3CZD

Crystal structure of human glutaminase in complex with L-glutamate

Summary for 3CZD

• Entry DOI: 10.2210/pdb3czd/pdb
• Descriptor: Glutaminase kidney isoform, SULFATE ION, GLUTAMIC ACID, ... (5 entities in total)
• Functional Keywords: glutamine, glutamate, kidney isoform, k-glutaminase, sgc, structural genomics consortium, ank repeat, hydrolase, mitochondrion, transit peptide
• Biological source: Homo sapiens
• Cellular location: Isoform 1: Cytoplasm, cytosol. Isoform 3: Mitochondrion: O94925
• Total number of polymer chains: 1
• Total formula weight: 35115.99

Authors

Karlberg, T.,Welin, M.,Andersson, J.,Arrowsmith, C.H.,Berglund, H.,Busam, R.D.,Collins, R.,Dahlgren, L.G.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Kallas, A.,Kotenyova, T.,Lehtio, L.,Moche, M.,Nilsson, M.E.,Nordlund, P.,Nyman, T.,Persson, C.,Sagemark, J.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,Van Den Berg, S.,Wikstrom, M.,Schuler, H.,Structural Genomics Consortium (SGC) (deposition date: 2008-04-29, release date: 2008-07-01, Last modification date: 2023-08-30)

• Primary citation: Thangavelu, K.,Pan, C.Q.,Karlberg, T.,Balaji, G.,Uttamchandani, M.,Suresh, V.,Schuler, H.,Low, B.C.,Sivaraman, J.; Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism.; Proc.Natl.Acad.Sci.USA, 109:7705-7710, 2012; PubMed: 22538822; DOI: 10.1073/pnas.1116573109

Experimental method

X-RAY DIFFRACTION (2.4 Å)