1TTM
Human carbonic anhydrase II complexed with 667-coumate
Summary for 1TTM
Entry DOI | 10.2210/pdb1ttm/pdb |
Descriptor | Carbonic anhydrase II, ZINC ION, 6-OXO-8,9,10,11-TETRAHYDRO-7H-CYCLOHEPTA[C][1]BENZOPYRAN-3-O-SULFAMATE, ... (4 entities in total) |
Functional Keywords | cancer, human carbonic anhydrase inhibitors, 667-coumate, obesity, steroid sulfatase inhibitor, lyase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29598.02 |
Authors | Lloyd, M.D.,Pederick, R.L.,Natesh, R.,Woo, L.W.L.,Purohit, A.,Reed, M.J.,Acharya, K.R.,Potter, B.V.L. (deposition date: 2004-06-23, release date: 2004-10-05, Last modification date: 2023-08-23) |
Primary citation | Lloyd, M.D.,Pederick, R.L.,Natesh, R.,Woo, L.W.L.,Purohit, A.,Reed, M.J.,Acharya, K.R.,Potter, B.V.L. Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, a novel anti-cancer agent Biochem.J., 385:715-720, 2005 Cited by PubMed: 15453828DOI: 10.1042/BJ20041037 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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