1FO7
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![BU of 1fo7 by Molmil](/molmil-images/mine/1fo7) | HUMAN PRION PROTEIN MUTANT E200K FRAGMENT 90-231 | Descriptor: | PRION PROTEIN | Authors: | Zhang, Y, Swietnicki, W, Zagorski, M.G, Surewicz, W.K, Soennichsen, F.D. | Deposit date: | 2000-08-25 | Release date: | 2000-09-21 | Last modified: | 2018-03-14 | Method: | SOLUTION NMR | Cite: | Solution structure of the E200K variant of human prion protein. Implications for the mechanism of pathogenesis in familial prion diseases. J.Biol.Chem., 275, 2000
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5GMS
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![BU of 5gms by Molmil](/molmil-images/mine/5gms) | Crystal structure of the mutant S202W/I203F of the esterase E40 | Descriptor: | Esterase | Authors: | Zhang, Y.-Z, Li, P.-Y. | Deposit date: | 2016-07-15 | Release date: | 2017-07-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural and Mechanistic Insights into the Improvement of the Halotolerance of a Marine Microbial Esterase by Increasing Intra- and Interdomain Hydrophobic Interactions. Appl. Environ. Microbiol., 83, 2017
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5GMR
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1MEJ
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![BU of 1mej by Molmil](/molmil-images/mine/1mej) | Human Glycinamide Ribonucleotide Transformylase domain at pH 8.5 | Descriptor: | GLYCEROL, PHOSPHATE ION, Phosphoribosylglycinamide formyltransferase | Authors: | Zhang, Y, Desharnais, J, Greasley, S.E, Beardsley, G.P, Boger, D.L, Wilson, I.A. | Deposit date: | 2002-08-08 | Release date: | 2002-12-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of human GAR Tfase of low and high pH and with substrate beta-GAR Biochemistry, 41, 2002
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1MEO
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![BU of 1meo by Molmil](/molmil-images/mine/1meo) | human glycinamide ribonucleotide Transformylase at pH 4.2 | Descriptor: | PHOSPHATE ION, Phosphoribosylglycinamide formyltransferase, SULFATE ION | Authors: | Zhang, Y, Desharnais, J, Greasley, S.E, Beardsley, G.P, Boger, D.L, Wilson, I.A. | Deposit date: | 2002-08-08 | Release date: | 2002-12-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Crystal structures of human GAR Tfase of low and high pH and with substrate beta-GAR Biochemistry, 41, 2002
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1MEN
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![BU of 1men by Molmil](/molmil-images/mine/1men) | complex structure of human GAR Tfase and substrate beta-GAR | Descriptor: | GLYCINAMIDE RIBONUCLEOTIDE, Phosphoribosylglycinamide formyltransferase | Authors: | Zhang, Y, Desharnais, J, Greasley, S.E, Beardsley, G.P, Boger, D.L, Wilson, I.A. | Deposit date: | 2002-08-08 | Release date: | 2002-12-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Crystal structures of human GAR Tfase of low and high pH and with substrate beta-GAR Biochemistry, 41, 2002
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5HYN
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![BU of 5hyn by Molmil](/molmil-images/mine/5hyn) | Structure of Human Polycomb Repressive Complex 2 (PRC2) with oncogenic histone H3K27M peptide | Descriptor: | H3K27M, Histone-lysine N-methyltransferase EZH2, JARID2 K116me3, ... | Authors: | Zhang, Y, Justin, N, Wilson, J.R, Gamblin, S.J. | Deposit date: | 2016-02-01 | Release date: | 2016-05-11 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2. Nat Commun, 7, 2016
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1YFW
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![BU of 1yfw by Molmil](/molmil-images/mine/1yfw) | Crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase from Ralstonia metallidurans complexed with 4-chloro-3-hydroxyanthranilic acid and O2 | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-hydroxyanthranilate-3,4-dioxygenase, 4-CHLORO-3-HYDROXYANTHRANILIC ACID, ... | Authors: | Zhang, Y, Colabroy, K.L, Begley, T.P, Ealick, S.E. | Deposit date: | 2005-01-04 | Release date: | 2005-05-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Studies on 3-Hydroxyanthranilate-3,4-dioxygenase: The Catalytic Mechanism of a Complex Oxidation Involved in NAD Biosynthesis. Biochemistry, 44, 2005
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1YFX
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![BU of 1yfx by Molmil](/molmil-images/mine/1yfx) | Crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase from Ralstonia metallidurans complexed with 4-chloro-3-hydroxyanthranilic acid and NO | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-hydroxyanthranilate-3,4-dioxygenase, 4-CHLORO-3-HYDROXYANTHRANILIC ACID, ... | Authors: | Zhang, Y, Colabroy, K.L, Begley, T.P, Ealick, S.E. | Deposit date: | 2005-01-04 | Release date: | 2005-05-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Studies on 3-Hydroxyanthranilate-3,4-dioxygenase: The Catalytic Mechanism of a Complex Oxidation Involved in NAD Biosynthesis. Biochemistry, 44, 2005
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1YFU
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![BU of 1yfu by Molmil](/molmil-images/mine/1yfu) | Crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase from Ralstonia metallidurans | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-hydroxyanthranilate-3,4-dioxygenase, CHLORIDE ION, ... | Authors: | Zhang, Y, Colabroy, K.L, Begley, T.P, Ealick, S.E. | Deposit date: | 2005-01-04 | Release date: | 2005-05-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Studies on 3-Hydroxyanthranilate-3,4-dioxygenase: The Catalytic Mechanism of a Complex Oxidation Involved in NAD Biosynthesis. Biochemistry, 44, 2005
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1YFY
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![BU of 1yfy by Molmil](/molmil-images/mine/1yfy) | Crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase from Ralstonia metallidurans complexed with 3-hydroxyanthranilic acid | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-HYDROXYANTHRANILIC ACID, 3-hydroxyanthranilate-3,4-dioxygenase, ... | Authors: | Zhang, Y, Colabroy, K.L, Begley, T.P, Ealick, S.E. | Deposit date: | 2005-01-04 | Release date: | 2005-05-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural Studies on 3-Hydroxyanthranilate-3,4-dioxygenase: The Catalytic Mechanism of a Complex Oxidation Involved in NAD Biosynthesis. Biochemistry, 44, 2005
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2A8Y
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![BU of 2a8y by Molmil](/molmil-images/mine/2a8y) | Crystal structure of 5'-deoxy-5'methylthioadenosine phosphorylase complexed with 5'-deoxy-5'methylthioadenosine and sulfate | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, 5'-methylthioadenosine phosphorylase (mtaP), SULFATE ION | Authors: | Zhang, Y, Porcelli, M, Cacciapuoti, G, Ealick, S.E. | Deposit date: | 2005-07-10 | Release date: | 2006-03-28 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | The crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase II from Sulfolobus solfataricus, a thermophilic enzyme stabilized by intramolecular disulfide bonds. J.Mol.Biol., 357, 2006
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3OGG
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![BU of 3ogg by Molmil](/molmil-images/mine/3ogg) | Crystal structure of the receptor binding domain of botulinum neurotoxin D | Descriptor: | Botulinum neurotoxin type D | Authors: | Zhang, Y, Gao, X, Qin, L, Buchko, G.W, Robinson, H, Varnum, S.M. | Deposit date: | 2010-08-16 | Release date: | 2010-09-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.651 Å) | Cite: | Structural analysis of the receptor binding domain of botulinum neurotoxin serotype D. Biochem.Biophys.Res.Commun., 401, 2010
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2A7Q
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![BU of 2a7q by Molmil](/molmil-images/mine/2a7q) | Crystal structure of human dCK complexed with clofarabine and ADP | Descriptor: | 2-CHLORO-9-(2-DEOXY-2-FLUORO-B -D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE, ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase, ... | Authors: | Zhang, Y, Secrist III, J.A, Ealick, S.E. | Deposit date: | 2005-07-05 | Release date: | 2006-01-24 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation. Acta Crystallogr.,Sect.D, 62, 2006
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8YM1
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![BU of 8ym1 by Molmil](/molmil-images/mine/8ym1) | Structure of SADS-CoV Virus Nucleocapsid Protein | Descriptor: | nucleocapsid phosphoprotein | Authors: | Zhang, Y, Wu, F, Xu, W. | Deposit date: | 2024-03-08 | Release date: | 2024-07-24 | Last modified: | 2024-09-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Unraveling the assembly mechanism of SADS-CoV virus nucleocapsid protein: insights from RNA binding, dimerization, and epitope diversity profiling. J.Virol., 98, 2024
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5LQ6
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![BU of 5lq6 by Molmil](/molmil-images/mine/5lq6) | Salmonella effector SpvD - R161 variant | Descriptor: | SODIUM ION, Virulence protein vsdE | Authors: | Zhang, Y, Grabe, G.J, Rolhion, N, Yang, Y, Holden, D.W, Hare, S.A. | Deposit date: | 2016-08-16 | Release date: | 2016-11-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | The Salmonella Effector SpvD Is a Cysteine Hydrolase with a Serovar-specific Polymorphism Influencing Catalytic Activity, Suppression of Immune Responses, and Bacterial Virulence. J. Biol. Chem., 291, 2016
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5WMD
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![BU of 5wmd by Molmil](/molmil-images/mine/5wmd) | N-terminal bromodomain of BRD4 in complex with OTX-015 | Descriptor: | 2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(4-hydroxyphenyl)acetamide, Bromodomain-containing protein 4 | Authors: | Zhang, Y. | Deposit date: | 2017-07-28 | Release date: | 2018-08-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.27 Å) | Cite: | BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor. Cancer Discov, 8, 2018
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2GHQ
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2GHT
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5WMG
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![BU of 5wmg by Molmil](/molmil-images/mine/5wmg) | N-terminal bromodomain of BRD4 in complex with OTX-015 | Descriptor: | 1,2-ETHANEDIOL, 4-{6-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1S)-1-(pyridin-2-yl)ethyl]-1H-pyrrolo[3,2-b]pyridin-3-yl}benzoic acid, Bromodomain-containing protein 4 | Authors: | Zhang, Y. | Deposit date: | 2017-07-28 | Release date: | 2018-08-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.19 Å) | Cite: | BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor. Cancer Discov, 8, 2018
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5WMA
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![BU of 5wma by Molmil](/molmil-images/mine/5wma) | N-terminal bromodomain of BRD4 in complex with PLX5981 | Descriptor: | 1,2-ETHANEDIOL, 5-(3,5-dimethyl-1,2-oxazol-4-yl)-1H-pyrrolo[2,3-b]pyridine, Bromodomain-containing protein 4 | Authors: | Zhang, Y. | Deposit date: | 2017-07-28 | Release date: | 2018-08-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.401 Å) | Cite: | BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor. Cancer Discov, 8, 2018
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3PDU
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1T8W
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![BU of 1t8w by Molmil](/molmil-images/mine/1t8w) | |
1T8S
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7K65
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![BU of 7k65 by Molmil](/molmil-images/mine/7k65) | Hedgehog receptor Patched (PTCH1) in complex with conformation selective nanobody TI23 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ... | Authors: | Zhang, Y, Bulkley, D.P, Liang, J, Manglik, A, Cheng, Y, Beachy, P.A. | Deposit date: | 2020-09-18 | Release date: | 2021-03-17 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit. Proc.Natl.Acad.Sci.USA, 117, 2020
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