1BAF
| 2.9 ANGSTROMS RESOLUTION STRUCTURE OF AN ANTI-DINITROPHENYL-SPIN-LABEL MONOCLONAL ANTIBODY FAB FRAGMENT WITH BOUND HAPTEN | Descriptor: | IGG1-KAPPA AN02 FAB (HEAVY CHAIN), IGG1-KAPPA AN02 FAB (LIGHT CHAIN), N-(2-AMINO-ETHYL)-4,6-DINITRO-N'-(2,2,6,6-TETRAMETHYL-1-OXY-PIPERIDIN-4-YL)-BENZENE-1,3-DIAMINE | Authors: | Leahy, D.J, Brunger, A.T, Fox, R.O, Hynes, T.R. | Deposit date: | 1992-01-16 | Release date: | 1994-01-31 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | 2.9 A resolution structure of an anti-dinitrophenyl-spin-label monoclonal antibody Fab fragment with bound hapten. J.Mol.Biol., 221, 1991
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1FNF
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1TEN
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1M6B
| Structure of the HER3 (ERBB3) Extracellular Domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor protein-tyrosine kinase erbB-3, ... | Authors: | Leahy, D.J, Cho, H.-S. | Deposit date: | 2002-07-15 | Release date: | 2002-08-02 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of the extracellular region of HER3 reveals an interdomain tether. Science, 297, 2002
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1LFA
| CD11A I-DOMAIN WITH BOUND MN++ | Descriptor: | CD11A, CHLORIDE ION, MANGANESE (II) ION | Authors: | Leahy, D.J, Qu, A. | Deposit date: | 1995-09-08 | Release date: | 1996-01-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin. Proc.Natl.Acad.Sci.USA, 92, 1995
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1CD8
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1ZOP
| CD11A I-DOMAIN WITH BOUND MAGNESIUM ION | Descriptor: | CHLORIDE ION, I-DOMAIN FRAGMENT OF LFA-1, MANGANESE (II) ION | Authors: | Leahy, D.J, Qu, A. | Deposit date: | 1996-06-21 | Release date: | 1996-12-07 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin. Structure, 4, 1996
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1ZOO
| CD11A I-DOMAIN WITH BOUND MAGNESIUM ION | Descriptor: | CHLORIDE ION, LEUKOCYTE ADHESION GLYCOPROTEIN, MAGNESIUM ION | Authors: | Leahy, D.J, Qu, A. | Deposit date: | 1996-06-21 | Release date: | 1996-12-07 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin. Structure, 4, 1996
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1ZON
| CD11A I-DOMAIN WITHOUT BOUND CATION | Descriptor: | LEUKOCYTE ADHESION GLYCOPROTEIN | Authors: | Leahy, D.J, Qu, A. | Deposit date: | 1996-06-20 | Release date: | 1996-12-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin. Structure, 4, 1996
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6JFV
| The crystal structure of 2B-2B complex from keratins 5 and 14 (C367A mutant of K14) | Descriptor: | Keratin, type I cytoskeletal 14, type II cytoskeletal 5 | Authors: | Kim, M.S, Lee, C.H, Coulombe, P.A, Leahy, D.J. | Deposit date: | 2019-02-12 | Release date: | 2020-01-22 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure-Function Analyses of a Keratin Heterotypic Complex Identify Specific Keratin Regions Involved in Intermediate Filament Assembly. Structure, 28, 2020
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2IC2
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1SZH
| Crystal Structure of C. elegans HER-1 | Descriptor: | ACETATE ION, Her-1 protein | Authors: | Hamaoka, B.Y, Dann III, C.E, Geisbrecht, B.V, Leahy, D.J. | Deposit date: | 2004-04-05 | Release date: | 2004-08-10 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2A. Proc.Natl.Acad.Sci.USA, 101, 2004
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1S78
| Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Pertuzumab Fab heavy chain, ... | Authors: | Franklin, M.C, Carey, K.D, Vajdos, F.F, Leahy, D.J, de Vos, A.M, Sliwkowski, M.X. | Deposit date: | 2004-01-29 | Release date: | 2004-04-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex. Cancer Cell, 5, 2004
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4X3X
| The crystal structure of Arc C-lobe | Descriptor: | Activity-regulated cytoskeleton-associated protein | Authors: | Zhang, W, Ward, M, Leahy, D, Worley, P. | Deposit date: | 2014-12-01 | Release date: | 2015-06-03 | Last modified: | 2017-09-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis of arc binding to synaptic proteins: implications for cognitive disease. Neuron, 86, 2015
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4X3H
| CRYSTAL STRUCTURE OF ARC N-LOBE COMPLEXED WITH STARGAZIN PEPTIDE | Descriptor: | Activity-regulated cytoskeleton-associated protein, VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT | Authors: | zhang, W, ward, m, leahy, d, worley, p. | Deposit date: | 2014-11-30 | Release date: | 2015-06-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.401 Å) | Cite: | Structural basis of arc binding to synaptic proteins: implications for cognitive disease. Neuron, 86, 2015
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4X3I
| The crystal structure of Arc N-lobe complexed with CAMK2A fragment | Descriptor: | Activity-regulated cytoskeleton-associated protein, CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA | Authors: | Zhang, W, Ward, M, Leahy, D, Worley, P. | Deposit date: | 2014-11-30 | Release date: | 2015-06-03 | Last modified: | 2017-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis of arc binding to synaptic proteins: implications for cognitive disease. Neuron, 86, 2015
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3ODN
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2OGB
| Crystal structure of the C-terminal domain of mouse Nrdp1 | Descriptor: | GLYCEROL, RING finger protein 41, THIOCYANATE ION | Authors: | Bouyain, S, Leahy, D.J. | Deposit date: | 2007-01-05 | Release date: | 2007-01-16 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure-based mutagenesis of the substrate-recognition domain of Nrdp1/FLRF identifies the binding site for the receptor tyrosine kinase ErbB3. Protein Sci., 16, 2007
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1OT8
| Structure of the Ankyrin Domain of the Drosophila Notch Receptor | Descriptor: | MAGNESIUM ION, Neurogenic locus Notch protein | Authors: | Zweifel, M.E, Leahy, D.J, Hughson, F.M, Barrick, D. | Deposit date: | 2003-03-21 | Release date: | 2003-10-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and stability of the ankyrin domain of the Drosophila Notch receptor Protein Sci., 12, 2003
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4PFJ
| The structure of bi-acetylated SAHH | Descriptor: | ADENOSINE, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Kavran, J.M, Wang, Y, Cole, P.A, Leahy, D.J. | Deposit date: | 2014-04-29 | Release date: | 2014-10-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Regulation of s-adenosylhomocysteine hydrolase by lysine acetylation. J.Biol.Chem., 289, 2014
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4PGF
| The structure of mono-acetylated SAHH | Descriptor: | ADENOSINE, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Kavran, J.M, Wang, Y, Cole, P.A, Leahy, D.J. | Deposit date: | 2014-05-01 | Release date: | 2014-10-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Regulation of s-adenosylhomocysteine hydrolase by lysine acetylation. J.Biol.Chem., 289, 2014
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1VHH
| A POTENTIAL CATALYTIC SITE WITHIN THE AMINO-TERMINAL SIGNALLING DOMAIN OF SONIC HEDGEHOG | Descriptor: | SONIC HEDGEHOG, SULFATE ION, ZINC ION | Authors: | Hall, T.M.T, Porter, J.A, Beachy, P.A, Leahy, D.J. | Deposit date: | 1995-10-03 | Release date: | 1996-01-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog. Nature, 378, 1995
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2ORZ
| Structural Basis for Ligand Binding and Heparin Mediated Activation of Neuropilin | Descriptor: | Neuropilin-1, Tuftsin | Authors: | Vander Kooi, C.W, Jusino, M.A, Perman, B, Neau, D.B, Bellamy, H.D, Leahy, D.J. | Deposit date: | 2007-02-05 | Release date: | 2007-04-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural basis for ligand and heparin binding to neuropilin B domains. Proc.Natl.Acad.Sci.Usa, 104, 2007
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2ORX
| Structural Basis for Ligand Binding and Heparin Mediated Activation of Neuropilin | Descriptor: | Neuropilin-1 | Authors: | Vander Kooi, C.W, Jusino, M.A, Perman, B, Neau, D.B, Bellamy, H.D, Leahy, D.J. | Deposit date: | 2007-02-05 | Release date: | 2007-04-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for ligand and heparin binding to neuropilin B domains Proc.Natl.Acad.Sci.Usa, 104, 2007
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1IJY
| CRYSTAL STRUCTURE OF THE CYSTEINE-RICH DOMAIN OF MOUSE FRIZZLED 8 (MFZ8) | Descriptor: | FRIZZLED HOMOLOG 8 | Authors: | Dann III, C.E, Hsieh, J.C, Rattner, A, Sharma, D, Nathans, J, Leahy, D.J. | Deposit date: | 2001-05-01 | Release date: | 2001-07-11 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature, 412, 2001
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