8JBL
 
 | | Crystal structure of Na+,K+-ATPase in the E1.Mg2+ state | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Kanai, R, Vilsen, B, Cornelius, F, Toyoshima, C. | | Deposit date: | 2023-05-09 | | Release date: | 2023-08-09 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structures of Na + ,K + -ATPase reveal the mechanism that converts the K + -bound form to Na + -bound form and opens and closes the cytoplasmic gate.
Febs Lett., 597, 2023
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8JBK
 | | Crystal structure of Na+,K+-ATPase in the E1.3Na+ state | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Kanai, R, Vilsen, B, Cornelius, F, Toyoshima, C. | | Deposit date: | 2023-05-09 | | Release date: | 2023-08-09 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structures of Na + ,K + -ATPase reveal the mechanism that converts the K + -bound form to Na + -bound form and opens and closes the cytoplasmic gate.
Febs Lett., 597, 2023
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8JMN
 | | Cryo-EM structure of the gastric proton pump with bound DQ-21 | | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[4-[[2-[(4-chlorophenyl)methoxy]phenyl]methoxy]phenyl]-N-methyl-methanamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Abe, K, Yokoshima, S, Yoshimori, A. | | Deposit date: | 2023-06-05 | | Release date: | 2023-08-30 | | Last modified: | 2023-10-04 | | Method: | ELECTRON MICROSCOPY (2.26 Å) | | Cite: | Deep learning driven de novo drug design based on gastric proton pump structures.
Commun Biol, 6, 2023
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8IWW
 | | hSPCA1 in the CaE1P-ADP state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Calcium-transporting ATPase type 2C member 1, ... | | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | | Deposit date: | 2023-03-31 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.71 Å) | | Cite: | Structure and transport mechanism of the human calcium pump SPCA1.
Cell Res., 33, 2023
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8IWS
 | | hSPCA1 in the CaE2P state | | Descriptor: | BERYLLIUM TRIFLUORIDE ION, CALCIUM ION, Calcium-transporting ATPase type 2C member 1, ... | | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | | Deposit date: | 2023-03-31 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.42 Å) | | Cite: | Structure and transport mechanism of the human calcium pump SPCA1.
Cell Res., 33, 2023
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8IWT
 | | hSPCA1 in the early E2P state | | Descriptor: | BERYLLIUM TRIFLUORIDE ION, Calcium-transporting ATPase type 2C member 1, MAGNESIUM ION | | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | | Deposit date: | 2023-03-31 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Structure and transport mechanism of the human calcium pump SPCA1.
Cell Res., 33, 2023
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8IWU
 | | hSPCA1 in the E2~P state | | Descriptor: | Calcium-transporting ATPase type 2C member 1, MAGNESIUM ION, TETRAFLUOROALUMINATE ION | | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | | Deposit date: | 2023-03-31 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.31 Å) | | Cite: | Structure and transport mechanism of the human calcium pump SPCA1.
Cell Res., 33, 2023
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8IWR
 | | hSPCA1 in the CaE1-ATP state | | Descriptor: | CALCIUM ION, Calcium-transporting ATPase type 2C member 1, MAGNESIUM ION, ... | | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | | Deposit date: | 2023-03-31 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.52 Å) | | Cite: | Structure and transport mechanism of the human calcium pump SPCA1.
Cell Res., 33, 2023
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8IWP
 | | hSPCA1 in the CaE1 state | | Descriptor: | CALCIUM ION, Calcium-transporting ATPase type 2C member 1 | | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | | Deposit date: | 2023-03-30 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.59 Å) | | Cite: | Structure and transport mechanism of the human calcium pump SPCA1.
Cell Res., 33, 2023
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2YFY
 | | SERCA in the HnE2 State Complexed With Debutanoyl Thapsigargin | | Descriptor: | DEBUTANOYL THAPSIGARGIN, MAGNESIUM ION, POTASSIUM ION, ... | | Authors: | Sonntag, Y, Musgaard, M, Olesen, C, Schiott, B, Moller, J.V, Nissen, P, Thogersen, L. | | Deposit date: | 2011-04-11 | | Release date: | 2011-06-29 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Mutual Adaptation of a Membrane Protein and its Lipid Bilayer During Conformational Changes.
Nat.Commun., 2, 2011
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2ZBG
 | | Calcium pump crystal structure with bound AlF4 and TG in the absence of calcium | | Descriptor: | MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, 3ABETA, ... | | Authors: | Toyoshima, C, Ogawa, H, Norimatsu, Y. | | Deposit date: | 2007-10-20 | | Release date: | 2007-12-11 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | How processing of aspartylphosphate is coupled to lumenal gating of the ion pathway in the calcium pump
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2ZBD
 | | Crystal Structure of the SR Calcium Pump with Bound Aluminium Fluoride, ADP and Calcium | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... | | Authors: | Toyoshima, C, Nomura, H, Tsuda, T, Ogawa, H, Norimatsu, Y. | | Deposit date: | 2007-10-20 | | Release date: | 2007-11-20 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Lumenal gating mechanism revealed in calcium pump crystal structures with phosphate analogues
Nature, 432, 2004
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2ZBE
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2ZXE
 | | Crystal structure of the sodium - potassium pump in the E2.2K+.Pi state | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | Authors: | Shinoda, T, Ogawa, H, Cornelius, F, Toyoshima, C. | | Deposit date: | 2008-12-22 | | Release date: | 2009-05-19 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of the sodium - potassium pump at 2.4 A resolution
Nature, 459, 2009
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3A3Y
 | | Crystal structure of the sodium-potassium pump with bound potassium and ouabain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, MAGNESIUM ION, ... | | Authors: | Ogawa, H, Shinoda, T, Cornelius, F, Toyoshima, C. | | Deposit date: | 2009-06-23 | | Release date: | 2009-09-08 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of the sodium-potassium pump (Na+,K+-ATPase) with bound potassium and ouabain.
Proc.Natl.Acad.Sci.USA, 106, 2009
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2ZBF
 | | Calcium pump crystal structure with bound BeF3 and TG in the absence of calcium | | Descriptor: | BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, ... | | Authors: | Toyoshima, C, Ogawa, H, Norimatsu, Y. | | Deposit date: | 2007-10-20 | | Release date: | 2007-12-11 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | How processing of aspartylphosphate is coupled to lumenal gating of the ion pathway in the calcium pump
Proc.Natl.Acad.Sci.Usa, 104, 2007
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3BA6
 | | Structure of the Ca2E1P phosphoenzyme intermediate of the SERCA Ca2+-ATPase | | Descriptor: | AMP PHOSPHORAMIDATE, CALCIUM ION, POTASSIUM ION, ... | | Authors: | Picard, M, Winther, A.M.L, Olesen, C, Gyrup, C, Morth, J.P, Oxvig, C, Moller, J.V, Nissen, P. | | Deposit date: | 2007-11-07 | | Release date: | 2007-12-18 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The structural basis of calcium transport by the calcium pump.
Nature, 450, 2007
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3AR4
 | | Calcium pump crystal structure with bound ATP and TG in the absence of Ca2+ | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, ... | | Authors: | Toyoshima, C, Yonekura, S, Tsueda, J, Iwasawa, S. | | Deposit date: | 2010-11-24 | | Release date: | 2011-02-02 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Trinitrophenyl derivatives bind differently from parent adenine nucleotides to Ca2+-ATPase in the absence of Ca2+
Proc.Natl.Acad.Sci.USA, 108, 2011
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3AR3
 | | Calcium pump crystal structure with bound ADP and TG | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, ... | | Authors: | Toyoshima, C, Yonekura, S, Tsueda, J, Iwasawa, S. | | Deposit date: | 2010-11-24 | | Release date: | 2011-02-02 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Trinitrophenyl derivatives bind differently from parent adenine nucleotides to Ca2+-ATPase in the absence of Ca2+
Proc.Natl.Acad.Sci.USA, 108, 2011
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3AR9
 | | Calcium pump crystal structure with bound BeF3, TNP-AMP and TG in the absence of calcium | | Descriptor: | 2',3'-O-[(1r)-2,4,6-trinitrocyclohexa-2,5-diene-1,1-diyl]adenosine 5'-(dihydrogen phosphate), BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | | Authors: | Toyoshima, C, Yonekura, S, Tsueda, J, Iwasawa, S. | | Deposit date: | 2010-11-24 | | Release date: | 2011-02-02 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Trinitrophenyl derivatives bind differently from parent adenine nucleotides to Ca2+-ATPase in the absence of Ca2+
Proc.Natl.Acad.Sci.USA, 108, 2011
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3AR5
 | | Calcium pump crystal structure with bound TNP-AMP and TG | | Descriptor: | 2',3'-O-[(1r)-2,4,6-trinitrocyclohexa-2,5-diene-1,1-diyl]adenosine 5'-(dihydrogen phosphate), OCTANOIC ACID [3S-[3ALPHA, 3ABETA, ... | | Authors: | Toyoshima, C, Yonekura, S, Tsueda, J, Iwasawa, S. | | Deposit date: | 2010-11-24 | | Release date: | 2011-02-02 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Trinitrophenyl derivatives bind differently from parent adenine nucleotides to Ca2+-ATPase in the absence of Ca2+
Proc.Natl.Acad.Sci.USA, 108, 2011
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3AR7
 | | Calcium pump crystal structure with bound TNP-ATP and TG in the absence of Ca2+ | | Descriptor: | OCTANOIC ACID [3S-[3ALPHA, 3ABETA, 4ALPHA, ... | | Authors: | Toyoshima, C, Yonekura, S, Tsueda, J, Iwasawa, S. | | Deposit date: | 2010-11-24 | | Release date: | 2011-02-02 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Trinitrophenyl derivatives bind differently from parent adenine nucleotides to Ca2+-ATPase in the absence of Ca2+
Proc.Natl.Acad.Sci.USA, 108, 2011
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3B8E
 | | Crystal structure of the sodium-potassium pump | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, MAGNESIUM ION, Na+/K+ ATPase gamma subunit transcript variant a, ... | | Authors: | Morth, J.P, Pedersen, P.B, Toustrup-Jensen, M.S, Soerensen, T.L.M, Petersen, J, Andersen, J.P, Vilsen, B, Nissen, P. | | Deposit date: | 2007-11-01 | | Release date: | 2007-12-18 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Crystal structure of the sodium-potassium pump.
Nature, 450, 2007
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2YN9
 | | Cryo-EM structure of gastric H+,K+-ATPase with bound rubidium | | Descriptor: | POTASSIUM-TRANSPORTING ATPASE ALPHA CHAIN 1, POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA | | Authors: | Abe, K, Tani, K, Friedrich, T, Fujiyoshi, Y. | | Deposit date: | 2012-10-13 | | Release date: | 2012-11-07 | | Last modified: | 2014-07-16 | | Method: | ELECTRON CRYSTALLOGRAPHY (8 Å) | | Cite: | Cryo-Em Structure of Gastric H+,K+-ATPase with a Single Occupied Cation-Binding Site.
Proc.Natl.Acad.Sci.USA, 109, 2012
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3B9B
 | | Structure of the E2 beryllium fluoride complex of the SERCA Ca2+-ATPase | | Descriptor: | BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, SODIUM ION, ... | | Authors: | Olesen, C, Picard, M, Winther, A.M.L, Morth, J.P, Moller, J.V, Nissen, P. | | Deposit date: | 2007-11-04 | | Release date: | 2007-12-18 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | The structural basis of calcium transport by the calcium pump.
Nature, 450, 2007
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