Crystal structure of the human BRPF1 bromodomain in complex with Bromosporine

Summary for 5C7N

DescriptorPeregrin, Bromosporine, NITRATE ION, ... (4 entities in total)
Functional Keywordsdna binding protein, bromodomain and phd finger-containing protein 1, histone acetyltransferase(hat), transferase
Biological sourceHomo sapiens (Human)
Cellular locationNucleus  P55201
Total number of polymer chains1
Total molecular weight14170.15
Zhu, J.,Caflisch, A. (deposition date: 2015-06-24, release date: 2015-07-08, Last modification date: 2016-06-22)
Primary citation
Zhu, J.,Caflisch, A.
Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
J.Med.Chem., 59:5555-5561, 2016
PubMed: 27167503 (PDB entries with the same primary citation)
DOI: 10.1021/acs.jmedchem.6b00215
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2204000MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-28