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PDB: 182 件
1H9G
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FadR, FATTY ACID RESPONSIVE TRANSCRIPTION FACTOR FROM E. COLI, in complex with myristoyl-CoA
分子名称: COENZYME A, FATTY ACID METABOLISM REGULATOR PROTEIN, MYRISTIC ACID
著者Van Aalten, D.M.F, Dirusso, C.C, Knudsen, J.
登録日2001-03-09
公開日2001-03-09
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Structural Basis of Acyl Coenzyme A-Dependent Regulation of the Transcription Factor Fadr
Embo J., 20, 2001
1H9T
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FADR, FATTY ACID RESPONSIVE TRANSCRIPTION FACTOR FROM E. COLI IN COMPLEX WITH FADB OPERATOR
分子名称: 5'-D(*CP*AP*TP*CP*TP*GP*GP*TP*AP*CP*GP*AP* CP*CP*AP*GP*AP*TP*C)-3', 5'-D(*GP*AP*TP*CP*TP*GP*GP*TP*CP*GP*TP*AP* CP*CP*AP*GP*AP*TP*G)-3', CHLORIDE ION, ...
著者Van Aalten, D.M.F, Dirusso, C.C, Knudsen, J.
登録日2001-03-19
公開日2001-04-04
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献The Structural Basis of Acyl Coenzyme A-Dependent Regulation of the Transcription Factor Fadr
Embo J., 20, 2001
1F57
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CARBOXYPEPTIDASE A COMPLEX WITH D-CYSTEINE AT 1.75 A
分子名称: CARBOXYPEPTIDASE A, D-CYSTEINE, ZINC ION
著者van Aalten, D.M, Chong, C.R, Joshua-Tor, L.
登録日2000-06-13
公開日2000-09-06
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Crystal structure of carboxypeptidase A complexed with D-cysteine at 1.75 A - inhibitor-induced conformational changes.
Biochemistry, 39, 2000
1GSW
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CRYSTAL STRUCTURE OF THE P65 CRYSTAL FORM OF PHOTOACTIVE YELLOW PROTEIN G51S MUTANT
分子名称: 4'-HYDROXYCINNAMIC ACID, PHOTOACTIVE YELLOW PROTEIN
著者Van Aalten, D.M.F, Crielaard, W, Hellingwerf, K.J, Joshua-Tor, L.
登録日2002-01-09
公開日2002-02-14
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Engineering Photocycle Dynamics: Crystal Structures and Kinetics of Three Photoactive Yellow Protein Hinge-Bending Mutants
J.Biol.Chem., 227, 2002
1GSX
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CRYSTAL STRUCTURE OF THE P65 CRYSTAL FORM OF PHOTOACTIVE YELLOW PROTEIN G47S/G51S MUTANT
分子名称: 4'-HYDROXYCINNAMIC ACID, PHOTOACTIVE YELLOW PROTEIN
著者Van Aalten, D.M.F, Crielaard, W, Hellingwerf, K.J, Joshua-Tor, L.
登録日2002-01-09
公開日2002-02-14
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Engineering Photocycle Dynamics: Crystal Structures and Kinetics of Three Photoactive Yellow Protein Hinge-Bending Mutants
J.Biol.Chem., 227, 2002
1GSV
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Crystal structure of the P65 crystal form of photoactive yellow protein G47S mutant
分子名称: 4'-HYDROXYCINNAMIC ACID, PHOTOACTIVE YELLOW PROTEIN
著者Van Aalten, D.M.F, Crielaard, W, Hellingwerf, K.J, Joshua-Tor, L.
登録日2002-01-08
公開日2002-02-14
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Engineering Photocycle Dynamics: Crystal Structures and Kinetics of Three Photoactive Yellow Protein Hinge-Bending Mutants
J.Biol.Chem., 227, 2002
4TX6
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AfChiA1 in complex with compound 1
分子名称: 3-(2-methoxyphenyl)-6-methyl[1,2]oxazolo[5,4-d]pyrimidin-4(5H)-one, Class III chitinase ChiA1, PHOSPHATE ION
著者van Aalten, D.M.F.
登録日2014-07-02
公開日2014-08-06
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Screening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors
FEBS Lett, 588, 2014
1KOU
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Crystal Structure of the Photoactive Yellow Protein Reconstituted with Caffeic Acid at 1.16 A Resolution
分子名称: CAFFEIC ACID, N-BUTANE, PHOTOACTIVE YELLOW PROTEIN
著者van Aalten, D.M.F, Crielaard, W, Hellingwerf, K.J, Joshua-Tor, L.
登録日2001-12-22
公開日2002-04-03
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.16 Å)
主引用文献Structure of the photoactive yellow protein reconstituted with caffeic acid at 1.16 A resolution.
Acta Crystallogr.,Sect.D, 58, 2002
4EZA
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Crystal structure of the atypical phosphoinositide (aPI) binding domain of IQGAP2
分子名称: Ras GTPase-activating-like protein IQGAP2
著者Van Aalten, D.M.F, Dixon, M.J, Gray, A, Schenning, M, Agacan, M, Leslie, N.R, Downes, C.P, Batty, I.H, Nedyalkova, L, Tempel, W, Tong, Y, Zhong, N, Crombet, L, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
登録日2012-05-02
公開日2012-05-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献IQGAP Proteins Reveal an Atypical Phosphoinositide (aPI) Binding Domain with a Pseudo C2 Domain Fold.
J.Biol.Chem., 287, 2012
1CW9
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DNA DECAMER WITH AN ENGINEERED CROSSLINK IN THE MINOR GROOVE
分子名称: 5'-D(*CP*CP*AP*GP*(G47)P*CP*CP*TP*GP*G)-3', CALCIUM ION
著者van Aalten, D.M.F, Erlanson, D.A, Verdine, G.L, Joshua-Tor, L.
登録日1999-08-26
公開日1999-10-14
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献A structural snapshot of base-pair opening in DNA.
Proc.Natl.Acad.Sci.USA, 96, 1999
1E2X
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FadR, fatty acid responsive transcription factor from E. coli
分子名称: FATTY ACID METABOLISM REGULATOR PROTEIN, SULFATE ION
著者Van Aalten, D.M.F, Dirusso, C.C, Knudsen, J, Wierenga, R.K.
登録日2000-05-30
公開日2000-12-03
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of Fadr, a Fatty Acid-Responsive Transcription Factor with a Novel Acyl Coenzyme A-Binding Fold
Embo J., 19, 2000
1D7E
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CRYSTAL STRUCTURE OF THE P65 CRYSTAL FORM OF PHOTOACTIVE YELLOW PROTEIN
分子名称: 4'-HYDROXYCINNAMIC ACID, PHOTOACTIVE YELLOW PROTEIN
著者Van Aalten, D.M.F, Crielaard, W, Hellingwerf, K.J, Joshua-Tor, L.
登録日1999-10-17
公開日2000-03-31
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.39 Å)
主引用文献Conformational substates in different crystal forms of the photoactive yellow protein--correlation with theoretical and experimental flexibility.
Protein Sci., 9, 2000
1HBK
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Acyl-CoA binding protein from Plasmodium falciparum
分子名称: ACYL-COA BINDING PROTEIN, COENZYME A, MYRISTIC ACID, ...
著者van Aalten, D.M.F.
登録日2001-04-16
公開日2001-05-15
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Binding site differences revealed by crystal structures of Plasmodium falciparum and bovine acyl-CoA binding protein.
J. Mol. Biol., 309, 2001
1E15
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Chitinase B from Serratia Marcescens
分子名称: CHITINASE B
著者Van Aalten, D.M.F, Synstad, B, Brurberg, M.B, Hough, E, Riise, B.W, Eijsink, V.G.H, Wierenga, R.K.
登録日2000-04-18
公開日2000-08-18
最終更新日2019-07-24
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of a Two-Domain Chitotriosidase from Serratia Marcescens at 1.9 Angstrom Resoltuion
Proc.Natl.Acad.Sci.USA, 97, 2000
5A0F
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Crystal structure of Yersinia Afp18-modified RhoA
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ...
著者Jank, T, Schimpl, M, van Aalten, D.M.
登録日2015-04-20
公開日2015-07-22
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos.
Nat Commun, 6, 2015
6Z2F
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Crystal structure of human AGX1 mutant complexed with UDPGLCNAC
分子名称: UDP-N-acetylhexosamine pyrophosphorylase, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE
著者Chen, X, van Aalten, D.M.F.
登録日2020-05-15
公開日2021-05-26
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of human AGX1 mutant complexed with UDPGLCNAC
To Be Published
6EOU
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O-GlcNAc transferase TPR domain with the intellectual disability associated mutation L254F
分子名称: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
著者Gundogdu, M, van Aalten, D.M.F.
登録日2017-10-10
公開日2018-05-09
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献The O-GlcNAc Transferase Intellectual Disability Mutation L254F Distorts the TPR Helix.
Cell Chem Biol, 25, 2018
5OXD
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Complex of a C. perfringens O-GlcNAcase with a fragment hit
分子名称: 5-(trifluoromethyl)-2,3-dihydro-1~{H}-1,4-diazepine, CADMIUM ION, O-GlcNAcase NagJ
著者Rafie, K, van Aalten, D.M.F.
登録日2017-09-06
公開日2018-05-16
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献O-GlcNAcase Fragment Discovery with Fluorescence Polarimetry.
ACS Chem. Biol., 13, 2018
2XGM
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Substrate and product analogues as human O-GlcNAc transferase inhibitors.
分子名称: ALLOXAN, XCOGT
著者Dorfmueller, H.C, Borodkin, V.S, Blair, D.E, Pathak, S, Navratilova, I, van Aalten, D.M.
登録日2010-06-07
公開日2010-08-25
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Substrate and Product Analogues as Human O-Glcnac Transferase Inhibitors.
Amino Acids, 40, 2011
2XGS
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XcOGT in complex with C-UDP
分子名称: 5'-O-[(S)-HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]URIDINE, XCOGT
著者Dorfmueller, H.C, Borodkin, V.S, Blair, D.E, Pathak, S, Navratilova, I, van Aalten, D.M.
登録日2010-06-07
公開日2010-08-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Substrate and Product Analogues as Human O-Glcnac Transferase Inhibitors.
Amino Acids, 40, 2011
2XGO
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XcOGT in complex with UDP-S-GlcNAc
分子名称: URIDINE-DIPHOSPHATE-1-DEOXY-1-THIO-N-ACETYLGLUCOSAMINE, XCOGT
著者Dorfmueller, H.C, Borodkin, V.S, Blair, D.E, Pathak, S, Navratilova, I, van Aalten, D.M.
登録日2010-06-07
公開日2010-08-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Substrate and Product Analogues as Human O-Glcnac Transferase Inhibitors.
Amino Acids, 40, 2011
1GPF
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CHITINASE B FROM SERRATIA MARCESCENS IN COMPLEX WITH INHIBITOR PSAMMAPLIN
分子名称: CHITINASE B, SULFATE ION
著者Komander, D, Van Aalten, D.M.
登録日2001-11-03
公開日2002-10-31
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Psammaplin A, a Chitinase Inhibitor Isolated from the Fijian Marine Sponge Aplysinella Rhax
Bioorg.Med.Chem., 10, 2002
2A3C
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Crystal structure of Aspergillus fumigatus chitinase B1 in complex with pentoxifylline
分子名称: 3,7-DIMETHYL-1-(5-OXOHEXYL)-3,7-DIHYDRO-1H-PURINE-2,6-DIONE, SULFATE ION, chitinase
著者Rao, F.V, Andersen, O.A, Vora, K.A, DeMartino, J.A, van Aalten, D.M.F.
登録日2005-06-24
公開日2005-09-27
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes.
Chem.Biol., 12, 2005
2A3E
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Crystal structure of Aspergillus fumigatus chitinase B1 in complex with allosamidin
分子名称: 2-acetamido-2-deoxy-beta-D-allopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-allopyranose, ALLOSAMIZOLINE, SULFATE ION, ...
著者Rao, F.V, Andersen, O.A, Vora, K.A, DeMartino, J.A, van Aalten, D.M.F.
登録日2005-06-24
公開日2005-09-27
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes.
Chem.Biol., 12, 2005
2A3B
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Crystal structure of Aspergillus fumigatus chitinase B1 in complex with caffeine
分子名称: CAFFEINE, SULFATE ION, chitinase
著者Rao, F.V, Andersen, O.A, Vora, K.A, DeMartino, J.A, van Aalten, D.M.F.
登録日2005-06-24
公開日2005-09-27
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes.
Chem.Biol., 12, 2005

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