5ZIO
| |
5ZJ2
| Crystal structure of NDM-1 in complex with D-captopril | 分子名称: | 1-(3-MERCAPTO-2-METHYL-PROPIONYL)-PYRROLIDINE-2-CARBOXYLIC ACID, Metallo-beta-lactamase type 2, ZINC ION | 著者 | Zhang, H, Hao, Q. | 登録日 | 2018-03-18 | 公開日 | 2019-03-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors Bioorg.Med.Chem., 29, 2020
|
|
5Z4P
| |
5ZGP
| Crystal structure of NDM-1 at pH6.2 (Bis-Tris) in complex with hydrolyzed ampicillin | 分子名称: | (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Zhang, H, Hao, Q. | 登録日 | 2018-03-10 | 公開日 | 2018-08-22 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Antimicrob. Agents Chemother., 62, 2018
|
|
7W0T
| |
7W0S
| TRIM7 in complex with C-terminal peptide of 2C | 分子名称: | DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase TRIM7, GLYCEROL, ... | 著者 | Zhang, H, Liang, X, Li, X.Z. | 登録日 | 2021-11-18 | 公開日 | 2022-08-10 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures. Nat.Chem.Biol., 18, 2022
|
|
7W72
| Structure of a human glycosylphosphatidylinositol (GPI) transamidase | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GPI transamidase component PIG-S, ... | 著者 | Zhang, H, Su, J, Li, B, Gao, Y, Zhang, X.C, Zhao, Y. | 登録日 | 2021-12-02 | 公開日 | 2022-02-16 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of human glycosylphosphatidylinositol transamidase. Nat.Struct.Mol.Biol., 29, 2022
|
|
7X1N
| Crystal structure of MEF2D-MRE complex | 分子名称: | DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*G)-3'), DNA (5'-D(P*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3'), Myocyte enhancer factor 2D/deleted in azoospermia associated protein 1 fusion protein | 著者 | Zhang, H, Zhang, M, Wang, Q.Q, Chen, Z, Chen, S.J, Meng, G. | 登録日 | 2022-02-24 | 公開日 | 2022-05-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.315 Å) | 主引用文献 | Functional, structural, and molecular characterizations of the leukemogenic driver MEF2D-HNRNPUL1 fusion. Blood, 140, 2022
|
|
5ZGZ
| |
5ZGF
| Crystal structure of NDM-1 Q123G mutant | 分子名称: | HYDROXIDE ION, Metallo-beta-lactamase type 2, ZINC ION | 著者 | Zhang, H, Hao, Q. | 登録日 | 2018-03-08 | 公開日 | 2018-08-22 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Antimicrob. Agents Chemother., 62, 2018
|
|
8GMY
| |
8GMZ
| |
8HS8
| |
7EJ3
| UTP cyclohydrolase | 分子名称: | DIPHOSPHATE, GLYCINE, GTP cyclohydrolase II, ... | 著者 | Zhang, H, Zhang, Y, Yuchi, Z. | 登録日 | 2021-04-01 | 公開日 | 2022-09-21 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural and biochemical investigation of UTP cyclohydrolase Acs Catalysis, 2021
|
|
7X32
| |
6J2L
| Crystal structure of Bi-functional enzyme | 分子名称: | Histidine biosynthesis bifunctional protein HisIE, MAGNESIUM ION, ZINC ION | 著者 | Zhang, H, Shang, G, Wang, Y. | 登録日 | 2019-01-01 | 公開日 | 2020-01-01 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Structural analysis of Shigella flexneri bi-functional enzyme HisIE in histidine biosynthesis. Biochem.Biophys.Res.Commun., 516, 2019
|
|
7DW5
| Crystal structure of DUX4 HD1-HD2 domain complexed with ERG sites | 分子名称: | BROMIDE ION, DNA (5'-D(P*CP*GP*AP*CP*TP*TP*GP*AP*TP*GP*AP*GP*AP*TP*TP*AP*GP*AP*CP*TP*G)-3'), Double homeobox protein 4-like protein 2 | 著者 | Zhang, H, Cheng, N, Li, Z, Zhang, W, Dong, X, Huang, J, Meng, G. | 登録日 | 2021-01-15 | 公開日 | 2021-11-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | DNA crosslinking and recombination-activating genes 1/2 (RAG1/2) are required for oncogenic splicing in acute lymphoblastic leukemia. Cancer Commun (Lond), 41, 2021
|
|
6LJ8
| |
7Y1B
| 3.2 angstrom cryo-EM structure of extracellular region of mouse Basigin-2 in complex with the Fab fragment of antibody 6E7F1 | 分子名称: | Heavy chain of 6E7F1, Isoform 2 of Basigin, Light chain of 6E7F1 | 著者 | Zhang, H, Yang, X, Xue, Y, Huang, Y, Mo, X, Zhang, H, Li, N, Gao, N, Li, X, Wang, S, Gao, Y, Liao, J. | 登録日 | 2022-06-08 | 公開日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Allosteric modulation of monocarboxylate transporters 1 and 4 by targeting their chaperon Basigin To Be Published
|
|
3NSN
| Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with TMG-chitotriomycin | 分子名称: | 2-deoxy-2-(trimethylammonio)-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetylglucosaminidase | 著者 | Zhang, H, Liu, T, Liu, F, Yang, Q, Shen, X. | 登録日 | 2010-07-02 | 公開日 | 2010-11-24 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Determinants of an Insect {beta}-N-Acetyl-D-hexosaminidase Specialized as a Chitinolytic Enzyme J.Biol.Chem., 286, 2011
|
|
3NSM
| Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 from Ostrinia furnacalis | 分子名称: | N-acetylglucosaminidase | 著者 | Zhang, H, Liu, T, Liu, F, Yang, Q, Shen, X. | 登録日 | 2010-07-02 | 公開日 | 2010-11-24 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Determinants of an Insect {beta}-N-Acetyl-D-hexosaminidase Specialized as a Chitinolytic Enzyme J.Biol.Chem., 286, 2011
|
|
5XOO
| The structure of hydra Fam20 with sugar | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE, Glycosaminoglycan xylosylkinase, ... | 著者 | Zhang, H, Xiao, J. | 登録日 | 2017-05-29 | 公開日 | 2018-04-11 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Structure and evolution of the Fam20 kinases Nat Commun, 9, 2018
|
|
3OZO
| Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with NGT | 分子名称: | 3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL, N-acetylglucosaminidase | 著者 | Zhang, H, Liu, T, Liu, F, Shen, X, Yang, Q. | 登録日 | 2010-09-27 | 公開日 | 2011-09-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with NGT To be Published
|
|
3OZP
| Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with PUGNAc | 分子名称: | N-acetylglucosaminidase, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE | 著者 | Zhang, H, Liu, T, Liu, F, Shen, X, Yang, Q. | 登録日 | 2010-09-27 | 公開日 | 2011-08-17 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Active-pocket size differentiating insectile from bacterial chitinolytic beta-N-acetyl-D-hexosaminidases Biochem.J., 438, 2011
|
|
5YH0
| |