1C8L

SYNERGISTIC INHIBITION OF GLYCOGEN PHOSPHORYLASE A BY A POTENTIAL ANTIDIABETIC DRUG AND CAFFEINE

Summary for 1C8L

Entry DOI	10.2210/pdb1c8l/pdb
Descriptor	PROTEIN (GLYCOGEN PHOSPHORYLASE), PYRIDOXAL-5'-PHOSPHATE, 2,3-DICARBOXY-4-(2-CHLORO-PHENYL)-1-ETHYL-5-ISOPROPOXYCARBONYL-6-METHYL-PYRIDINIUM, ... (6 entities in total)
Functional Keywords	glycogen metabolism, diabetes, phosphorylase a, synergistic inhibition, allosteric site, inhibitor site, transferase
Biological source	Oryctolagus cuniculus (rabbit)
Total number of polymer chains	1
Total formula weight	98311.44
Authors	Tsitsanou, K.E.,Skamnaki, V.T.,Oikonomakos, N.G. (deposition date: 2000-05-16, release date: 2000-05-31, Last modification date: 2023-08-09)
Primary citation	Tsitsanou, K.E.,Skamnaki, V.T.,Oikonomakos, N.G. Structural basis of the synergistic inhibition of glycogen phosphorylase a by caffeine and a potential antidiabetic drug. Arch.Biochem.Biophys., 384:245-254, 2000 Cited by PubMed: 11368311 DOI: 10.1006/abbi.2000.2121 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation