1GPF

CHITINASE B FROM SERRATIA MARCESCENS IN COMPLEX WITH INHIBITOR PSAMMAPLIN

Summary for 1GPF

• Entry DOI: 10.2210/pdb1gpf/pdb
• Related: 1E15 1E6N 1E6P 1E6R 1E6Z 1GOI
• Descriptor: CHITINASE B, SULFATE ION (3 entities in total)
• Functional Keywords: hydrolase, chitin degradation, inhibitor psammaplin
• Biological source: SERRATIA MARCESCENS
• Total number of polymer chains: 2
• Total formula weight: 111324.21

Authors

Komander, D.,Van Aalten, D.M. (deposition date: 2001-11-03, release date: 2002-10-31, Last modification date: 2024-10-23)

Primary citation

Tabudravu, J.N.,Eijsink, V.G.,Gooday, G.W.,Jaspars, M.,Komander, D.,Legg, M.,Synstad, B.,Van Aalten, D.M.
Psammaplin A, a Chitinase Inhibitor Isolated from the Fijian Marine Sponge Aplysinella Rhax
Bioorg.Med.Chem., 10:1123-, 2002

PubMed Abstract: Several brominated tyrosine derived compounds, psammaplins A (1), K (2) and L (3) as well as bisaprasin (4) were isolated from the Fijian marine sponge Aplysinella rhax during a bioassay guided isolation protocol. Their structures were determined using NMR and MS techniques. Psammaplin A was found to moderately inhibit chitinase B from Serratia marcescens, the mode of inhibition being non-competitive. Crystallographic studies suggest that a disordered psammaplin A molecule is bound near the active site. Interestingly, psammaplin A was found to be a potent antifungal agent.

PubMed: 11836123
DOI: 10.1016/S0968-0896(01)00372-8

Experimental method

X-RAY DIFFRACTION (1.85 Å)