1DGL
 
 | | LECTIN FROM DIOCLEA GRANDIFLORA COMPLEXED TO TRIMANNOSIDE | | Descriptor: | CALCIUM ION, LECTIN, MANGANESE (II) ION, ... | | Authors: | Rozwarski, D.A, Swami, B.M, Brewer, C.F, Sacchettini, J.C. | | Deposit date: | 1998-02-10 | | Release date: | 1999-06-01 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of the lectin from Dioclea grandiflora complexed with core trimannoside of asparagine-linked carbohydrates.
J.Biol.Chem., 273, 1998
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1GWM
 | | Carbohydrate binding module family29 complexed with glucohexaose | | Descriptor: | 1,2-ETHANEDIOL, COBALT (II) ION, NON-CATALYTIC PROTEIN 1, ... | | Authors: | Charnock, S.J, Nurizzo, D, Davies, G.J. | | Deposit date: | 2002-03-19 | | Release date: | 2003-03-20 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.15 Å) | | Cite: | Promiscuity in Ligand-Binding: The Three-Dimensional Structure of a Piromyces Carbohydrate-Binding Module,Cbm29-2,in Complex with Cello- and Mannohexaose
Proc.Natl.Acad.Sci.USA, 99, 2002
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1GZW
 | | X-RAY CRYSTAL STRUCTURE OF HUMAN GALECTIN-1 | | Descriptor: | BETA-MERCAPTOETHANOL, GALECTIN-1, SULFATE ION, ... | | Authors: | Lopez-Lucendo, M.I.F, Gabius, H.J, Romero, A. | | Deposit date: | 2002-06-07 | | Release date: | 2004-01-08 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Growth-Regulatory Human Galectin-1: Crystallographic Characterisation of the Structural Changes Induced by Single-Site Mutations and Their Impact on the Thermodynamics of Ligand Binding
J.Mol.Biol., 343, 2004
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1HBJ
 | | X-ray Crystal structure of complex between Torpedo californica AChE and a reversible inhibitor, 4-Amino-5-fluoro-2-methyl-3-(3-trifluoroacetylbenzylthiomethyl)quinoline | | Descriptor: | 1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Greenblatt, H.M, Kryger, G, Lewis, T.L, Doucet, C, Viner, R, Silman, I, Sussman, J.L. | | Deposit date: | 2001-04-16 | | Release date: | 2001-09-25 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A Structure-Based Design Approach to the Development of Novel, Reversible Ache Inhibitors
J.Med.Chem., 44, 2001
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1H6M
 | | Covalent glycosyl-enzyme intermediate of hen egg white lysozyme | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-deoxy-2-fluoro-alpha-D-glucopyranose, LYSOZYME C, SODIUM ION | | Authors: | Vocadlo, D.J, Davies, G.J, Laine, R, Withers, S.G. | | Deposit date: | 2001-06-19 | | Release date: | 2001-08-30 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Catalysis by Hen Egg-White Lysozyme Proceeds Via a Covalent Intermediate
Nature, 412, 2001
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1HFU
 | | TYPE-2 CU-DEPLETED LACCASE FROM COPRINUS CINEREUS at 1.68 A resolution | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COPPER (II) ION, LACCASE 1, ... | | Authors: | Ducros, V, Brzozowski, A.M. | | Deposit date: | 2000-12-08 | | Release date: | 2001-12-06 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Structure of the Laccase from Coprinus Cinereus at 1.68A Resolution: Evidence for Different Type 2 Cu-Depleted Isoforms
Acta Crystallogr.,Sect.D, 57, 2001
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1HGH
 | | BINDING OF INFLUENZA VIRUS HEMAGGLUTININ TO ANALOGS OF ITS CELL-SURFACE RECEPTOR, SIALIC ACID: ANALYSIS BY PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY | | Descriptor: | 2-O-methyl-5-N-acetyl-alpha-D-neuraminic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, HEMAGGLUTININ, ... | | Authors: | Sauter, N.K, Hanson, J.E, Glick, G.D, Brown, J.H, Crowther, R.L, Park, S.-J, Skehel, J.J, Wiley, D.C. | | Deposit date: | 1991-11-01 | | Release date: | 1994-01-31 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography.
Biochemistry, 31, 1992
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1GU3
 | | CBM4 structure and function | | Descriptor: | ENDOGLUCANASE C, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose | | Authors: | Nurizzo, D, Notenboom, V, Davies, G.J. | | Deposit date: | 2002-01-22 | | Release date: | 2002-09-26 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Differential Oligosaccharide Recognition by Evolutionarily-Related Beta-1,4 and Beta-1,3 Glucan-Binding Modules
J.Mol.Biol., 319, 2002
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1GVI
 | | Thermus maltogenic amylase in complex with beta-CD | | Descriptor: | Cycloheptakis-(1-4)-(alpha-D-glucopyranose), MALTOGENIC AMYLASE | | Authors: | Kim, M.-S, Kim, J.-I, Oh, B.-H. | | Deposit date: | 2002-02-14 | | Release date: | 2002-06-06 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Cyclomaltodextrinase, Neopullulanase, and Maltogenic Amylase are Nearly Indistinguishable from Each Other
J.Biol.Chem., 277, 2002
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1GXO
 | | Mutant D189A of Family 10 polysaccharide lyase from Cellvibrio cellulosa in complex with trigalaturonic acid | | Descriptor: | CALCIUM ION, PECTATE LYASE, alpha-D-galactopyranuronic acid-(1-4)-alpha-D-galactopyranuronic acid-(1-4)-alpha-D-galactopyranuronic acid | | Authors: | Charnock, S.J, Brown, I.E, Turkenburg, J.P, Black, G.W, Davies, G.J. | | Deposit date: | 2002-04-08 | | Release date: | 2002-10-04 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Convergent Evolution Sheds Light on the Anti-Beta-Elimination Mechanism Common to Family 1 and 10 Polysaccharide Lyases
Proc.Natl.Acad.Sci.USA, 99, 2002
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1GW1
 | | Substrate distortion by beta-mannanase from Pseudomonas cellulosa | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DINITROPHENYLENE, MANNAN ENDO-1,4-BETA-MANNOSIDASE, ... | | Authors: | Ducros, V, Zechel, D.L, Gilbert, H.J, Szabo, L, Withers, S.G, Davies, G.J. | | Deposit date: | 2002-03-01 | | Release date: | 2002-09-05 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Substrate Distortion by a Beta-Mannanase: Snapshots of the Michaelis and Covalent-Intermediate Complexes Suggest a B2,5 Conformation for the Transition State
Angew.Chem.Int.Ed.Engl., 41, 2002
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1H3V
 | | CRYSTAL STRUCTURE OF THE HUMAN IGG1 FC-FRAGMENT,GLYCOFORM (G2F)2,SG P212121 | | Descriptor: | IG GAMMA-1 CHAIN C REGION, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Krapp, S, Mimura, Y, Jefferis, R, Huber, R, Sondermann, P. | | Deposit date: | 2002-09-19 | | Release date: | 2003-01-23 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural Analysis of Human Igg-Fc Glycoforms Reveals a Correlation between Glycosylation and Structural Integrity
J.Mol.Biol., 325, 2003
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1H8L
 | | Duck Carboxypeptidase D Domain II in complex with GEMSA | | Descriptor: | (2-GUANIDINOETHYLMERCAPTO)SUCCINIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Gomis-Rueth, F.X, Coll, M, Aviles, F.X, Vendrell, J, Fricker, L.D. | | Deposit date: | 2001-02-09 | | Release date: | 2002-02-08 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The crystal structure of the inhibitor-complexed carboxypeptidase D domain II and the modeling of regulatory carboxypeptidases.
J. Biol. Chem., 276, 2001
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1H4H
 | | Oligosaccharide-binding to family 11 xylanases: both covalent intermediate and mutant-product complexes display 2,5B conformations at the active-centre | | Descriptor: | XYLANASE, beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-alpha-D-xylopyranose | | Authors: | Sabini, E, Wilson, K.S, Danielsen, S, Schulein, M, Davies, G.J. | | Deposit date: | 2001-05-11 | | Release date: | 2002-05-09 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Catalysis and Specificity in Enzymatic Glycoside Hydrolysis: A 2,5B Conformation for the Glycosyl-Enzyme Intermediate Revealed by the Structure of the Bacillus Agaradhaerens Family 11 Xylanase.
Chem.Biol., 6, 1999
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9CPC
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9AXS
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9BEZ
 | | MID domain of human Argo2 bound to RNA | | Descriptor: | Protein argonaute-2, [(3~{S},4~{R},5~{R})-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-4-oxidanyl-oxolan-3-yl] [oxidanyl(phosphonooxy)phosphoryl] hydrogen phosphate | | Authors: | Harp, J.M, Egli, M. | | Deposit date: | 2024-04-16 | | Release date: | 2024-07-10 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth.
Curr Protoc, 4, 2024
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9CC3
 | | Human Mitochondrial LONP1 Stall State + casein | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Endogenous Co-purified substrate modeled as unknown residues, Lon protease homolog, ... | | Authors: | Mindrebo, J.T, Lander, G.C. | | Deposit date: | 2024-06-20 | | Release date: | 2024-08-07 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Structural and mechanistic studies on human LONP1 redefine the hand-over-hand translocation mechanism.
Biorxiv, 2024
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9B2X
 | | Cryo-EM structure of Prefusion RSV F (RSV220975) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0 | | Authors: | Yu, X, Langedijk, J.P.M. | | Deposit date: | 2024-03-17 | | Release date: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.28 Å) | | Cite: | An efficacious foldon-free prefusion F trimer vaccine for Respiratory Syncytial Virus by stabilizing trimerization-induced regions of instability
To Be Published
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7Y4M
 | | Crystal structure of Ricin A chain bound with N2-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)glycyl-L-phenylalanyl-N6-((benzyloxy)carbonyl)-L-lysine | | Descriptor: | (2S)-2-[[(2S)-2-[2-[(2-azanyl-4-oxidanylidene-3H-pteridin-7-yl)carbonylamino]ethanoylamino]-3-phenyl-propanoyl]amino]-6-(phenylmethoxycarbonylamino)hexanoic acid, Ricin A chain, SULFATE ION | | Authors: | Katakura, S, Goto, M, Ohba, T, Kawata, R, Nagatsu, K, Higashi, S, Matsumoto, K, Kurisu, K, Ohtsuka, K, Saito, R. | | Deposit date: | 2022-06-15 | | Release date: | 2022-11-16 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Pterin-based small molecule inhibitor capable of binding to the secondary pocket in the active site of ricin-toxin A chain.
Plos One, 17, 2022
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9BA5
 | | Cross-linked Contactin 2 Ig1-Ig6 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Contactin-2 | | Authors: | Liu, J.L, Fan, S.F, Ren, G.R, Rudenko, G.R. | | Deposit date: | 2024-04-03 | | Release date: | 2024-07-17 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.51 Å) | | Cite: | Molecular mechanism of contactin 2 homophilic interaction.
Structure, 32, 2024
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9B8S
 | | Human polymerase epsilon bound to PCNA and DNA in the nucleotide exchange state | | Descriptor: | DNA (5'-D(P*AP*AP*AP*GP*TP*GP*AP*AP*AP*AP*AP*TP*CP*TP*AP*AP*AP*GP*CP*AP*TP*CP*AP*C)-3'), DNA (5'-D(P*GP*TP*GP*AP*TP*GP*CP*TP*TP*TP*AP*GP*AP*TP*TP*TP*TP*TP*C)-3'), DNA polymerase epsilon catalytic subunit A, ... | | Authors: | Wang, F, He, Q, Li, H. | | Deposit date: | 2024-03-31 | | Release date: | 2024-09-11 | | Last modified: | 2024-10-02 | | Method: | ELECTRON MICROSCOPY (5.01 Å) | | Cite: | Structures of the human leading strand Pol epsilon-PCNA holoenzyme.
Nat Commun, 15, 2024
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9CK0
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9BHK
 | | MerTK in complex with small molecule inhibitor 6-{1-[6-(3-hydroxy-3-methylbutoxy)-1,3-benzoxazol-2-yl]azetidin-3-yl}-3-[(1-methyl-1H-pyrazol-4-yl)amino]pyrazine-2-carboxamide | | Descriptor: | 6-{1-[6-(3-hydroxy-3-methylbutoxy)-1,3-benzoxazol-2-yl]azetidin-3-yl}-3-[(1-methyl-1H-pyrazol-4-yl)amino]pyrazine-2-carboxamide, CHLORIDE ION, Tyrosine-protein kinase Mer | | Authors: | Jakob, C.G, Gurbani, D, Qiu, W. | | Deposit date: | 2024-04-20 | | Release date: | 2024-10-09 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.106 Å) | | Cite: | Discovery of Potent Azetidine-Benzoxazole MerTK Inhibitors with In Vivo Target Engagement.
J.Med.Chem., 67, 2024
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9AXV
 | | Translating S. pombe ribosome | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... | | Authors: | Gluc, M, Gemin, O, Purdy, M, Mattei, S, Jomaa, A. | | Deposit date: | 2024-03-06 | | Release date: | 2024-10-16 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Ribosomes hibernate on mitochondria during cellular stress.
Nat Commun, 15, 2024
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