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PDB: 318 results

5C85
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BU of 5c85 by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with SEED1
Descriptor: 6-bromo-3,4-dihydroquinoxalin-2(1H)-one, NITRATE ION, Peregrin
Authors:Zhu, J, Caflisch, A.
Deposit date:2015-06-25
Release date:2016-05-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
J.Med.Chem., 59, 2016
5C7N
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BU of 5c7n by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with Bromosporine
Descriptor: Bromosporine, NITRATE ION, Peregrin
Authors:Zhu, J, Caflisch, A.
Deposit date:2015-06-24
Release date:2015-07-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
J.Med.Chem., 59, 2016
5C87
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BU of 5c87 by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with SEED2
Descriptor: NITRATE ION, Peregrin, isoquinolin-1(2H)-one
Authors:Zhu, J, Caflisch, A.
Deposit date:2015-06-25
Release date:2016-05-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
J.Med.Chem., 59, 2016
7FBJ
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BU of 7fbj by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing nanobody 17F6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, New antigen receptor variable domain, ...
Authors:Zhu, J, Xu, T, Feng, B, Liu, J.
Deposit date:2021-07-11
Release date:2022-07-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:A Class of Shark-Derived Single-Domain Antibodies can Broadly Neutralize SARS-Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape.
Small Methods, 6, 2022
7FBK
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BU of 7fbk by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain N501Y mutant in complex with neutralizing nanobody 20G6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, New antigen receptor variable domain, Spike protein S1
Authors:Zhu, J, Xu, T, Feng, B, Liu, J.
Deposit date:2021-07-11
Release date:2022-07-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A Class of Shark-Derived Single-Domain Antibodies can Broadly Neutralize SARS-Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape.
Small Methods, 6, 2022
5E3G
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BU of 5e3g by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with SEED8
Descriptor: 2-thioxo-2,3,7,9-tetrahydro-1H-purine-6,8-dione, NITRATE ION, Peregrin
Authors:Zhu, J, Caflisch, A.
Deposit date:2015-10-02
Release date:2016-05-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
J.Med.Chem., 59, 2016
5DY7
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BU of 5dy7 by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with SEED4
Descriptor: 7-(trifluoromethyl)-3,4-dihydroquinoxalin-2(1H)-one, NITRATE ION, Peregrin
Authors:Zhu, J, Caflisch, A.
Deposit date:2015-09-24
Release date:2016-05-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
J.Med.Chem., 59, 2016
5DYC
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BU of 5dyc by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with SEED6
Descriptor: 7-bromo-3,4-dihydroquinoxalin-2(1H)-one, NITRATE ION, Peregrin
Authors:Zhu, J, Caflisch, A.
Deposit date:2015-09-24
Release date:2016-05-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
J.Med.Chem., 59, 2016
5EPR
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BU of 5epr by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with SEED11
Descriptor: (3~{S})-3-methyl-3,4-dihydro-1~{H}-quinoxalin-2-one, NITRATE ION, Peregrin
Authors:Zhu, J, Caflisch, A.
Deposit date:2015-11-12
Release date:2016-05-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
J.Med.Chem., 59, 2016
5EQ1
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BU of 5eq1 by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with SEED12
Descriptor: 5-METHYL-1,2,4-TRIAZOLO[3,4-B]BENZOTHIAZOLE, NITRATE ION, Peregrin
Authors:Zhu, J, Caflisch, A.
Deposit date:2015-11-12
Release date:2016-05-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
J.Med.Chem., 59, 2016
5ETD
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BU of 5etd by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with SEED14
Descriptor: 1-(1~{H}-indol-3-yl)ethanone, NITRATE ION, Peregrin
Authors:Zhu, J, Caflisch, A.
Deposit date:2015-11-17
Release date:2016-05-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
J.Med.Chem., 59, 2016
5EVA
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BU of 5eva by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with SEED16
Descriptor: NITRATE ION, Peregrin, ~{N}-[2,4-bis(fluoranyl)phenyl]-2-methyl-pyrazole-3-carboxamide
Authors:Zhu, J, Caflisch, A.
Deposit date:2015-11-19
Release date:2016-06-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
J.Med.Chem., 59, 2016
5EV9
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BU of 5ev9 by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with SEED15
Descriptor: NITRATE ION, Peregrin, ~{N}-[5-(1~{H}-pyrazol-4-yl)quinolin-8-yl]ethanamide
Authors:Zhu, J, Caflisch, A.
Deposit date:2015-11-19
Release date:2016-06-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
J.Med.Chem., 59, 2016
5EWW
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BU of 5eww by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with SEED21
Descriptor: NITRATE ION, Peregrin, ~{N}-[(2~{R})-butan-2-yl]-1-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-amine
Authors:Zhu, J, Wiedmer, L, Caflisch, A.
Deposit date:2015-11-21
Release date:2016-11-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Crystal structure of the human BRPF1 bromodomain in complex with SEED21
To Be Published
5EWH
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BU of 5ewh by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with SEED19
Descriptor: NITRATE ION, Peregrin, isoquinolin-5-ol
Authors:Zhu, J, Caflisch, A.
Deposit date:2015-11-20
Release date:2016-06-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
J.Med.Chem., 59, 2016
5EWC
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BU of 5ewc by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with SEED17
Descriptor: NITRATE ION, Peregrin, ethyl (2~{R})-2-methyl-3-oxidanylidene-2,4-dihydro-1~{H}-quinoxaline-6-carboxylate
Authors:Zhu, J, Caflisch, A.
Deposit date:2015-11-20
Release date:2016-05-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
J.Med.Chem., 59, 2016
5EWV
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BU of 5ewv by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with SEED20
Descriptor: 1,5-dimethyl-[1,2,4]triazolo[4,3-a]quinoline, NITRATE ION, Peregrin
Authors:Zhu, J, Wiedmer, L, Caflisch, A.
Deposit date:2015-11-21
Release date:2016-11-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Crystal structure of the human BRPF1 bromodomain in complex with SEED20
To Be Published
5ETB
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BU of 5etb by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with SEED13
Descriptor: 1-(7-methyl-1~{H}-indol-3-yl)ethanone, NITRATE ION, Peregrin
Authors:Zhu, J, Caflisch, A.
Deposit date:2015-11-17
Release date:2016-05-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
J.Med.Chem., 59, 2016
5DYA
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BU of 5dya by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with SEED5
Descriptor: (2R)-2-ethyl-3-oxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylic acid, NITRATE ION, Peregrin
Authors:Zhu, J, Caflisch, A.
Deposit date:2015-09-24
Release date:2016-05-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
J.Med.Chem., 59, 2016
5E3D
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BU of 5e3d by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with SEED7
Descriptor: 2,8-dithioxo-1,2,3,7,8,9-hexahydro-6H-purin-6-one, NITRATE ION, Peregrin
Authors:Zhu, J, Caflisch, A.
Deposit date:2015-10-02
Release date:2016-05-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
J.Med.Chem., 59, 2016
5EM3
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BU of 5em3 by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with SEED9
Descriptor: NITRATE ION, Peregrin, quinolin-5-ol
Authors:Zhu, J, Caflisch, A.
Deposit date:2015-11-05
Release date:2016-06-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
J.Med.Chem., 59, 2016
5EPS
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BU of 5eps by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with SEED10
Descriptor: 1-methyl-3,4-dihydroquinoxalin-2-one, NITRATE ION, Peregrin
Authors:Zhu, J, Caflisch, A.
Deposit date:2015-11-12
Release date:2016-05-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
J.Med.Chem., 59, 2016
6TS3
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BU of 6ts3 by Molmil
EF-hands 3 and 4 of alpha-actinin in complex with CaMKII regulatory segment
Descriptor: ACE-ASN-ALA-ARG-ARG-LYS-LEU-LYS-GLY-ALA-ILE-LEU-THR-THR-MET-LEU-ALA-THR-ARG-ASN-PHE, ACETYL GROUP, Alpha-actinin-2
Authors:Zhu, J, Gold, M.
Deposit date:2019-12-19
Release date:2021-01-13
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:EF-hands 3 and 4 of alpha-actinin in complex with CaMKII regulatory segment
To Be Published
5OWK
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BU of 5owk by Molmil
Crystal structure of CREBBP bromodomain complexed with DSPB2A002
Descriptor: CREB-binding protein, ethyl 4-chloranyl-1-methyl-6-oxidanylidene-pyridine-3-carboxylate
Authors:Zhu, J, Spiliotopoulos, D, Caflisch, A.
Deposit date:2017-09-01
Release date:2018-08-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9, 2018
5O55
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BU of 5o55 by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with BZ047
Descriptor: NITRATE ION, Peregrin, ~{N}-[(1~{S})-1-(1,5-dimethylpyrazol-4-yl)ethyl]-1-ethyl-3-methyl-2-oxidanylidene-quinoxaline-6-carboxamide
Authors:Zhu, J, Caflisch, A.
Deposit date:2017-05-31
Release date:2018-06-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure-based discovery of selective BRPF1 bromodomain inhibitors.
Eur J Med Chem, 155, 2018

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数据于2024-07-24公开中

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