8AK9

Human Sirt6 in complex with ADP-ribose and fragment Isatin

Summary for 8AK9

Entry DOI	10.2210/pdb8ak9/pdb
Descriptor	NAD-dependent protein deacetylase sirtuin-6, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ZINC ION, ... (10 entities in total)
Functional Keywords	deacylase, fragment, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	70405.13
Authors	You, W.,Steegborn, C. (deposition date: 2022-07-29, release date: 2023-08-16)
Primary citation	You, W.,Steegborn, C. Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen To Be Published,
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation