6GWH
 
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6FHZ
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8V65
 | | Nanorana parkeri saxiphilin:dcGTX2 (co-crystal) | | Descriptor: | (3aS,4R,7R,9R,10aS)-2,6-diamino-10,10-dihydroxy-4-(hydroxymethyl)-3a,4,9,10-tetrahydro-1H,8H-pyrrolo[1,2-c]purin-9-yl hydrogen sulfate, PENTAETHYLENE GLYCOL, Saxiphilin | | Authors: | Zakrzewska, S, Minor, D.L. | | Deposit date: | 2023-12-01 | | Release date: | 2025-05-07 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins.
Nat Commun, 16, 2025
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8V69
 | | Nanorana parkeri saxiphilin:GTX2 (co-crystal) | | Descriptor: | PENTAETHYLENE GLYCOL, Saxiphilin, [(3aS,4R,7R,9R,10aS)-2,6-diamino-10,10-dihydroxy-9-(sulfooxy)-3a,4,9,10-tetrahydro-1H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate | | Authors: | Zakrzewska, S, Minor, D.L. | | Deposit date: | 2023-12-01 | | Release date: | 2025-05-07 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins.
Nat Commun, 16, 2025
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8V67
 | | Nanorana parkeri saxiphilin:C1 (co-crystal) | | Descriptor: | ({[(3aS,4R,7R,9R,10aS)-2,6-diamino-10,10-dihydroxy-9-(sulfooxy)-3a,4,9,10-tetrahydro-1H,8H-pyrrolo[1,2-c]purin-4-yl]methoxy}carbonyl)sulfamic acid, PENTAETHYLENE GLYCOL, Saxiphilin | | Authors: | Zakrzewska, S, Minor, D.L. | | Deposit date: | 2023-12-01 | | Release date: | 2025-05-07 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins.
Nat Commun, 16, 2025
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8V68
 | | Nanorana parkeri saxiphilin:dcSTX (co-crystal) | | Descriptor: | (3aS,4R,7R,10aS)-2,6-diamino-4-(hydroxymethyl)-3a,4,8,9-tetrahydro-1H,10H-pyrrolo[1,2-c]purine-10,10-diol, PENTAETHYLENE GLYCOL, Saxiphilin | | Authors: | Zakrzewska, S, Minor, D.L. | | Deposit date: | 2023-12-01 | | Release date: | 2025-05-07 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins.
Nat Commun, 16, 2025
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8V66
 | | Nanorana parkeri saxiphilin:GTX5 (co-crystal) | | Descriptor: | ({[(3aS,4R,7S,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-1H,8H-pyrrolo[1,2-c]purin-4-yl]methoxy}carbonyl)sulfamic acid, PENTAETHYLENE GLYCOL, Saxiphilin | | Authors: | Zakrzewska, S, Minor, D.L. | | Deposit date: | 2023-12-01 | | Release date: | 2025-05-07 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins.
Nat Commun, 16, 2025
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8D6O
 | | Nanorana parkeri saxiphilin:F-STX (soaked) | | Descriptor: | (2P)-4-({6-[({[(3aS,4R,7R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methoxy}carbonyl)amino]hexyl}carbamoyl)-2-{[4aP,9(9a)P]-6-hydroxy-3-oxo-3H-xanthen-9-yl}benzoic acid, PENTAETHYLENE GLYCOL, Saxiphilin | | Authors: | Zakrzewska, S, Chen, Z, Minor, D.L. | | Deposit date: | 2022-06-06 | | Release date: | 2022-11-02 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8D6M
 | | Nanorana parkeri saxiphilin:STX (co-crystal) | | Descriptor: | PENTAETHYLENE GLYCOL, Saxiphilin, [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate | | Authors: | Zakrzewska, S, Chen, Z, Minor, D.L. | | Deposit date: | 2022-06-06 | | Release date: | 2022-11-02 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8D6G
 | | Nanorana parkeri saxiphilin | | Descriptor: | PENTAETHYLENE GLYCOL, Saxiphilin | | Authors: | Zakrzewska, S, Chen, Z, Minor, D.L. | | Deposit date: | 2022-06-06 | | Release date: | 2022-11-02 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.
Proc.Natl.Acad.Sci.USA, 119, 2022
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6HFB
 | | Outward-facing conformation of a multidrug resistance MATE family transporter of the MOP superfamily. | | Descriptor: | CESIUM ION, Uncharacterized protein | | Authors: | Nonaka, T, Zakrzewska, S, Safarian, S, Michel, H. | | Deposit date: | 2018-08-21 | | Release date: | 2019-06-12 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.495 Å) | | Cite: | Inward-facing conformation of a multidrug resistance MATE family transporter.
Proc.Natl.Acad.Sci.USA, 116, 2019
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8D6P
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8D6Q
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8D6S
 | | Rana catesbeiana saxiphilin mutant - Y558A:STX (co-crystal) | | Descriptor: | Saxiphilin, [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate | | Authors: | Chen, Z, Zakrzewska, S, Minor, D.L. | | Deposit date: | 2022-06-06 | | Release date: | 2022-11-02 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8D6U
 | | Rana catesbeiana saxiphilin:F-STX (soaked) | | Descriptor: | (2P)-4-({6-[({[(3aS,4R,7R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methoxy}carbonyl)amino]hexyl}carbamoyl)-2-{[4aP,9(9a)P]-6-hydroxy-3-oxo-3H-xanthen-9-yl}benzoic acid, Saxiphilin | | Authors: | Chen, Z, Zakrzewska, S, Minor, D.L. | | Deposit date: | 2022-06-06 | | Release date: | 2022-11-02 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8D6T
 | | Rana catesbeiana saxiphilin mutant - Y558I:STX (co-crystal) | | Descriptor: | CACODYLATE ION, Saxiphilin, [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate | | Authors: | Chen, Z, Zakrzewska, S, Minor, D.L. | | Deposit date: | 2022-06-06 | | Release date: | 2022-11-02 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.
Proc.Natl.Acad.Sci.USA, 119, 2022
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