5GZC
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![BU of 5gzc by Molmil](/molmil-images/mine/5gzc) | Crystal structure of Galectin-8 N-CRD with part of linker | Descriptor: | GLYCEROL, Galectin-8, SODIUM ION | Authors: | Su, J.Y, Si, Y.L. | Deposit date: | 2016-09-28 | Release date: | 2016-12-21 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | Crystallization of Galectin-8 Linker Reveals Intricate Relationship between the N-terminal Tail and the Linker. Int J Mol Sci, 17, 2016
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5GZD
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![BU of 5gzd by Molmil](/molmil-images/mine/5gzd) | Galectin-8 N-terminal domain carbohydrate recognition domain | Descriptor: | Galectin-8, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | Authors: | Su, J.Y, Si, Y.L. | Deposit date: | 2016-09-28 | Release date: | 2016-12-21 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.19 Å) | Cite: | Crystallization of Galectin-8 Linker Reveals Intricate Relationship between the N-terminal Tail and the Linker. Int J Mol Sci, 17, 2016
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8CM8
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![BU of 8cm8 by Molmil](/molmil-images/mine/8cm8) | Galectin-8 N-terminal carbohydrate recognition domain in complex with 4-(bromophenyl)phthalazinone D-galactal ligand | Descriptor: | 4-(4-bromophenyl)-2-[[(2~{R},3~{R},4~{R})-2-(hydroxymethyl)-3-oxidanyl-3,4-dihydro-2~{H}-pyran-4-yl]oxymethyl]phthalazin-1-one, CHLORIDE ION, Galectin-8 | Authors: | Van Klaveren, S, Hakansson, M, Diehl, C, Nilsson, N.J. | Deposit date: | 2023-02-17 | Release date: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.22 Å) | Cite: | Halogenated Galactal-Phenylphthalazinone Hybrids as Highly Selective Galectin-8N Ligands To Be Published
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5GZE
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![BU of 5gze by Molmil](/molmil-images/mine/5gze) | Galectin-8 N-terminal domain carbohydrate recognition domain | Descriptor: | Galectin-8, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | Authors: | Su, J.Y, Si, Y.L. | Deposit date: | 2016-09-28 | Release date: | 2016-12-21 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | Crystallization of Galectin-8 Linker Reveals Intricate Relationship between the N-terminal Tail and the Linker. Int J Mol Sci, 17, 2016
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3AP9
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![BU of 3ap9 by Molmil](/molmil-images/mine/3ap9) | Crystal structure of the galectin-8 N-terminal carbohydrate recognition domain in complex with Lacto-N-fucopentaose III | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Galectin-8, ... | Authors: | Matsuzaka, T, Ideo, H, Yamashita, K, Nonaka, T. | Deposit date: | 2010-10-12 | Release date: | 2011-02-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans J.Biol.Chem., 286, 2011
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6Z6Y
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![BU of 6z6y by Molmil](/molmil-images/mine/6z6y) | |
7ALS
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![BU of 7als by Molmil](/molmil-images/mine/7als) | Alpha and beta Lactose isomer structure of Galectin 8, N-terminal domain | Descriptor: | CHLORIDE ION, Galectin-8, beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose, ... | Authors: | Hakansson, M, Walse, B, Diehl, C, Kovacic, R. | Deposit date: | 2020-10-07 | Release date: | 2021-11-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Alpha and beta Lactose isomer structure of Galectin 8, N-terminal domain To Be Published
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4BMB
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![BU of 4bmb by Molmil](/molmil-images/mine/4bmb) | Crystal structure of the N terminal domain of human Galectin 8 | Descriptor: | GALECTIN-8, GLYCEROL, SODIUM ION, ... | Authors: | Buzamet, E, Ruiz, F.M, Menendez, M, Romero, A, Gabius, H.J, Solis, D. | Deposit date: | 2013-05-07 | Release date: | 2014-03-19 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.351 Å) | Cite: | Natural Single Amino Acid Polymorphism (F19Y) in Human Galectin-8: Detection of Structural Alterations and Increased Growth-Regulatory Activity on Tumor Cells. FEBS J., 281, 2014
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7P1M
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![BU of 7p1m by Molmil](/molmil-images/mine/7p1m) | Galectin-8 N-terminal carbohydrate recognition domain in complex with benzimidazole D-galactal ligand | Descriptor: | 2-[[(2R,3R,4R)-2-(hydroxymethyl)-3-oxidanyl-3,4-dihydro-2H-pyran-4-yl]oxymethyl]-3-methyl-benzimidazole-5-carboxylic acid, CHLORIDE ION, Galectin-8 | Authors: | Hassan, M, Hakansson, M, Nilsson, J.U, Kovacic, R. | Deposit date: | 2021-07-02 | Release date: | 2021-12-15 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain. Acs Med.Chem.Lett., 12, 2021
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3AP7
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![BU of 3ap7 by Molmil](/molmil-images/mine/3ap7) | Crystal structure of the galectin-8 N-terminal carbohydrate recognition domain in complex with lactose sialic acid | Descriptor: | CHLORIDE ION, Galectin-8, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | Authors: | Matsuzaka, T, Ideo, H, Yamashita, K, Nonaka, T. | Deposit date: | 2010-10-12 | Release date: | 2011-01-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans J.Biol.Chem., 286, 2011
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3AP6
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![BU of 3ap6 by Molmil](/molmil-images/mine/3ap6) | Crystal structure of the galectin-8 N-terminal carbohydrate recognition domain in complex with lactose 3'-sulfate | Descriptor: | Galectin-8, SULFATE ION, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | Authors: | Matsuzaka, T, Ideo, H, Yamashita, K, Nonaka, T. | Deposit date: | 2010-10-12 | Release date: | 2011-01-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans J.Biol.Chem., 286, 2011
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5T7U
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![BU of 5t7u by Molmil](/molmil-images/mine/5t7u) | Crystal structure of galectin-8N in complex with Glycerol | Descriptor: | CHLORIDE ION, GLYCEROL, Galectin-8, ... | Authors: | Bohari, M.H, Yu, X, Blanchard, H. | Deposit date: | 2016-09-05 | Release date: | 2017-01-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Structure-based rationale for differential recognition of lacto- and neolacto- series glycosphingolipids by the N-terminal domain of human galectin-8. Sci Rep, 6, 2016
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6W4Z
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![BU of 6w4z by Molmil](/molmil-images/mine/6w4z) | Galectin-8N terminal domain in complex with Methyl 3-O-[3-O-benzyloxy]-malonyl-beta-D-galactopyranoside | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Galectin-8, ... | Authors: | Patel, B, Kishor, C, Blanchard, H. | Deposit date: | 2020-03-12 | Release date: | 2020-09-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Rational Design and Synthesis of Methyl-beta-d-galactomalonyl Phenyl Esters as Potent Galectin-8 N Antagonists. J.Med.Chem., 63, 2020
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8HL9
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![BU of 8hl9 by Molmil](/molmil-images/mine/8hl9) | Crystal structure of Galectin-8 C-CRD with part of linker | Descriptor: | Galectin-8 | Authors: | Si, Y.L. | Deposit date: | 2022-11-29 | Release date: | 2023-07-05 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Linker remodels human Galectin-8 structure and regulates its hemagglutination and pro-apoptotic activity. Int.J.Biol.Macromol., 245, 2023
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7AEN
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![BU of 7aen by Molmil](/molmil-images/mine/7aen) | Galectin-8 N-terminal carbohydrate recognition domain in complex with methyl 3-O-((7-carboxy)quinolin-2-yl)-methoxy)-beta-D-galactopyranoside | Descriptor: | CHLORIDE ION, GLYCEROL, Isoform 2 of Galectin-8, ... | Authors: | Hassan, M, Klavern, V.S, Hakansson, M, Anderluh, M, Tomasic, T, Jakopin, Z, Nilsson, J.U, Kovacic, R, Walse, B, Diehl, C. | Deposit date: | 2020-09-17 | Release date: | 2021-07-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain Acs Med.Chem.Lett., 12, 2021
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5T7S
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![BU of 5t7s by Molmil](/molmil-images/mine/5t7s) | Crystal structure of galectin-8N in complex with Lactose | Descriptor: | GLYCEROL, Galectin-8, beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Bohari, M.H, Yu, X, Blanchard, H. | Deposit date: | 2016-09-05 | Release date: | 2017-01-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure-based rationale for differential recognition of lacto- and neolacto- series glycosphingolipids by the N-terminal domain of human galectin-8. Sci Rep, 6, 2016
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3AP5
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![BU of 3ap5 by Molmil](/molmil-images/mine/3ap5) | |
2YV8
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![BU of 2yv8 by Molmil](/molmil-images/mine/2yv8) | Crystal structure of N-terminal domain of human galectin-8 | Descriptor: | Galectin-8 variant | Authors: | Kishishita, S, Nishino, A, Murayama, K, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-04-10 | Release date: | 2008-04-15 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Crystal structure of N-terminal domain of human galectin-8 To be Published
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3APB
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![BU of 3apb by Molmil](/molmil-images/mine/3apb) | |
5T7T
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![BU of 5t7t by Molmil](/molmil-images/mine/5t7t) | Galectin-8 N terminal domain in complex with LNT | Descriptor: | CHLORIDE ION, Galectin-8, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Bohari, M.H, Yu, X, Blanchard, H. | Deposit date: | 2016-09-05 | Release date: | 2017-01-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Structure-based rationale for differential recognition of lacto- and neolacto- series glycosphingolipids by the N-terminal domain of human galectin-8. Sci Rep, 6, 2016
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3VKN
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![BU of 3vkn by Molmil](/molmil-images/mine/3vkn) | Galectin-8 N-terminal domain in free form | Descriptor: | CHLORIDE ION, Galectin-8 | Authors: | Kamitori, S, Yoshida, H. | Deposit date: | 2011-11-18 | Release date: | 2012-09-12 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | X-ray structure of a protease-resistant mutant form of human galectin-8 with two carbohydrate recognition domains Febs J., 279, 2012
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5GZG
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![BU of 5gzg by Molmil](/molmil-images/mine/5gzg) | Galectin-8 N-terminal domain carbohydrate recognition domain | Descriptor: | Galectin-8, NICKEL (II) ION, SODIUM ION, ... | Authors: | Su, J.Y, Si, Y.L. | Deposit date: | 2016-09-28 | Release date: | 2016-12-21 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.997 Å) | Cite: | Crystallization of Galectin-8 Linker Reveals Intricate Relationship between the N-terminal Tail and the Linker. Int J Mol Sci, 17, 2016
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4BME
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![BU of 4bme by Molmil](/molmil-images/mine/4bme) | Crystal structure of the N terminal domain of human Galectin 8, F19Y mutant | Descriptor: | GALECTIN-8, beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Buzamet, E, Ruiz, F.M, Menendez, M, Romero, A, Gabius, H.J, Solis, D. | Deposit date: | 2013-05-07 | Release date: | 2014-03-19 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Natural Single Amino Acid Polymorphism (F19Y) in Human Galectin-8: Detection of Structural Alterations and Increased Growth-Regulatory Activity on Tumor Cells. FEBS J., 281, 2014
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5T7I
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![BU of 5t7i by Molmil](/molmil-images/mine/5t7i) | Crystal structure of galectin-8N in complex with LNnT | Descriptor: | Galectin-8, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | Authors: | Bohari, M.H, Yu, X, Blanchard, H. | Deposit date: | 2016-09-05 | Release date: | 2017-01-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-based rationale for differential recognition of lacto- and neolacto- series glycosphingolipids by the N-terminal domain of human galectin-8. Sci Rep, 6, 2016
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5GZF
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![BU of 5gzf by Molmil](/molmil-images/mine/5gzf) | Galectin-8 N-terminal domain carbohydrate recognition domain | Descriptor: | Galectin-8, NICKEL (II) ION, SODIUM ION, ... | Authors: | Su, J.Y, Si, Y.L. | Deposit date: | 2016-09-28 | Release date: | 2016-12-21 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.002 Å) | Cite: | Crystallization of Galectin-8 Linker Reveals Intricate Relationship between the N-terminal Tail and the Linker. Int J Mol Sci, 17, 2016
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