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1C70	ALTERNATE BINDING SITE FOR THE P1-P3 GROUP OF A CLASS OF POTENT HIV-1 PROTEASE INHIBITORS AS A RESULT OF CONCERTED STRUCTURAL CHANGE IN 80'S LOOP. Descriptor: N-[2(R)-HYDROXY-1(S)-INDANYL]-2(R)-PHENYLMETHYL-4(S)-HYDROXY-5-[4-[2-BENZOFURANYLMETHYL]-2(S)-[TERT-BUTYLAMINOCARBONYL]-PIPERAZINYL]-PENTANEAMIDE, PROTEIN (PROTEASE) Authors: Munshi, S. Deposit date: 1999-12-29 Release date: 2000-12-28 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.5 Å) Cite: An alternate binding site for the P1-P3 group of a class of potent HIV-1 protease inhibitors as a result of concerted structural change in the 80s loop of the protease. Acta Crystallogr.,Sect.D, 56, 2000
1CB8	CHONDROITINASE AC LYASE FROM FLAVOBACTERIUM HEPARINUM Descriptor: CALCIUM ION, GLYCEROL, PROTEIN (CHONDROITINASE AC), ... Authors: Fethiere, J, Eggimann, B, Cygler, M. Deposit date: 1999-03-02 Release date: 1999-05-14 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of chondroitin AC lyase, a representative of a family of glycosaminoglycan degrading enzymes. J.Mol.Biol., 288, 1999
1C8U	CRYSTAL STRUCTURE OF THE E.COLI THIOESTERASE II, A HOMOLOGUE OF THE HUMAN NEF-BINDING ENZYME Descriptor: ACYL-COA THIOESTERASE II, LAURYL DIMETHYLAMINE-N-OXIDE Authors: Li, J, Derewenda, Z.S. Deposit date: 1999-07-29 Release date: 2000-07-14 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of the Escherichia coli thioesterase II, a homolog of the human Nef binding enzyme. Nat.Struct.Biol., 7, 2000
1CA6	INTERCALATION SITE OF HYPERTHERMOPHILE CHROMOSOMAL PROTEIN SSO7D/SAC7D BOUND TO DNA Descriptor: 5'-D(*GP*TP*GP*AP*TP*CP*GP*C)-3', CHROMOSOMAL PROTEIN SAC7D Authors: Su, S, Gao, Y.-G, Robinson, H, Shriver, J.W, Wang, A.H.-J. Deposit date: 1999-02-23 Release date: 2000-02-23 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structures of the chromosomal proteins Sso7d/Sac7d bound to DNA containing T-G mismatched base-pairs J.Mol.Biol., 303, 2000
1CA9	STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A PEPTIDE FROM TNF-R2 Descriptor: PROTEIN (TNF RECEPTOR ASSOCIATED FACTOR 2), PROTEIN (TNF-R2) Authors: Park, Y.C, Burkitt, V, Villa, A.R, Tong, L, Wu, H. Deposit date: 1999-02-25 Release date: 1999-04-12 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for self-association and receptor recognition of human TRAF2. Nature, 398, 1999
1CBS	CRYSTAL STRUCTURE OF CELLULAR RETINOIC-ACID-BINDING PROTEINS I AND II IN COMPLEX WITH ALL-TRANS-RETINOIC ACID AND A SYNTHETIC RETINOID Descriptor: CELLULAR RETINOIC ACID BINDING PROTEIN TYPE II, RETINOIC ACID Authors: Kleywegt, G.J, Bergfors, T, Jones, T.A. Deposit date: 1994-09-28 Release date: 1995-01-26 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid. Structure, 2, 1994
1CBI	APO-CELLULAR RETINOIC ACID BINDING PROTEIN I Descriptor: CELLULAR RETINOIC ACID BINDING PROTEIN I Authors: Thompson, J.R, Bratt, J.M, Banaszak, L.J. Deposit date: 1995-07-12 Release date: 1995-11-14 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structure of cellular retinoic acid binding protein I shows increased access to the binding cavity due to formation of an intermolecular beta-sheet. J.Mol.Biol., 252, 1995
1C8L	SYNERGISTIC INHIBITION OF GLYCOGEN PHOSPHORYLASE A BY A POTENTIAL ANTIDIABETIC DRUG AND CAFFEINE Descriptor: 2,3-DICARBOXY-4-(2-CHLORO-PHENYL)-1-ETHYL-5-ISOPROPOXYCARBONYL-6-METHYL-PYRIDINIUM, CAFFEINE, GLYCEROL, ... Authors: Tsitsanou, K.E, Skamnaki, V.T, Oikonomakos, N.G. Deposit date: 2000-05-16 Release date: 2000-05-31 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis of the synergistic inhibition of glycogen phosphorylase a by caffeine and a potential antidiabetic drug. Arch.Biochem.Biophys., 384, 2000
1C93	Endo-Beta-N-Acetylglucosaminidase H, D130N/E132Q Double Mutant Descriptor: ENDO-BETA-N-ACETYLGLUCOSAMINIDASE H Authors: Rao, V, Cui, T, Guan, C, Van Roey, P. Deposit date: 1999-07-30 Release date: 1999-11-26 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Mutations of endo-beta-N-acetylglucosaminidase H active site residues Asp130 and Glu132: activities and conformations. Protein Sci., 8, 1999
1CBO	CHOLESTEROL OXIDASE FROM STREPTOMYCES HIS447ASN MUTANT Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, PROTEIN (CHOLESTEROL OXIDASE) Authors: Vrielink, A, Yue, Q.K. Deposit date: 1999-02-26 Release date: 1999-03-10 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure determination of cholesterol oxidase from Streptomyces and structural characterization of key active site mutants. Biochemistry, 38, 1999
1BS3	P.SHERMANII SOD(FE+3) FLUORIDE Descriptor: FE (III) ION, FLUORIDE ION, SUPEROXIDE DISMUTASE Authors: Schmidt, M. Deposit date: 1998-08-31 Release date: 1999-06-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Manipulating the coordination mumber of the ferric iron within the cambialistic superoxide dismutase of Propionibacterium shermanii by changing the pH-value A crystallographic analysis Eur.J.Biochem., 262, 1999
1CBQ	CRYSTAL STRUCTURE OF CELLULAR RETINOIC-ACID-BINDING PROTEINS I AND II IN COMPLEX WITH ALL-TRANS-RETINOIC ACID AND A SYNTHETIC RETINOID Descriptor: 6-(2,3,4,5,6,7-HEXAHYDRO-2,4,4-TRIMETHYL-1-METYLENEINDEN-2-YL)-3-METHYLHEXA-2,4-DIENOIC ACID, CELLULAR RETINOIC ACID BINDING PROTEIN TYPE II, PHOSPHATE ION Authors: Kleywegt, G.J, Bergfors, T, Jones, T.A. Deposit date: 1994-09-28 Release date: 1995-01-26 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid. Structure, 2, 1994
1C86	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (R47V,D48N) COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID Descriptor: 2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) Authors: Iversen, L.F, Andersen, H.S, Mortensen, S.B, Moller, N.P. Deposit date: 2000-04-16 Release date: 2000-05-03 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J.Biol.Chem., 275, 2000
1CBK	7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE FROM HAEMOPHILUS INFLUENZAE Descriptor: 7,8-DIHYDRO-7,7-DIMETHYL-6-HYDROXYPTERIN, PROTEIN (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE), SULFATE ION Authors: Hennig, M, D'Arcy, A, Dale, G, Oefner, C. Deposit date: 1999-02-26 Release date: 2000-03-01 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.02 Å) Cite: The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae. J.Mol.Biol., 287, 1999
1CBW	BOVINE CHYMOTRYPSIN COMPLEXED TO BPTI Descriptor: BOVINE CHYMOTRYPSIN, BPTI, SULFATE ION Authors: Hynes, T.R, Scheidig, A.J, Kossiakoff, A.A. Deposit date: 1996-12-22 Release date: 1997-07-23 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities. Protein Sci., 6, 1997
1BN4	CARBONIC ANHYDRASE II INHIBITOR Descriptor: CARBONIC ANHYDRASE, MERCURY (II) ION, N-[(4-METHOXYPHENYL)METHYL]2,5-THIOPHENEDESULFONAMIDE, ... Authors: Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. Deposit date: 1998-07-31 Release date: 1999-05-18 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BQN	TYR 188 LEU HIV-1 RT/HBY 097 Descriptor: (S)-4-ISOPROPOXYCARBONYL-6-METHOXY-3-METHYLTHIOMETHYL-3,4-DIHYDROQUINOXALIN-2(1H)-THIONE, REVERSE TRANSCRIPTASE Authors: Hsiou, Y, Das, K, Ding, J, Arnold, E. Deposit date: 1998-08-17 Release date: 1999-01-06 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance. J.Mol.Biol., 284, 1998
1CCJ	CONFORMER SELECTION BY LIGAND BINDING OBSERVED WITH PROTEIN CRYSTALLOGRAPHY Descriptor: CYTOCHROME C PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE Authors: Cao, Y, Musah, R.A, Wilcox, S.K, Goodin, D.B, Mcree, D.E. Deposit date: 1997-01-22 Release date: 1997-07-23 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Protein conformer selection by ligand binding observed with crystallography. Protein Sci., 7, 1998
1CDI	STRUCTURES OF AN HIV AND MHC BINDING FRAGMENT FROM HUMAN CD4 AS REFINED IN TWO CRYSTAL LATTICES Descriptor: T CELL SURFACE GLYCOPROTEIN CD4 Authors: Ryu, S.E, Truneh, A, Sweet, R.W, Hendrickson, W.A. Deposit date: 1994-01-26 Release date: 1994-04-30 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structures of an HIV and MHC binding fragment from human CD4 as refined in two crystal lattices. Structure, 2, 1994
1BQM	HIV-1 RT/HBY 097 Descriptor: (S)-4-ISOPROPOXYCARBONYL-6-METHOXY-3-METHYLTHIOMETHYL-3,4-DIHYDROQUINOXALIN-2(1H)-THIONE, REVERSE TRANSCRIPTASE Authors: Hsiou, Y, Das, K, Ding, J, Arnold, E. Deposit date: 1998-08-17 Release date: 1999-01-06 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance. J.Mol.Biol., 284, 1998
1BQ2	E. COLI THYMIDYLATE SYNTHASE MUTANT N177A Descriptor: PHOSPHATE ION, THYMIDYLATE SYNTHASE Authors: Reyes, C.L, Sage, C.R, Rutenber, E.E, Finer-Moore, J.S, Stroud, R.M. Deposit date: 1998-08-20 Release date: 1999-04-27 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Inactivity of N229A thymidylate synthase due to water-mediated effects: isolating a late stage in methyl transfer. J.Mol.Biol., 284, 1998
1BSM	P.SHERMANII SOD(FE+3) 140K PH8 Descriptor: FE (III) ION, SUPEROXIDE DISMUTASE Authors: Schmidt, M. Deposit date: 1998-08-28 Release date: 1999-06-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Manipulating the coordination mumber of the ferric iron within the cambialistic superoxide dismutase of Propionibacterium shermanii by changing the pH-value A crystallographic analysis Eur.J.Biochem., 262, 1999
1BRY	BRYODIN TYPE I RIP Descriptor: BRYODIN I Authors: Klei, H.E, Chang, C.Y. Deposit date: 1997-02-14 Release date: 1998-03-04 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Molecular, biological, and preliminary structural analysis of recombinant bryodin 1, a ribosome-inactivating protein from the plant Bryonia dioica. Biochemistry, 36, 1997
1BMS	CRYSTAL STRUCTURE OF MS2 CAPSIDS WITH MUTATIONS IN THE SUBUNIT FG LOOP Descriptor: BACTERIOPHAGE MS2 CAPSID Authors: Liljas, L, Stonehouse, N.J. Deposit date: 1995-08-29 Release date: 1996-03-08 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structures of MS2 capsids with mutations in the subunit FG loop. J.Mol.Biol., 256, 1996
1CDY	STRUCTURE OF T-CELL SURFACE GLYCOPROTEIN CD4 MUTANT WITH GLY 47 REPLACED BY SER Descriptor: T-CELL SURFACE GLYCOPROTEIN CD4 Authors: Wu, H, Myszka, D, Tendian, S.W, Brouillette, C.G, Sweet, R.W, Chaiken, I.M, Hendrickson, W.A. Deposit date: 1996-11-11 Release date: 1997-04-01 Last modified: 2021-11-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding. Proc.Natl.Acad.Sci.USA, 93, 1996

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