8BL0
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![BU of 8bl0 by Molmil](/molmil-images/mine/8bl0) | Human Sirt6 in complex with the inhibitor S6023 and ADP-ribose | 分子名称: | 3-[4-[[5-(2-fluorophenyl)thiophen-2-yl]methyl]piperazin-1-yl]sulfonylbenzenesulfonamide, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | You, W, Steegborn, C. | 登録日 | 2022-11-09 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen To Be Published
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8BL1
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![BU of 8bl1 by Molmil](/molmil-images/mine/8bl1) | Human Sirt6 in complex with the inhibitor S6039 and ADP-ribose | 分子名称: | 2-azanyl-5-[4-[[5-(2-fluorophenyl)thiophen-2-yl]methyl]piperazin-1-yl]sulfonyl-benzenesulfonamide, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | You, W, Steegborn, C. | 登録日 | 2022-11-09 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen To Be Published
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8CNO
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![BU of 8cno by Molmil](/molmil-images/mine/8cno) | |
8CNM
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![BU of 8cnm by Molmil](/molmil-images/mine/8cnm) | |
6QCD
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![BU of 6qcd by Molmil](/molmil-images/mine/6qcd) | Human Sirt6 in complex with ADP-ribose and the activator quercetin | 分子名称: | 1,2-ETHANEDIOL, 3,5,7,3',4'-PENTAHYDROXYFLAVONE, NAD-dependent protein deacetylase sirtuin-6, ... | 著者 | You, W, Steegborn, C. | 登録日 | 2018-12-27 | 公開日 | 2019-12-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives. Sci Rep, 9, 2019
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6QCE
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![BU of 6qce by Molmil](/molmil-images/mine/6qce) | |
6QCH
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![BU of 6qch by Molmil](/molmil-images/mine/6qch) | |
6XV6
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![BU of 6xv6 by Molmil](/molmil-images/mine/6xv6) | |
6XVG
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![BU of 6xvg by Molmil](/molmil-images/mine/6xvg) | |
6QCJ
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![BU of 6qcj by Molmil](/molmil-images/mine/6qcj) | Human Sirt6 in complex with ADP-ribose and the inhibitor catechin gallate | 分子名称: | (2R,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, 1,2-ETHANEDIOL, NAD-dependent protein deacetylase sirtuin-6, ... | 著者 | You, W, Steegborn, C. | 登録日 | 2018-12-28 | 公開日 | 2019-12-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives. Sci Rep, 9, 2019
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6ZU4
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![BU of 6zu4 by Molmil](/molmil-images/mine/6zu4) | Human Sirt6 13-308 in complex with ADP-ribose and the activator fluvastatin | 分子名称: | (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid, GLYCEROL, NAD-dependent protein deacetylase sirtuin-6, ... | 著者 | You, W, Steegborn, C. | 登録日 | 2020-07-21 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | Structural Basis for Activation of Human Sirtuin 6 by Fluvastatin. Acs Med.Chem.Lett., 11, 2020
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6XV1
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6XUY
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![BU of 6xuy by Molmil](/molmil-images/mine/6xuy) | |
8AK9
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![BU of 8ak9 by Molmil](/molmil-images/mine/8ak9) | |
8AK7
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![BU of 8ak7 by Molmil](/molmil-images/mine/8ak7) | |
8AKC
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![BU of 8akc by Molmil](/molmil-images/mine/8akc) | |
8AKA
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![BU of 8aka by Molmil](/molmil-images/mine/8aka) | |
8AK8
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![BU of 8ak8 by Molmil](/molmil-images/mine/8ak8) | |
8AKG
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9G7H
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![BU of 9g7h by Molmil](/molmil-images/mine/9g7h) | Human Sirt6 in complex with ADP-ribose and the inhibitor 2-Pr | 分子名称: | 2,4-bis(oxidanylidene)-1-[2-oxidanylidene-2-[[(2S)-3-oxidanylidene-3-(propylamino)-2-[3-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)propanoylamino]propyl]amino]ethyl]pyrimidine-5-carboxamide, NAD-dependent protein deacetylase sirtuin-6, SULFATE ION, ... | 著者 | You, W, Steegborn, C. | 登録日 | 2024-07-21 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Elucidating the Unconventional Binding Mode of a DNA-Encoded Library Hit Provides a Blueprint for Sirtuin 6 Inhibitor Development. Chemmedchem, 2024
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8AK5
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8AKB
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8AKF
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8AKD
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![BU of 8akd by Molmil](/molmil-images/mine/8akd) | |
8AK6
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![BU of 8ak6 by Molmil](/molmil-images/mine/8ak6) | |