4YWP
 
 | | Sucrose Binding Site in genetically engineered Carbonic anhydrase IX | | Descriptor: | Carbonic anhydrase 2, ZINC ION, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | | Authors: | Pinard, M.A, Aggarwal, M. | | Deposit date: | 2015-03-20 | | Release date: | 2015-10-14 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX.
Acta Crystallogr F Struct Biol Commun, 71, 2015
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7PRI
 | | Carbonic Anhydrase from Schistosoma Mansoni in complex with clorsulon | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-azanyl-6-[1,2,2-tris(chloranyl)ethenyl]benzene-1,3-disulfonamide, Carbonic anhydrase, ... | | Authors: | Angeli, A, Ferraroni, M. | | Deposit date: | 2021-09-21 | | Release date: | 2022-10-05 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.679 Å) | | Cite: | Inhibition of Schistosoma mansoni carbonic anhydrase by the antiparasitic drug clorsulon: X-ray crystallographic and in vitro studies.
Acta Crystallogr D Struct Biol, 78, 2022
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1DDZ
 | | X-RAY STRUCTURE OF A BETA-CARBONIC ANHYDRASE FROM THE RED ALGA, PORPHYRIDIUM PURPUREUM R-1 | | Descriptor: | CARBONIC ANHYDRASE, ZINC ION | | Authors: | Mitsuhashi, S, Mizushima, T, Yamashita, E, Miyachi, S, Tsukihara, T. | | Deposit date: | 1999-11-12 | | Release date: | 2000-03-08 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | X-ray structure of beta-carbonic anhydrase from the red alga, Porphyridium purpureum, reveals a novel catalytic site for CO(2) hydration.
J.Biol.Chem., 275, 2000
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3S78
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7P1A
 | | Carbonic Anhydrase VII Sultam Based Inhibitors | | Descriptor: | 4-[2-[4-[(4-methylphenyl)methyl]-1,1-bis(oxidanylidene)-1,2,4-thiadiazinan-2-yl]ethyl]benzenesulfonamide, Carbonic anhydrase 7, GLYCEROL, ... | | Authors: | D'Ambrosio, K, De Simone, G. | | Deposit date: | 2021-07-01 | | Release date: | 2021-11-17 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain.
Eur.J.Med.Chem., 227, 2021
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3S75
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6LUW
 | | Zn- Carbonic Anhydrase II pH 7.8 0 atm CO2 | | Descriptor: | Carbonic anhydrase 2, GLYCEROL, ZINC ION | | Authors: | Kim, C.U, Kim, J.K. | | Deposit date: | 2020-02-02 | | Release date: | 2020-08-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Elucidating the role of metal ions in carbonic anhydrase catalysis.
Nat Commun, 11, 2020
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6LV7
 | | Ni- Carbonic Anhydrase II pH 11.0 0 atm CO2 | | Descriptor: | Carbonic anhydrase 2, GLYCEROL, NICKEL (II) ION | | Authors: | Kim, C.U, Kim, J.K. | | Deposit date: | 2020-02-02 | | Release date: | 2020-08-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Elucidating the role of metal ions in carbonic anhydrase catalysis.
Nat Commun, 11, 2020
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6LUU
 | | apo- Carbonic Anhydrase II pH 7.8 0 atm CO2 | | Descriptor: | Carbonic anhydrase 2, GLYCEROL | | Authors: | Kim, C.U, Kim, J.K. | | Deposit date: | 2020-02-02 | | Release date: | 2020-08-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Elucidating the role of metal ions in carbonic anhydrase catalysis.
Nat Commun, 11, 2020
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6LUY
 | | Zn- Carbonic Anhydrase II pH 11.0 0 atm CO2 | | Descriptor: | Carbonic anhydrase 2, GLYCEROL, ZINC ION | | Authors: | Kim, C.U, Kim, J.K. | | Deposit date: | 2020-02-02 | | Release date: | 2020-08-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Elucidating the role of metal ions in carbonic anhydrase catalysis.
Nat Commun, 11, 2020
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6LV5
 | | Ni- Carbonic Anhydrase II pH 7.8 0 atm CO2 | | Descriptor: | Carbonic anhydrase 2, GLYCEROL, NICKEL (II) ION | | Authors: | Kim, C.U, Kim, J.K. | | Deposit date: | 2020-02-02 | | Release date: | 2020-08-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Elucidating the role of metal ions in carbonic anhydrase catalysis.
Nat Commun, 11, 2020
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3RG3
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3RG4
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3RGE
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6GWU
 | | Carbonic anhydrase CaNce103p from Candida albicans | | Descriptor: | BETA-MERCAPTOETHANOL, Carbonic anhydrase, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Brynda, J, Dostal, J, Heidingsfeld, O, Machacek, S, Blaha, J, Pichova, I. | | Deposit date: | 2018-06-26 | | Release date: | 2018-11-07 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of carbonic anhydrase CaNce103p from the pathogenic yeast Candida albicans.
BMC Struct. Biol., 18, 2018
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3M1K
 | | Carbonic Anhydrase in complex with fragment | | Descriptor: | (4-CARBOXYPHENYL)(CHLORO)MERCURY, 1-hydroxy-2-sulfanylpyridinium, Carbonic anhydrase 2, ... | | Authors: | Schulze Wischeler, J, Heine, A, Klebe, G. | | Deposit date: | 2010-03-05 | | Release date: | 2010-11-17 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Bidentate Zinc chelators for alpha-carbonic anhydrases that produce a trigonal bipyramidal coordination geometry.
Chemmedchem, 5, 2010
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4M2W
 | | Genetically engineered Carbonic Anhydrase IX in complex with Dorzolamide | | Descriptor: | (4S-TRANS)-4-(ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE, Carbonic anhydrase 2, ZINC ION | | Authors: | Pinard, M.P, Boone, C.D, Rife, B.D, Supuran, C.T, McKenna, R. | | Deposit date: | 2013-08-05 | | Release date: | 2013-11-06 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.658 Å) | | Cite: | Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.
Bioorg.Med.Chem., 21, 2013
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2FNK
 | | Activation of Human Carbonic Anhydrase II by exogenous proton donors | | Descriptor: | Carbonic anhydrase 2, ZINC ION | | Authors: | Bhatt, D, Fisher, S.Z, Tu, C, McKenna, R, Silverman, D.N. | | Deposit date: | 2006-01-11 | | Release date: | 2006-11-28 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Location of binding sites in small molecule rescue of human carbonic anhydrase II.
Biophys.J., 92, 2007
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6FE2
 | | Three dimensional structure of human carbonic anhydrase IX | | Descriptor: | Carbonic anhydrase 9, ZINC ION | | Authors: | Leitans, J, Tars, K. | | Deposit date: | 2017-12-28 | | Release date: | 2018-07-04 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells.
Oncotarget, 9, 2018
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1ZNC
 | | HUMAN CARBONIC ANHYDRASE IV | | Descriptor: | CARBONIC ANHYDRASE IV, SULFATE ION, ZINC ION | | Authors: | Stams, T, Christianson, D.W. | | Deposit date: | 1996-09-17 | | Release date: | 1997-09-17 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution.
Proc.Natl.Acad.Sci.USA, 93, 1996
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2CBC
 | | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES | | Descriptor: | CARBONIC ANHYDRASE II, FORMIC ACID, MERCURY (II) ION, ... | | Authors: | Hakansson, K, Carlsson, M, Svensson, L.A, Liljas, A. | | Deposit date: | 1992-06-01 | | Release date: | 1993-10-31 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Structure of native and apo carbonic anhydrase II and structure of some of its anion-ligand complexes.
J.Mol.Biol., 227, 1992
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2CBB
 | | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES | | Descriptor: | CARBONIC ANHYDRASE II, ZINC ION | | Authors: | Hakansson, K, Carlsson, M, Svensson, L.A, Liljas, A. | | Deposit date: | 1992-06-01 | | Release date: | 1993-10-31 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Structure of native and apo carbonic anhydrase II and structure of some of its anion-ligand complexes.
J.Mol.Biol., 227, 1992
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2CBE
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2CBD
 | | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES | | Descriptor: | CARBONIC ANHYDRASE II, SULFITE ION, ZINC ION | | Authors: | Hakansson, K, Carlsson, M, Svensson, L.A, Liljas, A. | | Deposit date: | 1992-06-01 | | Release date: | 1993-10-31 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Structure of native and apo carbonic anhydrase II and structure of some of its anion-ligand complexes.
J.Mol.Biol., 227, 1992
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2CBA
 | | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES | | Descriptor: | CARBONIC ANHYDRASE II, ZINC ION | | Authors: | Hakansson, K, Carlsson, M, Svensson, L.A, Liljas, A. | | Deposit date: | 1992-06-01 | | Release date: | 1993-10-31 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.54 Å) | | Cite: | Structure of native and apo carbonic anhydrase II and structure of some of its anion-ligand complexes.
J.Mol.Biol., 227, 1992
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