2NCA
 
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5GMF
 | | Crystal structure of monkey TLR7 in complex with guanosine and polyU | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Zhang, Z, Ohto, U, Shimizu, T. | | Deposit date: | 2016-07-14 | | Release date: | 2016-11-02 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
Immunity, 45, 2016
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5GMG
 | | Crystal structure of monkey TLR7 in complex with loxoribine and polyU | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-7-prop-2-enyl-1~{H}-purine-6,8-dione, ... | | Authors: | Zhang, Z, Ohto, U, Shimizu, T. | | Deposit date: | 2016-07-14 | | Release date: | 2016-11-02 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
Immunity, 45, 2016
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5GMH
 | | Crystal structure of monkey TLR7 in complex with R848 | | Descriptor: | 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Zhang, Z, Ohto, U, Shimizu, T. | | Deposit date: | 2016-07-14 | | Release date: | 2016-11-02 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
Immunity, 45, 2016
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2OPW
 | | Crystal structure of human phytanoyl-CoA dioxygenase PHYHD1 (apo) | | Descriptor: | PHYHD1 protein | | Authors: | Zhang, Z, Butler, D, McDonough, M.A, Kavanagh, K.L, Bray, J.E, Ng, S.S, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Sundstrom, M, Schofield, C.J, Oppermann, U, Structural Genomics Consortium (SGC) | | Deposit date: | 2007-01-30 | | Release date: | 2007-03-06 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of human phytanoyl-CoA dioxygenase PHYHD1 (apo)
To be Published
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8F56
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8F4N
 | | Dimer of aminoglycoside efflux pump AcrD | | Descriptor: | Efflux pump membrane transporter | | Authors: | Zhang, Z. | | Deposit date: | 2022-11-11 | | Release date: | 2022-12-28 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | Cryo-EM Structures of AcrD Illuminate a Mechanism for Capturing Aminoglycosides from Its Central Cavity.
Mbio, 14, 2023
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8F3E
 | | Trimer of aminoglycoside efflux pump AcrD | | Descriptor: | Efflux pump membrane transporter | | Authors: | Zhang, Z. | | Deposit date: | 2022-11-10 | | Release date: | 2022-12-28 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Cryo-EM Structures of AcrD Illuminate a Mechanism for Capturing Aminoglycosides from Its Central Cavity.
Mbio, 14, 2023
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8EOJ
 | | Microsomal triglyceride transfer protein | | Descriptor: | Microsomal triglyceride transfer protein large subunit, Protein disulfide-isomerase | | Authors: | Zhang, Z. | | Deposit date: | 2022-10-03 | | Release date: | 2023-05-03 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | High-resolution structural-omics of human liver enzymes.
Cell Rep, 42, 2023
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8ENE
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8EOR
 | | Liver carboxylesterase 1 | | Descriptor: | ETHYL ACETATE, Liver carboxylesterase 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Zhang, Z, Yu, E. | | Deposit date: | 2022-10-04 | | Release date: | 2023-05-03 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (2.67 Å) | | Cite: | High-resolution structural-omics of human liver enzymes.
Cell Rep, 42, 2023
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8F4R
 | | Gentamicin bound aminoglycoside efflux pump AcrD | | Descriptor: | (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, Efflux pump membrane transporter | | Authors: | Zhang, Z. | | Deposit date: | 2022-11-11 | | Release date: | 2022-12-28 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | Cryo-EM Structures of AcrD Illuminate a Mechanism for Capturing Aminoglycosides from Its Central Cavity.
Mbio, 14, 2023
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8FFK
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8FFS
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6WGN
 | | Crystal structure of K-Ras(G12D) GppNHp bound to cyclic peptide ligand KD2 | | Descriptor: | Cyclic Peptide KD2, GTPase KRas, MAGNESIUM ION, ... | | Authors: | Zhang, Z, Gao, R, Hu, Q, Peacock, H, Peacock, D.M, Shokat, K.M, Suga, H. | | Deposit date: | 2020-04-06 | | Release date: | 2020-10-14 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.601 Å) | | Cite: | GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf.
Acs Cent.Sci., 6, 2020
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8SK6
 | | human liver mitochondrial Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase | | Descriptor: | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial | | Authors: | Zhang, Z, Tringides, M. | | Deposit date: | 2023-04-18 | | Release date: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (2.96 Å) | | Cite: | High-Resolution Structural Proteomics of Mitochondria Using the 'Build and Retrieve' Methodology.
Mol.Cell Proteomics, 22, 2023
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8SGV
 | | human liver mitochondrial Catalase | | Descriptor: | Catalase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Zhang, Z. | | Deposit date: | 2023-04-13 | | Release date: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (2.58 Å) | | Cite: | High-Resolution Structural Proteomics of Mitochondria Using the 'Build and Retrieve' Methodology.
Mol.Cell Proteomics, 22, 2023
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8SHS
 | | human liver mitochondrial Aldehyde dehydrogenase ALDH2 | | Descriptor: | Aldehyde dehydrogenase, mitochondrial | | Authors: | Zhang, Z. | | Deposit date: | 2023-04-14 | | Release date: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (2.66 Å) | | Cite: | High-Resolution Structural Proteomics of Mitochondria Using the 'Build and Retrieve' Methodology.
Mol.Cell Proteomics, 22, 2023
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8SKR
 | | human liver mitochondrial Aspartate aminotransferase | | Descriptor: | Aspartate aminotransferase, mitochondrial, PYRIDOXAL-5'-PHOSPHATE | | Authors: | Zhang, Z, Tringides, M. | | Deposit date: | 2023-04-20 | | Release date: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (2.99 Å) | | Cite: | High-Resolution Structural Proteomics of Mitochondria Using the 'Build and Retrieve' Methodology.
Mol.Cell Proteomics, 22, 2023
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8SKS
 | | human liver mitochondrial Superoxide dismutase [Mn] | | Descriptor: | MANGANESE (II) ION, Superoxide dismutase [Mn], mitochondrial | | Authors: | Zhang, Z, Tringides, M. | | Deposit date: | 2023-04-20 | | Release date: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (2.91 Å) | | Cite: | High-Resolution Structural Proteomics of Mitochondria Using the 'Build and Retrieve' Methodology.
Mol.Cell Proteomics, 22, 2023
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8SGP
 | | human liver mitochondrial Medium-chain specific acyl-CoA dehydrogenase | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | | Authors: | Zhang, Z. | | Deposit date: | 2023-04-12 | | Release date: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (2.69 Å) | | Cite: | High-Resolution Structural Proteomics of Mitochondria Using the 'Build and Retrieve' Methodology.
Mol.Cell Proteomics, 22, 2023
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8SGR
 | | human liver mitochondrial Isovaleryl-CoA dehydrogenase | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Isovaleryl-CoA dehydrogenase, mitochondrial | | Authors: | Zhang, Z. | | Deposit date: | 2023-04-13 | | Release date: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (2.84 Å) | | Cite: | High-Resolution Structural Proteomics of Mitochondria Using the 'Build and Retrieve' Methodology.
Mol.Cell Proteomics, 22, 2023
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8SGS
 | | human liver mitochondrial Short-chain specific acyl-CoA dehydrogenase | | Descriptor: | COENZYME A, FLAVIN-ADENINE DINUCLEOTIDE, Short-chain specific acyl-CoA dehydrogenase, ... | | Authors: | Zhang, Z. | | Deposit date: | 2023-04-13 | | Release date: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | High-Resolution Structural Proteomics of Mitochondria Using the 'Build and Retrieve' Methodology.
Mol.Cell Proteomics, 22, 2023
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8SK8
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8T4V
 | | Crystal structure of compound 1 bound to K-Ras(G12D) | | Descriptor: | 4-{(1R,5S)-3-[(7P)-7-(8-ethynylnaphthalen-1-yl)-8-fluoro-2-{[(4s,7as)-tetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl}-4-oxobutanoic acid, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Zhang, Z, Zheng, Q, Guiley, K.Z, Shokat, K.M. | | Deposit date: | 2023-06-10 | | Release date: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.47 Å) | | Cite: | Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D.
Nat.Chem.Biol., 2024
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