1S3S
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![BU of 1s3s by Molmil](/molmil-images/mine/1s3s) | Crystal structure of AAA ATPase p97/VCP ND1 in complex with p47 C | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)- ATPase p97 subunit) (Valosin containing protein) (VCP) [Contains: Valosin], p47 protein | Authors: | Dreveny, I, Kondo, H, Uchiyama, K, Shaw, A, Zhang, X, Freemont, P.S. | Deposit date: | 2004-01-14 | Release date: | 2004-03-30 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47. Embo J., 23, 2004
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3J95
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![BU of 3j95 by Molmil](/molmil-images/mine/3j95) | Structure of ADP-bound N-ethylmaleimide sensitive factor determined by single particle cryoelectron microscopy | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Vesicle-fusing ATPase | Authors: | Zhao, M, Wu, S, Cheng, Y, Brunger, A.T. | Deposit date: | 2014-12-05 | Release date: | 2015-01-28 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (7.6 Å) | Cite: | Mechanistic insights into the recycling machine of the SNARE complex. Nature, 518, 2015
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5C18
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![BU of 5c18 by Molmil](/molmil-images/mine/5c18) | p97-delta709-728 in complex with ATP-gamma-S | Descriptor: | CHLORIDE ION, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Haenzelmann, P, Schindelin, H. | Deposit date: | 2015-06-13 | Release date: | 2016-01-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural Basis of ATP Hydrolysis and Intersubunit Signaling in the AAA+ ATPase p97. Structure, 24, 2016
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5KIW
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![BU of 5kiw by Molmil](/molmil-images/mine/5kiw) | p97 ND1-L198W in complex with VIMP | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Selenoprotein S, ... | Authors: | Tang, W.K, Xia, D. | Deposit date: | 2016-06-17 | Release date: | 2018-03-07 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.41 Å) | Cite: | Structural basis for nucleotide-modulated p97 association with the ER membrane. Cell Discov, 3, 2017
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5KIY
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![BU of 5kiy by Molmil](/molmil-images/mine/5kiy) | p97 ND1-A232E in complex with VIMP | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Selenoprotein S, ... | Authors: | Tang, W.K, Xia, D. | Deposit date: | 2016-06-17 | Release date: | 2017-12-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Structural basis for nucleotide-modulated p97 association with the ER membrane. Cell Discov, 3, 2017
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1R7R
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![BU of 1r7r by Molmil](/molmil-images/mine/1r7r) | The crystal structure of murine p97/VCP at 3.6A | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | Authors: | Huyton, T, Pye, V.E, Briggs, L.C, Flynn, T.C, Beuron, F, Kondo, H, Ma, J, Zhang, X, Freemont, P.S. | Deposit date: | 2003-10-22 | Release date: | 2003-12-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | The crystal structure of murine p97/VCP at 3.6A J.Struct.Biol., 144, 2003
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8KG2
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![BU of 8kg2 by Molmil](/molmil-images/mine/8kg2) | |
3CF2
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![BU of 3cf2 by Molmil](/molmil-images/mine/3cf2) | Structure of P97/vcp in complex with ADP/AMP-PNP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | Authors: | Davies, J.M, Delabarre, B, Brunger, A.T, Weis, W.I. | Deposit date: | 2008-03-01 | Release date: | 2008-04-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change. Structure, 16, 2008
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3CF3
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![BU of 3cf3 by Molmil](/molmil-images/mine/3cf3) | Structure of P97/vcp in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | Authors: | Davies, J.M, Delabarre, B, Brunger, A.T, Weis, W.I. | Deposit date: | 2008-03-01 | Release date: | 2008-04-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (4.25 Å) | Cite: | Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change. Structure, 16, 2008
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3CF1
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![BU of 3cf1 by Molmil](/molmil-images/mine/3cf1) | Structure of P97/vcp in complex with ADP/ADP.alfx | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Transitional endoplasmic reticulum ATPase | Authors: | Davies, J.M, Delabarre, B, Brunger, A.T, Weis, W.I. | Deposit date: | 2008-03-01 | Release date: | 2008-04-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (4.4 Å) | Cite: | Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change. Structure, 16, 2008
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6HD3
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![BU of 6hd3 by Molmil](/molmil-images/mine/6hd3) | Common mode of remodeling AAA ATPases p97/CDC48 by their disassembly cofactors ASPL/PUX1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 48 homolog A, PHOSPHATE ION | Authors: | Heinemann, U, Roske, Y, Banchenko, S, Arumughan, A, Petrovic, S. | Deposit date: | 2018-08-17 | Release date: | 2019-08-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Common Mode of Remodeling AAA ATPases p97/CDC48 by Their Disassembling Cofactors ASPL/PUX1. Structure, 27, 2019
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1E32
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![BU of 1e32 by Molmil](/molmil-images/mine/1e32) | Structure of the N-Terminal domain and the D1 AAA domain of membrane fusion ATPase p97 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, P97 | Authors: | Zhang, X, Shaw, A, Bates, P.A, Gorman, M.A, Kondo, H, Dokurno, P, Leonard M, G, Sternberg, J.E, Freemont, P.S. | Deposit date: | 2000-06-05 | Release date: | 2001-05-31 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of the Aaa ATPase P97 Mol.Cell, 6, 2000
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3J94
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![BU of 3j94 by Molmil](/molmil-images/mine/3j94) | Structure of ATP-bound N-ethylmaleimide sensitive factor determined by single particle cryoelectron microscopy | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Vesicle-fusing ATPase | Authors: | Zhao, M, Wu, S, Cheng, Y, Brunger, A.T. | Deposit date: | 2014-12-05 | Release date: | 2015-01-28 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Mechanistic insights into the recycling machine of the SNARE complex. Nature, 518, 2015
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8VKU
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![BU of 8vku by Molmil](/molmil-images/mine/8vku) | Structure of VCP in complex with an ATPase activator (D2 domains only, hexameric form) | Descriptor: | (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, Transitional endoplasmic reticulum ATPase | Authors: | Jones, N.H, Urnivicius, L, Kapoor, T.M. | Deposit date: | 2024-01-09 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry. Proc.Natl.Acad.Sci.USA, 121, 2024
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3J97
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![BU of 3j97 by Molmil](/molmil-images/mine/3j97) | Structure of 20S supercomplex determined by single particle cryoelectron microscopy (State II) | Descriptor: | Alpha-soluble NSF attachment protein, Synaptosomal-associated protein 25, Syntaxin-1A, ... | Authors: | Zhao, M, Wu, S, Cheng, Y, Brunger, A.T. | Deposit date: | 2014-12-05 | Release date: | 2015-01-28 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (7.8 Å) | Cite: | Mechanistic insights into the recycling machine of the SNARE complex. Nature, 518, 2015
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3J98
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![BU of 3j98 by Molmil](/molmil-images/mine/3j98) | Structure of 20S supercomplex determined by single particle cryoelectron microscopy (State IIIa) | Descriptor: | Alpha-soluble NSF attachment protein, Synaptosomal-associated protein 25, Syntaxin-1A, ... | Authors: | Zhao, M, Wu, S, Cheng, Y, Brunger, A.T. | Deposit date: | 2014-12-05 | Release date: | 2015-01-28 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (8.4 Å) | Cite: | Mechanistic insights into the recycling machine of the SNARE complex. Nature, 518, 2015
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8VLS
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![BU of 8vls by Molmil](/molmil-images/mine/8vls) | Structure of VCP in complex with an ATPase activator (D2 domains only, dodecameric form) | Descriptor: | (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, Transitional endoplasmic reticulum ATPase | Authors: | Jones, N.H, Urnivicius, L, Kapoor, T.M. | Deposit date: | 2024-01-12 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry. Proc.Natl.Acad.Sci.USA, 121, 2024
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8VOV
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![BU of 8vov by Molmil](/molmil-images/mine/8vov) | Structure of VCP in complex with an ATPase activator and ADP (D2 domains only, hexameric form) | Descriptor: | (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | Authors: | Jones, N.H, Urnivicius, L, Kapoor, T.M. | Deposit date: | 2024-01-16 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry. Proc.Natl.Acad.Sci.USA, 121, 2024
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6HD0
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![BU of 6hd0 by Molmil](/molmil-images/mine/6hd0) | |
6IP2
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![BU of 6ip2 by Molmil](/molmil-images/mine/6ip2) | NSF-D1D2 part in the whole 20S complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Vesicle-fusing ATPase | Authors: | Huang, X, Sun, S, Wang, X, Fan, F, Zhou, Q, Sui, S.F. | Deposit date: | 2018-11-01 | Release date: | 2019-04-24 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Mechanistic insights into the SNARE complex disassembly. Sci Adv, 5, 2019
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7WUB
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![BU of 7wub by Molmil](/molmil-images/mine/7wub) | Cryo-EM structure of dodecamer P97 | Descriptor: | 3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | Authors: | Liu, S, Wang, T. | Deposit date: | 2022-02-08 | Release date: | 2022-03-23 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM structure of dodecamer P97 at 2.99 Angstroms resolution To Be Published
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3QC8
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![BU of 3qc8 by Molmil](/molmil-images/mine/3qc8) | Crystal Structure of FAF1 UBX Domain In Complex with p97/VCP N Domain Reveals The Conserved FcisP Touch-Turn Motif of UBX Domain Suffering Conformational Change | Descriptor: | FAS-associated factor 1, Transitional endoplasmic reticulum ATPase | Authors: | Kim, K.H, Kang, W, Suh, S.W, Yang, J.K. | Deposit date: | 2011-01-15 | Release date: | 2011-07-20 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of FAF1 UBX domain in complex with p97/VCP N domain reveals a conformational change in the conserved FcisP touch-turn motif of UBX domain Proteins, 79, 2011
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3HU2
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![BU of 3hu2 by Molmil](/molmil-images/mine/3hu2) | Structure of p97 N-D1 R86A mutant in complex with ATPgS | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | Authors: | Tang, W.-K. | Deposit date: | 2009-06-12 | Release date: | 2010-06-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants. Embo J., 29, 2010
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3QQ8
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![BU of 3qq8 by Molmil](/molmil-images/mine/3qq8) | |
3HU1
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![BU of 3hu1 by Molmil](/molmil-images/mine/3hu1) | Structure of p97 N-D1 R95G mutant in complex with ATPgS | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | Authors: | Tang, W.-K. | Deposit date: | 2009-06-12 | Release date: | 2010-06-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants. Embo J., 29, 2010
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