5Y3R
| Cryo-EM structure of Human DNA-PK Holoenzyme | Descriptor: | DNA (34-MER), DNA (36-MER), DNA-dependent protein kinase catalytic subunit, ... | Authors: | Yin, X, Liu, M, Tian, Y, Wang, J, Xu, Y. | Deposit date: | 2017-07-29 | Release date: | 2017-09-06 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (6.6 Å) | Cite: | Cryo-EM structure of human DNA-PK holoenzyme Cell Res., 27, 2017
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6KL9
| Structure of LbCas12a-crRNA complex bound to AcrVA4 (form A complex) | Descriptor: | AcrVA4, LbCas12a, MAGNESIUM ION, ... | Authors: | Peng, R, Li, Z, Xu, Y, He, S, Peng, Q, Shi, Y, Gao, G.F. | Deposit date: | 2019-07-30 | Release date: | 2019-09-11 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Structural insight into multistage inhibition of CRISPR-Cas12a by AcrVA4. Proc.Natl.Acad.Sci.USA, 116, 2019
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6KLB
| Structure of LbCas12a-crRNA complex bound to AcrVA4 (form B complex) | Descriptor: | AcrVA4, LbCas12a, MAGNESIUM ION, ... | Authors: | Peng, R, Li, Z, Xu, Y, He, S, Peng, Q, Shi, Y, Gao, G.F. | Deposit date: | 2019-07-30 | Release date: | 2019-09-11 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural insight into multistage inhibition of CRISPR-Cas12a by AcrVA4. Proc.Natl.Acad.Sci.USA, 116, 2019
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4Y07
| Crystal structure of the HECT domain of human WWP2 | Descriptor: | NEDD4-like E3 ubiquitin-protein ligase WWP2 | Authors: | Gong, W, Li, J, Li, Z, Xu, Y. | Deposit date: | 2015-02-05 | Release date: | 2015-11-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.507 Å) | Cite: | Structure of the HECT domain of human WWP2 Acta Crystallogr.,Sect.F, 71, 2015
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5Y9Q
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5YA5
| CRYSTAL STRUCTURE OF c-MET IN COMPLEX WITH NOVEL INHIBITOR | Descriptor: | 2-[3-(4-methoxybenzyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]-1H-indole, Hepatocyte growth factor receptor | Authors: | Liu, Q, Xu, Y. | Deposit date: | 2017-08-30 | Release date: | 2018-07-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Discovery, optimization and biological evaluation for novel c-Met kinase inhibitors Eur J Med Chem, 143, 2018
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5YXC
| Crystal structure of Zinc binding protein ZinT in complex with citrate from E. coli | Descriptor: | CITRIC ACID, Metal-binding protein ZinT, ZINC ION | Authors: | Chen, J, Wang, L, Shang, F, Xu, Y. | Deposit date: | 2017-12-04 | Release date: | 2017-12-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.763 Å) | Cite: | Crystal structure of E. coli ZinT with one zinc-binding mode and complexed with citrate Biochem. Biophys. Res. Commun., 500, 2018
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5ZN8
| Crystal structure of nicotinamidase PncA from Bacillus subtilis | Descriptor: | Isochorismatase, ZINC ION | Authors: | Shang, F, Chen, J, Wang, L, Xu, Y. | Deposit date: | 2018-04-08 | Release date: | 2018-04-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the nicotinamidase/pyrazinamidase PncA from Bacillus subtilis. Biochem.Biophys.Res.Commun., 503, 2018
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5ZZO
| Crystal structure of CcpE regulatory domain in complex with citrate from Staphyloccocus aureus | Descriptor: | CITRATE ANION, LysR family transcriptional regulator | Authors: | Chen, J, Wang, L, Shang, F, Xu, Y. | Deposit date: | 2018-06-04 | Release date: | 2018-06-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and Biochemical Analysis of the Citrate-Responsive Mechanism of the Regulatory Domain of Catabolite Control Protein E from Staphylococcus aureus Biochemistry, 57, 2018
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6A8L
| Crystal structure of nicotinamidase/ pyrazinamidase PncA from Bacillus subtilis | Descriptor: | Isochorismatase, ZINC ION | Authors: | Shang, F, Chen, J, Wang, L, Xu, Y. | Deposit date: | 2018-07-09 | Release date: | 2018-08-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the nicotinamidase/pyrazinamidase PncA from Bacillus subtilis. Biochem. Biophys. Res. Commun., 503, 2018
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6K28
| Crystal structure of the 5-(Hydroxyethyl)-methylthiazole Kinase ThiM from Klebsiella pneumonia in complex with TZE | Descriptor: | 2-(4-METHYL-THIAZOL-5-YL)-ETHANOL, Hydroxyethylthiazole kinase, MAGNESIUM ION | Authors: | Chen, Y, Wang, L, Shang, F, Lan, J, Liu, W, Xu, Y. | Deposit date: | 2019-05-13 | Release date: | 2019-07-10 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.002 Å) | Cite: | Structural insight of the 5-(Hydroxyethyl)-methylthiazole kinase ThiM involving vitamin B1 biosynthetic pathway from the Klebsiella pneumoniae. Biochem.Biophys.Res.Commun., 518, 2019
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6JYY
| Crystal structure of the 5-(Hydroxyethyl)-methylthiazole Kinase ThiM from Klebsiella pneumonia | Descriptor: | Hydroxyethylthiazole kinase | Authors: | Chen, Y, Wang, L, Shang, F, Lan, J, Liu, W, Xu, Y. | Deposit date: | 2019-04-29 | Release date: | 2019-06-26 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural insight of the 5-(Hydroxyethyl)-methylthiazole kinase ThiM involving vitamin B1 biosynthetic pathway from the Klebsiella pneumoniae. Biochem.Biophys.Res.Commun., 518, 2019
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6K63
| The crystal structure of cytidine deaminase from Klebsiella pneumoniae | Descriptor: | 1,4-DIETHYLENE DIOXIDE, Cytidine deaminase, ZINC ION | Authors: | Liu, W, Shang, F, Lan, J, Chen, Y, Wang, L, Xu, Y. | Deposit date: | 2019-06-01 | Release date: | 2019-07-31 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.073 Å) | Cite: | Biochemical and structural analysis of the Klebsiella pneumoniae cytidine deaminase CDA. Biochem.Biophys.Res.Commun., 519, 2019
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6K2Q
| Aeromonas hydrophila MtaN-2 complexed with adenine | Descriptor: | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, ADENINE | Authors: | Chen, J, Liu, W, Wang, L, Shang, F, Lan, J, Chen, Y, Xu, Y. | Deposit date: | 2019-05-15 | Release date: | 2019-05-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of Aeromonas hydrophila Cytoplasmic 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase. Biochemistry, 58, 2019
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6KUA
| Crystal structure of the nicotinamidase SaPncA from Staphylococcus aureus | Descriptor: | Cysteine hydrolase, ZINC ION | Authors: | Shang, F, Lan, J, Liu, W, Xu, Y, Chen, Y. | Deposit date: | 2019-08-31 | Release date: | 2019-10-02 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.104 Å) | Cite: | Crystal structure of the nicotinamidase SaPncA from Staphylococcus aureus To Be Published
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8HFW
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6KZW
| Crystal structure of YggS family pyridoxal phosphate-dependent enzyme PipY from Fusobacterium nucleatum | Descriptor: | PHOSPHATE ION, Pyridoxal phosphate homeostasis protein | Authors: | Chen, Y, Wang, L, Shang, F, Lan, J, Liu, W, Xu, Y. | Deposit date: | 2019-09-25 | Release date: | 2019-10-16 | Last modified: | 2021-01-13 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Crystal structure of YggS family pyridoxal phosphate-dependent enzyme PipY from Fusobacterium nucleatum To Be Published
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6L3E
| Crystal structure of Salmonella enterica sugar-binding protein MalE | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ... | Authors: | Wang, L, Chen, Y, Liu, W, Lan, J, Shang, F, Xu, Y. | Deposit date: | 2019-10-10 | Release date: | 2019-10-23 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The crystal structure of Salmonella enterica sugar-binding protein MalE To Be Published
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4I11
| Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates. | Descriptor: | Beta-secretase 1, N-(3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)-L-phenylalanine, ZINC ION | Authors: | Bowers, B, Xu, Y, Yuan, S, Probst, G.D, Hom, R.K, Chan, W, Konradi, A.W, Sham, H.L, Zhu, Y.L, Beroza, P, Pan, H, Brecht, E, Yao, N, Lougheed, J, Artis, D.R, Tam, D, Bova, M. | Deposit date: | 2012-11-19 | Release date: | 2013-03-06 | Last modified: | 2013-04-24 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates. Bioorg.Med.Chem.Lett., 23, 2013
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7EGB
| TFIID-based holo PIC on SCP promoter | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | Authors: | Chen, X, Wu, Z, Hou, H, Qi, Y, Wang, X, Li, J, Xu, Y. | Deposit date: | 2021-03-24 | Release date: | 2021-05-05 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural insights into preinitiation complex assembly on core promoters. Science, 372, 2021
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6L0Z
| The crystal structure of Salmonella enterica sugar-binding protein MalE | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,5-anhydro-D-glucitol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | Authors: | Wang, L, Chen, Y, Liu, W, Lan, J, Shang, F, Xu, Y. | Deposit date: | 2019-09-27 | Release date: | 2019-10-16 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The crystal structure of Salmonella enterica sugar-binding protein MalE To Be Published
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6L1K
| Crystal structure of NADH-dependent butanol dehydrogenase A from Fusobacterium nucleatum | Descriptor: | NADH-dependent butanol dehydrogenase A, PHOSPHATE ION | Authors: | Lan, J, Shang, F, Liu, W, Xu, Y, Chen, Y. | Deposit date: | 2019-09-29 | Release date: | 2019-10-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Crystal structure of NADH-dependent butanol dehydrogenase A from Fusobacterium nucleatum To Be Published
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6L19
| The crystal structure of competence or damage-inducible protein from Enterobacter asburiae | Descriptor: | CHLORIDE ION, GLYCEROL, PncC family amidohydrolase, ... | Authors: | Wang, L, Chen, Y, Liu, W, Lan, J, Shang, F, Xu, Y. | Deposit date: | 2019-09-28 | Release date: | 2019-10-16 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | The crystal structure of Competence or damage-inducible protein from Enterobacter asburiae To Be Published
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6LTH
| Structure of human BAF Base module | Descriptor: | AT-rich interactive domain-containing protein 1A, SWI/SNF complex subunit SMARCC2, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, ... | Authors: | He, S, Wu, Z, Tian, Y, Yu, Z, Yu, J, Wang, X, Li, J, Liu, B, Xu, Y. | Deposit date: | 2020-01-22 | Release date: | 2020-02-12 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure of nucleosome-bound human BAF complex. Science, 367, 2020
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6LTJ
| Structure of nucleosome-bound human BAF complex | Descriptor: | AT-rich interactive domain-containing protein 1A, Actin, cytoplasmic 1, ... | Authors: | He, S, Wu, Z, Tian, Y, Yu, Z, Yu, J, Wang, X, Li, J, Liu, B, Xu, Y. | Deposit date: | 2020-01-22 | Release date: | 2020-02-12 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structure of nucleosome-bound human BAF complex. Science, 367, 2020
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