5QBL
 
 | | Crystal structure of Endothiapepsin-NAT17-347147 complex | | Descriptor: | (1S,2S,3S,4R,5R)-2-({[5-(hydroxymethyl)furan-2-yl]methyl}amino)-4-(morpholin-4-yl)-6,8-dioxabicyclo[3.2.1]octan-3-ol, 1,2-ETHANEDIOL, ACETATE ION, ... | | Authors: | Huschmann, F. | | Deposit date: | 2017-08-04 | | Release date: | 2020-04-22 | | Last modified: | 2021-11-17 | | Method: | X-RAY DIFFRACTION (1.619 Å) | | Cite: | Crystal structure of Endothiapepsin
To be published
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5QB8
 | | Crystal structure of Endothiapepsin-FRG080 complex | | Descriptor: | (1S,2S,3S,4R,5R)-2-amino-4-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-6,8-dioxabicyclo[3.2.1]octan-3-ol, ACETATE ION, Endothiapepsin, ... | | Authors: | Huschmann, F. | | Deposit date: | 2017-08-04 | | Release date: | 2020-04-22 | | Last modified: | 2021-11-17 | | Method: | X-RAY DIFFRACTION (1.24 Å) | | Cite: | Crystal structure of Endothiapepsin
To be published
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5QBP
 | | Crystal structure of Endothiapepsin-NAT17-347290a complex | | Descriptor: | 1-cyclohexyl-3-[(1S,2S,3S,4R,5R)-3-hydroxy-4-(piperidin-1-yl)-6,8-dioxabicyclo[3.2.1]octan-2-yl]urea, ACETATE ION, DIMETHYL SULFOXIDE, ... | | Authors: | Huschmann, F. | | Deposit date: | 2017-08-04 | | Release date: | 2020-04-22 | | Last modified: | 2021-11-17 | | Method: | X-RAY DIFFRACTION (1.297 Å) | | Cite: | Crystal structure of Endothiapepsin
To be published
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5QB7
 | | Crystal structure of Endothiapepsin-FRG075 complex | | Descriptor: | (3R,5R)-5-{3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}pyrrolidin-3-ol, DIMETHYL SULFOXIDE, Endothiapepsin, ... | | Authors: | Huschmann, F. | | Deposit date: | 2017-08-04 | | Release date: | 2020-04-22 | | Last modified: | 2021-11-17 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal structure of Endothiapepsin
To be published
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5QBG
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5QBQ
 | | Crystal structure of Endothiapepsin | | Descriptor: | 4-[2-({methyl[(pyridin-3-yl)methyl]amino}methyl)-1,3-thiazol-4-yl]piperidin-4-ol, ACETATE ION, Endothiapepsin, ... | | Authors: | Huschmann, F. | | Deposit date: | 2017-08-04 | | Release date: | 2020-04-22 | | Last modified: | 2021-11-17 | | Method: | X-RAY DIFFRACTION (1.697 Å) | | Cite: | Crystal structure of Endothiapepsin
To be published
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5QBD
 | | Crystal structure of Endothiapepsin-FRG166 complex | | Descriptor: | (1R,2S,3R,4R)-3-amino-4-cyclohexylcyclopentane-1,2-diol, DIMETHYL SULFOXIDE, Endothiapepsin, ... | | Authors: | Huschmann, F. | | Deposit date: | 2017-08-04 | | Release date: | 2020-04-22 | | Last modified: | 2021-11-17 | | Method: | X-RAY DIFFRACTION (1.419 Å) | | Cite: | Crystal structure of Endothiapepsin
To be published
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5QBN
 | | Crystal structure of Endothiapepsin-NAT14-350193 complex | | Descriptor: | 2-{(3R,4S)-3-[(5-{[benzyl(methyl)amino]methyl}-1,2-oxazol-3-yl)methyl]piperidin-4-yl}-N-(1,3-thiazol-2-yl)acetamide, ACETATE ION, DIMETHYL SULFOXIDE, ... | | Authors: | Huschmann, F. | | Deposit date: | 2017-08-04 | | Release date: | 2020-04-22 | | Last modified: | 2021-11-17 | | Method: | X-RAY DIFFRACTION (1.403 Å) | | Cite: | Crystal structure of Endothiapepsin
To be published
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5QB9
 | | Crystal structure of Endothiapepsin-FRG081 complex | | Descriptor: | (1S,2S,3S,4R,5R)-2-amino-4-[benzyl(methyl)amino]-6,8-dioxabicyclo[3.2.1]octan-3-ol, ACETATE ION, Endothiapepsin, ... | | Authors: | Huschmann, F. | | Deposit date: | 2017-08-04 | | Release date: | 2020-04-22 | | Last modified: | 2021-11-17 | | Method: | X-RAY DIFFRACTION (1.478 Å) | | Cite: | Crystal structure of Endothiapepsin
To be published
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5QBK
 | | Crystal structure of Endothiapepsin-NAT17-347144 complex | | Descriptor: | (1S,2S,3S,4R,5R)-4-(morpholin-4-yl)-2-[(quinolin-3-ylmethyl)amino]-6,8-dioxabicyclo[3.2.1]octan-3-ol, DIMETHYL SULFOXIDE, Endothiapepsin | | Authors: | Huschmann, F. | | Deposit date: | 2017-08-04 | | Release date: | 2020-04-22 | | Last modified: | 2021-11-17 | | Method: | X-RAY DIFFRACTION (1.279 Å) | | Cite: | Crystal structure of Endothiapepsin
To be published
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5QBI
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5QBT
 | | Crystal structure of Endothiapepsin-NAT17-346985 complex | | Descriptor: | (1S,2S,3S,4R,5R)-2-[(cyclopropylmethyl)amino]-4-(phenylsulfanyl)-6,8-dioxabicyclo[3.2.1]octan-3-ol, 1,2-ETHANEDIOL, ACETATE ION, ... | | Authors: | Huschmann, F. | | Deposit date: | 2017-08-04 | | Release date: | 2020-04-22 | | Last modified: | 2021-11-17 | | Method: | X-RAY DIFFRACTION (1.299 Å) | | Cite: | Crystal structure of Endothiapepsin
To be published
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5QBA
 | | Crystal structure of Endothiapepsin-FRG134 complex | | Descriptor: | 2-[(3S)-pyrrolidin-3-yl]-1H-benzimidazole, ACETATE ION, DIMETHYL SULFOXIDE, ... | | Authors: | Huschmann, F. | | Deposit date: | 2017-08-04 | | Release date: | 2020-04-22 | | Last modified: | 2021-11-17 | | Method: | X-RAY DIFFRACTION (1.338 Å) | | Cite: | Crystal structure of Endothiapepsin
To be published
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5QBM
 | | Crystal structure of Endothiapepsin-NAT17-347151 complex | | Descriptor: | (1S,2S,3S,4R,5R)-4-(morpholin-4-yl)-2-[(pyridin-4-ylmethyl)amino]-6,8-dioxabicyclo[3.2.1]octan-3-ol, DIMETHYL SULFOXIDE, Endothiapepsin, ... | | Authors: | Huschmann, F. | | Deposit date: | 2017-08-04 | | Release date: | 2020-04-22 | | Last modified: | 2021-11-17 | | Method: | X-RAY DIFFRACTION (1.569 Å) | | Cite: | Crystal structure of Endothiapepsin
To be published
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5QBE
 | | Crystal structure of Endothiapepsin-FRG175 complex | | Descriptor: | 1-[(1R)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]-L-proline, ACETATE ION, Endothiapepsin, ... | | Authors: | Huschmann, F. | | Deposit date: | 2017-08-04 | | Release date: | 2020-04-22 | | Last modified: | 2021-11-17 | | Method: | X-RAY DIFFRACTION (1.498 Å) | | Cite: | Crystal structure of Endothiapepsin
To be published
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5QBO
 | | Crystal structure of Endothiapepsin-NAT17-347283 complex | | Descriptor: | (1S,2S,3S,4R,5R)-2-[(furan-2-ylmethyl)amino]-4-(piperidin-1-yl)-6,8-dioxabicyclo[3.2.1]octan-3-ol, ACETATE ION, DIMETHYL SULFOXIDE, ... | | Authors: | Huschmann, F. | | Deposit date: | 2017-08-04 | | Release date: | 2020-04-22 | | Last modified: | 2021-11-17 | | Method: | X-RAY DIFFRACTION (1.123 Å) | | Cite: | Crystal structure of Endothiapepsin
To be published
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5QB5
 | | Crystal structure of Endothiapepsin-FRG056 complex | | Descriptor: | (1S,2S,3S,4R,5R)-2-amino-4-(phenylsulfanyl)-6,8-dioxabicyclo[3.2.1]octan-3-ol, ACETATE ION, Endothiapepsin, ... | | Authors: | Huschmann, F. | | Deposit date: | 2017-08-04 | | Release date: | 2020-04-22 | | Last modified: | 2021-11-17 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Crystal structure of Endothiapepsin
To be published
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5QBH
 | | Crystal structure of Endothiapepsin-FRG270 complex | | Descriptor: | 2-[(2S,3R,4S,5R)-5-(aminomethyl)-3,4-dihydroxytetrahydrofuran-2-yl]-N-(pyridin-2-ylmethyl)acetamide, ACETATE ION, Endothiapepsin, ... | | Authors: | Huschmann, F. | | Deposit date: | 2017-08-04 | | Release date: | 2020-04-22 | | Last modified: | 2021-11-17 | | Method: | X-RAY DIFFRACTION (1.469 Å) | | Cite: | Crystal structure of Endothiapepsin
To be published
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5QB6
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5QBF
 | | Crystal structure of Endothiapepsin-FRG203 complex | | Descriptor: | 2-amino-1,4-anhydro-2,5-dideoxy-5-[(4-fluorobenzene-1-carbonyl)amino]-D-arabinitol, ACETATE ION, Endothiapepsin, ... | | Authors: | Huschmann, F. | | Deposit date: | 2017-08-04 | | Release date: | 2020-04-22 | | Last modified: | 2021-11-17 | | Method: | X-RAY DIFFRACTION (1.268 Å) | | Cite: | Crystal structure of Endothiapepsin
To be published
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5QBS
 | | Crystal structure of Endothiapepsin-NAT17-346976 complex | | Descriptor: | (1S,2S,3S,4R,5R)-2-(benzylamino)-4-(phenylsulfanyl)-6,8-dioxabicyclo[3.2.1]octan-3-ol, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Huschmann, F. | | Deposit date: | 2017-08-04 | | Release date: | 2020-04-22 | | Last modified: | 2021-11-17 | | Method: | X-RAY DIFFRACTION (1.528 Å) | | Cite: | Crystal structure of Endothiapepsin
To be published
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6ROW
 | | Haemonchus galactose containing glycoprotein complex | | Descriptor: | Cysteine Protease, Parasite pepsinogen, Putative zinc metallopeptidase | | Authors: | Scarff, C.A, Thompson, R.F, Newlands, G.F.J, Jamson, H, Kennaway, C, da Silva, V.J, Rabelo, E.M, Song, C.F, Trinick, J, Smith, W.D, Muench, S.P. | | Deposit date: | 2019-05-13 | | Release date: | 2020-03-25 | | Last modified: | 2020-04-22 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Structure of the protective nematode protease complex H-gal-GP and its conservation across roundworm parasites.
Plos Pathog., 16, 2020
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6QBG
 | | Crystal structure of human cathepsin D in complex with macrocyclic inhibitor 14 | | Descriptor: | (3~{S},7~{S},8~{S})-8-(naphthalen-2-ylmethyl)-7-oxidanyl-3-propan-2-yl-1,4,9-triazacyclohenicosane-2,5,10-trione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Brynda, J, Houstecka, R, Majer, P, Mares, M. | | Deposit date: | 2018-12-21 | | Release date: | 2020-01-29 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure-Activity Relationship and Binding Mode Analysis.
J.Med.Chem., 63, 2020
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6QBH
 | | Crystal structure of human cathepsin D in complex with macrocyclic inhibitor 33 | | Descriptor: | (4~{S},5~{S},9~{S})-5-oxidanyl-4-(phenylmethyl)-9-propan-2-yl-1-oxa-3,8,11-triazacyclodocosane-2,7,10-trione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Brynda, J, Houstecka, R, Majer, P, Mares, M. | | Deposit date: | 2018-12-21 | | Release date: | 2020-01-29 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure-Activity Relationship and Binding Mode Analysis.
J.Med.Chem., 63, 2020
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6QCB
 | | Crystal structure of human cathepsin D in complex with macrocyclic inhibitor 9 | | Descriptor: | (3~{S},7~{S},8~{S})-7-oxidanyl-8-(phenylmethyl)-3-propan-2-yl-1,4,9-triazacyclohenicosane-2,5,10-trione, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cathepsin D, ... | | Authors: | Brynda, J, Houstecka, R, Majer, P, Mares, M. | | Deposit date: | 2018-12-27 | | Release date: | 2020-01-29 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure-Activity Relationship and Binding Mode Analysis.
J.Med.Chem., 63, 2020
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