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8OLM
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BU of 8olm by Molmil
Carbonic Anhydrase 2 in Complex with Steriod_Sulphamoyl AKI1
Descriptor: Carbonic anhydrase 2, ZINC ION, [(3~{S},5~{S},8~{S},13~{R},14~{R})-5,14-dimethyl-16-oxidanylidene-1,2,3,4,6,7,8,11,12,13,15,17-dodecahydrocyclopenta[a]phenanthren-3-yl] sulfamate
Authors:Brynda, J, Rezacova, P.M, Kudova, E.
Deposit date:2023-03-30
Release date:2024-04-10
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Carbonic Anhydrase in Complex with Steriod_Sulphamoyl
To Be Published
8OMP
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BU of 8omp by Molmil
Carbonic Anhydrase 2 in Complex with Steriod_Sulphamoyl AKI33
Descriptor: Carbonic anhydrase 2, ZINC ION, [(3~{R},5~{R},8~{R},9~{S},10~{S},13~{S},14~{S},15~{R})-10,13,15-trimethyl-17-oxidanylidene-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-3-yl] sulfamate
Authors:Brynda, J, Rezacova, P.M, Kudova, E.
Deposit date:2023-03-31
Release date:2024-04-10
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Carbonic Anhydrase in Complex with Steriod_Sulphamoyl
To Be Published
8OKO
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BU of 8oko by Molmil
Carbonic Anhydrase IX like mutant in Complex with Steriod_Sulphamoyl inhibitor AKI_2
Descriptor: Carbonic anhydrase 2, ZINC ION, [(3~{S},8~{S},9~{S},10~{R},13~{S},14~{S})-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1~{H}-cyclopenta[a]phenanthren-3-yl] sulfamate
Authors:Brynda, J, Rezacova, P.M, Kudova, E.
Deposit date:2023-03-28
Release date:2024-04-10
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Carbonic Anhydrase II in Complex with Steriod_Sulphamoyl
To Be Published
8OO8
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BU of 8oo8 by Molmil
Three-Dimensional Structure of Human Carbonic Anhydrase II in Complex with a Covalent Inhibitor
Descriptor: 3-(cyclooctylamino)-4-ethylsulfonyl-2,5,6-tris(fluoranyl)benzenesulfonamide, Carbonic anhydrase 2, ZINC ION
Authors:Leitans, J, Tars, K.
Deposit date:2023-04-04
Release date:2024-04-10
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Three-Dimensional Structure of Human Carbonic Anhydrase II in Complex with a Covalent Inhibitor
To Be Published
8OLI
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BU of 8oli by Molmil
Carbonic Anhydrase 2 in Complex with Steriod_Sulphamoyl AKI_12
Descriptor: Carbonic anhydrase 2, ZINC ION, [(3~{R},5~{S},8~{R},9~{S},10~{S},13~{S},14~{S},17~{S})-17-ethanoyl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{H}-cyclopenta[a]phenanthren-3-yl] sulfamate
Authors:Brynda, J, Rezacova, P.M, Kudova, E.
Deposit date:2023-03-30
Release date:2024-04-10
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Carbonic Anhydrase in Complex with Steriod_Sulphamoyl
To Be Published
8OMB
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BU of 8omb by Molmil
Carbonic Anhydrase 2 in Complex with Steriod_Sulphamoyl VK42
Descriptor: Carbonic anhydrase 2, ZINC ION, [(8~{R},9~{S},13~{S},14~{S})-13-methyl-17-oxidanylidene-7,8,9,11,12,14,15,16-octahydro-6~{H}-cyclopenta[a]phenanthren-3-yl] sulfamate
Authors:Brynda, J, Rezacova, P.M, Kudova, E.
Deposit date:2023-03-31
Release date:2024-04-10
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Carbonic Anhydrase in Complex with Steriod_Sulphamoyl
To Be Published
8OMH
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BU of 8omh by Molmil
Carbonic Anhydrase II in Complex with Steriod_Sulphamoyl (BS1982)
Descriptor: Carbonic anhydrase 2, ZINC ION, [(8~{S},9~{S},13~{S},14~{S})-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] sulfamate
Authors:Brynda, J, Rezacova, P.M, Kudova, E.
Deposit date:2023-03-31
Release date:2024-04-10
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Carbonic Anhydrase II in Complex with Steriod_Sulphamoyl
To Be Published
1RAY
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BU of 1ray by Molmil
THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE
Descriptor: AZIDE ION, CARBONIC ANHYDRASE II, ZINC ION
Authors:Jonsson, B.M, Hakansson, K, Liljas, A.
Deposit date:1993-04-02
Release date:1993-10-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structure of human carbonic anhydrase II in complex with bromide and azide.
FEBS Lett., 322, 1993
1RJ6
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BU of 1rj6 by Molmil
Crystal Structure of the Extracellular Domain of Murine Carbonic Anhydrase XIV in Complex with Acetazolamide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase XIV, ...
Authors:Whittington, D.A, Grubb, J.H, Waheed, A, Shah, G.N, Sly, W.S, Christianson, D.W.
Deposit date:2003-11-18
Release date:2004-03-09
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes.
J.Biol.Chem., 279, 2004
8OKG
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BU of 8okg by Molmil
Carbonic Anhydrase IX like mutant in Complex with Steriod_Sulphamoyl inhibitor AKI_13
Descriptor: Carbonic anhydrase 2, ZINC ION, [(3~{S},8~{S},9~{S},10~{R},13~{S},14~{S},17~{S})-17-methanoyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1~{H}-cyclopenta[a]phenanthren-3-yl] sulfamate
Authors:Brynda, J, Rezacova, P.M, Kudova, E.
Deposit date:2023-03-28
Release date:2024-04-24
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Carbonic Anhydrase II in Complex with Steriod_Sulphamoyl
To Be Published
8OTP
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BU of 8otp by Molmil
Crystal structure of human carbonic anhydrase II with 1-cyclopropyl-6-fluoro-4-oxo-7-(4-(4-sulfamoylbenzoyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
Descriptor: 1-cyclopropyl-6-fluoranyl-4-oxidanylidene-7-[4-(4-sulfamoylphenyl)carbonylpiperazin-1-yl]quinoline-3-carboxylic acid, Carbonic anhydrase 2, GLYCEROL, ...
Authors:Angeli, A, Ferraroni, M.
Deposit date:2023-04-21
Release date:2024-05-01
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of human carbonic anhydrase II with 1-cyclopropyl-6-fluoro-4-oxo-7-(4-(4-sulfamoylbenzoyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
To Be Published
3D9Z
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BU of 3d9z by Molmil
Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
Descriptor: 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide, Carbonic anhydrase 2, ZINC ION
Authors:Genis, C, Sippel, K.H, Case, N, Govindasamy, L, Agbandje-Mckenna, M, Mckenna, R.
Deposit date:2008-05-28
Release date:2009-03-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
8OUB
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BU of 8oub by Molmil
The crystal structure of human carbonic anhydrase II with 1-cyclopropyl-6-fluoro-4-oxo-7-(4-((4-sulfamoylbenzyl)carbamoyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
Descriptor: 1-cyclopropyl-6-fluoranyl-4-oxidanylidene-7-[4-[(4-sulfamoylphenyl)methylcarbamoyl]piperazin-1-yl]quinoline-3-carboxylic acid, Carbonic anhydrase 2, ZINC ION
Authors:Angeli, A, Ferraroni, M.
Deposit date:2023-04-22
Release date:2024-05-01
Method:X-RAY DIFFRACTION (1.178 Å)
Cite:The crystal structure of human carbonic anhydrase II with 1-cyclopropyl-6-fluoro-4-oxo-7-(4-((4-sulfamoylbenzyl)carbamoyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
To Be Published
3DCS
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BU of 3dcs by Molmil
Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
Descriptor: Carbonic anhydrase 2, N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide, ZINC ION
Authors:Genis, C, Sippel, K.H, Case, N, Govindasamy, L, Agbandje-Mckenna, M, Mckenna, R.
Deposit date:2008-06-04
Release date:2009-03-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3D92
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BU of 3d92 by Molmil
Human carbonic anhydrase II bound with substrate carbon dioxide
Descriptor: CARBON DIOXIDE, GLYCEROL, ZINC ION, ...
Authors:Domsic, J.F, Avvaru, B.S, McKenna, R.
Deposit date:2008-05-26
Release date:2008-09-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Entrapment of carbon dioxide in the active site of carbonic anhydrase II
J.Biol.Chem., 283, 2008
3DA2
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BU of 3da2 by Molmil
X-ray structure of human carbonic anhydrase 13 in complex with inhibitor
Descriptor: CHLORIDE ION, Carbonic anhydrase 13, N-(4-chlorobenzyl)-N-methylbenzene-1,4-disulfonamide, ...
Authors:Pilka, E.S, Picaud, S.S, Yue, W.W, King, O.N.F, Bray, J.E, Filippakopoulos, P, Roos, A.K, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Wikstrom, M, Edwards, A.M, Bountra, C, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2008-05-28
Release date:2008-07-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:X-ray structure of human carbonic anhydrase 13 in complex with inhibitor.
To be Published
1LG5
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BU of 1lg5 by Molmil
Crystal Structure Analysis of the HCA II Mutant T199P in complex with beta-mercaptoethanol
Descriptor: BETA-MERCAPTOETHANOL, Carbonic anhydrase II, ZINC ION
Authors:Huang, S, Sjoblom, B, Sauer-Eriksson, A.E, Jonsson, B.-H.
Deposit date:2002-04-15
Release date:2002-07-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Organization of an efficient carbonic anhydrase: implications for the mechanism based on structure-function studies of a T199P/C206S mutant.
Biochemistry, 41, 2002
6IM1
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BU of 6im1 by Molmil
Crystal structure of a highly thermostable carbonic anhydrase from Persephonella marina EX-H1
Descriptor: CALCIUM ION, Carbonic anhydrase (Carbonate dehydratase), TETRAETHYLENE GLYCOL, ...
Authors:Jin, M.S, Kim, S, Sung, J, Yeon, J, Choi, S.H.
Deposit date:2018-10-21
Release date:2019-07-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of a Highly Thermostable alpha-Carbonic Anhydrase from Persephonella marina EX-H1.
Mol.Cells, 42, 2019
6HXD
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BU of 6hxd by Molmil
Human Carbonic Anhydrase II in complex with 4-Butylbenzenesulfonamide
Descriptor: 4-butylbenzenesulfonamide, Carbonic anhydrase 2, MERCURIBENZOIC ACID, ...
Authors:Gloeckner, S, Heine, A, Klebe, G.
Deposit date:2018-10-17
Release date:2019-10-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.119 Å)
Cite:Conformational Changes in Alkyl Chains Determine the Thermodynamic and Kinetic Binding Profiles of Carbonic Anhydrase Inhibitors.
Acs Chem.Biol., 15, 2020
1KEQ
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BU of 1keq by Molmil
Crystal Structure of F65A/Y131C Carbonic Anhydrase V, covalently modified with 4-chloromethylimidazole
Descriptor: 4-METHYLIMIDAZOLE, ACETIC ACID, F65A/Y131C-MI Carbonic Anhydrase V, ...
Authors:Jude, K.M, Wright, S.K, Tu, C, Silverman, D.N, Viola, R.E, Christianson, D.W.
Deposit date:2001-11-16
Release date:2002-03-06
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Crystal structure of F65A/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle.
Biochemistry, 41, 2002
1LGD
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BU of 1lgd by Molmil
Crystal Structure Analysis of HCA II Mutant T199P in Complex with Bicarbonate
Descriptor: BICARBONATE ION, Carbonic anhydrase II, ZINC ION
Authors:Huang, S, Sjoblom, B, Sauer-Eriksson, A.E, Jonsson, B.-H.
Deposit date:2002-04-15
Release date:2002-07-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Organization of an efficient carbonic anhydrase: implications for the mechanism based on structure-function studies of a T199P/C206S mutant.
Biochemistry, 41, 2002
8Q3U
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BU of 8q3u by Molmil
Crystal structure of a fentanyl derivative in complex with human CA VII
Descriptor: Carbonic anhydrase 7, GLYCEROL, ZINC ION, ...
Authors:Alterio, V, Di Fiore, A, De Simone, G.
Deposit date:2023-08-04
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Discovery of a novel series of potent carbonic anhydrase inhibitors with selective affinity for mu Opioid receptor for Safer and long-lasting analgesia.
Eur.J.Med.Chem., 260, 2023
3DVB
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BU of 3dvb by Molmil
X-ray crystal structure of mutant N62V human Carbonic Anhydrase II
Descriptor: Carbonic anhydrase 2, ZINC ION
Authors:Avvaru, B.S.
Deposit date:2008-07-18
Release date:2008-11-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II.
Biochemistry, 47, 2008
6HR3
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BU of 6hr3 by Molmil
Human Carbonic Anhydrase II in complex with 4-Propylbenzenesulfonamide
Descriptor: 4-propylbenzenesulfonamide, Carbonic anhydrase 2, MERCURIBENZOIC ACID, ...
Authors:Gloeckner, S, Heine, A, Klebe, G.
Deposit date:2018-09-26
Release date:2019-10-09
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.02 Å)
Cite:Conformational Changes in Alkyl Chains Determine the Thermodynamic and Kinetic Binding Profiles of Carbonic Anhydrase Inhibitors.
Acs Chem.Biol., 15, 2020
3CZV
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BU of 3czv by Molmil
Crystal structure of the human carbonic anhydrase XIII in complex with acetazolamide
Descriptor: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase 13, GLYCEROL, ...
Authors:Di Fiore, A, De Simone, G.
Deposit date:2008-04-30
Release date:2008-07-29
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide.
Proteins, 74, 2008

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