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PDB: 784 件
6LJ4
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BU of 6lj4 by Molmil
Crystal structure of NDM-1 in complex with D-captopril derivative wss04146
分子名称: (3S)-1-[(2S)-2-methyl-3-sulfanyl-propanoyl]piperidine-3-carboxylic acid, Metallo-beta-lactamase type 2, ZINC ION
著者Zhang, H, Ma, G.
登録日2019-12-13
公開日2020-12-16
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors.
Bioorg.Med.Chem., 29, 2020
6LIP
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BU of 6lip by Molmil
Crystal structure of NDM-1 in complex with D-captopril derivative wss0218
分子名称: (2R)-1-[3-sulfanyl-2-(sulfanylmethyl)propanoyl]pyrrolidine-2-carboxylic acid, Metallo-beta-lactamase type 2, ZINC ION
著者Zhang, H, Ma, G.
登録日2019-12-12
公開日2020-12-16
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (0.98 Å)
主引用文献Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors.
Bioorg.Med.Chem., 29, 2020
6LIZ
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BU of 6liz by Molmil
Crystal structure of NDM-1 in complex with D-captopril derivative wss02120
分子名称: (2R)-1-[(2S)-2-methyl-3-sulfanyl-propanoyl]azepane-2-carboxylic acid, Metallo-beta-lactamase type 2, ZINC ION
著者Zhang, H, Ma, G.
登録日2019-12-13
公開日2020-12-16
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.05 Å)
主引用文献Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors.
Bioorg.Med.Chem., 29, 2020
6LJ7
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BU of 6lj7 by Molmil
Crystal structure of NDM-1 in complex with D-captopril derivative wss05010
分子名称: 2-[1-[(2S)-2-methyl-3-sulfanyl-propanoyl]piperidin-4-yl]ethanamide, Metallo-beta-lactamase type 2, ZINC ION
著者Zhang, H, Ma, G.
登録日2019-12-13
公開日2020-12-16
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.16 Å)
主引用文献Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors.
Bioorg.Med.Chem., 29, 2020
6LL9
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BU of 6ll9 by Molmil
Crystal structure of D-alanine-D-alanine ligase from Aeromonas hydrophila
分子名称: D-ALANINE, D-alanine--D-alanine ligase
著者Zhang, H.
登録日2019-12-22
公開日2020-07-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Insights into the Inhibition ofAeromonas hydrophilad-Alanine-d-Alanine Ligase by Integration of Kinetics and Structural Analysis.
J.Agric.Food Chem., 68, 2020
4E2P
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BU of 4e2p by Molmil
Crystal Structure of a Post-tailoring Hydroxylase (HmtN) Involved in the Himastatin Biosynthesis
分子名称: Cytochrome P450 107B1 (P450CVIIB1), MAGNESIUM ION, PROTOPORPHYRIN IX CONTAINING FE
著者Zhang, H.D, Chen, J, Wang, H, Huang, L, Zhang, H.J.
登録日2012-03-09
公開日2013-03-13
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.36 Å)
主引用文献Crystal Structure of a Post-tailoring Hydroxylase (HmtN) Involved in the Himastatin Biosynthesis
To be Published
4TMF
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BU of 4tmf by Molmil
Crystal structure of human CD38 in complex with hydrolysed compound JMS713
分子名称: 5-O-[(R)-{[(S)-[4-(8-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)butoxy](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-alpha-D- ribofuranose, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
著者Zhang, H, Swarbrick, J, Potter, B, Hao, Q.
登録日2014-06-01
公開日2015-05-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Cyclic adenosine 5'-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38.
J.Med.Chem., 57, 2014
1HS8
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BU of 1hs8 by Molmil
SOLUTION STRUCTURE OF RNA HAIRPIN LOOP UCAAUU AS PART OF HAIRPIN R(GCGUCAAUUCGCA)
分子名称: 5'-R(*GP*CP*GP*UP*CP*AP*AP*UP*UP*CP*GP*CP*A)-3'
著者Zhang, H, Ricart, B, Huck, M, Krugh, T.R.
登録日2000-12-25
公開日2003-09-02
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structural Characterization of Six-Nucleotide RNA Hairpin loops r(UCAAUU)
To be Published
1HS2
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BU of 1hs2 by Molmil
SOLUTION STRUCTURE OF RNA HAIRPIN LOOP UUAAGU AS PART OF HAIRPIN R(GCGUUAAGUCGCA)
分子名称: 5'-R(*GP*CP*GP*UP*UP*AP*AP*GP*UP*CP*GP*CP*A)-3'
著者Zhang, H, Fountain, M.A, Krugh, T.R.
登録日2000-12-22
公開日2001-08-29
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structural characterization of a six-nucleotide RNA hairpin loop found in Escherichia coli, r(UUAAGU).
Biochemistry, 40, 2001
6OYC
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BU of 6oyc by Molmil
Glycosylation Associate Protein (Gap123) complex from Streptococcus agalactiae
分子名称: GLYCEROL, Glycosylation Associate Protein 1, Glycosylation Associate Protein 2, ...
著者zhang, H, Wu, H.
登録日2019-05-14
公開日2020-05-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.351 Å)
主引用文献Glycosylation Associate Protein (Gap123) complex from Streptococcus agalactiae
To Be Published
3OFS
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BU of 3ofs by Molmil
Dynamic conformations of the CD38-mediated NAD cyclization captured using multi-copy crystallography
分子名称: ADP-ribosyl cyclase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
著者Zhang, H, Lee, H.C, Hao, Q.
登録日2010-08-16
公開日2010-12-15
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Dynamic Conformations of the CD38-Mediated NAD Cyclization Captured in a Single Crystal
J.Mol.Biol., 405, 2011
4GGV
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BU of 4ggv by Molmil
Crystal Structure of HmtT Involved in Himastatin Biosynthesis
分子名称: Cytochrome P450 superfamily protein, PROTOPORPHYRIN IX CONTAINING FE
著者Zhang, H, Chen, J, Wang, H, Zhang, H.
登録日2012-08-07
公開日2013-07-17
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.331 Å)
主引用文献Structural analysis of HmtT and HmtN involved in the tailoring steps of himastatin biosynthesis
Febs Lett., 587, 2013
5H21
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BU of 5h21 by Molmil
Trimethoxy-ring inhibitor in complex with the first bromodomain of BRD4
分子名称: 3,4,5-trimethoxy-~{N}-(2-thiophen-2-ylethyl)benzamide, Bromodomain-containing protein 4
著者Zhang, H, Luo, C.
登録日2016-10-13
公開日2017-07-05
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.591 Å)
主引用文献Discovery of novel trimethoxy-ring BRD4 bromodomain inhibitors: AlphaScreen assay, crystallography and cell-based assay.
Medchemcomm, 8, 2017
4HFK
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BU of 4hfk by Molmil
Crystal structure of the type VI effector-immunity complex Tae4-Tai4 from Enterobacter cloacae
分子名称: Putative cytoplasmic protein, Putative uncharacterized protein, SULFATE ION
著者Zhang, H, Gao, Z.Q, Dong, Y.H.
登録日2012-10-05
公開日2013-01-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of the type VI effector-immunity complex (Tae4-Tai4) provides novel insights into the inhibition mechanism of the effector by its immunity protein.
J.Biol.Chem., 288, 2013
5NBG
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BU of 5nbg by Molmil
Structure of the cytoplasmic domain I of OutF in the D. dadantii type II secretion system
分子名称: General secretion pathway protein F
著者Zhang, H, Gu, S.
登録日2017-03-01
公開日2018-03-21
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structure of the first cytoplasmic domain of OutF and assembly of the inner-membrane platform proteins of the D. dadantii type II secretion system
To Be Published
5GS5
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BU of 5gs5 by Molmil
Crystal structure of apo rat STING
分子名称: SULFATE ION, Stimulator of interferon genes protein
著者Zhang, H, Han, M.J, Tao, J.L, Ye, Z.Y, Du, X.X, Deng, M.J, Zhang, X.Y, Li, L.F, Jiang, Z.F, Su, X.D.
登録日2016-08-13
公開日2017-10-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Crystal structure of apo ratSTING
To Be Published
5E09
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BU of 5e09 by Molmil
Structural Insight of a Trimodular Halophilic Cellulase with a Family 46 Carbohydrate-Binding Module
分子名称: Cellulase
著者Zhang, H.J, Zhang, H.D.
登録日2015-09-28
公開日2016-10-05
実験手法X-RAY DIFFRACTION (2.347 Å)
主引用文献Structural Insight of a Trimodular Halophilic Cellulase with a Family 46 Carbohydrate-Binding Module
To Be Published
5E0C
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BU of 5e0c by Molmil
Structural Insight of a Trimodular Halophilic Cellulase with a Family 46 Carbohydrate-Binding Module
分子名称: Cellulase
著者Zhang, H.D, Zhang, H.J.
登録日2015-09-28
公開日2016-10-05
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.351 Å)
主引用文献Structural Insight of a Trimodular Halophilic Cellulase with a Family 46 Carbohydrate-Binding Module
To Be Published
4HFF
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BU of 4hff by Molmil
Crystal structure of the type VI effector-immunity complex Tae4-Tai4 from Salmonella Typhimurium
分子名称: Putative cytoplasmic protein, Putative periplasmic protein
著者Zhang, H, Gao, Z.Q, Dong, Y.H.
登録日2012-10-05
公開日2013-01-16
最終更新日2013-07-24
実験手法X-RAY DIFFRACTION (2.398 Å)
主引用文献Structure of the type VI effector-immunity complex (Tae4-Tai4) provides novel insights into the inhibition mechanism of the effector by its immunity protein
J.Biol.Chem., 288, 2013
6OAW
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BU of 6oaw by Molmil
Crystal structure of a CRISPR Cas-related protein
分子名称: UNKNOWN ATOM OR ION, WYL1
著者Zhang, H, Dong, C, Li, L, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium, Structural Genomics Consortium (SGC)
登録日2019-03-18
公開日2019-04-10
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural insights into the modulatory role of the accessory protein WYL1 in the Type VI-D CRISPR-Cas system.
Nucleic Acids Res., 47, 2019
4HFL
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BU of 4hfl by Molmil
Crystal structure of the type VI effector Tae4 from Enterobacter cloacae
分子名称: Putative cytoplasmic protein
著者Zhang, H, Gao, Z.Q, Dong, Y.H.
登録日2012-10-05
公開日2013-01-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.002 Å)
主引用文献Structure of the type VI effector-immunity complex (Tae4-Tai4) provides novel insights into the inhibition mechanism of the effector by its immunity protein.
J.Biol.Chem., 288, 2013
8I87
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BU of 8i87 by Molmil
Cryo-EM structure of TIR-APAZ/Ago-gRNA-DNA complex
分子名称: DNA (5'-D(P*TP*AP*TP*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*A)-3'), MAGNESIUM ION, Piwi domain-containing protein, ...
著者Zhang, H, Deng, Z.Q, Yu, G.M, Li, X.Z, Wang, X.S.
登録日2023-02-03
公開日2023-07-19
最終更新日2023-09-13
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity.
Cell Res., 33, 2023
5F1K
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BU of 5f1k by Molmil
human CD38 in complex with nanobody MU1053
分子名称: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, nanobody MU1053
著者Zhang, H, Hao, Q.
登録日2015-11-30
公開日2016-06-15
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Immuno-targeting the multifunctional CD38 using nanobody
Sci Rep, 6, 2016
8GS4
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BU of 8gs4 by Molmil
Cryo-EM structure of human Neuroligin 2
分子名称: Neuroligin-2
著者Zhang, H, Zhang, Z, Hou, M.
登録日2022-09-04
公開日2023-03-01
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders.
Front Endocrinol, 13, 2022
8GS3
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BU of 8gs3 by Molmil
Cryo-EM structure of human Neuroligin 3
分子名称: Neuroligin-3
著者Zhang, H, Zhang, Z, Hou, M.
登録日2022-09-04
公開日2023-09-20
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders.
Front Endocrinol, 13, 2022

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