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5V62	Phospho-ERK2 bound to bivalent inhibitor SBP3 Descriptor: 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE, GLYCEROL, Mitogen-activated protein kinase 1, ... Authors: Lechtenberg, B.C, Riedl, S.J. Deposit date: 2017-03-15 Release date: 2017-07-26 Last modified: 2024-07-10 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors. ACS Med Chem Lett, 8, 2017
5V61	Phospho-ERK2 bound to bivalent inhibitor SBP2 Descriptor: 2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oic acid, 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE, GLYCEROL, ... Authors: Lechtenberg, B.C, Riedl, S.J. Deposit date: 2017-03-15 Release date: 2017-07-26 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors. ACS Med Chem Lett, 8, 2017
2OJG	Crystal structure of ERK2 in complex with N,N-dimethyl-4-(4-phenyl-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide Descriptor: Mitogen-activated protein kinase 1, N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE, SULFATE ION Authors: Xie, X, Jacobs, M.D. Deposit date: 2007-01-12 Release date: 2007-02-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors. J.Med.Chem., 50, 2007
2OJJ	Crystal structure of ERK2 in complex with (S)-N-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide Descriptor: (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE, Mitogen-activated protein kinase 1, SULFATE ION Authors: Xie, X, Jacobs, M.D. Deposit date: 2007-01-12 Release date: 2007-02-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors. J.Med.Chem., 50, 2007
2OJI	Crystal structure of ERK2 in complex with N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide Descriptor: Mitogen-activated protein kinase 1, N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE, SULFATE ION Authors: Xie, X, Jacobs, M.D. Deposit date: 2007-01-12 Release date: 2007-02-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors. J.Med.Chem., 50, 2007
5UMO	STRUCTURE OF EXTRACELLULAR SIGNAL-REGULATED KINASE Descriptor: Mitogen-activated protein kinase 1, SULFATE ION Authors: CHLEBOWICZ, J, ZHANG, F, GOLDSMITH, E.J. Deposit date: 2017-01-27 Release date: 2017-03-01 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Atomic structure of the MAP kinase ERK2 at 2.3 A resolution. Nature, 367, 1994
5UPW	CryoEM Structure Refinement by Integrating NMR Chemical Shifts with Molecular Dynamics Simulations Descriptor: Gag polyprotein Authors: Perilla, J.R. Deposit date: 2017-02-04 Release date: 2017-03-01 Last modified: 2022-03-30 Method: ELECTRON MICROSCOPY (5 Å) Cite: CryoEM Structure Refinement by Integrating NMR Chemical Shifts with Molecular Dynamics Simulations. J Phys Chem B, 121, 2017
8CKW	HIV-1 mature capsid pentamer from CA-IP6 CLPs Descriptor: Gag polyprotein Authors: Stacey, J.C.V, Briggs, J.A.G. Deposit date: 2023-02-16 Release date: 2023-04-26 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3.12 Å) Cite: Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CL4	HIV-1 mature capsid pentamer from CA-IP6 CLPs bound to Sec24C peptide Descriptor: Gag polyprotein Authors: Stacey, J.C.V, Briggs, J.A.G. Deposit date: 2023-02-16 Release date: 2023-04-26 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3.14 Å) Cite: Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CKZ	HIV-1 mature capsid pentamer from CA-IP6 CLPs bound to Nup153 peptide Descriptor: Gag polyprotein Authors: Stacey, J.C.V, Briggs, J.A.G. Deposit date: 2023-02-16 Release date: 2023-04-26 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3.07 Å) Cite: Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CKX	HIV-1 mature capsid hexamer next to pentamer (type I) from CA-IP6 CLPs Descriptor: Gag polyprotein Authors: Stacey, J.C.V, Briggs, J.A.G. Deposit date: 2023-02-16 Release date: 2023-04-26 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (2.97 Å) Cite: Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CL1	HIV-1 mature capsid hexamer from CA-IP6 CLPs, bound to CPSF6 peptide. Descriptor: Cleavage and polyadenylation specificity factor subunit 6, Gag polyprotein Authors: Stacey, J.C.V, Briggs, J.A.G. Deposit date: 2023-02-16 Release date: 2023-04-26 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3.35 Å) Cite: Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CKY	HIV-1 mature capsid hexamer from CA-IP6 CLPs, bound to Nup153 peptide Descriptor: Gag polyprotein, Nuclear pore complex protein Nup153 Authors: Stacey, J.C.V, Briggs, J.A.G. Deposit date: 2023-02-16 Release date: 2023-04-26 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CKV	HIV-1 mature capsid hexamer from CA-IP6 CLPs Descriptor: Gag polyprotein Authors: Stacey, J.C.V, Briggs, J.A.G. Deposit date: 2023-02-16 Release date: 2023-04-26 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (2.89 Å) Cite: Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CL3	HIV-1 mature capsid hexamer from CA-IP6 CLPs, bound to Sec24C peptide. Descriptor: Gag polyprotein, Protein transport protein Sec24C Authors: Stacey, J.C.V, Briggs, J.A.G. Deposit date: 2023-02-16 Release date: 2023-04-26 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3.14 Å) Cite: Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8D3B	Hexameric HIV-1 (M-group) Q50Y/R120 mutant Descriptor: Capsid protein p24 Authors: Jacques, D.A, Govasli, M.L, Pinotsis, N, James, L.C. Deposit date: 2022-06-01 Release date: 2022-10-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Evasion of cGAS and TRIM5 defines pandemic HIV. Nat Microbiol, 7, 2022
5VVT	Structural Investigations of the Substrate Specificity of Human O-GlcNAcase Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ELK1 peptide, Protein O-GlcNAcase Authors: Li, B, Jiang, J, Li, H, Hu, C.-W. Deposit date: 2017-05-20 Release date: 2017-09-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase. Nat Commun, 8, 2017
5V60	Phospho-ERK2 bound to AMP-PCP Descriptor: GLYCEROL, MAGNESIUM ION, Mitogen-activated protein kinase 1, ... Authors: Lechtenberg, B.C, Riedl, S.J. Deposit date: 2017-03-15 Release date: 2017-07-26 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors. ACS Med Chem Lett, 8, 2017
2P55	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP Descriptor: 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE, ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, ... Authors: Ohren, J.F, Pavlovsky, A.G. Deposit date: 2007-03-14 Release date: 2007-10-02 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.8 Å) Cite: 4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase. J.Med.Chem., 50, 2007
5W4Q	Structure of the R18A/E28A mutant of the HIV-1 capsid protein Descriptor: CHLORIDE ION, Capsid protein p24, IODIDE ION Authors: Gres, A.T, Kirby, K.A, Sarafianos, S.G. Deposit date: 2017-06-12 Release date: 2018-06-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.285 Å) Cite: Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket. MBio, 10, 2019
5W4P	Structure of the E28A mutant of the HIV-1 capsid protein Descriptor: CHLORIDE ION, Capsid protein p24, IODIDE ION Authors: Gres, A.T, Kirby, K.A, Sarafianos, S.G. Deposit date: 2017-06-12 Release date: 2018-06-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.19 Å) Cite: Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket. MBio, 10, 2019
5W4O	Structure of the R18A mutant of the HIV-1 capsid protein Descriptor: CHLORIDE ION, Capsid protein p24, IODIDE ION Authors: Gres, A.T, Kirby, K.A, Sarafianos, S.G. Deposit date: 2017-06-12 Release date: 2018-06-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.093 Å) Cite: Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket. MBio, 10, 2019
2PWO	Crystal Structure of HIV-1 CA146 A92E Psuedo Cell Descriptor: CHLORIDE ION, Gag-Pol polyprotein (Pr160Gag-Pol) Authors: Kelly, B.N. Deposit date: 2007-05-11 Release date: 2007-09-25 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein. J.Mol.Biol., 373, 2007
2PWM	Crystal Structure of HIV-1 CA146 A92E real cell Descriptor: CHLORIDE ION, Gag-Pol polyprotein Authors: Kelly, B.N. Deposit date: 2007-05-11 Release date: 2007-09-25 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein. J.Mol.Biol., 373, 2007
2PXR	Crystal Structure of HIV-1 CA146 in the Presence of CAP-1 Descriptor: CHLORIDE ION, Gag-Pol polyprotein (Pr160Gag-Pol), ZINC ION Authors: Kelly, B.N. Deposit date: 2007-05-14 Release date: 2007-09-25 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein. J.Mol.Biol., 373, 2007

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