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PDB: 48 件
1HKA
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6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
分子名称: 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
著者Xiao, B, Shi, G, Chen, X, Yan, H, Ji, X.
登録日1998-09-29
公開日1999-06-08
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, a potential target for the development of novel antimicrobial agents.
Structure Fold.Des., 7, 1999
1EQM
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CRYSTAL STRUCTURE OF BINARY COMPLEX OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE WITH ADENOSINE-5'-DIPHOSPHATE
分子名称: 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Xiao, B, Blaszczyk, J, Ji, X.
登録日2000-04-05
公開日2001-04-05
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Unusual conformational changes in 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase as revealed by X-ray crystallography and NMR.
J.Biol.Chem., 276, 2001
1B48
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CRYSTAL STRUCTURE OF MGSTA4-4 IN COMPLEX WITH GSH CONJUGATE OF 4-HYDROXYNONENAL IN ONE SUBUNIT AND GSH IN THE OTHER: EVIDENCE OF SIGNALING ACROSS DIMER INTERFACE IN MGSTA4-4
分子名称: 4-S-GLUTATHIONYL-5-PENTYL-TETRAHYDRO-FURAN-2-OL, GLUTATHIONE, PROTEIN (GLUTATHIONE S-TRANSFERASE)
著者Xiao, B, Zimniak, P, Ji, X.
登録日1999-01-06
公開日1999-09-29
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of a murine glutathione S-transferase in complex with a glutathione conjugate of 4-hydroxynon-2-enal in one subunit and glutathione in the other: evidence of signaling across the dimer interface.
Biochemistry, 38, 1999
4CFH
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Structure of an active form of mammalian AMPK
分子名称: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
著者Xiao, B, Sanders, M.J, Underwood, E, Heath, R, Mayer, F, Carmena, D, Jing, C, Walker, P.A, Eccleston, J.F, Haire, L.F, Saiu, P, Howell, S.A, Aasland, R, Martin, S.R, Carling, D, Gamblin, S.J.
登録日2013-11-18
公開日2013-12-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.24 Å)
主引用文献Structure of Mammalian Ampk and its Regulation by Adp
Nature, 472, 2011
1IZB
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ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN
分子名称: INSULIN, ZINC ION
著者Xiao, B, Dodson, G.G.
登録日1992-10-16
公開日1993-10-31
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Role of B13 Glu in insulin assembly. The hexamer structure of recombinant mutant (B13 Glu-->Gln) insulin.
J.Mol.Biol., 228, 1992
1IZA
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ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN
分子名称: INSULIN
著者Xiao, B, Dodson, G.G.
登録日1992-10-16
公開日1993-10-31
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Role of B13 Glu in insulin assembly. The hexamer structure of recombinant mutant (B13 Glu-->Gln) insulin.
J.Mol.Biol., 228, 1992
2Y8Q
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Structure of the regulatory fragment of mammalian AMPK in complex with one ADP
分子名称: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
著者Xiao, B, Sanders, M.J, Underwood, E, Heath, R, Mayer, F, Carmena, D, Jing, C, Walker, P.A, Eccleston, J.F, Haire, L.F, Saiu, P, Howell, S.A, Aasland, R, Martin, S.R, Carling, D, Gamblin, S.J.
登録日2011-02-09
公開日2011-03-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure of Mammalian Ampk and its Regulation by Adp
Nature, 472, 2011
2Y8L
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Structure of the regulatory fragment of mammalian aMPK in complex with two ADP
分子名称: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
著者Xiao, B, Sanders, M.J, Underwood, E, Heath, R, Mayer, F, Carmena, D, Jing, C, Walker, P.A, Eccleston, J.F, Haire, L.F, Saiu, P, Howell, S.A, Aasland, R, Martin, S.R, Carling, D, Gamblin, S.J.
登録日2011-02-07
公開日2011-03-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of Mammalian Ampk and its Regulation by Adp
Nature, 472, 2011
2YA3
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STRUCTURE OF THE REGULATORY FRAGMENT OF MAMMALIAN AMPK IN COMPLEX WITH COUMARIN ADP
分子名称: 3'-(7-diethylaminocoumarin-3-carbonylamino)-3'-deoxy-ADP, 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, ...
著者Xiao, B, Sanders, M.J, Underwood, E, Heath, R, Mayer, F, Carmena, D, Jing, C, Walker, P.A, Eccleston, J.F, Haire, L.F, Saiu, P, Howell, S.A, Aasland, R, Martin, S.R, Carling, D, Gamblin, S.J.
登録日2011-02-17
公開日2011-03-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Structure of Mammalian Ampk and its Regulation by Adp
Nature, 472, 2011
2BQZ
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Crystal structure of a ternary complex of the human histone methyltransferase Pr-SET7 (also known as SET8)
分子名称: HISTONE H4, S-ADENOSYL-L-HOMOCYSTEINE, SET8 PROTEIN
著者Xiao, B, Jing, C, Kelly, G, Walker, P.A, Muskett, F.W, Frenkiel, T.A, Martin, S.R, Sarma, K, Reinberg, D, Gamblin, S.J, Wilson, J.R.
登録日2005-04-28
公開日2005-06-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Specificity and Mechanism of the Histone Methyltransferase Pr-Set7
Genes Dev., 19, 2005
4CFF
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Structure of full length human AMPK in complex with a small molecule activator, a thienopyridone derivative (A-769662)
分子名称: 3-[4-(2-hydroxyphenyl)phenyl]-4-oxidanyl-6-oxidanylidene-7H-thieno[2,3-b]pyridine-5-carbonitrile, 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1, ...
著者Xiao, B, Sanders, M.J, Carmena, D, Bright, N.J, Haire, L.F, Underwood, E, Patel, B.R, Heath, R.B, Walker, P.A, Hallen, S, Giordanetto, F, Martin, S.R, Carling, D, Gamblin, S.J.
登録日2013-11-14
公開日2013-12-25
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (3.924 Å)
主引用文献Structural Basis of Ampk Regulation by Small Molecule Activators.
Nat.Commun., 4, 2013
4CFE
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Structure of full length human AMPK in complex with a small molecule activator, a benzimidazole derivative (991)
分子名称: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
著者Xiao, B, Sanders, M.J, Carmena, D, Bright, N.J, Haire, L.F, Underwood, E, Patel, B.R, Heath, R.B, Walker, P.A, Hallen, S, Giordanetto, F, Martin, S.R, Carling, D, Gamblin, S.J.
登録日2013-11-14
公開日2013-12-25
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3.023 Å)
主引用文献Structural Basis of Ampk Regulation by Small Molecule Activators.
Nat.Commun., 4, 2013
1O9K
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Crystal structure of the retinoblastoma tumour suppressor protein bound to E2F peptide
分子名称: RETINOBLASTOMA-ASSOCIATED PROTEIN, TRANSCRIPTION FACTOR E2F1
著者Xiao, B, Spencer, J, Clements, A, Ali-Khan, N, Mittnacht, S, Broceno, C, Burghammer, M, Perrakis, A, Marmorstein, R, Gamblin, S.J.
登録日2002-12-16
公開日2003-03-06
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structure of the Retinoblastoma Tumor Suppressor Protein Bound to E2F and the Molecular Basis of its Regulation
Proc.Natl.Acad.Sci.USA, 100, 2003
1O9S
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Crystal structure of a ternary complex of the human histone methyltransferase SET7/9
分子名称: GENE FRAGMENT FOR HISTONE H3, HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-4 SPECIFIC, ...
著者Xiao, B, Jing, C, Wilson, J.R, Walker, P.A, Vasisht, N, Kelly, G, Howell, S, Taylor, I.A, Blackburn, G.M, Gamblin, S.J.
登録日2002-12-18
公開日2003-02-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure and Catalytic Mechanism of the Human Histone Methyltransferase Set7/9
Nature, 421, 2003
5IQP
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14-3-3 PROTEIN TAU ISOFORM
分子名称: 14-3-3 protein theta, SULFATE ION
著者Xiao, B, Smerdon, S.J, Gamblin, S.J.
登録日2016-03-11
公開日2016-03-23
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.602 Å)
主引用文献Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways
Nature, 376, 1995
5ISO
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STRUCTURE OF FULL LENGTH HUMAN AMPK (NON-PHOSPHORYLATED AT T-LOOP) IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR, A BENZIMIDAZOLE DERIVATIVE (991)
分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
著者Xiao, B, Hubbard, J.A, Gamblin, S.J.
登録日2016-03-15
公開日2017-03-29
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献STRUCTURE OF FULL LENGTH HUMAN AMPK (NON-PHOSPHORYLATED AT T-LOOP) IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR, A BENZIMIDAZOLE DERIVATIVE (991)
To Be Published
2V9J
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Crystal structure of the regulatory fragment of mammalian AMPK in complexes with Mg.ATP-AMP
分子名称: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
著者Xiao, B, Heath, R, Saiu, P, Leiper, F.C, Leone, P, Jing, C, Walker, P.A, Haire, L, Eccleston, J.F, Davis, C.T, Martin, S.R, Carling, D, Gamblin, S.J.
登録日2007-08-23
公開日2007-09-25
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Structural Basis for AMP Binding to Mammalian AMP-Activated Protein Kinase
Nature, 449, 2007
2V92
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Crystal structure of the regulatory fragment of mammalian AMPK in complexes with ATP-AMP
分子名称: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
著者Xiao, B, Heath, R, Saiu, P, Leiper, F.C, Leone, P, Jing, C, Walker, P.A, Haire, L, Eccleston, J.F, Davis, C.T, Martin, S.R, Carling, D, Gamblin, S.J.
登録日2007-08-20
公開日2007-09-25
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural Basis for AMP Binding to Mammalian AMP-Activated Protein Kinase
Nature, 449, 2007
2V8Q
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Crystal structure of the regulatory fragment of mammalian AMPK in complexes with AMP
分子名称: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
著者Xiao, B, Heath, R, Saiu, P, Leiper, F.C, Leone, P, Jing, C, Walker, P.A, Haire, L, Eccleston, J.F, Davis, C.T, Martin, S.R, Carling, D, Gamblin, S.J.
登録日2007-08-13
公開日2007-09-25
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Basis for AMP Binding to Mammalian AMP-Activated Protein Kinase
Nature, 449, 2007
6LQI
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Cryo-EM structure of the mouse Piezo1 isoform Piezo1.1
分子名称: Piezo-type mechanosensitive ion channel component 1
著者Geng, J, Liu, W, Zhou, H, Zhang, T, Wang, L, Zhang, M, Shen, B, Li, X, Xiao, B.
登録日2020-01-13
公開日2020-03-04
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel.
Neuron, 106, 2020
1DDW
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HOMER EVH1 DOMAIN UNLIGANDED
分子名称: GLGF-DOMAIN PROTEIN HOMER
著者Beneken, J, Tu, J.C, Xiao, B, Worley, P.F, Leahy, D.J.
登録日1999-11-11
公開日2000-05-10
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition.
Neuron, 26, 2000
1DDV
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CRYSTAL STRUCTURE OF THE HOMER EVH1 DOMAIN WITH BOUND MGLUR PEPTIDE
分子名称: GLGF-DOMAIN PROTEIN HOMER, METABOTROPIC GLUTAMATE RECEPTOR MGLUR5
著者Beneken, J, Tu, J.C, Xiao, B, Worley, P.F, Leahy, D.J.
登録日1999-11-11
公開日2000-05-10
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition.
Neuron, 26, 2000
3PGT
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CRYSTAL STRUCTURE OF HGSTP1-1[I104] COMPLEXED WITH THE GSH CONJUGATE OF (+)-ANTI-BPDE
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-4-[1-(CARBOXYMETHYL-CARBAMOYL)-2-(9-HYDROXY-7,8-DIOXO-7,8,9,10-TETRAHYDRO-BENZO[DEF]CHRYSEN-10-YLSULFANYL)-ETHYLCARBAMOYL]-BUTYRIC ACID, PROTEIN (GLUTATHIONE S-TRANSFERASE), ...
著者Ji, X, Xiao, B.
登録日1999-03-22
公開日1999-09-01
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Structure and function of residue 104 and water molecules in the xenobiotic substrate-binding site in human glutathione S-transferase P1-1.
Biochemistry, 38, 1999
1H3I
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Crystal structure of the Histone Methyltransferase SET7/9
分子名称: HISTONE H3 LYSINE 4 SPECIFIC METHYLTRANSFERASE, MAGNESIUM ION
著者Wilson, J.R, Jing, C, Walker, P.A, Martin, S.R, Howell, S.A, Blackburn, G.M, Gamblin, S.J, Xiao, B.
登録日2002-09-04
公開日2002-11-11
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structure and Functional Analysis of the Histone Methyltransferase Set7/9
Cell(Cambridge,Mass.), 111, 2002
3JAC
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Cryo-EM study of a channel
分子名称: Piezo-type mechanosensitive ion channel component 1
著者Ge, J, Li, W, Zhao, Q, Li, N, Xiao, B, Gao, N, Yang, M.
登録日2015-06-05
公開日2015-09-23
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (4.8 Å)
主引用文献Architecture of the mammalian mechanosensitive Piezo1 channel
Nature, 527, 2015

 

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