7AEN

Galectin-8 N-terminal carbohydrate recognition domain in complex with methyl 3-O-((7-carboxy)quinolin-2-yl)-methoxy)-beta-D-galactopyranoside

Summary for 7AEN

• Entry DOI: 10.2210/pdb7aen/pdb
• Descriptor: Isoform 2 of Galectin-8, methyl 3-O-((7-carboxy) quinolin-2-yl)-methyl)-beta-D-galactopyranoside, GLYCEROL, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, sugar binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 34821.20

Authors

Hassan, M.,Klavern, V.S.,Hakansson, M.,Anderluh, M.,Tomasic, T.,Jakopin, Z.,Nilsson, J.U.,Kovacic, R.,Walse, B.,Diehl, C. (deposition date: 2020-09-17, release date: 2021-07-28, Last modification date: 2024-01-31)

• Primary citation: Hassan, M.,Baussiere, F.,Guzelj, S.,Sundin, A.P.,Hakansson, M.,Kovacic, R.,Leffler, H.,Tomasic, T.,Anderluh, M.,Jakopin, Z.,Nilsson, U.J.; Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain; Acs Med.Chem.Lett., 12:1745-1752, 2021; DOI: 10.1021/acsmedchemlett.1c00371

Experimental method

X-RAY DIFFRACTION (1.6 Å)