4PJK
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![BU of 4pjk by Molmil](/molmil-images/mine/4pjk) | Dicty myosin II R238E.E459R mutant (with ADP.Pi) in the Pi release state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | Authors: | Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A. | Deposit date: | 2014-05-12 | Release date: | 2015-04-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | How actin initiates the motor activity of Myosin. Dev.Cell, 33, 2015
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3MNQ
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![BU of 3mnq by Molmil](/molmil-images/mine/3mnq) | Crystal structure of myosin-2 motor domain in complex with ADP-metavanadate and resveratrol | Descriptor: | 1,2-ETHANEDIOL, ADP METAVANADATE, MAGNESIUM ION, ... | Authors: | Schneider, J, Taft, M, Backhaus, A, Baruch, P, Fedorov, R, Manstein, D.J. | Deposit date: | 2010-04-22 | Release date: | 2011-04-27 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis of resveratrol regulation of myosin activity. To be Published
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3MJX
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![BU of 3mjx by Molmil](/molmil-images/mine/3mjx) | Crystal structure of myosin-2 motor domain in complex with ADP-Metavanadate and blebbistatin | Descriptor: | (-)-1-PHENYL-1,2,3,4-TETRAHYDRO-4-HYDROXYPYRROLO[2,3-B]-7-METHYLQUINOLIN-4-ONE, ADP METAVANADATE, MAGNESIUM ION, ... | Authors: | Fedorov, R, Baruch, P, Bauer, S, Manstein, D.J. | Deposit date: | 2010-04-13 | Release date: | 2011-04-27 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The mechanism of pentabromopseudilin inhibition of myosin motor activity. Nat.Struct.Mol.Biol., 16, 2009
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3BZ8
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![BU of 3bz8 by Molmil](/molmil-images/mine/3bz8) | Crystal Structures of (S)-(-)-Blebbistatin Analogs bound to Dictyostelium discoideum myosin II | Descriptor: | (3aS)-3a-hydroxy-7-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one, 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Allingham, J.S, Rayment, I. | Deposit date: | 2008-01-17 | Release date: | 2008-02-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The small molecule tool (S)-(-)-blebbistatin: novel insights of relevance to myosin inhibitor design. Org.Biomol.Chem., 6, 2008
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2JJ9
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![BU of 2jj9 by Molmil](/molmil-images/mine/2jj9) | Crystal structure of myosin-2 in complex with ADP-metavanadate | Descriptor: | ADP METAVANADATE, MAGNESIUM ION, MYOSIN-2 HEAVY CHAIN | Authors: | Fedorov, R, Boehl, M, Tsiavaliaris, G, Hartmann, F.K, Baruch, P, Brenner, B, Martin, R, Knoelker, H.J, Gutzeit, H.O, Manstein, D.J. | Deposit date: | 2008-03-25 | Release date: | 2009-01-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Mechanism of Pentabromopseudilin Inhibition of Myosin Motor Activity. Nat.Struct.Mol.Biol., 16, 2009
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1JX2
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![BU of 1jx2 by Molmil](/molmil-images/mine/1jx2) | CRYSTAL STRUCTURE OF THE NUCLEOTIDE-FREE DYNAMIN A GTPASE DOMAIN, DETERMINED AS MYOSIN FUSION | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin-2 heavy chain,Dynamin-A, ... | Authors: | Niemann, H.H, Knetsch, M.L.W, Scherer, A, Manstein, D.J, Kull, F.J. | Deposit date: | 2001-09-05 | Release date: | 2001-11-07 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of a dynamin GTPase domain in both nucleotide-free and GDP-bound forms. EMBO J., 20, 2001
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1D1C
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![BU of 1d1c by Molmil](/molmil-images/mine/1d1c) | DICTYOSTELIUM MYOSIN S1DC (MOTOR DOMAIN FRAGMENT) COMPLEXED WITH N-METHYL-O-NITROPHENYL AMINOETHYLDIPHOSPHATE BERYLLIUM TRIFLUORIDE. | Descriptor: | MAGNESIUM ION, MYOSIN, N-METHYL O-NITROPHENYL AMINOETHYLDIPHOSPHATE BERYLLIUM TRIFLUORIDE | Authors: | Gulick, A.M, Bauer, C.B, Thoden, J.B, Pate, E, Yount, R.G, Rayment, I. | Deposit date: | 1999-09-15 | Release date: | 2000-01-12 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | X-ray structures of the Dictyostelium discoideum myosin motor domain with six non-nucleotide analogs. J.Biol.Chem., 275, 2000
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1JWY
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![BU of 1jwy by Molmil](/molmil-images/mine/1jwy) | CRYSTAL STRUCTURE OF THE DYNAMIN A GTPASE DOMAIN COMPLEXED WITH GDP, DETERMINED AS MYOSIN FUSION | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Niemann, H.H, Knetsch, M.L.W, Scherer, A, Manstein, D.J, Kull, F.J. | Deposit date: | 2001-09-05 | Release date: | 2001-11-07 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of a dynamin GTPase domain in both nucleotide-free and GDP-bound forms. EMBO J., 20, 2001
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3MKD
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![BU of 3mkd by Molmil](/molmil-images/mine/3mkd) | Crystal structure of myosin-2 dictyostelium discoideum motor domain S456Y mutant in complex with adp-orthovanadate | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin-2 heavy chain, ... | Authors: | Kathmann, D, Diensthuber, R.P, Fedorov, R, Manstein, D.J, Tsiavaliaris, G. | Deposit date: | 2010-04-14 | Release date: | 2011-04-06 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Switch-2 dependent modulation of the myosin power stroke To be Published
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2XO8
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![BU of 2xo8 by Molmil](/molmil-images/mine/2xo8) | Crystal Structure of Myosin-2 in Complex with Tribromodichloropseudilin | Descriptor: | 2,4-DICHLORO-6-(3,4,5-TRIBROMO-1H-PYRROL-2-YL)PHENOL, ADP METAVANADATE, MAGNESIUM ION, ... | Authors: | Preller, M, Chinthalapudi, K, Martin, R, Knoelker, H.J, Manstein, D.J. | Deposit date: | 2010-08-10 | Release date: | 2011-05-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Inhibition of Myosin ATPase Activity by Halogenated Pseudilins: A Structure-Activity Study. J.Med.Chem., 54, 2011
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4AE3
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![BU of 4ae3 by Molmil](/molmil-images/mine/4ae3) | Crystal structure of ammosamide 272:myosin-2 motor domain complex | Descriptor: | 1,2-ETHANEDIOL, ADP ORTHOVANADATE, AMMOSAMIDE 272, ... | Authors: | Chinthalapudi, K, Heissler, S.M, Fenical, W, Manstein, D.J. | Deposit date: | 2012-01-05 | Release date: | 2013-01-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Basis for Ammosamide Mediated Myosin Motor Activity Inhibition To be Published
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2XEL
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![BU of 2xel by Molmil](/molmil-images/mine/2xel) | Molecular Mechanism of Pentachloropseudilin Mediated Inhibition of Myosin Motor Activity | Descriptor: | 2,4-DICHLORO-6-(3,4,5-TRICHLORO-1H-PYRROL-2YL)PHENOL, ADP METAVANADATE, MAGNESIUM ION, ... | Authors: | Chinthalapudi, K, Taft, M.H, Martin, R, Hartmann, F.K, Heissler, S.M, Tsiavaliaris, G, Gutzeit, H.O, Knoelker, H.J, Coluccio, L.M, Fedorov, R, Manstein, D.J. | Deposit date: | 2010-05-16 | Release date: | 2011-06-15 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mechanism and Specificity of Pentachloropseudilin-Mediated Inhibition of Myosin Motor Activity. J.Biol.Chem., 286, 2011
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7B19
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![BU of 7b19 by Molmil](/molmil-images/mine/7b19) | Mutant Myosin-II-GGG motor domain | Descriptor: | ADP METAVANADATE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Ewert, W, Preller, M. | Deposit date: | 2020-11-24 | Release date: | 2021-01-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Unraveling a Force-Generating Allosteric Pathway of Actomyosin Communication Associated with ADP and P i Release. Int J Mol Sci, 22, 2020
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6Z7U
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![BU of 6z7u by Molmil](/molmil-images/mine/6z7u) | Myosin-II motor domain complexed with blebbistatin in a new ADP-release conformation | Descriptor: | (-)-1-PHENYL-1,2,3,4-TETRAHYDRO-4-HYDROXYPYRROLO[2,3-B]-7-METHYLQUINOLIN-4-ONE, 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Ewert, W, Preller, M. | Deposit date: | 2020-06-01 | Release date: | 2020-10-21 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Structural and Computational Insights into a Blebbistatin-Bound Myosin•ADP Complex with Characteristics of an ADP-Release Conformation along the Two-Step Myosin Power Stoke. Int J Mol Sci, 21, 2020
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1MND
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![BU of 1mnd by Molmil](/molmil-images/mine/1mnd) | |
7B1A
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![BU of 7b1a by Molmil](/molmil-images/mine/7b1a) | Myosin-II-AA mutant motor domain | Descriptor: | 1,2-ETHANEDIOL, ADP METAVANADATE, MAGNESIUM ION, ... | Authors: | Ewert, W, Preller, M. | Deposit date: | 2020-11-24 | Release date: | 2021-01-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Unraveling a Force-Generating Allosteric Pathway of Actomyosin Communication Associated with ADP and P i Release. Int J Mol Sci, 22, 2020
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1MNE
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![BU of 1mne by Molmil](/molmil-images/mine/1mne) | |
2X9H
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![BU of 2x9h by Molmil](/molmil-images/mine/2x9h) | CRYSTAL STRUCTURE OF MYOSIN-2 MOTOR DOMAIN IN COMPLEX WITH ADP- METAVANADATE AND PENTACHLOROCARBAZOLE | Descriptor: | 2,3,4,6,8-PENTACHLORO-9H-CARBAZOL-1-OL, ADP METAVANADATE, MAGNESIUM ION, ... | Authors: | Selvadurai, J, Kirst, J, Knoelker, H.J, Manstein, D.J. | Deposit date: | 2010-03-19 | Release date: | 2011-05-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal Structure of Myosin-2 Motor Domain in Complex with Adp-Metavanadate and Pentachlorocarbazole To be Published
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2JHR
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![BU of 2jhr by Molmil](/molmil-images/mine/2jhr) | Crystal structure of myosin-2 motor domain in complex with ADP- metavanadate and pentabromopseudilin | Descriptor: | ADP METAVANADATE, MAGNESIUM ION, MYOSIN-2 HEAVY CHAIN, ... | Authors: | Fedorov, R, Boehl, M, Tsiavaliaris, G, Hartmann, F.K, Baruch, P, Brenner, B, Martin, R, Knoelker, H.J, Gutzeit, H.O, Manstein, D.J. | Deposit date: | 2008-03-25 | Release date: | 2009-01-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The Mechanism of Pentabromopseudilin Inhibition of Myosin Motor Activity. Nat.Struct.Mol.Biol., 16, 2009
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1G8X
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![BU of 1g8x by Molmil](/molmil-images/mine/1g8x) | STRUCTURE OF A GENETICALLY ENGINEERED MOLECULAR MOTOR | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MYOSIN II HEAVY CHAIN FUSED TO ALPHA-ACTININ 3 | Authors: | Kliche, W, Fujita-Becker, S, Kollmar, M, Manstein, D.J, Kull, F.J. | Deposit date: | 2000-11-21 | Release date: | 2001-01-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of a genetically engineered molecular motor. EMBO J., 20, 2001
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2Y0R
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![BU of 2y0r by Molmil](/molmil-images/mine/2y0r) | Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of Dictyostelium myosin-2 | Descriptor: | MYOSIN-2 HEAVY CHAIN | Authors: | Preller, M, Bauer, S, Adamek, N, Fujita-Becker, S, Fedorov, R, Geeves, M.A, Manstein, D.J. | Deposit date: | 2010-12-07 | Release date: | 2011-07-20 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V. J.Biol.Chem., 286, 2011
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2Y8I
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![BU of 2y8i by Molmil](/molmil-images/mine/2y8i) | Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of Dictyostelium myosin-2 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MYOSIN-2 HEAVY CHAIN | Authors: | Preller, M, Bauer, S, Adamek, N, Fujita-Becker, S, Fedorov, R, Geeves, M.A, Manstein, D.J. | Deposit date: | 2011-02-07 | Release date: | 2011-07-20 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.132 Å) | Cite: | Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V. J.Biol.Chem., 286, 2011
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6Z2S
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![BU of 6z2s by Molmil](/molmil-images/mine/6z2s) | Crystal structure of adhibin analogue-bound myosin-2 | Descriptor: | 3,6-dibromo-1-(hydroxymethyl)carbazole, ACETATE ION, ADP METAVANADATE, ... | Authors: | Ewert, W, Knoelker, H.-J, Tsiavaliaris, G, Preller, M. | Deposit date: | 2020-05-18 | Release date: | 2021-06-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The synthetic carbazole adhibin acts as selective myosin class-IX inhibitor in lung cancer cells To Be Published
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2Y9E
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![BU of 2y9e by Molmil](/molmil-images/mine/2y9e) | Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of Dictyostelium myosin-2 | Descriptor: | MYOSIN-2 | Authors: | Preller, M, Bauer, S, Adamek, N, Fujita-Becker, S, Fedorov, R, Geeves, M.A, Manstein, D.J. | Deposit date: | 2011-02-14 | Release date: | 2011-07-20 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.397 Å) | Cite: | Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V. J.Biol.Chem., 286, 2011
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