8ISS
 
 | | Cryo-EM structure of wild-type human tRNA Splicing Endonuclease Complex bound to pre-tRNA-ARG at 3.19 A resolution | | Descriptor: | MAGNESIUM ION, RNA (88-MER), tRNA-splicing endonuclease subunit Sen15, ... | | Authors: | Sun, Y, Zhang, Y, Yuan, L, Han, Y. | | Deposit date: | 2023-03-21 | | Release date: | 2023-10-18 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Recognition and cleavage mechanism of intron-containing pre-tRNA by human TSEN endonuclease complex.
Nat Commun, 14, 2023
|
|
6J0G
 | | Crystal structure of intracellular B30.2 domain of BTN3A3 mutant in complex with HMBPP | | Descriptor: | (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate, Butyrophilin subfamily 3 member A3 | | Authors: | Yang, Y.Y, Liu, W.D, Cai, N.N, Chen, C.C, Guo, R.T, Zhang, Y.H. | | Deposit date: | 2018-12-24 | | Release date: | 2019-04-03 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated V gamma 9V delta 2 T Cell Activation.
Immunity, 50, 2019
|
|
6J06
 | | Crystal structure of intracellular B30.2 domain of BTN3A1 in complex with HMBPP-08 | | Descriptor: | (2E)-3-(hydroxymethyl)-4-(4-methylphenyl)but-2-en-1-yl trihydrogen diphosphate, Butyrophilin subfamily 3 member A1, CALCIUM ION, ... | | Authors: | Yang, Y.Y, Liu, W.D, Cai, N.N, Chen, C.C, Guo, R.T, Zhang, Y.H. | | Deposit date: | 2018-12-21 | | Release date: | 2019-04-03 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated V gamma 9V delta 2 T Cell Activation.
Immunity, 50, 2019
|
|
7ESI
 | | Crystal structure of the collagenase unit of a Vibrio collagenase from Vibrio harveyi VHJR7 at 1. 8 angstrom resolution. | | Descriptor: | CALCIUM ION, Collagenase unit (CU), Peptide P1, ... | | Authors: | Cao, H.Y, Wang, Y, Peng, M, Zhang, Y.Z. | | Deposit date: | 2021-05-11 | | Release date: | 2022-02-09 | | Last modified: | 2023-02-22 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure of Vibrio collagenase VhaC provides insight into the mechanism of bacterial collagenolysis.
Nat Commun, 13, 2022
|
|
8IMZ
 | | Cryo-EM structure of mouse Piezo1-MDFIC complex (composite map) | | Descriptor: | MyoD family inhibitor domain-containing protein, Piezo-type mechanosensitive ion channel component 1 | | Authors: | Zhou, Z, Ma, X, Lin, Y, Cheng, D, Bavi, N, Li, J.V, Sutton, D, Yao, M, Harvey, N, Corry, B, Zhang, Y, Cox, C.D. | | Deposit date: | 2023-03-07 | | Release date: | 2023-08-09 | | Last modified: | 2023-08-30 | | Method: | ELECTRON MICROSCOPY (3.66 Å) | | Cite: | MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels.
Science, 381, 2023
|
|
7FIN
 | | Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GIPR-Gs complex | | Descriptor: | CHOLESTEROL, GAMMA-L-GLUTAMIC ACID, Gastric inhibitory polypeptide receptor,human glucose-dependent insulinotropic polypeptide receptor, ... | | Authors: | Zhao, F.h, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W. | | Deposit date: | 2021-07-31 | | Release date: | 2022-02-23 | | Last modified: | 2022-03-16 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Nat Commun, 13, 2022
|
|
6IXJ
 | | The crystal structure of sulfoacetaldehyde reductase from Klebsiella oxytoca | | Descriptor: | 2-hydroxyethylsulfonic acid, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Sulfoacetaldehyde reductase | | Authors: | Zhou, Y, Xu, T, Lin, L, Zhang, Y, Yuchi, Z. | | Deposit date: | 2018-12-10 | | Release date: | 2019-02-13 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Biochemical and structural investigation of sulfoacetaldehyde reductase fromKlebsiella oxytoca.
Biochem. J., 476, 2019
|
|
7FIY
 | | Cryo-EM structure of the tirzepatide-bound human GIPR-Gs complex | | Descriptor: | CHOLESTEROL, Gastric inhibitory polypeptide receptor,Gastric inhibitory polypeptide receptor,human glucose-dependent insulinotropic polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Zhao, F.H, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W. | | Deposit date: | 2021-08-01 | | Release date: | 2022-03-02 | | Last modified: | 2022-03-16 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Nat Commun, 13, 2022
|
|
7EPX
 | | S protein of SARS-CoV-2 in complex with GW01 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | Authors: | Shen, Y.P, Zhang, Y.Y, Yan, R.H, Li, Y.N, Zhou, Q. | | Deposit date: | 2021-04-28 | | Release date: | 2022-05-18 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses.
Cell Discov, 8, 2022
|
|
7FIM
 | | Cryo-EM structure of the tirzepatide (LY3298176)-bound human GLP-1R-Gs complex | | Descriptor: | Glucagon-like peptide 1 receptor,Glucagon-like peptide 1 receptor,Glucagon-like peptide 1 receptor,Glucagon-like peptide 1 receptor,human glucagon like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Zhao, F.H, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W. | | Deposit date: | 2021-07-31 | | Release date: | 2022-03-02 | | Last modified: | 2022-03-16 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Nat Commun, 13, 2022
|
|
8UWU
 | | EmrE structure in the proton-bound state (WT/L51I heterodimer) | | Descriptor: | SMR family multidrug efflux protein EmrE | | Authors: | Li, J, Sae Her, A, Besch, A, Ramirez, B, Crames, M, Banigan, J.R, Mueller, C, Marsiglia, W.M, Zhang, Y, Traaseth, N.J. | | Deposit date: | 2023-11-08 | | Release date: | 2024-05-29 | | Method: | SOLID-STATE NMR, SOLUTION NMR | | Cite: | Molecular Basis of Drug Recognition by EmrE
To Be Published
|
|
5Y1K
 | | Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-(3-(2-chlorobenzyl)ureido)-N-hydroxy-4-methylpentanamide | | Descriptor: | (2S)-2-[(2-chlorophenyl)methylcarbamoylamino]-4-methyl-N-oxidanyl-pentanamide, GLYCEROL, M1 family aminopeptidase, ... | | Authors: | Marapaka, A.K, Zhang, Y, Addlagatta, A. | | Deposit date: | 2017-07-20 | | Release date: | 2018-08-01 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | Development of peptidomimetic hydroxamates as PfA-M1 and PfA-M17 dual inhibitors: Biological evaluation and structural characterization by cocrystallization
Chin.Chem.Lett., 33, 2022
|
|
5YPS
 | | The structural basis of histone chaperoneVps75 | | Descriptor: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | Authors: | Chen, Y, Zhang, Y, Dou, Y, Wang, M, Xu, S, Jiang, H, Limper, A, Su, D. | | Deposit date: | 2017-11-03 | | Release date: | 2018-11-07 | | Last modified: | 2020-06-10 | | Method: | X-RAY DIFFRACTION (2.097 Å) | | Cite: | Structural basis for the acetylation of histone H3K9 and H3K27 mediated by the histone chaperone Vps75 inPneumocystis carinii.
Signal Transduct Target Ther, 4, 2019
|
|
5Y1Q
 | | Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-(3-(3-chlorobenzyl)ureido)-N-hydroxy-4-methylpentanamide | | Descriptor: | (2S)-2-[(3-chlorophenyl)methylcarbamoylamino]-4-methyl-N-oxidanyl-pentanamide, M1 family aminopeptidase, MAGNESIUM ION, ... | | Authors: | Marapaka, A.K, Zhang, Y, Addlagatta, A. | | Deposit date: | 2017-07-21 | | Release date: | 2018-08-01 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Development of peptidomimetic hydroxamates as PfA-M1 and PfA-M17 dual inhibitors: Biological evaluation and structural characterization by cocrystallization
Chin.Chem.Lett., 33, 2022
|
|
4QC2
 | | Crystal structure of lipopolysaccharide transport protein LptB in complex with ATP and Magnesium ions | | Descriptor: | ABC transporter related protein, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | | Authors: | Wang, Z, Xiang, Q, Zhu, X, Dong, H, He, C, Wang, H, Zhang, Y, Wang, W, Dong, C. | | Deposit date: | 2014-05-09 | | Release date: | 2014-10-22 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | Structural and functional studies of conserved nucleotide-binding protein LptB in lipopolysaccharide transport.
Biochem.Biophys.Res.Commun., 452, 2014
|
|
6JIX
 | | The cyrstal structure of taurine:2-oxoglutarate aminotransferase from Bifidobacterium kashiwanohense, in complex with PLP and glutamate | | Descriptor: | GLUTAMIC ACID, PYRIDOXAL-5'-PHOSPHATE, taurine:2-oxoglutarate aminotransferase | | Authors: | Li, M, Lin, L, Zhang, Y, Yuchi, Z. | | Deposit date: | 2019-02-23 | | Release date: | 2020-01-01 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.647 Å) | | Cite: | Biochemical and structural investigation of taurine:2-oxoglutarate aminotransferase fromBifidobacterium kashiwanohense.
Biochem.J., 476, 2019
|
|
7FCV
 | | Cryo-EM structure of the Potassium channel AKT1 mutant from Arabidopsis thaliana | | Descriptor: | PHOSPHATIDYLETHANOLAMINE, POTASSIUM ION, Potassium channel AKT1 | | Authors: | Yang, G.H, Lu, Y.M, Jia, Y.T, Zhang, Y.M, Tang, R.F, Xu, X, Li, X.M, Lei, J.L. | | Deposit date: | 2021-07-15 | | Release date: | 2022-11-09 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural basis for the activity regulation of a potassium channel AKT1 from Arabidopsis.
Nat Commun, 13, 2022
|
|
7FIH
 | | luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs-Org43553 complex | | Descriptor: | 5-azanyl-N-tert-butyl-2-methylsulfanyl-4-[3-(2-morpholin-4-ylethanoylamino)phenyl]thieno[2,3-d]pyrimidine-6-carboxamide, Choriogonadotropin subunit beta 3, Engineered Guanine nucleotide-binding protein G(s) subunit alpha, ... | | Authors: | Duan, J, Xu, P, Cheng, X, Mao, C, Croll, T, He, X, Shi, J, Luan, X, Yin, W, You, E, Liu, Q, Zhang, S, Jiang, H, Zhang, Y, Jiang, Y, Xu, H.E. | | Deposit date: | 2021-07-31 | | Release date: | 2021-09-29 | | Last modified: | 2022-02-16 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structures of full-length glycoprotein hormone receptor signalling complexes.
Nature, 598, 2021
|
|
7FII
 | | luteinizing hormone/choriogonadotropin receptor-chorionic gonadotropin-Gs complex | | Descriptor: | Choriogonadotropin subunit beta 3, Engineered Guanine nucleotide-binding protein G(s) subunit alpha, Glycoprotein hormones alpha chain, ... | | Authors: | Duan, J, Xu, P, Cheng, X, Mao, C, Croll, T, He, X, Shi, J, Luan, X, Yin, W, You, E, Liu, Q, Zhang, S, Jiang, H, Zhang, Y, Jiang, Y, Xu, H.E. | | Deposit date: | 2021-07-31 | | Release date: | 2021-09-29 | | Last modified: | 2022-02-16 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Structures of full-length glycoprotein hormone receptor signalling complexes.
Nature, 598, 2021
|
|
7FIG
 | | luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Camelid antibody VHH fragment Nb35, Choriogonadotropin subunit beta 3, ... | | Authors: | Duan, J, Xu, P, Cheng, X, Mao, C, Croll, T, He, X, Shi, J, Luan, X, Yin, W, You, E, Liu, Q, Zhang, S, Jiang, H, Zhang, Y, Jiang, Y, Xu, H.E. | | Deposit date: | 2021-07-31 | | Release date: | 2021-09-29 | | Last modified: | 2022-02-16 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structures of full-length glycoprotein hormone receptor signalling complexes.
Nature, 598, 2021
|
|
6IVP
 | | Crystal structure of a membrane protein P262A | | Descriptor: | CHLORIDE ION, ZINC ION, bestrophin | | Authors: | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | | Deposit date: | 2018-12-04 | | Release date: | 2019-11-06 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations.
Commun Biol, 2, 2019
|
|
6IVN
 | | Crystal structure of a membrane protein G264A | | Descriptor: | CHLORIDE ION, GLUTAMIC ACID, Ibestrophin, ... | | Authors: | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | | Deposit date: | 2018-12-04 | | Release date: | 2019-11-06 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations.
Commun Biol, 2, 2019
|
|
6IVL
 | | Crystal structure of a membrane protein L259A | | Descriptor: | ACETIC ACID, CHLORIDE ION, Ibestrophin, ... | | Authors: | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | | Deposit date: | 2018-12-04 | | Release date: | 2019-11-06 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations.
Commun Biol, 2, 2019
|
|
6IVJ
 | | Crystal structure of a membrane protein G18A | | Descriptor: | ACETIC ACID, CHLORIDE ION, Ibestrophin, ... | | Authors: | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | | Deposit date: | 2018-12-04 | | Release date: | 2019-11-06 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.77 Å) | | Cite: | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations.
Commun Biol, 2, 2019
|
|
7EU0
 | | The cryo-EM structure of A. thaliana Pol IV-RDR2 backtracked complex | | Descriptor: | DNA (33-MER), DNA (5'-D(*CP*TP*GP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*GP*AP*GP*TP*G)-3'), DNA-directed RNA polymerase IV subunit 1, ... | | Authors: | Fang, C.L, Wu, X.X, Huang, K, Zhang, Y. | | Deposit date: | 2021-05-15 | | Release date: | 2021-12-29 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | Pol IV and RDR2: A two-RNA-polymerase machine that produces double-stranded RNA.
Science, 374, 2021
|
|
