6JUN
| MsDpo4-DNA complex 3 | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(P*TP*AP*GP*GP*AP*CP*CP*C)-3'), DNA polymerase IV, ... | Authors: | Nair, D.T, Johnson, M.K. | Deposit date: | 2019-04-15 | Release date: | 2020-02-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | A polar filter in DNA polymerases prevents ribonucleotide incorporation. Nucleic Acids Res., 47, 2019
|
|
6JX5
| Hect domain of AREL1 | Descriptor: | Apoptosis-resistant E3 ubiquitin protein ligase 1 | Authors: | Sivaraman, J, Singh, S, Ng, J, Nayak, D. | Deposit date: | 2019-04-22 | Release date: | 2019-12-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.402 Å) | Cite: | Structural insights into a HECT-type E3 ligase AREL1 and its ubiquitination activitiesin vitro. J.Biol.Chem., 294, 2019
|
|
4KRD
| Crystal Structure of Pho85-Pcl10 Complex | Descriptor: | Cyclin-dependent protein kinase PHO85, PHO85 cyclin-10 | Authors: | Quiocho, F.A, Zheng, F. | Deposit date: | 2013-05-16 | Release date: | 2013-09-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.952 Å) | Cite: | New Structural Insights into Phosphorylation-free Mechanism for Full Cyclin-dependent Kinase (CDK)-Cyclin Activity and Substrate Recognition. J.Biol.Chem., 288, 2013
|
|
4HBX
| Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand | Descriptor: | 3-methyl-6-(pyrrolidin-1-ylsulfonyl)-3,4-dihydroquinazolin-2(1H)-one, Bromodomain-containing protein 4 | Authors: | Filippakopoulos, P, Picaud, S, Qi, J, Felletar, I, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Fish, P.V, Bunnage, M.E, Cook, A.S, Owen, D.R, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2012-09-28 | Release date: | 2012-10-31 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit. J.Med.Chem., 55, 2012
|
|
4O8V
| O-Acetyltransferase Domain of Pseudomonas putida AlgJ | Descriptor: | Alginate biosynthesis protein AlgJ | Authors: | Ricer, T, Little, D.J, Whitney, J.C, Robinson, H, Howell, P.L. | Deposit date: | 2013-12-30 | Release date: | 2014-10-01 | Method: | X-RAY DIFFRACTION (1.815 Å) | Cite: | P. aeruginosa SGNH Hydrolase-Like Proteins AlgJ and AlgX Have Similar Topology but Separate and Distinct Roles in Alginate Acetylation. Plos Pathog., 10, 2014
|
|
6LES
| |
6LI6
| Crystal structure of MCR-1-S treated by Au(PEt3)Cl | Descriptor: | GOLD ION, Probable phosphatidylethanolamine transferase Mcr-1, TRIETHYLPHOSPHANE | Authors: | Zhang, Q, Wang, M, Sun, H. | Deposit date: | 2019-12-10 | Release date: | 2020-09-16 | Last modified: | 2020-10-28 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin. Nat Commun, 11, 2020
|
|
4OND
| Ancestral Steroid Receptor 2 DBD helix mutant - ERE DNA complex | Descriptor: | 5'-D(*CP*CP*AP*GP*GP*TP*CP*AP*GP*AP*GP*TP*GP*AP*CP*CP*TP*G)-3', 5'-D(*TP*CP*AP*GP*GP*TP*CP*AP*CP*TP*CP*TP*GP*AP*CP*CP*TP*G)-3', Ancestral SR2 Helix Mutant, ... | Authors: | Ortlund, E.O, Murphy, M.N. | Deposit date: | 2014-01-28 | Release date: | 2014-10-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.253 Å) | Cite: | Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module. Cell(Cambridge,Mass.), 159, 2014
|
|
4OE5
| Structure of Human ALDH4A1 Crystallized in Space Group P21 | Descriptor: | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial, MAGNESIUM ION, ... | Authors: | Tanner, J.J. | Deposit date: | 2014-01-11 | Release date: | 2014-02-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural Studies of Yeast Delta (1)-Pyrroline-5-carboxylate Dehydrogenase (ALDH4A1): Active Site Flexibility and Oligomeric State. Biochemistry, 53, 2014
|
|
6I05
| |
4K9B
| Structure of Ternary Complex of cGAS with dsDNA and Bound c[G(2 ,5 )pA(3 ,5 )p] | Descriptor: | ADENOSINE MONOPHOSPHATE, Cyclic GMP-AMP synthase, DNA-F, ... | Authors: | Gao, P, Wu, Y, Patel, D.J. | Deposit date: | 2013-04-19 | Release date: | 2013-05-15 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell(Cambridge,Mass.), 153, 2013
|
|
4KAM
| |
4KCA
| Crystal Structure of Endo-1,5-alpha-L-arabinanase from a Bovine Ruminal Metagenomic Library | Descriptor: | Endo-1,5-alpha-L-arabinanase, GLYCEROL, IODIDE ION, ... | Authors: | Santos, C.R, Polo, C.C, Costa, M.C.M.F, Nascimento, A.F.Z, Wong, D.W.S, Murakami, M.T. | Deposit date: | 2013-04-24 | Release date: | 2014-02-05 | Last modified: | 2014-04-09 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Mechanistic strategies for catalysis adopted by evolutionary distinct family 43 arabinanases. J.Biol.Chem., 289, 2014
|
|
4MUA
| Schistosoma mansoni (Blood Fluke) Sulfotransferase | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, SODIUM ION, Sulfotransferase | Authors: | Valentim, C.L.L, Cioli, D, Chevalier, F.D, Cao, X, Taylor, A.B, Holloway, S.P, Pica-Mattoccia, L, Guidi, A, Basso, A, Tsai, I.J, Berriman, M, Carvalho-Queiroz, C, Almeida, M, Aguilar, H, Frantz, D.E, Hart, P.J, Anderson, T.J.C, LoVerde, P.T. | Deposit date: | 2013-09-21 | Release date: | 2013-12-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Genetic and molecular basis of drug resistance and species-specific drug action in schistosome parasites. Science, 342, 2013
|
|
4K96
| Structure of Binary Complex of cGAS with Bound dsDNA | Descriptor: | Cyclic GMP-AMP synthase, DNA-F, DNA-R, ... | Authors: | Gao, P, Wu, Y, Patel, D.J. | Deposit date: | 2013-04-19 | Release date: | 2013-05-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.084 Å) | Cite: | Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell(Cambridge,Mass.), 153, 2013
|
|
4K98
| Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG | Descriptor: | Cyclic GMP-AMP synthase, DNA-F, DNA-R, ... | Authors: | Gao, P, Wu, Y, Patel, D.J. | Deposit date: | 2013-04-19 | Release date: | 2013-05-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell(Cambridge,Mass.), 153, 2013
|
|
6J0I
| Structure of [Co2+-(Chromomycin A3)2]-d(TTGGCGAA)2 complex | Descriptor: | 1,2-HYDRO-1-OXY-3,4-HYDRO-3-(1-METHOXY-2-OXY-3,4-DIHYDROXYPENTYL)-8,9-DIHYROXY-7-METHYLANTHRACENE, 2,6-dideoxy-4-O-methyl-alpha-D-galactopyranose-(1-3)-(2R,3R,6R)-6-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate, 3-C-methyl-4-O-acetyl-alpha-L-Olivopyranose-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol, ... | Authors: | Satange, R.B, Chuang, C.Y, Hou, M.H. | Deposit date: | 2018-12-24 | Release date: | 2019-07-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Polymorphic G:G mismatches act as hotspots for inducing right-handed Z DNA by DNA intercalation. Nucleic Acids Res., 47, 2019
|
|
4OMB
| Phosphate binding protein | Descriptor: | PHOSPHATE ION, PLATINUM (II) ION, Phosphate binding protein | Authors: | Neznansky, A, Opatowsky, Y. | Deposit date: | 2014-01-27 | Release date: | 2014-12-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The Pseudomonas aeruginosa phosphate transport protein PstS plays a phosphate-independent role in biofilm formation. Faseb J., 28, 2014
|
|
4OV7
| Ancestral Steroid Receptor 2 DBD helix mutant - SRE DNA complex | Descriptor: | 5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3', 5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3', Ancestral Steroid Receptor 2 DBD helix mutant, ... | Authors: | Ortlund, E.A. | Deposit date: | 2014-02-20 | Release date: | 2014-10-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.701 Å) | Cite: | Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module. Cell(Cambridge,Mass.), 159, 2014
|
|
6J2P
| |
4NJN
| Crystal Structure of E.coli GlpG at pH 4.5 | Descriptor: | Rhomboid protease GlpG | Authors: | Dickey, S.W, Baker, R.P, Cho, S, Urban, S. | Deposit date: | 2013-11-11 | Release date: | 2013-12-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate Affinity. Cell(Cambridge,Mass.), 155, 2013
|
|
4HOQ
| Crystal Structure of Full-Length Human IFIT5 | Descriptor: | Interferon-induced protein with tetratricopeptide repeats 5 | Authors: | Abbas, Y.M, Pichlmair, A, Gorna, M.W, Superti-Furga, G, Nagar, B. | Deposit date: | 2012-10-22 | Release date: | 2013-01-23 | Last modified: | 2013-02-27 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. Nature, 494, 2013
|
|
4NN7
| Cytokine receptor complex - Crystal form 2 | Descriptor: | Cytokine receptor-like factor 2, Interleukin-7 receptor subunit alpha, Thymic stromal lymphopoietin | Authors: | Verstraete, K, van Schie, L, Savvides, S.N. | Deposit date: | 2013-11-16 | Release date: | 2014-03-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.775 Å) | Cite: | Structural basis of the proinflammatory signaling complex mediated by TSLP. Nat.Struct.Mol.Biol., 21, 2014
|
|
3CZD
| Crystal structure of human glutaminase in complex with L-glutamate | Descriptor: | GLUTAMIC ACID, GLYCEROL, Glutaminase kidney isoform, ... | Authors: | Karlberg, T, Welin, M, Andersson, J, Arrowsmith, C.H, Berglund, H, Busam, R.D, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kallas, A, Kotenyova, T, Lehtio, L, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Wikstrom, M, Schuler, H, Structural Genomics Consortium (SGC) | Deposit date: | 2008-04-29 | Release date: | 2008-07-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism. Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
4KCB
| Crystal Structure of Exo-1,5-alpha-L-arabinanase from Bovine Ruminal Metagenomic Library | Descriptor: | Arabinan endo-1,5-alpha-L-arabinosidase, PHOSPHATE ION | Authors: | Santos, C.R, Polo, C.C, Costa, M.C.M.F, Nascimento, A.F.Z, Wong, D.W.S, Murakami, M.T. | Deposit date: | 2013-04-24 | Release date: | 2014-02-05 | Last modified: | 2014-04-09 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Mechanistic strategies for catalysis adopted by evolutionary distinct family 43 arabinanases. J.Biol.Chem., 289, 2014
|
|