5V9J
| Crystal structure of catalytic domain of GLP with MS0105 | 分子名称: | CHLORIDE ION, DIMETHYL SULFOXIDE, Histone-lysine N-methyltransferase EHMT1, ... | 著者 | Dong, A, Zeng, H, Liu, J, Xiong, Y, Babault, N, Jin, J, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Wu, H, Brown, P.J, Structural Genomics Consortium (SGC) | 登録日 | 2017-03-23 | 公開日 | 2018-03-21 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Crystal structure of catalytic domain of GLP with MS0105 to be published
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6BRG
| The SAM domain of mouse SAMHD1 is critical for its activation and regulation | 分子名称: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, MAGNESIUM ION | 著者 | Buzovetsky, O, Tang, C, Knecht, K.M, Antonucci, J.M, Wu, L, Ji, X, Xiong, Y. | 登録日 | 2017-11-30 | 公開日 | 2018-02-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | The SAM domain of mouse SAMHD1 is critical for its activation and regulation. Nat Commun, 9, 2018
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6CM2
| SAMHD1 HD domain bound to decitabine triphosphate | 分子名称: | 6-amino-3-{2-deoxy-5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-erythro-pentofuranosyl}-3,4-dihydro-1,3,5-triazin-2(1H)-one, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Oellerich, T, Schneider, C, Thomas, D, Knecht, K.M, Buzovetsky, O, Kaderali, L, Schliemann, C, Bohnenberger, H, Angenendt, L, Hartmann, W, Wardelmann, E, Rothenburger, T, Mohr, S, Scheich, S, Comoglio, F, Wilke, A, Strobel, P, Serve, H, Michaelis, M, Ferreiros, N, Geisslinger, G, Xiong, Y, Keppler, O.T, Cinatl, J. | 登録日 | 2018-03-02 | 公開日 | 2019-06-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML. Nat Commun, 10, 2019
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7E58
| interferon-inducible anti-viral protein 2 | 分子名称: | Guanylate-binding protein 2 | 著者 | Cui, W, Wang, W, Chen, C, Slater, B, Xiong, Y, Ji, X.Y, Yang, H.T. | 登録日 | 2021-02-18 | 公開日 | 2021-05-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins. Proc.Natl.Acad.Sci.USA, 118, 2021
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7E59
| interferon-inducible anti-viral protein truncated | 分子名称: | Guanylate-binding protein 5 | 著者 | Cui, W, Wang, W, Chen, C, Slater, B, Xiong, Y, Ji, X.Y, Yang, H.T. | 登録日 | 2021-02-18 | 公開日 | 2021-05-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins. Proc.Natl.Acad.Sci.USA, 118, 2021
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7E5A
| interferon-inducible anti-viral protein R356A | 分子名称: | ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, Guanylate-binding protein 5, ... | 著者 | Cui, W, Wang, W, Chen, C, Slater, B, Xiong, Y, Ji, X.Y, Yang, H.T. | 登録日 | 2021-02-18 | 公開日 | 2021-05-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins. Proc.Natl.Acad.Sci.USA, 118, 2021
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7JQB
| SARS-CoV-2 Nsp1 and rabbit 40S ribosome complex | 分子名称: | 40S ribosomal protein S21, 40S ribosomal protein S24, 40S ribosomal protein S26, ... | 著者 | Yuan, S, Xiong, Y. | 登録日 | 2020-08-10 | 公開日 | 2020-12-02 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA. Mol.Cell, 80, 2020
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7JQC
| SARS-CoV-2 Nsp1, CrPV IRES and rabbit 40S ribosome complex | 分子名称: | 40S ribosomal protein S21, 40S ribosomal protein S24, 40S ribosomal protein S26, ... | 著者 | Yuan, S, Xiong, Y. | 登録日 | 2020-08-10 | 公開日 | 2020-12-02 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA. Mol.Cell, 80, 2020
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5V9I
| Crystal structure of catalytic domain of G9a with MS0105 | 分子名称: | GLYCEROL, Histone-lysine N-methyltransferase EHMT2, N~2~-cyclohexyl-N~4~-(1-ethylpiperidin-4-yl)-6,7-dimethoxy-N~2~-methylquinazoline-2,4-diamine, ... | 著者 | Dong, A, Zeng, H, Liu, J, Xiong, Y, Babault, N, Jin, J, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Wu, H, Brown, P.J, Structural Genomics Consortium (SGC) | 登録日 | 2017-03-23 | 公開日 | 2018-03-21 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Crystal structure of catalytic domain of G9a with MS0105 to be published
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6CIU
| Structure of a Thr-rich interface in an Azami Green tetramer | 分子名称: | Azami-Green | 著者 | Oi, C, Lim, C.S, Knecht, K.M, Xiong, Y, Regan, L. | 登録日 | 2018-02-25 | 公開日 | 2018-09-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | A threonine zipper that mediates protein-protein interactions: Structure and prediction. Protein Sci., 27, 2018
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6MQO
| Structure of HIV-1 CA G208R | 分子名称: | Capsid protein, IODIDE ION | 著者 | Smaga, S.S, Xiong, Y. | 登録日 | 2018-10-10 | 公開日 | 2019-06-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | MxB Restricts HIV-1 by Targeting the Tri-hexamer Interface of the Viral Capsid. Structure, 27, 2019
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6BRH
| The SAM domain of mouse SAMHD1 is critical for its activation and regulation | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, MAGNESIUM ION | 著者 | Buzovetsky, O, Tang, C, Knecht, K.M, Antonucci, J.M, Wu, L, Ji, X, Xiong, Y. | 登録日 | 2017-11-30 | 公開日 | 2018-02-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | The SAM domain of mouse SAMHD1 is critical for its activation and regulation. Nat Commun, 9, 2018
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4ZWG
| Crystal structure of the GTP-dATP-bound catalytic core of SAMHD1 phosphomimetic T592E mutant | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Tang, C, Ji, X, Xiong, Y. | 登録日 | 2015-05-19 | 公開日 | 2015-09-02 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Impaired dNTPase Activity of SAMHD1 by Phosphomimetic Mutation of Thr-592. J.Biol.Chem., 290, 2015
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4ZWE
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6MQA
| Structure of HIV-1 CA P207S | 分子名称: | CHLORIDE ION, Capsid protein, IODIDE ION | 著者 | Smaga, S.S, Xiong, Y. | 登録日 | 2018-10-09 | 公開日 | 2019-06-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.199 Å) | 主引用文献 | MxB Restricts HIV-1 by Targeting the Tri-hexamer Interface of the Viral Capsid. Structure, 27, 2019
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6MQP
| Structure of HIV-1 CA T210K | 分子名称: | CHLORIDE ION, Capsid protein, IODIDE ION | 著者 | Smaga, S.S, Xiong, Y. | 登録日 | 2018-10-10 | 公開日 | 2019-06-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.296 Å) | 主引用文献 | MxB Restricts HIV-1 by Targeting the Tri-hexamer Interface of the Viral Capsid. Structure, 27, 2019
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1LNT
| Crystal Structure of the Highly Conserved RNA Internal Loop of SRP | 分子名称: | 5'-R(*CP*GP*GP*AP*AP*GP*CP*AP*GP*(CBV)P*GP*C)-3', 5'-R(*GP*CP*GP*UP*CP*AP*GP*GP*UP*CP*(CBV)P*G)-3', CALCIUM ION, ... | 著者 | Deng, J, Xiong, Y, Pan, B, Sundaralingam, M. | 登録日 | 2002-05-03 | 公開日 | 2003-06-03 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure of an RNA dodecamer containing a fragment from SRP domain IV of Escherichia coli. Acta Crystallogr.,Sect.D, 59, 2003
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1NA0
| Design of Stable alpha-Helical Arrays from an Idealized TPR Motif | 分子名称: | 1-methylethyl 1-thio-beta-D-galactopyranoside, ACETATE ION, CHLORIDE ION, ... | 著者 | Main, E, Xiong, Y, Cocco, M, D'Andrea, L, Regan, L. | 登録日 | 2002-11-26 | 公開日 | 2003-06-03 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Design of Stable alpha-Helical Arrays from an Idealized TPR Motif Structure, 11, 2003
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3OVA
| How the CCA-adding Enzyme Selects Adenine over Cytosine in Position 76 of tRNA | 分子名称: | 1,2-ETHANEDIOL, CCA-adding enzyme, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... | 著者 | Pan, B.C, Xiong, Y, Steitz, T.A. | 登録日 | 2010-09-16 | 公開日 | 2010-12-01 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | How the CCA-Adding Enzyme Selects Adenine over Cytosine at Position 76 of tRNA. Science, 330, 2010
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1MIY
| Crystal structure of Bacillus stearothermophilus CCA-adding enzyme in complex with CTP | 分子名称: | CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, tRNA CCA-adding enzyme | 著者 | Li, F, Xiong, Y, Wang, J, Cho, H.D, Weiner, A.M, Steitz, T.A. | 登録日 | 2002-08-23 | 公開日 | 2002-12-13 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.52 Å) | 主引用文献 | Crystal structures of the Bacillus stearothermophilus CCA-adding enzyme and
its complexes with ATP or CTP Cell(Cambridge,Mass.), 111, 2002
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1MIV
| Crystal structure of Bacillus stearothermophilus CCA-adding enzyme | 分子名称: | MAGNESIUM ION, tRNA CCA-adding enzyme | 著者 | Li, F, Xiong, Y, Wang, J, Cho, H.D, Weiner, A.M, Steitz, T.A. | 登録日 | 2002-08-23 | 公開日 | 2002-12-13 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Crystal structures of the Bacillus stearothermophilus CCA-adding enzyme and
its complexes with ATP or CTP Cell(Cambridge,Mass.), 111, 2002
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1MIW
| Crystal structure of Bacillus stearothermophilus CCA-adding enzyme in complex with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, tRNA CCA-adding enzyme | 著者 | Li, F, Xiong, Y, Wang, J, Cho, H.D, Weiner, A.M, Steitz, T.A. | 登録日 | 2002-08-23 | 公開日 | 2002-12-13 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal structures of the Bacillus stearothermophilus CCA-adding enzyme and
its complexes with ATP or CTP Cell(Cambridge,Mass.), 111, 2002
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1NA3
| Design of Stable alpha-Helical Arrays from an Idealized TPR Motif | 分子名称: | 1-methylethyl 1-thio-beta-D-galactopyranoside, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION, ... | 著者 | Main, E, Xiong, Y, Cocco, M, D'Andrea, L, Regan, L. | 登録日 | 2002-11-26 | 公開日 | 2003-06-03 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Design of Stable alpha-Helical Arrays from an Idealized TPR Motif Structure, 11, 2003
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1U6G
| Crystal Structure of The Cand1-Cul1-Roc1 Complex | 分子名称: | Cullin homolog 1, RING-box protein 1, TIP120 protein, ... | 著者 | Goldenberg, S.J, Shumway, S.D, Cascio, T.C, Garbutt, K.C, Liu, J, Xiong, Y, Zheng, N. | 登録日 | 2004-07-29 | 公開日 | 2004-12-14 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases Cell(Cambridge,Mass.), 119, 2004
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5VSC
| Structure of human G9a SET-domain (EHMT2) in complex with inhibitor 13 | 分子名称: | 6,7-dimethoxy-N~2~-methyl-N~4~-(1-methylpiperidin-4-yl)-N~2~-propylquinazoline-2,4-diamine, Histone-lysine N-methyltransferase EHMT2, S-ADENOSYLMETHIONINE, ... | 著者 | Babault, N, Xiong, Y, Liu, J, Jin, J. | 登録日 | 2017-05-11 | 公開日 | 2017-07-12 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structure-activity relationship studies of G9a-like protein (GLP) inhibitors. Bioorg. Med. Chem., 25, 2017
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