09-09 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Structural Evidence for Substrate-Induced Synergism and Half-Sites Reactivity in Biotin Carboxylase. Protein Sci., 17, 2008
2W6O	Crystal structure of Biotin carboxylase from E. coli in complex with 4-Amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment Descriptor: 4-amino-7,7-dimethyl-7,8-dihydroquinazolin-5(6H)-one, BIOTIN CARBOXYLASE, CHLORIDE ION Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-12-18 Release date: 2009-05-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
2VPQ	Crystal structure of biotin carboxylase from S. aureus complexed with AMPPNP Descriptor: ACETYL-COA CARBOXYLASE, CHLORIDE ION, MAGNESIUM ION, ... Authors: Mochalkin, I. Deposit date: 2008-03-03 Release date: 2008-09-09 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural Evidence for Substrate-Induced Synergism and Half-Sites Reactivity in Biotin Carboxylase. Protein Sci., 17, 2008
2W6M	Crystal structure of Biotin carboxylase from E. coli in complex with amino-oxazole fragment series Descriptor: (2-AMINO-1,3-OXAZOL-5-YL)-(3-BROMOPHENYL)METHANONE, BIOTIN CARBOXYLASE, CHLORIDE ION Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-12-18 Release date: 2009-05-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009

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