3MRC
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![BU of 3mrc by Molmil](/molmil-images/mine/3mrc) | Crystal Structure of MHC class I HLA-A2 molecule complexed with HCMV pp65-495-503 nonapeptide V6C variant | Descriptor: | 9-meric peptide from Tegument protein pp65, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | Authors: | Gras, S, Reiser, J.-B, Chouquet, A, Debeaupuis, E, Echasserieau, K, Saulquin, X, Bonneville, M, Housset, D. | Deposit date: | 2010-04-29 | Release date: | 2011-05-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Analysis of Relationships between Peptide/MHC Structural Features and Naive T Cell Frequency in Humans. J.Immunol., 193, 2014
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3B6S
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![BU of 3b6s by Molmil](/molmil-images/mine/3b6s) | Crystal Structure of hla-b*2705 Complexed with the Citrullinated Vasoactive Intestinal Peptide Type 1 Receptor (vipr) Peptide (residues 400-408) | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B-27 alpha chain, ... | Authors: | Beltrami, A, Rossmann, M, Fiorillo, M.T, Sorrentino, R, Saenger, W, Ziegler, A, Uchanska-Ziegler, A. | Deposit date: | 2007-10-29 | Release date: | 2008-07-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Citrullination-dependent Differential Presentation of a Self-peptide by HLA-B27 Subtypes. J.Biol.Chem., 283, 2008
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6PUG
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![BU of 6pug by Molmil](/molmil-images/mine/6pug) | Structure of human MAIT A-F7 TCR in complex with human MR1-2`OH-Ethyl-5-OP-U | Descriptor: | 6-[(2-hydroxyethyl)amino]-5-[(E)-(2-oxopropylidene)amino]pyrimidine-2,4(1H,3H)-dione, Beta-2-microglobulin, CHLORIDE ION, ... | Authors: | Awad, W, Rossjohn, J. | Deposit date: | 2019-07-18 | Release date: | 2020-02-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The molecular basis underpinning the potency and specificity of MAIT cell antigens. Nat.Immunol., 21, 2020
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2Z9T
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![BU of 2z9t by Molmil](/molmil-images/mine/2z9t) | Crystal structure of the human beta-2 microglobulin mutant W60G | Descriptor: | Beta-2-microglobulin | Authors: | Ricagno, S, Bolognesi, M, Bellotti, V, Corazza, A, Rennella, E, Gural, D, Mimmi, M.C, Betto, E, Pucillo, C, Fogolari, F, Viglino, P, Raimondi, S, Giorgetti, S, Bolognesi, B, Merlini, G, Stoppini, M. | Deposit date: | 2007-09-26 | Release date: | 2008-04-22 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties J.Mol.Biol., 378, 2008
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3BP7
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![BU of 3bp7 by Molmil](/molmil-images/mine/3bp7) | The high resolution crystal structure of HLA-B*2709 in complex with a Cathepsin A signal sequence peptide, pCatA | Descriptor: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | Authors: | Kumar, P, Vahedi-Faridi, A, Saenger, W, Uchanska-Ziegler, B, Ziegler, A. | Deposit date: | 2007-12-18 | Release date: | 2008-12-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for T cell alloreactivity among three HLA-B14 and HLA-B27 antigens J.Biol.Chem., 284, 2009
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3SKM
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![BU of 3skm by Molmil](/molmil-images/mine/3skm) | Crystal structure of the HLA-B8FLRGRAYVL, mutant G8V of the FLR peptide | Descriptor: | Beta-2-microglobulin, Epstein-Barr nuclear antigen 3, HLA class I histocompatibility antigen, ... | Authors: | Gras, S, Wilmann, P.G, Zhenjun, C, Hanim, H, Yu Chih, L, Kjer-Nielsen, L, Purcell, A.W, Burrows, S.R, Mccluskey, J, Rossjohn, J. | Deposit date: | 2011-06-22 | Release date: | 2012-02-29 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A structural basis for varied alpha-beta TCR usage against an immunodominant EBV antigen restricted to a HLA-B8 molecule. J.Immunol., 188, 2012
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3VXS
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![BU of 3vxs by Molmil](/molmil-images/mine/3vxs) | The complex between H27-14 TCR and HLA-A24 bound to HIV-1 Nef134-10(6L) peptide | Descriptor: | 10-mer peptide from Protein Nef, Beta-2-microglobulin, H27-14 TCR alpha chain, ... | Authors: | Shimizu, A, Fukai, S, Yamagata, A, Iwamoto, A. | Deposit date: | 2012-09-20 | Release date: | 2013-10-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection SCI REP, 3, 2013
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3VH8
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![BU of 3vh8 by Molmil](/molmil-images/mine/3vh8) | KIR3DL1 in complex with HLA-B*5701 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | Authors: | Vivian, J.P, Rossjohn, J. | Deposit date: | 2011-08-24 | Release date: | 2011-10-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B Nature, 479, 2011
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8RBV
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![BU of 8rbv by Molmil](/molmil-images/mine/8rbv) | SARS-CoV-2 Spike-derived peptide S976-984 S982A mutant (VLNDILARL) presented by HLA-A*02:01 | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Beta-2-microglobulin, ... | Authors: | Ahn, Y.M, Maddumage, J.C, Szeto, C, Gras, S. | Deposit date: | 2023-12-05 | Release date: | 2024-05-15 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The impact of SARS-CoV-2 spike mutation on peptide presentation is HLA allomorph-specific. Curr Res Struct Biol, 7, 2024
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7RZJ
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![BU of 7rzj by Molmil](/molmil-images/mine/7rzj) | CRYSTAL STRUCTURE OF HLA-B*07:02 IN COMPLEX WITH MLL(747-755) PHOSPHOPEPTIDE | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B-7 alpha chain, ... | Authors: | Patskovsky, Y, Patskovska, L, Nyovanie, S, Natarajan, A, Joshi, B, Morin, B, Brittsan, C, Huber, O, Gordon, S, Michelet, X, Schmitzberger, F, Stein, R, Findeis, M, Hurwitz, A, Van Dijk, M, Buell, J, Underwood, D, Krogsgaard, M. | Deposit date: | 2021-08-27 | Release date: | 2022-11-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular mechanism of phosphopeptide neoantigen immunogenicity. Nat Commun, 14, 2023
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7S8F
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![BU of 7s8f by Molmil](/molmil-images/mine/7s8f) | STRUCTURE OF HLA-B*07:02 IN COMPLEX WITH MLL(747-755) PEPTIDE AND BOUND GLYCEROL | Descriptor: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | Authors: | Patskovsky, Y, Nyovanie, S, Patskovska, L, Natarajan, A, Joshi, B, Morin, B, Brittsan, C, Huber, O, Gordon, S, Michelet, X, Schmitzberger, F, Stein, R, Findeis, M, Hurwitz, A, Van Dijk, M, Buell, J, Underwood, D, Krogsgaard, M. | Deposit date: | 2021-09-17 | Release date: | 2022-11-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular mechanism of phosphopeptide neoantigen immunogenicity. Nat Commun, 14, 2023
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5VWD
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![BU of 5vwd by Molmil](/molmil-images/mine/5vwd) | HLA-B*57:03 presenting LTVQVARVW | Descriptor: | Beta-2-microglobulin, MHC class I antigen, Noamer peptide: LEU-THR-VAL-GLN-VAL-ALA-ARG-VAL-TRP | Authors: | Pymm, P, Rossjohn, J, Vivian, J.P. | Deposit date: | 2017-05-21 | Release date: | 2018-10-03 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome. Nat Commun, 9, 2018
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3DHM
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![BU of 3dhm by Molmil](/molmil-images/mine/3dhm) | Beta 2 microglobulin mutant D59P | Descriptor: | Beta-2-microglobulin | Authors: | Ricagno, S, Colombo, M, de Rosa, M, Bolognesi, M, Giorgetti, S, Bellotti, V. | Deposit date: | 2008-06-18 | Release date: | 2008-11-18 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | DE loop mutations affect beta2-microglobulin stability and amyloid aggregation Biochem.Biophys.Res.Commun., 377, 2008
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1TVB
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![BU of 1tvb by Molmil](/molmil-images/mine/1tvb) | |
4PR5
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![BU of 4pr5 by Molmil](/molmil-images/mine/4pr5) | Crystal structure of a HLA-B*35:01-HPVG-D5 | Descriptor: | Beta-2-microglobulin, Epstein-Barr nuclear antigen 1, HLA class I histocompatibility antigen, ... | Authors: | Yu Chih, L, Rossjohn, J, Gras, S. | Deposit date: | 2014-03-05 | Release date: | 2014-04-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen Micropolymorphism. J.Biol.Chem., 289, 2014
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2H26
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![BU of 2h26 by Molmil](/molmil-images/mine/2h26) | human CD1b in complex with endogenous phosphatidylcholine and spacer | Descriptor: | (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, Beta-2-microglobulin, GLYCEROL, ... | Authors: | Garcia-Alles, L.F, Maveyraud, L, Vallina, A.T, Guillet, V, Mourey, L. | Deposit date: | 2006-05-18 | Release date: | 2006-07-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b. Embo J., 25, 2006
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5VWF
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![BU of 5vwf by Molmil](/molmil-images/mine/5vwf) | HLA-B*58:03 presenting LTVQVARVY | Descriptor: | Beta-2-microglobulin, MHC class I antigen, Nonamer peptide: LEU-THR-VAL-GLN-VAL-ALA-ARG-VAL-TYR | Authors: | Pymm, P, Rossjohn, J, Vivian, J.P. | Deposit date: | 2017-05-21 | Release date: | 2018-10-03 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome. Nat Commun, 9, 2018
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2AXF
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![BU of 2axf by Molmil](/molmil-images/mine/2axf) | The Immunogenicity of a Viral Cytotoxic T Cell Epitope is controlled by its MHC-bound Conformation | Descriptor: | 10-mer peptide from BZLF1 trans-activator protein, ACETIC ACID, Beta-2-microglobulin, ... | Authors: | Tynan, F.E, Elhassen, D, Purcell, A.W, Burrows, J.M, Borg, N.A, Miles, J.J, Williamson, N.A, Green, K.J, Tellam, J, Kjer-Nielsen, L, McCluskey, J, Rossjohn, J, Burrows, S.R. | Deposit date: | 2005-09-05 | Release date: | 2005-11-29 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation J.Exp.Med., 202, 2005
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5GSB
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![BU of 5gsb by Molmil](/molmil-images/mine/5gsb) | Mouse MHC class I H-2Kd with a MERS-CoV-derived peptide 37-3 | Descriptor: | Beta-2-microglobulin, H-2 class I histocompatibility antigen, K-D alpha chain, ... | Authors: | Liu, K, Chai, Y, Qi, J, Tan, W, Liu, W.J, Gao, G.F. | Deposit date: | 2016-08-15 | Release date: | 2017-07-12 | Last modified: | 2017-10-04 | Method: | X-RAY DIFFRACTION (1.801 Å) | Cite: | Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8+ T Cell Epitopes and Host MHC. J. Immunol., 198, 2017
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4HX1
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![BU of 4hx1 by Molmil](/molmil-images/mine/4hx1) | Structure of HLA-A68 complexed with a tumor antigen derived peptide | Descriptor: | 9-mer peptide from Tyrosinase-related protein-2, Beta-2-microglobulin, GLYCEROL, ... | Authors: | Niu, L, Cheng, H, Zhang, S, Tan, S, Zhang, Y, Qi, J, Liu, J, Gao, G.F. | Deposit date: | 2012-11-09 | Release date: | 2013-10-02 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | Structural basis for the differential classification of HLA-A*6802 and HLA-A*6801 into the A2 and A3 supertypes Mol.Immunol., 55, 2013
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4O2C
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![BU of 4o2c by Molmil](/molmil-images/mine/4o2c) | An Nt-acetylated peptide complexed with HLA-B*3901 | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B-39 alpha chain, ... | Authors: | Sun, M, Liu, J, Qi, J, Tefsen, B, Shi, Y, Yan, J, Gao, G.F. | Deposit date: | 2013-12-17 | Release date: | 2014-07-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | N alpha-terminal acetylation for T cell recognition: molecular basis of MHC class I-restricted n alpha-acetylpeptide presentation J.Immunol., 192, 2014
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1TVH
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![BU of 1tvh by Molmil](/molmil-images/mine/1tvh) | |
8EMF
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![BU of 8emf by Molmil](/molmil-images/mine/8emf) | |
7OW4
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![BU of 7ow4 by Molmil](/molmil-images/mine/7ow4) | Crystal structure of HLA-A*11:01 in complex with KRAS G12D peptide (VVVGADGVGK) | Descriptor: | Beta-2-microglobulin, KRAS G12D peptide (VVVGADGVGK), MHC class I antigen, ... | Authors: | Coles, C.H, Karuppiah, V, Robinson, R.A. | Deposit date: | 2021-06-16 | Release date: | 2022-07-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen Nat Commun, 13, 2022
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7CIR
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![BU of 7cir by Molmil](/molmil-images/mine/7cir) | Peptide phosphorylation modification of MHC class I molecules | Descriptor: | ARG-ARG-PHE-SEP-ARG-SER-PRO-ILE-ARG-ARG, Beta-2-microglobulin, MHC class I antigen | Authors: | Sun, M.W, Feng, L, Qi, J.X, Liu, W.J, Gao, G.F. | Deposit date: | 2020-07-08 | Release date: | 2022-03-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Phosphosite-dependent presentation of dual phosphorylated peptides by MHC class I molecules. Iscience, 25, 2022
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