8KBJ
 
 | | Structure of HgmTad2 complexed with 1',2'-cADPR | | Descriptor: | (1S,3R,4R,6R,9S,11R,14R,15S,16R,18R)-4-(6-amino-9H-purin-9-yl)-9,11,15,16,18-pentahydroxy-2,5,8,10,12,17-hexaoxa-9lambda~5~,11lambda~5~-diphosphatricyclo[12.2.1.1~3,6~]octadecane-9,11-dione, Inhibitor of Type II CRISPR-Cas system | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-21 | | Last modified: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure of HgmTad2 complexed with 1',2'-cADPR
To Be Published
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8KBG
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8KBC
 | | Structure of CmTad1 complexed with cAAA | | Descriptor: | (2-ACETYL-5-METHYLANILINO)(2,6-DIBROMOPHENYL)ACETAMIDE, Thoeris anti-defense 1, ZINC ION | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of CmTad1 complexed with cAAA
To Be Published
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8KBM
 | | Structure of AcrIIA7 complexed with cGG | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Inhibitor of Type II CRISPR-Cas system | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-07 | | Method: | X-RAY DIFFRACTION (1.38 Å) | | Cite: | Structure of AcrIIA7 complexed with cGG
To Be Published
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8KBH
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7SWF
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7SWQ
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7SVA
 | | Cryo-EM structure of Arabidopsis Ago10-guide RNA complex | | Descriptor: | MAGNESIUM ION, Protein argonaute 10, RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3') | | Authors: | Xiao, Y, MacRae, I.J. | | Deposit date: | 2021-11-18 | | Release date: | 2022-11-23 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.26 Å) | | Cite: | Structural basis for RNA slicing by a plant Argonaute.
Nat.Struct.Mol.Biol., 30, 2023
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5XVN
 | | E. far Cas1-Cas2/prespacer binary complex | | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ... | | Authors: | Xiao, Y, Ng, S, Nam, K.H, Ke, A. | | Deposit date: | 2017-06-28 | | Release date: | 2017-10-04 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (3.25 Å) | | Cite: | How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration.
Nature, 550, 2017
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5XVP
 | | E. fae Cas1-Cas2/prespacer/target ternary complex revealing the fully integrated states | | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (5'-D(P*TP*TP*CP*TP*CP*CP*GP*AP*G)-3'), ... | | Authors: | Xiao, Y, Ng, S, Nam, K.H, Ke, A. | | Deposit date: | 2017-06-28 | | Release date: | 2017-10-04 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration.
Nature, 550, 2017
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5XVO
 | | E. fae Cas1-Cas2/prespacer/target ternary complex revealing DNA sampling and half-integration states | | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ... | | Authors: | Xiao, Y, Ng, S, Nam, K.H, Ke, A. | | Deposit date: | 2017-06-28 | | Release date: | 2017-10-04 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration.
Nature, 550, 2017
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2AMN
 | | Solution structure of Fowlicidin-1, a novel Cathelicidin antimicrobial peptide from chicken | | Descriptor: | cathelicidin | | Authors: | Xiao, Y, Dai, H, Bommineni, Y.R, Prakash, O, Zhang, G. | | Deposit date: | 2005-08-09 | | Release date: | 2006-07-18 | | Last modified: | 2024-05-08 | | Method: | SOLUTION NMR | | Cite: | Structure-activity relationships of fowlicidin-1, a cathelicidin antimicrobial peptide in chicken.
Febs J., 273, 2006
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3QC7
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3R02
 | | The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors | | Descriptor: | 7-[(cis-4-aminocyclohexyl)amino]-5-bromo-1-benzofuran-2-carboxylic acid, IMIDAZOLE, Proto-oncogene serine/threonine-protein kinase pim-1 | | Authors: | Xiang, Y, Hirth, B, Asmussen, G, Biemann, H.-P, Good, A, Fitzgerald, M, Gladysheva, T, Jancsics, K, Liu, J, Metz, M, Papoulis, A, Skerlj, R, Stepp, D.J, Wei, R.R. | | Deposit date: | 2011-03-07 | | Release date: | 2011-05-11 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
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3SUC
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3UB0
 | | Crystal structure of the nonstructural protein 7 and 8 complex of Feline Coronavirus | | Descriptor: | Non-structural protein 6, nsp6,, Non-structural protein 7, ... | | Authors: | Xiao, Y, Hilgenfeld, R, Ma, Q. | | Deposit date: | 2011-10-22 | | Release date: | 2012-02-22 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Nonstructural proteins 7 and 8 of feline coronavirus form a 2:1 heterotrimer that exhibits primer-independent RNA polymerase activity.
J.Virol., 86, 2012
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3R04
 | | The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors | | Descriptor: | 5-{6-[(trans-4-aminocyclohexyl)amino]pyrazin-2-yl}-1-benzofuran-2-carboxylic acid, IMIDAZOLE, Proto-oncogene serine/threonine-protein kinase pim-1 | | Authors: | Xiang, Y, Hirth, B, Asmussen, G, Biemann, H.-P, Good, A, Fitzgerald, M, Gladysheva, T, Jancsics, K, Liu, J, Metz, M, Papoulis, A, Skerlj, R, Stepp, D.J, Wei, R.R. | | Deposit date: | 2011-03-07 | | Release date: | 2011-05-11 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
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3CSZ
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3CT5
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3CSR
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3CT1
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8WJD
 | | Structure of SptTad2 complexed with cGG | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), SptTad2 | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-09-25 | | Release date: | 2024-09-25 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | Structure of SptTad2 complexed with cGG
To Be Published
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8WJE
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8WJC
 | | Structure of AcrIIA7 complexed with 3'3'-cGAMP | | Descriptor: | 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, Inhibitor of Type II CRISPR-Cas system | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-09-25 | | Release date: | 2024-09-25 | | Method: | X-RAY DIFFRACTION (2.11 Å) | | Cite: | Structure of AcrIIA7 complexed with 3'3'-cGAMP
To Be Published
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7WNV
 | | Crystal structure of mutant estrogen receptor alpha Y537S in complex with CO9 | | Descriptor: | (~{Z})-4-[2-[4-[[2-(4-hydroxyphenyl)-6-oxidanyl-1-benzothiophen-3-yl]oxy]phenoxy]ethylamino]-~{N},~{N}-dimethyl-but-2-enamide, Estrogen receptor | | Authors: | Xiao, Y, Lv, Y. | | Deposit date: | 2022-01-19 | | Release date: | 2023-01-25 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | X-ray crystallography study and optimization of novel benzothiophene analogs as potent selective estrogen receptor covalent antagonists (SERCAs) with improved potency and safety profiles.
Bioorg.Chem., 141, 2023
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