1YE3
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![BU of 1ye3 by Molmil](/molmil-images/mine/1ye3) | |
4W6Z
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![BU of 4w6z by Molmil](/molmil-images/mine/4w6z) | YEAST ALCOHOL DEHYDROGENASE I, SACCHAROMYCES CEREVISIAE FERMENTATIVE ENZYME | Descriptor: | Alcohol dehydrogenase 1, NICOTINAMIDE-8-IODO-ADENINE-DINUCLEOTIDE, TRIFLUOROETHANOL, ... | Authors: | plapp, B.v, savarimuthu, b.r, ramaswamy, s. | Deposit date: | 2014-08-21 | Release date: | 2014-09-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Yeast alcohol dehydrogenase structure and catalysis. Biochemistry, 53, 2014
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7UA6
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![BU of 7ua6 by Molmil](/molmil-images/mine/7ua6) | Horse liver alcohol dehydrogenase with NAD and trifluoroethanol at 25K | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, Alcohol dehydrogenase E chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM), ... | Authors: | Plapp, B.V, Gakhar, L. | Deposit date: | 2022-03-11 | Release date: | 2022-03-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Dependence of crystallographic atomic displacement factors on temperature (25-150 K) for complexes of horse liver alcohol dehydrogenases Acta Crystallogr.,Sect.D, D78, 2022
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6XT2
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![BU of 6xt2 by Molmil](/molmil-images/mine/6xt2) | EQADH-NADH-HEPTAFLUOROBUTANOL, P21 | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2,2,3,3,4,4,4-heptafluorobutan-1-ol, ... | Authors: | Plapp, B.V, Ramaswamy, S. | Deposit date: | 2020-07-16 | Release date: | 2020-08-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Alternative binding modes in abortive NADH-alcohol complexes of horse liver alcohol dehydrogenase. Arch.Biochem.Biophys., 701, 2021
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5ENV
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![BU of 5env by Molmil](/molmil-images/mine/5env) | YEAST ALCOHOL DEHYDROGENASE WITH BOUND COENZYME | Descriptor: | Alcohol dehydrogenase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRIFLUOROETHANOL, ... | Authors: | Plapp, B.V, Charlier Jr, H.A, Ramaswamy, S. | Deposit date: | 2015-11-09 | Release date: | 2015-11-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Mechanistic implications from structures of yeast alcohol dehydrogenase complexed with coenzyme and an alcohol. Arch.Biochem.Biophys., 591, 2015
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3OQ6
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![BU of 3oq6 by Molmil](/molmil-images/mine/3oq6) | Horse liver alcohol dehydrogenase A317C mutant complexed with NAD+ and 2,3,4,5,6-pentafluorobenzyl alcohol | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 2,3,4,5,6-PENTAFLUOROBENZYL ALCOHOL, Alcohol dehydrogenase E chain, ... | Authors: | Plapp, B.V, Herdendorf, T.J. | Deposit date: | 2010-09-02 | Release date: | 2010-11-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Origins of the high catalytic activity of human alcohol dehydrogenase 4 studied with horse liver A317C alcohol dehydrogenase. Chem.Biol.Interact, 191, 2011
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4DWV
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![BU of 4dwv by Molmil](/molmil-images/mine/4dwv) | Horse alcohol dehydrogenase complexed with NAD+ and 2,3,4,5,6-pentafluorobenzyl alcohol | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 2,3,4,5,6-PENTAFLUOROBENZYL ALCOHOL, Alcohol dehydrogenase E chain, ... | Authors: | Plapp, B.V, Ramaswamy, S. | Deposit date: | 2012-02-26 | Release date: | 2012-04-11 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.14 Å) | Cite: | Atomic-Resolution Structures of Horse Liver Alcohol Dehydrogenase with NAD(+) and Fluoroalcohols Define Strained Michaelis Complexes. Biochemistry, 51, 2012
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4DXH
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![BU of 4dxh by Molmil](/molmil-images/mine/4dxh) | Horse liver alcohol dehydrogenase complexed with NAD+ and 2,2,2-trifluoroethanol | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, Alcohol dehydrogenase E chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM), ... | Authors: | Plapp, B.V, Ramaswamy, S. | Deposit date: | 2012-02-27 | Release date: | 2012-04-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | Atomic-Resolution Structures of Horse Liver Alcohol Dehydrogenase with NAD(+) and Fluoroalcohols Define Strained Michaelis Complexes. Biochemistry, 51, 2012
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5VN1
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![BU of 5vn1 by Molmil](/molmil-images/mine/5vn1) | horse liver alcohol dehydrogenae complexed with NADH (R,S)-N-1-methylhexylformamide | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (R)-N-(1-METHYL-HEXYL)-FORMAMIDE, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | Authors: | Plapp, B.V, Ramaswamy, S, Ferraro, D.J, Baskar Raj, S. | Deposit date: | 2017-04-28 | Release date: | 2017-05-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Horse Liver Alcohol Dehydrogenase: Zinc Coordination and Catalysis. Biochemistry, 56, 2017
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5KJ1
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![BU of 5kj1 by Molmil](/molmil-images/mine/5kj1) | G173A horse liver alcohol dehydrogenase complexed with NAD+ and pentafluorobenzyl alcohol | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 2,3,4,5,6-PENTAFLUOROBENZYL ALCOHOL, Alcohol dehydrogenase E chain, ... | Authors: | Plapp, B.V. | Deposit date: | 2016-06-17 | Release date: | 2016-07-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Dependence of crystallographic atomic displacement parameters on temperature (25-150 K) for complexes of horse liver alcohol dehydrogenase. Acta Crystallogr D Struct Biol, 78, 2022
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4XD2
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![BU of 4xd2 by Molmil](/molmil-images/mine/4xd2) | Horse liver alcohol dehydrogenase-NADH complex | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Alcohol dehydrogenase E chain, ... | Authors: | Plapp, B.V, Baskar Raj, S, Ferraro, D.J. | Deposit date: | 2014-12-18 | Release date: | 2015-01-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Structure of Horse liver alcohol dehydrogenase complexed with NADH To Be Published
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6OWM
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![BU of 6owm by Molmil](/molmil-images/mine/6owm) | Horse liver F93W alcohol dehydrogenase complexed with NAD and pentafluorobenzyl alcohol | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 2,3,4,5,6-PENTAFLUOROBENZYL ALCOHOL, Alcohol dehydrogenase E chain, ... | Authors: | Plapp, B.V. | Deposit date: | 2019-05-10 | Release date: | 2019-05-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Substitutions of Amino Acid Residues in the Substrate Binding Site of Horse Liver Alcohol Dehydrogenase Have Small Effects on the Structures but Significantly Affect Catalysis of Hydrogen Transfer. Biochemistry, 59, 2020
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6O91
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![BU of 6o91 by Molmil](/molmil-images/mine/6o91) | Horse liver L57F alcohol dehydrogenase complexed with NAD and pentafluorobenzyl alcohol | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 2,3,4,5,6-PENTAFLUOROBENZYL ALCOHOL, Alcohol dehydrogenase E chain, ... | Authors: | Plapp, B.V. | Deposit date: | 2019-03-12 | Release date: | 2019-04-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Substitutions of Amino Acid Residues in the Substrate Binding Site of Horse Liver Alcohol Dehydrogenase Have Small Effects on the Structures but Significantly Affect Catalysis of Hydrogen Transfer. Biochemistry, 59, 2020
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6OA7
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![BU of 6oa7 by Molmil](/molmil-images/mine/6oa7) | Horse liver L57F alcohol dehydrogenase E complexed with NAD and trifluoroethanol | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, Alcohol dehydrogenase E chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM), ... | Authors: | Plapp, B.V. | Deposit date: | 2019-03-15 | Release date: | 2019-04-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Substitutions of Amino Acid Residues in the Substrate Binding Site of Horse Liver Alcohol Dehydrogenase Have Small Effects on the Structures but Significantly Affect Catalysis of Hydrogen Transfer. Biochemistry, 59, 2020
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6OWP
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![BU of 6owp by Molmil](/molmil-images/mine/6owp) | Horse liver F93W alcohol dehydrogenase complexed with NAD and trifluoroethanol | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, Alcohol dehydrogenase E chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM), ... | Authors: | Plapp, B.V. | Deposit date: | 2019-05-10 | Release date: | 2019-05-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.14 Å) | Cite: | Substitutions of Amino Acid Residues in the Substrate Binding Site of Horse Liver Alcohol Dehydrogenase Have Small Effects on the Structures but Significantly Affect Catalysis of Hydrogen Transfer. Biochemistry, 59, 2020
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5KJE
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![BU of 5kje by Molmil](/molmil-images/mine/5kje) | F322L horse liver alcohol dehydrogenase complexed with NAD+ and pentafluorobenzyl alcohol | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 2,3,4,5,6-PENTAFLUOROBENZYL ALCOHOL, Alcohol dehydrogenase E chain, ... | Authors: | Plapp, B.V. | Deposit date: | 2016-06-18 | Release date: | 2016-07-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.26 Å) | Cite: | Contribution of buried distal amino acid residues in horse liver alcohol dehydrogenase to structure and catalysis. Protein Sci., 27, 2018
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5VJ5
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![BU of 5vj5 by Molmil](/molmil-images/mine/5vj5) | Horse Liver Alcohol Dehydrogenase Complexed with 1,10-Phenanthroline | Descriptor: | 1,10-PHENANTHROLINE, Alcohol dehydrogenase E chain, ZINC ION | Authors: | Plapp, B.V, Baskar Raj, S, Ramaswamy, S. | Deposit date: | 2017-04-18 | Release date: | 2017-05-03 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Horse Liver Alcohol Dehydrogenase: Zinc Coordination and Catalysis. Biochemistry, 56, 2017
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5VJG
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8G41
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![BU of 8g41 by Molmil](/molmil-images/mine/8g41) | Horse liver alcohol dehydrogense His-51-Gln form complexed with NADH | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | Authors: | Plapp, B.V. | Deposit date: | 2023-02-08 | Release date: | 2023-02-15 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Histidine-51 facilitates deprotonatation of the zinc-bound ligand during catalysis by horse liver alcohol dehydrogenase To Be Published
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8G2X
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5VL0
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![BU of 5vl0 by Molmil](/molmil-images/mine/5vl0) | horse liver alcohol dehydrogenase complexed with NADH and N-benzyformamide | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Alcohol dehydrogenase E chain, ... | Authors: | Plapp, B.V, Brown, E.N, Ramaswamy, S, Baskar Raj, S. | Deposit date: | 2017-04-24 | Release date: | 2017-05-03 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Horse Liver Alcohol Dehydrogenase: Zinc Coordination and Catalysis. Biochemistry, 56, 2017
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8G2L
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![BU of 8g2l by Molmil](/molmil-images/mine/8g2l) | |
8G2S
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![BU of 8g2s by Molmil](/molmil-images/mine/8g2s) | |
8G39
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![BU of 8g39 by Molmil](/molmil-images/mine/8g39) | |
8G4V
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![BU of 8g4v by Molmil](/molmil-images/mine/8g4v) | Horse liver alcohol dehydrogense His-51-Gln form complexed with NAD+ and 2,3,4,5,6-pentafluorobenzyl alcohol | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2,3,4,5,6-PENTAFLUOROBENZYL ALCOHOL, Alcohol dehydrogenase E chain, ... | Authors: | Plapp, B.V, Subramanian, R. | Deposit date: | 2023-02-10 | Release date: | 2023-02-22 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Histidine-51 facilitates deprotonation of the zinc-bound ligand during catalysis by horse liver alcohol dehydrogenase To Be Published
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