4DWV

Horse alcohol dehydrogenase complexed with NAD+ and 2,3,4,5,6-pentafluorobenzyl alcohol

Summary for 4DWV

Related1HLD 4DXH 1N92 3OQ6 1P1R
DescriptorAlcohol dehydrogenase E chain, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM), ... (6 entities in total)
Functional Keywordsalcohol dehydrogenase, nad+, pentafluorobenzyl alcohol, michaelis complex, rossmann fold, oxidoreductase
Biological sourceEquus caballus (domestic horse,equine)
Cellular locationCytoplasm P00327
Total number of polymer chains2
Total molecular weight82163.91
Authors
Plapp, B.V.,Ramaswamy, S. (deposition date: 2012-02-26, release date: 2012-04-11, Last modification date: 2012-06-27)
Primary citation
Plapp, B.V.,Ramaswamy, S.
Atomic-Resolution Structures of Horse Liver Alcohol Dehydrogenase with NAD(+) and Fluoroalcohols Define Strained Michaelis Complexes.
Biochemistry, 51:4035-4048, 2012
PubMed: 22531044 (PDB entries with the same primary citation)
DOI: 10.1021/bi300378n
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.14 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.154200.3%0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution