PDB: 30672 resultsInfo pagesStatus searchChemie searchBIRD

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8Q4L	GBP1 bound by 14-3-3sigma Descriptor: 14-3-3 protein sigma, Guanylate-binding protein 1 Authors: Pfleiderer, M.M, Liu, X, Fisch, D, Anastasakou, E, Frickel, E.M, Galej, W.P. Deposit date: 2023-08-07 Release date: 2023-10-11 Last modified: 2023-10-18 Method: ELECTRON MICROSCOPY (5.12 Å) Cite: PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection. Science, 382, 2023
8Q4O	RNA G-quadruplex from the 5'-UTR of human tyrosine kinase 2 (TYK2) Descriptor: RNA (5'-R(*CP*GP*GP*UP*AP*GP*CP*GP*GP*GP*UP*AP*UP*GP*GP*GP*UP*CP*CP*GP*GP*GP*U)-3') Authors: Toplishek, M, Kocman, V. Deposit date: 2023-08-07 Release date: 2024-03-06 Method: SOLUTION NMR Cite: High-Resolution Structure of RNA G-Quadruplex Containing Unique Structural Motifs Originating from the 5'-UTR of Human Tyrosine Kinase 2 (TYK2). Acs Omega, 9, 2024
8Q4W	Crystal structure of YTHDC1 in complex with Compound 40 (CS_3a) Descriptor: 5-chloranyl-3-[(3-chlorophenyl)methyl]-~{N}-methyl-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine, SULFATE ION, YTH domain-containing protein 1 Authors: Bedi, R.K, Zalesak, F, Caflisch, A. Deposit date: 2023-08-07 Release date: 2023-12-06 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Crystal structure of YTHDC1 in complex with Compound 40 (CS_3a) To Be Published
8Q4U	Crystal structure of YTHDC1 in complex with Compound 36 (ZA_540b) Descriptor: 9-[(3-chlorophenyl)methyl]-2-fluoranyl-~{N}-methyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1 Authors: Bedi, R.K, Zalesak, F, Caflisch, A. Deposit date: 2023-08-07 Release date: 2023-12-06 Method: X-RAY DIFFRACTION (1.37 Å) Cite: Crystal structure of YTHDC1 in complex with Compound 36 (ZA_540b) To Be Published
8Q4V	Crystal structure of YTHDC1 in complex with Compound 37 (ZA_356) Descriptor: 2-chloranyl-9-[(3-chlorophenyl)methyl]-~{N}-cyclopropyl-7,8-dihydropurin-6-amine, SULFATE ION, YTH domain-containing protein 1 Authors: Bedi, R.K, Zalesak, F, Caflisch, A. Deposit date: 2023-08-07 Release date: 2023-12-06 Method: X-RAY DIFFRACTION (1.36 Å) Cite: Crystal structure of YTHDC1 in complex with Compound 37 (ZA_356) To Be Published
8Q4P	Crystal structure of YTHDC1 in complex with Compound 27 (ZA_309) Descriptor: 2-chloranyl-9-[(3-methoxyphenyl)methyl]-~{N}-methyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1 Authors: Bedi, R.K, Zalesak, F, Caflisch, A. Deposit date: 2023-08-07 Release date: 2023-12-06 Method: X-RAY DIFFRACTION (1.43 Å) Cite: Crystal structure of YTHDC1 in complex with Compound 27 (ZA_309) To Be Published
8Q4T	Crystal structure of YTHDC1 in complex with Compound 31 (ZA_400) Descriptor: SULFATE ION, YTH domain-containing protein 1, ~{N}-[4-chloranyl-2-[[2-chloranyl-6-(methylamino)purin-9-yl]methyl]phenyl]methanesulfonamide Authors: Bedi, R.K, Zalesak, F, Caflisch, A. Deposit date: 2023-08-07 Release date: 2023-12-06 Method: X-RAY DIFFRACTION (1.51 Å) Cite: Crystal structure of YTHDC1 in complex with Compound 31 (ZA_400) To Be Published
8Q4N	Crystal structure of YTHDC1 in complex with Compound 26 (ZA_513) Descriptor: 3-[[2-chloranyl-6-(methylamino)purin-9-yl]methyl]benzenecarbonitrile, SULFATE ION, YTH domain-containing protein 1 Authors: Bedi, R.K, Zalesak, F, Caflisch, A. Deposit date: 2023-08-07 Release date: 2023-12-06 Method: X-RAY DIFFRACTION (1.42 Å) Cite: Crystal structure of YTHDC1 in complex with Compound 26 (ZA_513) To Be Published
8Q4M	Crystal structure of YTHDC1 in complex with Compound 25 (ZA_349) Descriptor: 2-chloranyl-9-[(3-chlorophenyl)methyl]-~{N}-methyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1 Authors: Bedi, R.K, Zalesak, F, Caflisch, A. Deposit date: 2023-08-07 Release date: 2023-12-06 Method: X-RAY DIFFRACTION (1.43 Å) Cite: Crystal structure of YTHDC1 in complex with Compound 25 (ZA_349) To Be Published
8Q4R	Crystal structure of YTHDC1 in complex with Compound 30 (ZA_326) Descriptor: SULFATE ION, YTH domain-containing protein 1, [4-[[2-chloranyl-6-(methylamino)purin-9-yl]methyl]phenyl]methanol Authors: Bedi, R.K, Zalesak, F, Caflisch, A. Deposit date: 2023-08-07 Release date: 2023-12-06 Method: X-RAY DIFFRACTION (1.43 Å) Cite: Crystal structure of YTHDC1 in complex with Compound 30 (ZA_326) To Be Published
8Q4Q	Crystal structure of YTHDC1 in complex with Compound 29 (ZA_337) Descriptor: 4-[[2-chloranyl-6-(methylamino)purin-9-yl]methyl]benzoic acid, SULFATE ION, YTH domain-containing protein 1 Authors: Bedi, R.K, Zalesak, F, Caflisch, A. Deposit date: 2023-08-07 Release date: 2023-12-06 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Crystal structure of YTHDC1 in complex with Compound 29 (ZA_337) To Be Published
8KCA	Crystal structure of DDX53 helicase domain Descriptor: Probable ATP-dependent RNA helicase DDX53 Authors: Park, S, Yang, J.B, Jung, H.S, Kim, H.Y. Deposit date: 2023-08-06 Release date: 2023-08-30 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Structural insight into crystal structure of helicase domain of DDX53. Biochem.Biophys.Res.Commun., 677, 2023
8KC7	Rpd3S histone deacetylase complex Descriptor: Chromatin modification-related protein EAF3, Histone deacetylase RPD3, Transcriptional regulatory protein RCO1, ... Authors: Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. Deposit date: 2023-08-06 Release date: 2023-09-13 Last modified: 2023-10-18 Method: ELECTRON MICROSCOPY (3.46 Å) Cite: Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
8TPY	Structure of human hypoxanthine guanine phosphoribzosyltransferase in complex with [2S,4R] 4-Guanin-9-yl-2-hydroxymethyl-1-N-(3-phosphonopropionyl)pyrrolidine Descriptor: Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, {3-[(2S,4R)-4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-oxopropyl}phosphonic acid Authors: Guddat, L.W. Deposit date: 2023-08-06 Release date: 2024-05-08 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Development of Prolinol Containing Inhibitors of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design. J.Med.Chem., 67, 2024
8TPV	Structure of human hypoxanthine guanine phosphoribzosyltransferase in complex with [2S,4R]-4-Guanin-9-yl-2-(2-phosphonoethoxymethyl)-1-N-(3-phosphonopropionyl)pyrrolidine Descriptor: (3-{(2S,4R)-4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2-phosphonoethoxy)methyl]pyrrolidin-1-yl}-3-oxopropyl)phosphonic acid, Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION Authors: Guddat, L.W. Deposit date: 2023-08-05 Release date: 2024-05-08 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.27 Å) Cite: Development of Prolinol Containing Inhibitors of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design. J.Med.Chem., 67, 2024
8Q3Q	Bacterial transcription termination factor Rho G152D mutant Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transcription termination factor Rho Authors: Said, N, Hilal, T, Wahl, M.C. Deposit date: 2023-08-04 Release date: 2023-09-27 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Transcription termination factor rho polymerizes under stress. Biorxiv, 2023
8Q3O	Bacterial transcription termination factor Rho + pppGpp Descriptor: MAGNESIUM ION, Transcription termination factor Rho, guanosine 5'-(tetrahydrogen triphosphate) 3'-(trihydrogen diphosphate) Authors: Said, N, Hilal, T, Wahl, M.C. Deposit date: 2023-08-04 Release date: 2023-09-27 Method: ELECTRON MICROSCOPY (3 Å) Cite: Transcription termination factor rho polymerizes under stress. Biorxiv, 2023
8Q3N	Bacterial transcription termination factor Rho + ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transcription termination factor Rho Authors: Said, N, Hilal, T, Wahl, M.C. Deposit date: 2023-08-04 Release date: 2023-09-27 Last modified: 2023-10-04 Method: ELECTRON MICROSCOPY (2.63 Å) Cite: Transcription termination factor rho polymerizes under stress. Biorxiv, 2023
8Q3P	Bacterial transcription termination factor Rho G150D mutant Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transcription termination factor Rho Authors: Said, N, Hilal, T, Wahl, M.C. Deposit date: 2023-08-04 Release date: 2023-09-27 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Transcription termination factor rho polymerizes under stress. Biorxiv, 2023
8Q42	Crystal structure of cA4-bound Can2 (E341A) in complex with oligo-A DNA Descriptor: Cyclic tetraadenosine monophosphate (cA4), DNA (5'-D(*AP*AP*AP*A)-3'), DUF1887 family protein, ... Authors: Jungfer, K, Sigg, A, Jinek, M. Deposit date: 2023-08-04 Release date: 2023-11-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2. Nucleic Acids Res., 52, 2024
8Q44	Crystal structure of cA4-bound Can2 (E364R) in complex with oligo-T DNA Descriptor: Cyclic tetraadenosine monophosphate (cA4), DNA (5'-D(*TP*TP*T)-3'), DUF1887 family protein, ... Authors: Jungfer, K, Sigg, A, Jinek, M. Deposit date: 2023-08-04 Release date: 2023-11-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2. Nucleic Acids Res., 52, 2024
8Q3Y	Crystal structure of apo Can2 from Thermoanaerobacter brockii Descriptor: DUF1887 family protein Authors: Jungfer, K, Sigg, A, Jinek, M. Deposit date: 2023-08-04 Release date: 2023-11-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.52 Å) Cite: Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2. Nucleic Acids Res., 52, 2024
8Q40	Crystal structure of cA4 activated Can2 in complex with a cleaved DNA substrate Descriptor: Cyclic tetraadenosine monophosphate (cA4), DNA (5'-D(*TP*CP*A)-3'), DUF1887 family protein, ... Authors: Jungfer, K, Sigg, A, Jinek, M. Deposit date: 2023-08-04 Release date: 2023-11-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.21 Å) Cite: Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2. Nucleic Acids Res., 52, 2024
8Q41	Crystal structure of Can2 (E341A) bound to cA4 and TTTAAA ssDNA Descriptor: Cyclic tetraadenosine monophosphate (cA4), DNA (5'-D(*TP*TP*AP*AP*A)-3'), DUF1887 family protein, ... Authors: Jungfer, K, Sigg, A, Jinek, M. Deposit date: 2023-08-04 Release date: 2023-11-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.38 Å) Cite: Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2. Nucleic Acids Res., 52, 2024
8Q3Z	Crystal structure of cA4-bound Can2 from Thermoanaerobacter brockii Descriptor: Cyclic tetraadenosine monophosphate (cA4), DUF1887 family protein, MANGANESE (II) ION Authors: Jungfer, K, Sigg, A, Jinek, M. Deposit date: 2023-08-04 Release date: 2023-11-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.15 Å) Cite: Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2. Nucleic Acids Res., 52, 2024

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