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PDB: 1659 件
7V1U
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Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor ZJ12
分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N}-(3-ethyl-6-methoxy-1,2-benzoxazol-5-yl)-2-methoxy-benzenesulfonamide
著者Zhang, M, Wang, C, Zhang, C, Zhang, Y, Xu, Y.
登録日2021-08-06
公開日2022-08-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia.
Acta Pharmacol.Sin., 43, 2022
4WVX
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Crystal structure of a phosphotriesterase-like lactonase Gkap in native form
分子名称: 1,2-ETHANEDIOL, COBALT (II) ION, Phosphotriesterase
著者An, J, Zhang, Y, Yang, G.Y, Feng, Y.
登録日2014-11-07
公開日2015-11-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Engineering a thermostable lactonase for enhanced phosphotriesterase activity against organophosphate pesticides
To Be Published
7V2J
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BU of 7v2j by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor 33
分子名称: Bromodomain-containing protein 4, ~{N}-(3-ethyl-6-methoxy-1,2-benzoxazol-5-yl)-4-methoxy-benzenesulfonamide
著者Zhang, M, Wang, C, Zhang, C, Zhang, Y, Xu, Y.
登録日2021-08-09
公開日2022-08-17
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia.
Acta Pharmacol.Sin., 43, 2022
1ZUT
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BU of 1zut by Molmil
Crystal Structure Of Mutant K8DP9SR58K Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch
分子名称: Alpha-like neurotoxin BmK-I, SULFATE ION
著者Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J.
登録日2005-06-01
公開日2006-05-23
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1
J.Mol.Biol., 353, 2005
4KON
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The structure of hemagglutinin from avian-origin H7N9 influenza virus in complex with human receptor analog 6'SLNLN (NeuAcα2-6Galβ1-4GlcNAcβ1-3Galβ1-4Glc)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, Hemagglutinin HA2, ...
著者Shi, Y, Zhang, W, Wang, F, Qi, J, Song, H, Wu, Y, Gao, F, Zhang, Y, Fan, Z, Gong, W, Wang, D, Shu, Y, Wang, Y, Yan, J, Gao, G.F.
登録日2013-05-12
公開日2013-11-06
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses.
Science, 342, 2013
8DO5
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BU of 8do5 by Molmil
Crystal structure of NahE in complex with intermediate (R)-4-hydroxy-4-(2-hydroxyphenyl)-2-iminobutanoate
分子名称: (4R)-4-hydroxy-4-(2-hydroxyphenyl)butanoic acid, DIMETHYL SULFOXIDE, Trans-ohydrobenzylidenepyruvate hydratase aldolase
著者LeVieux, J.A, Hardtke, H.A, Zhang, Y.J.
登録日2022-07-12
公開日2022-12-28
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A mutagenic analysis of NahE, a hydratase-aldolase in the naphthalene degradative pathway.
Arch.Biochem.Biophys., 733, 2023
1ZXC
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BU of 1zxc by Molmil
Crystal structure of catalytic domain of TNF-alpha converting enzyme (TACE) with inhibitor
分子名称: (3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE, ADAM 17, ZINC ION
著者Levin, J.I, Chen, J.M, Laakso, L.M, Du, M, Schmid, J, Xu, W, Cummons, T, Xu, J, Zhang, Y, Jin, G, Cowling, R, Barone, D, Skotnicki, J.S.
登録日2005-06-07
公開日2005-09-27
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates.
Bioorg.Med.Chem.Lett., 15, 2005
1ZYV
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Crystal Structure Of Mutant K8DP9SR58KV59G Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch
分子名称: Alpha-like neurotoxin BmK-I
著者Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J.
登録日2005-06-12
公開日2006-05-23
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1
J.Mol.Biol., 353, 2005
1ZU3
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Crystal Structure Of Mutant K8A Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch
分子名称: Alpha-like neurotoxin BmK-I
著者Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J.
登録日2005-05-30
公開日2006-05-23
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1
J.Mol.Biol., 353, 2005
1ZVE
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Crystal Structure Of Mutant K8G Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch
分子名称: ACETATE ION, Alpha-like neurotoxin BmK-I
著者Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J.
登録日2005-06-01
公開日2006-05-23
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1
J.Mol.Biol., 353, 2005
1ZCN
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human Pin1 Ng mutant
分子名称: PENTAETHYLENE GLYCOL, PHOSPHATE ION, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
著者Jager, M, Zhang, Y, Nguyen, H, Dendel, G, Bowman, M.E, Gruebele, M, Noel, J.P, Kelly, J.W.
登録日2005-04-12
公開日2006-06-20
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure-function-folding relationship in a WW domain.
Proc.Natl.Acad.Sci.Usa, 103, 2006
4LKH
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BU of 4lkh by Molmil
The structure of hemagglutinin from a avian-origin H7N9 influenza virus (A/Shanghai/1/2013) in complex with human receptor analog 6'SLNLN
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetyl-alpha-neuraminic acid, hemagglutinin
著者Shi, Y, Zhang, W, Wang, F, Qi, J, Song, H, Wu, Y, Gao, F, Zhang, Y, Fan, Z, Gong, W, Wang, D, Shu, Y, Wang, Y, Yan, J, Gao, G.F.
登録日2013-07-07
公開日2013-11-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.099 Å)
主引用文献Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses
Science, 342, 2013
4LCX
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BU of 4lcx by Molmil
The structure of hemagglutinin from avian-origin H7N9 influenza virus (A/Shanghai/1/2013)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, Hemagglutinin HA2
著者Shi, Y, Zhang, W, Wang, F, Qi, J, Song, H, Wu, Y, Gao, F, Zhang, Y, Fan, Z, Gong, W, Wang, D, Shu, Y, Wang, Y, Yan, J, Gao, G.F.
登録日2013-06-24
公開日2013-11-06
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.094 Å)
主引用文献Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses.
Science, 342, 2013
4LKJ
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BU of 4lkj by Molmil
The structure of hemagglutinin L226Q mutant (H3 numbering) from a avian-origin H7N9 influenza virus (A/Anhui/1/2013) in complex with avian receptor analog 3'SLNLN
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, hemagglutinin
著者Shi, Y, Zhang, W, Wang, F, Qi, J, Song, H, Wu, Y, Gao, F, Zhang, Y, Fan, Z, Gong, W, Wang, D, Shu, Y, Wang, Y, Yan, J, Gao, G.F.
登録日2013-07-07
公開日2013-11-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.798 Å)
主引用文献Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses
Science, 342, 2013
7V9G
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BU of 7v9g by Molmil
Native BEN4 domain of protein Bend3 with DNA
分子名称: BEN domain-containing protein 3, DNA (5'-D(*GP*CP*AP*CP*CP*GP*CP*GP*TP*GP*GP*GP*GP*CP*CP*A)-3'), DNA (5'-D(*TP*GP*GP*CP*CP*CP*CP*AP*CP*GP*CP*GP*GP*TP*GP*C)-3')
著者Zhang, J, Zhang, Y, You, Q, Huang, C, Zhang, T, Wang, M, Zhang, T, Yang, X, Xiong, J, Li, Y, Liu, C.P, Zhang, Z, Xu, R.M, Zhu, B.
登録日2021-08-25
公開日2022-02-16
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation.
Science, 375, 2022
7V9I
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The Monomer mutant of BEN4 domain of protein Bend3 with DNA
分子名称: BEN domain-containing protein 3, DNA (5'-D(*AP*CP*CP*GP*CP*GP*TP*GP*GP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*CP*CP*AP*CP*GP*CP*GP*GP*T)-3')
著者Zhang, J, Zhang, Y, You, Q, Huang, C, Zhang, T, Wang, M, Zhang, T, Yang, X, Xiong, J, Li, Y, Liu, C.P, Zhang, Z, Xu, R.M, Zhu, B.
登録日2021-08-25
公開日2022-02-16
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation.
Science, 375, 2022
7V9H
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The BEN3 domain of protein Bend3
分子名称: BEN domain-containing protein 3
著者Zhang, J, Zhang, Y, You, Q, Huang, C, Zhang, T, Wang, M, Zhang, T, Yang, X, Xiong, J, Li, Y, Liu, C.P, Zhang, Z, Xu, R.M, Zhu, B.
登録日2021-08-25
公開日2022-02-16
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.692 Å)
主引用文献Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation.
Science, 375, 2022
7V9F
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Selenomethionine mutant (L740Sem) of BEN4 domain of protein Bend3 with DNA
分子名称: BEN domain-containing protein 3, CITRIC ACID, DNA (5'-D(*GP*CP*AP*CP*CP*GP*CP*GP*TP*GP*GP*GP*GP*CP*CP*A)-3'), ...
著者Zhang, J, Zhang, Y, You, Q, Huang, C, Zhang, T, Wang, M, Zhang, T, Yang, X, Xiong, J, Li, Y, Liu, C.P, Zhang, Z, Xu, R.M, Zhu, B.
登録日2021-08-25
公開日2022-02-16
最終更新日2022-03-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation.
Science, 375, 2022
3J8G
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BU of 3j8g by Molmil
Electron cryo-microscopy structure of EngA bound with the 50S ribosomal subunit
分子名称: 23S rRNA, 50S ribosomal protein L1, 50S ribosomal protein L11, ...
著者Zhang, X, Yan, K, Zhang, Y, Li, N, Ma, C, Li, Z, Zhang, Y, Feng, B, Liu, J, Sun, Y, Xu, Y, Lei, J, Gao, N.
登録日2014-10-24
公開日2014-11-26
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (5 Å)
主引用文献Structural insights into the function of a unique tandem GTPase EngA in bacterial ribosome assembly
Nucleic Acids Res., 2014
4LKG
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The structure of hemagglutinin from a avian-origin H7N9 influenza virus (A/Shanghai/1/2013) in complex with avian receptor analog 3'SLNLN
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Shi, Y, Zhang, W, Wang, F, Qi, J, Song, H, Wu, Y, Gao, F, Zhang, Y, Fan, Z, Gong, W, Wang, D, Shu, Y, Wang, Y, Yan, J, Gao, G.F.
登録日2013-07-07
公開日2013-11-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.994 Å)
主引用文献Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses
Science, 342, 2013
4LKK
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The structure of hemagglutinin L226Q mutant (H3 numbering) from a avian-origin H7N9 influenza virus (A/Anhui/1/2013) in complex with human receptor analog 6'SLNLN
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose, hemagglutinin
著者Shi, Y, Zhang, W, Wang, F, Qi, J, Song, H, Wu, Y, Gao, F, Zhang, Y, Fan, Z, Gong, W, Wang, D, Shu, Y, Wang, Y, Yan, J, Gao, G.F.
登録日2013-07-07
公開日2013-11-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.491 Å)
主引用文献Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses
Science, 342, 2013
7VBH
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BU of 7vbh by Molmil
Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GLP-1R-Gs complex
分子名称: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhao, F.H, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W.
登録日2021-08-31
公開日2022-04-06
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Nat Commun, 13, 2022
3BGW
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The Structure Of A DnaB-Like Replicative Helicase And Its Interactions With Primase
分子名称: DNAB-Like Replicative Helicase
著者Wang, G, Klein, M.G, Tokonzaba, E, Zhang, Y, Holden, L.G, Chen, X.S.
登録日2007-11-27
公開日2007-12-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.91 Å)
主引用文献The structure of a DnaB-family replicative helicase and its interactions with primase.
Nat.Struct.Mol.Biol., 15, 2008
4LKI
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The structure of hemagglutinin L226Q mutant from a avian-origin H7N9 influenza virus (A/Anhui/1/2013)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, hemagglutinin
著者Shi, Y, Zhang, W, Wang, F, Qi, J, Song, H, Wu, Y, Gao, F, Zhang, Y, Fan, Z, Gong, W, Wang, D, Shu, Y, Wang, Y, Yan, J, Gao, G.F.
登録日2013-07-07
公開日2013-11-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses
Science, 342, 2013
3CIU
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Site-Selective Glycosylation of Cysteine-93 beta on the Surface of Bovine Hemoglobin and its Application as a Novel Oxygen Therapeutic
分子名称: 5-(2,5-dioxopyrrolidin-1-yl)-N-[2-(2-{2-[(4-O-alpha-D-idopyranosyl-alpha-D-mannopyranosyl)oxy]ethoxy}ethoxy)ethyl]pentanamide, Hemoglobin subunit alpha, Hemoglobin subunit beta, ...
著者Bhatt, V.S, Zhang, Y, Sun, G, Wang, P.G, Palmer, A.F.
登録日2008-03-11
公開日2008-04-15
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Site-Selective Glycosylation of Cysteine-93 beta on the Surface of Bovine Hemoglobin and its Application as a Novel Oxygen Therapeutic
To be Published

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