8HNE
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![BU of 8hne by Molmil](/molmil-images/mine/8hne) | Crystal structure of the ancestral GH19 chitinase Anc4 | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Anc4, ... | Authors: | Kozome, D, Laurino, P. | Deposit date: | 2022-12-07 | Release date: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.13 Å) | Cite: | Emergence of antifungal activity in GH19 chitinases through gain-of-function in a remote loop. To Be Published
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8HNF
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![BU of 8hnf by Molmil](/molmil-images/mine/8hnf) | Crystal structure of the ancestral GH19 chitinase Anc5 | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Anc5, ... | Authors: | Kozome, D, Laurino, P. | Deposit date: | 2022-12-07 | Release date: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Emergence of antifungal activity in GH19 chitinases through gain-of-function in a remote loop. To Be Published
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4OFS
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![BU of 4ofs by Molmil](/molmil-images/mine/4ofs) | Crystal structure of a truncated catalytic core of the 2-oxoacid dehydrogenase multienzyme complex from Thermoplasma acidophilum | Descriptor: | Probable lipoamide acyltransferase | Authors: | Marrot, N.L, Marshall, J.J.T, Svergun, D.I, Crennell, S.J, Hough, D.W, van den Elsen, J.M.H, Danson, M.J. | Deposit date: | 2014-01-15 | Release date: | 2014-12-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Why are the 2-oxoacid dehydrogenase complexes so large? Generation of an active trimeric complex. Biochem.J., 463, 2014
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6XTH
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![BU of 6xth by Molmil](/molmil-images/mine/6xth) | NMR solution structure of class IV lasso peptide felipeptin A1 from Amycolatopsis sp. YIM10 | Descriptor: | Felipeptin A1 | Authors: | Madland, E, Guerrero-Garzon, J.F, Zotchev, S.B, Aachmann, F.L, Courtade, G. | Deposit date: | 2020-01-16 | Release date: | 2020-11-25 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin. Iscience, 23, 2020
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2RKQ
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![BU of 2rkq by Molmil](/molmil-images/mine/2rkq) | |
1ILC
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![BU of 1ilc by Molmil](/molmil-images/mine/1ilc) | DNA Bending by an Adenine-Thymine Tract and Its Role in Gene Regulation. | Descriptor: | 5'-D(*AP*CP*CP*GP*AP*AP*TP*TP*CP*GP*GP*T)-3' | Authors: | Hizver, J, Rozenberg, H, Frolow, F, Rabinovich, D, Shakked, Z. | Deposit date: | 2001-05-08 | Release date: | 2002-05-08 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | DNA bending by an adenine--thymine tract and its role in gene regulation. Proc.Natl.Acad.Sci.USA, 98, 2001
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8ERM
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![BU of 8erm by Molmil](/molmil-images/mine/8erm) | Crystal structure of FliC D2/D3 domains from Pseudomonas aeruginosa PAO1 | Descriptor: | B-type flagellin, GLYCEROL, SULFATE ION | Authors: | Nedeljkovic, M, Bonsor, D.A, Postel, S, Sundberg, E.J. | Deposit date: | 2022-10-12 | Release date: | 2023-05-17 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.475 Å) | Cite: | An unbroken network of interactions connecting flagellin domains is required for motility in viscous environments. Plos Pathog., 19, 2023
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4D48
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![BU of 4d48 by Molmil](/molmil-images/mine/4d48) | Crystal Structure of glucose-1-phosphate uridylyltransferase GalU from Erwinia amylovora. | Descriptor: | GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE | Authors: | Toccafondi, M, Wuerges, J, Cianci, M, Benini, S. | Deposit date: | 2014-10-27 | Release date: | 2016-01-20 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Glucose-1-phosphate uridylyltransferase from Erwinia amylovora: Activity, structure and substrate specificity. Biochim. Biophys. Acta, 1865, 2017
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6XCQ
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![BU of 6xcq by Molmil](/molmil-images/mine/6xcq) | Erythromycin esterase EreC, mutant H289N in its closed conformation | Descriptor: | EreC, S-1,2-PROPANEDIOL | Authors: | Zielinski, M, Park, J, Berghuis, A.M. | Deposit date: | 2020-06-09 | Release date: | 2021-02-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and functional insights into esterase-mediated macrolide resistance. Nat Commun, 12, 2021
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4COQ
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![BU of 4coq by Molmil](/molmil-images/mine/4coq) | The complex of alpha-Carbonic anhydrase from Thermovibrio ammonificans with inhibitor sulfanilamide. | Descriptor: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, CARBONATE DEHYDRATASE, CHLORIDE ION, ... | Authors: | James, P, Isupov, M.N, Sayer, C, Berg, S, Lioliou, M, Kotlar, H, Littlechild, J.A. | Deposit date: | 2014-01-30 | Release date: | 2014-10-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | The Structure of a Tetrameric [Alpha]-Carbonic Anhydrase from Thermovibrio Ammonificans Reveals a Core Formed Around Intermolecular Disulfides that Contribute to its Thermostability Acta Crystallogr.,Sect.D, 70, 2014
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1NI1
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![BU of 1ni1 by Molmil](/molmil-images/mine/1ni1) | Imidazole and cyanophenyl farnesyl transferase inhibitors | Descriptor: | 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE, ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID, Protein farnesyltransferase alpha subunit, ... | Authors: | Tong, Y, Lin, N.H, Wang, L, Hasvold, L, Wang, W, Leonard, N, Li, T, Li, Q, Cohen, J, Gu, W.Z, Zhang, H, Stoll, V, Bauch, J, Marsh, K, Rosenberg, S.H, Sham, H.L. | Deposit date: | 2002-12-20 | Release date: | 2004-04-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability. Bioorg.Med.Chem.Lett., 13, 2003
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6XCS
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![BU of 6xcs by Molmil](/molmil-images/mine/6xcs) | |
1BFK
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6XP5
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![BU of 6xp5 by Molmil](/molmil-images/mine/6xp5) | Head-Middle module of Mediator | Descriptor: | HEAT, Med22, Mediator of RNA polymerase II transcription subunit 1, ... | Authors: | Zhang, H.Q, Chen, D.C, Kornberg, R.D. | Deposit date: | 2020-07-08 | Release date: | 2021-03-03 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Mediator structure and conformation change. Mol.Cell, 81, 2021
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4D51
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![BU of 4d51 by Molmil](/molmil-images/mine/4d51) | Crystal structure of CymA from Klebsiella oxytoca | Descriptor: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, CYMA | Authors: | van den Berg, B, Bhamidimarri, S.P, Kleinekathoefer, U, Winterhalter, M. | Deposit date: | 2014-11-01 | Release date: | 2015-06-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Outer-membrane translocation of bulky small molecules by passive diffusion. Proc. Natl. Acad. Sci. U.S.A., 112, 2015
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2STA
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![BU of 2sta by Molmil](/molmil-images/mine/2sta) | ANIONIC SALMON TRYPSIN IN COMPLEX WITH SQUASH SEED INHIBITOR (CUCURBITA MAXIMA TRYPSIN INHIBITOR I) | Descriptor: | CALCIUM ION, PROTEIN (TRYPSIN INHIBITOR), PROTEIN (TRYPSIN) | Authors: | Helland, R, Berglund, G.I, Otlewski, J, Apostoluk, W, Andersen, O.A, Willassen, N.P, Smalas, A.O. | Deposit date: | 1998-12-10 | Release date: | 2000-01-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | High-resolution structures of three new trypsin-squash-inhibitor complexes: a detailed comparison with other trypsins and their complexes. Acta Crystallogr.,Sect.D, 55, 1999
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1NYH
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![BU of 1nyh by Molmil](/molmil-images/mine/1nyh) | Crystal Structure of the Coiled-coil Dimerization Motif of Sir4 | Descriptor: | Regulatory protein SIR4 | Authors: | Chang, J.F, Hall, B.E, Tanny, J.C, Moazed, D, Filman, D, Ellenberger, T. | Deposit date: | 2003-02-12 | Release date: | 2003-06-24 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of the Coiled-coil Dimerization Motif of Sir4 and Its Interaction With Sir3 Structure, 11, 2003
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2ICY
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![BU of 2icy by Molmil](/molmil-images/mine/2icy) | Crystal Structure of a Putative UDP-glucose Pyrophosphorylase from Arabidopsis Thaliana with Bound UDP-glucose | Descriptor: | DIMETHYL SULFOXIDE, Probable UTP-glucose-1-phosphate uridylyltransferase 2, URIDINE-5'-DIPHOSPHATE-GLUCOSE, ... | Authors: | McCoy, J.G, Wesenberg, G.E, Phillips Jr, G.N, Bitto, E, Bingman, C.A, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2006-09-13 | Release date: | 2006-10-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Structure and Dynamics of UDP-Glucose Pyrophosphorylase from Arabidopsis thaliana with Bound UDP-Glucose and UTP. J.Mol.Biol., 366, 2007
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1II2
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![BU of 1ii2 by Molmil](/molmil-images/mine/1ii2) | Crystal Structure of Phosphoenolpyruvate Carboxykinase (PEPCK) from Trypanosoma cruzi | Descriptor: | PHOSPHOENOLPYRUVATE CARBOXYKINASE, SULFATE ION | Authors: | Trapani, S, Linss, J, Goldenberg, S, Fischer, H, Craievich, A.F, Oliva, G. | Deposit date: | 2001-04-20 | Release date: | 2001-11-21 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the dimeric phosphoenolpyruvate carboxykinase (PEPCK) from Trypanosoma cruzi at 2 A resolution. J.Mol.Biol., 313, 2001
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2STB
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![BU of 2stb by Molmil](/molmil-images/mine/2stb) | ANIONIC SALMON TRYPSIN IN COMPLEX WITH SQUASH SEED INHIBITOR (CUCURBITA PEPO TRYPSIN INHIBITOR II) | Descriptor: | CALCIUM ION, PROTEIN (TRYPSIN INHIBITOR), PROTEIN (TRYPSIN) | Authors: | Helland, R, Berglund, G.I, Otlewski, J, Apostoluk, W, Andersen, O.A, Willassen, N.P, Smalas, A.O. | Deposit date: | 1998-12-11 | Release date: | 2000-01-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | High-resolution structures of three new trypsin-squash-inhibitor complexes: a detailed comparison with other trypsins and their complexes. Acta Crystallogr.,Sect.D, 55, 1999
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4D06
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![BU of 4d06 by Molmil](/molmil-images/mine/4d06) | Bacterial chalcone isomerase complexed with naringenin | Descriptor: | (2E)-3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one, CHALCONE ISOMERASE, CHLORIDE ION, ... | Authors: | Thomsen, M, Palm, G.J, Hinrichs, W. | Deposit date: | 2014-04-24 | Release date: | 2015-04-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and Catalytic Mechanism of the Evolutionarily Unique Bacterial Chalcone Isomerase Acta Crystallogr.,Sect.D, 71, 2015
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1BFU
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![BU of 1bfu by Molmil](/molmil-images/mine/1bfu) | SUBTILISIN CARLSBERG IN 20% DIOXANE | Descriptor: | 1,4-DIETHYLENE DIOXIDE, CALCIUM ION, SUBTILISIN CARLSBERG | Authors: | Schmitke, J.L, Stern, L.J, Klibanov, A.M. | Deposit date: | 1998-05-22 | Release date: | 1998-10-28 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Organic solvent binding to crystalline subtilisin1 in mostly aqueous media and in the neat solvents. Biochem.Biophys.Res.Commun., 248, 1998
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1NMN
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![BU of 1nmn by Molmil](/molmil-images/mine/1nmn) | Structure of yqgF from Escherichia coli, a hypothetical protein | Descriptor: | Hypothetical protein yqgF | Authors: | Galkin, A, Sarikaya, E, Krajewski, W, Howard, A, Herzberg, O, Structure 2 Function Project (S2F) | Deposit date: | 2003-01-10 | Release date: | 2004-03-02 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of yqgF from Escherichia coli, a hypothetical protein To be Published
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1NTH
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![BU of 1nth by Molmil](/molmil-images/mine/1nth) | Crystal structure of the methanosarcina barkeri monomethylamine methyltransferase (MTMB) | Descriptor: | Monomethylamine methyltransferase mtmB1 | Authors: | Hao, B, Gong, W, Ferguson, T.K, James, C.M, Krzycki, J.A, Chan, M.K. | Deposit date: | 2003-01-30 | Release date: | 2003-02-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | A new UAG-encoded residue in the structure of a methanogen methyltransferase Science, 296, 2002
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4CP7
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![BU of 4cp7 by Molmil](/molmil-images/mine/4cp7) | Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol | Descriptor: | CHLORIDE ION, PROTEASE, methyl [(2S)-1-(2-{(4R)-4-hydroxy-5-{[(2S)-3-methyl-1-oxo-1-(prop-2-en-1-ylamino)butan-2-yl]amino}-5-oxo-4-[4-(prop-2-en-1-yl)benzyl]pentyl}-2-[4-(pyridin-4-yl)benzyl]hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl]carbamate | Authors: | deRosa, M, Unge, J, Motwani, H.V, Rosenquist, A, Vrang, L, Wallberg, H, Larhed, M. | Deposit date: | 2014-01-31 | Release date: | 2014-12-10 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Synthesis of P1'-Functionalized Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol. J.Med.Chem., 57, 2014
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